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Volumn 17, Issue 13, 2011, Pages 4208-4213

Adaptive changes result in activation of alternate signaling pathways and acquisition of resistance to aromatase inhibitors

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ANASTROZOLE; AROMATASE INHIBITOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR ALPHA; EVEROLIMUS; GROWTH FACTOR RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LAPATINIB; LETROZOLE; MITOGEN ACTIVATED PROTEIN KINASE; RAF PROTEIN; TAMOXIFEN; TRANSCRIPTION FACTOR AP 1; TRANSFORMING GROWTH FACTOR ALPHA; TRASTUZUMAB; UO 126; VASCULOTROPIN;

EID: 79960309783     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-10-2920     Document Type: Review
Times cited : (26)

References (61)
  • 4
    • 0037768569 scopus 로고    scopus 로고
    • Anastrozole as adjuvant therapy for early-stage breast cancer: Implications of the ATAC trial
    • Buzdar A. Anastrozole as adjuvant therapy for early-stage breast cancer: implications of the ATAC trial. Clin Breast Cancer 2003; 4[Suppl 1]:S42-8.
    • (2003) Clin Breast Cancer , vol.4 , Issue.SUPPL. 1
    • Buzdar, A.1
  • 5
    • 0037157603 scopus 로고    scopus 로고
    • Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: First results of the ATAC randomised trial
    • DOI 10.1016/S0140-6736(02)09088-8
    • Baum M, Budzar AU, Cuzick J, Forbes J, Houghton JH, Klijn JG, et al. Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: first results of the ATAC randomised trial. Lancet 2002;359:2131-9. (Pubitemid 34694019)
    • (2002) Lancet , vol.359 , Issue.9324 , pp. 2131-2139
    • Baum, M.1    Buzdar, A.U.2    Cuzick, J.3    Forbes, J.4    Houghton, J.5    Klijn, J.G.M.6    Sahmoud, T.7
  • 6
    • 18144387234 scopus 로고    scopus 로고
    • The role of growth factor receptor pathways in human breast cancer cells adapted to long-term estrogen deprivation
    • DOI 10.1158/0008-5472.CAN-04-4092
    • Sabnis GJ, Jelovac D, Long B, Brodie A. The role of growth factor receptor pathways in human breast cancer cells adapted to long-term estrogen deprivation. Cancer Res 2005;65:3903-10. (Pubitemid 40616372)
    • (2005) Cancer Research , vol.65 , Issue.9 , pp. 3903-3910
    • Sabnis, G.J.1    Jelovac, D.2    Long, B.3    Brodie, A.4
  • 8
    • 33845741050 scopus 로고    scopus 로고
    • Effects of novel retinoic acid metabolism blocking agent (VN/14-1) on letrozole-insensitive breast cancer cells
    • DOI 10.1158/0008-5472.CAN-06-2168
    • Belosay A, Brodie AM, Njar VC. Effects of novel retinoic acid metabolism blocking agent (VN/14-1) on letrozole-insensitive breast cancer cells. Cancer Res 2006;66:11485-93. (Pubitemid 46009982)
    • (2006) Cancer Research , vol.66 , Issue.23 , pp. 11485-11493
    • Belosay, A.1    Brodie, A.M.H.2    Njar, V.C.O.3
  • 10
    • 20644465808 scopus 로고    scopus 로고
    • Activation of mitogen-activated protein kinase in xenografts and cells during prolonged treatment with aromatase inhibitor letrozole
    • DOI 10.1158/0008-5472.CAN-04-4502
    • Jelovac D, Sabnis G, Long BJ, Macedo L, Goloubeva OG, Brodie AM. Activation of mitogen-activated protein kinase in xenografts and cells during prolonged treatment with aromatase inhibitor letrozole. Cancer Res 2005;65:5380-9. (Pubitemid 40834290)
    • (2005) Cancer Research , vol.65 , Issue.12 , pp. 5380-5389
    • Jelovac, D.1    Sabnis, G.2    Long, B.J.3    Macedo, L.4    Goloubeva, O.G.5    Brodie, A.M.H.6
  • 11
    • 60549089850 scopus 로고    scopus 로고
    • Trastuzumab reverses letrozole resistance and amplifies the sensitivity of breast cancer cells to estrogen
    • Sabnis G, Schayowitz A, Goloubeva O, Macedo L, Brodie A. Trastuzumab reverses letrozole resistance and amplifies the sensitivity of breast cancer cells to estrogen. Cancer Res 2009;69:1416-28.
