Is there evidence for neurotoxicity in the prodromal and early stages of schizophrenia

Neuropsychopharmacology

Volumn 36, Issue 9, 2011, Pages 1779-1780

  Lahti, Adrienne C ^a   Reid, Meredith A ^a,b  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b and Radiation Oncology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMIC ACID; NEUROLEPTIC AGENT;

DISEASE ASSOCIATION; HUMAN; NEUROTOXICITY; NOTE; PRIORITY JOURNAL; SCHIZOPHRENIA;

CAUDATE NUCLEUS; DISEASE PROGRESSION; GLUTAMIC ACID; HUMANS; NEUROTOXINS; SCHIZOPHRENIA;

EID: 79960314511     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2011.83     Document Type: Note

References (9)

1. Agid O, Arenovich T, Sajeev G, Zipursky RB, Kapur S, Foussias G et al (2011). An algorithm-based approach to first-episode schizophrenia: response rates over 3 prospective antipsychotic trials with a retrospective data analysis. J Clin Psychiatry; e-pub ahead ofprint 8 March 2011 (PMID: 21457676).
2. Cahn W, van Haren NEM, Hulshoff Pol HE, Schnack HG, Caspers E, Laponder DAJ et al (2006). Brain volume changes in the first year of illness and 5-year outcome of schizophrenia. Br JPsychiatry 189: 381-382. (Pubitemid 44606754)
3. de la Fuente-Sandoval C, Leon-Ortiz P, Favila R, Stephano S, Mamo D, Ramirez-Bermudez J et al (2011). Higher levels of glutamate in the associative-striatum of subjects with prodromal symptoms of schizophrenia and patients with first-episode psychosis. Neuropsychopharmacology 36: 1781-1791.
4. Howes OD, Montgomery AJ, Asselin MC, Murray RM, Valli I, Tabraham P et al (2009). Elevated striatal dopamine function linked to prodromal signs of schizophrenia. Arch Gen Psychiatry 66: 13-20.
5. Licata SC, Renshaw PF (2010). Neurochemistry of drug action: insights from proton magnetic resonance spectroscopic imaging and their relevance to addiction. Ann N Y Acad Sci 1187: 148-171.
6. Pantelis C, Velakoulis D, Mc Gorry P, Wood S, Suckling J, Phillips L et al (2003). Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparison. Lancet 361: 281-288. (Pubitemid 36126187)
7. Reid MA, Stoeckel LE, White DM, Avsar KB, Bolding MS, Akella NS et al (2010). Assessments of function and biochemistry of the anterior cingulate cortex in schizophrenia. Biol Psychiatry 68: 625-633.
8. Sesack SR (2010). Functional implications of dopamine D2 receptor localization in relation to glutamate neurons. In: Iversen LL, Iversen SD, Dunnett SB, Bjorklund A (eds). Dopamine Handbook. Oxford University Press: New York. pp 22-37.
9. Yung AR, Yuen HP, Mc Gorry PD, Phillips LJ, Kelly D, Dell'Olio M et al (2005). Mapping the onset ofpsychosis: the Comprehensive Assessment of At-Risk Mental States. Aust N Z J Psychiatry 39: 964-971. (Pubitemid 43904432)