    • (2009) Cancer Res , vol.69 , pp. 1416-1428
    • Sabnis, G.1    Schayowitz, A.2    Goloubeva, O.3    Macedo, L.4    Brodie, A.5
  • 12
    • 20444448539 scopus 로고    scopus 로고
    • Additive antitumor effect of aromatase inhibitor letrozole and antiestrogen fulvestrant in a postmenopausal breast cancer model
    • DOI 10.1158/0008-5472.CAN-04-2782
    • Jelovac D, Macedo L, Goloubeva OG, Handratta V, Brodie AM. Additive antitumor effect of aromatase inhibitor letrozole and antiestrogen fulvestrant in a postmenopausal breast cancer model. Cancer Res 2005;65:5439-44. (Pubitemid 40827357)
    • (2005) Cancer Research , vol.65 , Issue.12 , pp. 5439-5444
    • Jelovac, D.1    Macedo, L.2    Goloubeva, O.G.3    Handratta, V.4    Brodie, A.M.H.5
  • 13
    • 33645730357 scopus 로고    scopus 로고
    • Activation of mitogen-activated protein kinase in estrogen receptor alpha-positive breast cancer cells in vitro induces an in vivo molecular phenotype of estrogen receptor alpha-negative human breast tumors
    • Creighton CJ, Hilger AM, Murthy S, Rae JM, Chinnaiyan AM, El-Ashry D. Activation of mitogen-activated protein kinase in estrogen receptor alpha-positive breast cancer cells in vitro induces an in vivo molecular phenotype of estrogen receptor alpha-negative human breast tumors. Cancer Res 2006;66:3903-11.
    • (2006) Cancer Res , vol.66 , pp. 3903-3911
    • Creighton, C.J.1    Hilger, A.M.2    Murthy, S.3    Rae, J.M.4    Chinnaiyan, A.M.5    El-Ashry, D.6
  • 14
    • 0034899503 scopus 로고    scopus 로고
    • Hyperactivation of MAPK induces loss of ERalpha expression in breast cancer cells
    • DOI 10.1210/me.15.8.1344
    • Oh AS, Lorant LA, Holloway JN, Miller DL, Kern FG, El-Ashry D. Hyperactivation of MAPK induces loss of ERalpha expression in breast cancer cells. Mol Endocrinol 2001;15:1344-59. (Pubitemid 32703482)
    • (2001) Molecular Endocrinology , vol.15 , Issue.8 , pp. 1344-1359
    • Oh, A.S.1    Lorant, L.A.2    Holloway, J.N.3    Miller, D.L.4    Kern, F.G.5    El-Ashry, D.6
  • 15
    • 37249069903 scopus 로고    scopus 로고
    • Reversal of the estrogen receptor-negative phenotype in breast cancer and restoration of antiestrogen response
    • DOI 10.1158/1078-0432.CCR-07-0587
    • Bayliss J, Hilger A, Vishnu P, Diehl K, El-Ashry D. Reversal of the estrogen receptor negative phenotype in breast cancer and restoration of antiestrogen response. Clin Cancer Res 2007;13: 7029-36. (Pubitemid 350276884)
    • (2007) Clinical Cancer Research , vol.13 , Issue.23 , pp. 7029-7036
    • Bayliss, J.1    Hilger, A.2    Vishnu, P.3    Diehl, K.4    El-Ashry, D.5
  • 16
    • 62549106985 scopus 로고    scopus 로고
    • ER re-expression and re-sensitization to endocrine therapies in ER-negative breast cancers
    • Brinkman JA, El-Ashry D. ER re-expression and re-sensitization to endocrine therapies in ER-negative breast cancers. J Mammary Gland Biol Neoplasia 2009;14:67-78.
    • (2009) J Mammary Gland Biol Neoplasia , vol.14 , pp. 67-78
    • Brinkman, J.A.1    El-Ashry, D.2
  • 17
    • 73949118717 scopus 로고    scopus 로고
    • Sensitivity to the aromatase inhibitor letrozole is prolonged after a "break" in treatment
    • Sabnis G, Goloubeva O, Gilani R, Macedo L, Brodie A. Sensitivity to the aromatase inhibitor letrozole is prolonged after a "break" in treatment. Mol Cancer Ther 2010;9:46-56.
    • (2010) Mol Cancer Ther , vol.9 , pp. 46-56
    • Sabnis, G.1    Goloubeva, O.2    Gilani, R.3    Macedo, L.4    Brodie, A.5
  • 19
    • 74849124623 scopus 로고    scopus 로고
    • Tumor marker phenotype concordance in second primary breast cancer, California, 1999-2004
    • Brown M, Bauer K, Pare M. Tumor marker phenotype concordance in second primary breast cancer, California, 1999-2004. Breast Cancer Res Treat 2010;120:217-27.
    • (2010) Breast Cancer Res Treat , vol.120 , pp. 217-227
    • Brown, M.1    Bauer, K.2    Pare, M.3
  • 20
    • 69849090104 scopus 로고    scopus 로고
    • Does confirmatory tumor biopsy alter the management of breast cancer patients with distant metastases?
    • Simmons C, Miller N, Geddie W, Gianfelice D, Oldfield M, Dranitsaris G, et al. Does confirmatory tumor biopsy alter the management of breast cancer patients with distant metastases?Ann Oncol 2009; 20:1499-504.
    • (2009) Ann Oncol , vol.20 , pp. 1499-1504
    • Simmons, C.1    Miller, N.2    Geddie, W.3    Gianfelice, D.4    Oldfield, M.5    Dranitsaris, G.6
  • 21
    • 34247242607 scopus 로고    scopus 로고
    • Enhanced NF kappa B and AP-1 transcriptional activity associated with antiestrogen resistant breast cancer
    • Zhou Y, Yau C, Gray JW, Chew K, Dairkee SH, Moore DH, et al. Enhanced NF kappa B and AP-1 transcriptional activity associated with antiestrogen resistant breast cancer. BMC Cancer 2007;7:59.
    • (2007) BMC Cancer , vol.7 , pp. 59
    • Zhou, Y.1    Yau, C.2    Gray, J.W.3    Chew, K.4    Dairkee, S.H.5    Moore, D.H.6
  • 22
    • 11244296162 scopus 로고    scopus 로고
    • Mechanisms of tamoxifen resistance
    • DOI 10.1677/erc.1.00776
    • Ring A, Dowsett M. Mechanisms of tamoxifen resistance. Endocr Relat Cancer 2004;11:643-58. (Pubitemid 40065543)
    • (2004) Endocrine-Related Cancer , vol.11 , Issue.4 , pp. 643-658
    • Ring, A.1    Dowsett, M.2
  • 23
    • 69249137029 scopus 로고    scopus 로고
    • Biological determinants of endocrine resistance in breast cancer
    • Musgrove EA, Sutherland RL. Biological determinants of endocrine resistance in breast cancer. Nat Rev Cancer 2009;9:631-43.
    • (2009) Nat Rev Cancer , vol.9 , pp. 631-643
    • Musgrove, E.A.1    Sutherland, R.L.2
  • 24
    • 0037241499 scopus 로고    scopus 로고
    • Predictions from a preclinical model: Studies of aromatase inhibitors and antiestrogens
    • Brodie A, Jelovac D, Long BJ. Predictions from a preclinical model: studies of aromatase inhibitors and antiestrogens. Clin Cancer Res 2003;9:455S-9S.
    • (2003) Clin Cancer Res , vol.9
    • Brodie, A.1    Jelovac, D.2    Long, B.J.3
  • 25
    • 0027173997 scopus 로고
    • MCF-7 human breast carcinomas in nude mice as a model for evaluating aromatase inhibitors
    • Yue W, Brodie A. MCF-7 human breast carcinomas in nude mice as a model for evaluating aromatase inhibitors. J Steroid Biochem Mol Biol 1993;44:671-3. (Pubitemid 23126645)
    • (1993) Journal of Steroid Biochemistry and Molecular Biology , vol.44 , Issue.4-6 , pp. 671-673
    • Yue, W.1    Brodie, A.2
  • 26
    • 0027985528 scopus 로고
    • A new nude mouse model for postmenopausal breast cancer using MCF-7 cells transfected with the human aromatase gene
    • Yue W, Zhou D, Chen S, Brodie A. A new nude mouse model for postmenopausal breast cancer using MCF-7 cells transfected with the human aromatase gene. Cancer Res 1994;54:5092-5. (Pubitemid 24313482)
    • (1994) Cancer Research , vol.54 , Issue.19 , pp. 5092-5095
    • Yue, W.1    Zhou, D.2    Chen, S.3    Brodie, A.4
  • 27
    • 0025089197 scopus 로고
    • Stable expression of human aromatase complementary DNA in mammalian cells: A useful system for aromatase inhibitor screening
    • Zhou DJ, Pompon D, Chen SA. Stable expression of human aromatase complementary DNA in mammalian cells: a useful system for aromatase inhibitor screening. Cancer Res 1990;50:6949-54. (Pubitemid 20361096)
    • (1990) Cancer Research , vol.50 , Issue.21 , pp. 6949-6954
    • Zhou, D.1    Pompon, D.2    Chen, S.3
  • 28
    • 1842478456 scopus 로고    scopus 로고
    • Treatment of HER-2/neu Overexpressing Breast Cancer Xenograft Models with Trastuzumab (Herceptin) and Gefitinib (ZD1839): Drug Combination Effects on Tumor Growth, HER-2/neu and Epidermal Growth Factor Receptor Expression, and Viable Hypoxic Cell Fraction
    • DOI 10.1158/1078-0432.CCR-03-0244
    • Warburton C, Dragowska WH, Gelmon K, Chia S, Yan H, Masin D, et al. Treatment of HER-2/neu overexpressing breast cancer xenograft models with trastuzumab (Herceptin) and gefitinib (ZD1839): drug combination effects on tumor growth, HER-2/neu and epidermal growth factor receptor expression, and viable hypoxic cell fraction. Clin Cancer Res 2004;10:2512-24. (Pubitemid 38445713)
    • (2004) Clinical Cancer Research , vol.10 , Issue.7 , pp. 2512-2524
    • Warburton, C.1    Dragowska, W.H.2    Gelmon, K.3    Chia, S.4    Yan, H.5    Masin, D.6    Denyssevych, T.7    Wallis, A.E.8    Bally, M.B.9
  • 30
    • 0035992421 scopus 로고    scopus 로고
    • The effect of second-line antiestrogen therapy on breast tumor growth after first-line treatment with the aromatase inhibitor letrozole: Long-term studies using the intratumoral aromatase postmenopausal breast cancer model
    • Long BJ, Jelovac D, Thiantanawat A, Brodie AM. The effect of secondline antiestrogen therapy on breast tumor growth after first-line treatment with the aromatase inhibitor letrozole: long-term studies using the intratumoral aromatase postmenopausal breast cancer model. Clin Cancer Res 2002;8:2378-88. (Pubitemid 34753613)
    • (2002) Clinical Cancer Research , vol.8 , Issue.7 , pp. 2378-2388
    • Long, B.J.1    Jelovac, D.2    Thiantanawat, A.3    Brodie, A.M.4
  • 32
    • 63649099281 scopus 로고    scopus 로고
    • Novel actions of estrogen to promote proliferation: Integration of cytoplasmic and nuclear pathways
    • Fox EM, Andrade J, Shupnik MA. Novel actions of estrogen to promote proliferation: integration of cytoplasmic and nuclear pathways. Steroids 2009;74:622-7.
    • (2009) Steroids , vol.74 , pp. 622-627
    • Fox, E.M.1    Andrade, J.2    Shupnik, M.A.3
  • 33
    • 0037371627 scopus 로고    scopus 로고
    • Identification of a structural determinant necessary for the localization and function of estrogen receptor alpha at the plasma membrane
    • DOI 10.1128/MCB.23.5.1633-1646.2003
    • Razandi M, Alton G, Pedram A, Ghonshani S, Webb P, Levin ER. Identification of a structural determinant necessary for the localization and function of estrogen receptor alpha at the plasma membrane. Mol Cell Biol 2003;23:1633-46. (Pubitemid 36246045)
    • (2003) Molecular and Cellular Biology , vol.23 , Issue.5 , pp. 1633-1646
    • Razandi, M.1    Alton, G.2    Pedram, A.3    Ghonshani, S.4    Webb, P.5    Levin, E.R.6
  • 34
    • 8344223854 scopus 로고    scopus 로고
    • Crosstalk between steroid receptors and the c-Src-receptor tyrosine kinase pathways: Implications for cell proliferation
    • DOI 10.1038/sj.onc.1208076
    • Shupnik MA. Crosstalk between steroid receptors and the c-Srcreceptor tyrosine kinase pathways: implications for cell proliferation. Oncogene 2004;23:7979-89. (Pubitemid 39480682)
    • (2004) Oncogene , vol.23 , Issue.48 REV. ISS. 7 , pp. 7979-7989
    • Shupnik, M.A.1
  • 35
    • 33846882800 scopus 로고    scopus 로고
    • Role of receptor complexes in the extranuclear actions of estrogen receptor alpha in breast cancer
    • Song RX, Fan P, Yue W, Chen Y, Santen RJ. Role of receptor complexes in the extranuclear actions of estrogen receptor alpha in breast cancer. Endocr Relat Cancer 2006;13[Suppl 1]:S3-13.
    • (2006) Endocr Relat Cancer , vol.13 , Issue.SUPPL. 1
    • Song, R.X.1    Fan, P.2    Yue, W.3    Chen, Y.4    Santen, R.J.5
  • 36
    • 34249845380 scopus 로고    scopus 로고
    • Characterization of a novel tripartite nuclear localization sequence in the EGFR family
    • Hsu SC, Hung MC. Characterization of a novel tripartite nuclear localization sequence in the EGFR family. J Biol Chem 2007; 282:10432-40.
    • (2007) J Biol Chem , vol.282 , pp. 10432-10440
    • Hsu, S.C.1    Hung, M.C.2
  • 37
    • 33645217263 scopus 로고    scopus 로고
    • EGFR signaling pathway in breast cancers: From traditional signal transduction to direct nuclear translocalization
    • Lo HW, Hsu SC, Hung MC. EGFR signaling pathway in breast cancers: from traditional signal transduction to direct nuclear translocalization. Breast Cancer Res Treat 2006;95:211-8.
    • (2006) Breast Cancer Res Treat , vol.95 , pp. 211-218
    • Lo, H.W.1    Hsu, S.C.2    Hung, M.C.3
  • 38
    • 36849048584 scopus 로고    scopus 로고
    • Nuclear EGFR signalling network in cancers: Linking EGFR pathway to cell cycle progression, nitric oxide pathway and patient survival
    • Lo HW, Hung MC. Nuclear EGFR signalling network in cancers: linking EGFR pathway to cell cycle progression, nitric oxide pathway and patient survival. Br J Cancer 2007;96[Suppl]:R16-20.
    • (2007) Br J Cancer , vol.96 , Issue.SUPPL.
    • Lo, H.W.1    Hung, M.C.2
  • 39
    • 0028170686 scopus 로고
    • Nuclear localization of p185neu tyrosine kinase and its association with transcriptional transactivation
    • Xie Y, Hung MC. Nuclear localization of p185neu tyrosine kinase and its association with transcriptional transactivation. Biochem Biophys Res Commun 1994;203:1589-98.
    • (1994) Biochem Biophys Res Commun , vol.203 , pp. 1589-1598
    • Xie, Y.1    Hung, M.C.2
  • 40
    • 0028214293 scopus 로고
    • Dual immunocytochemical analysis of oestrogen and epidermal growth factor receptors in human breast cancer
    • Sharma AK, Horgan K, Douglas-Jones A, McClelland R, Gee J, Nicholson R. Dual immunocytochemical analysis of oestrogen and epidermal growth factor receptors in human breast cancer. Br J Cancer 1994;69:1032-7. (Pubitemid 24161855)
    • (1994) British Journal of Cancer , vol.69 , Issue.6 , pp. 1032-1037
    • Sharma, A.K.1    Horgan, K.2    Douglas-Jones, A.3    McClelland, R.4    Gee, J.5    Nicholson, R.6
  • 41
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 1987;235: 177-82. (Pubitemid 17231334)
    • (1987) Science , vol.235 , Issue.4785 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3
  • 42
    • 0028223731 scopus 로고
    • Differential expression of estrogen, progesterone, and epidermal growth factor receptors in normal, benign, and malignant human breast tissues using dual staining immunohistochemistry
    • van Agthoven T, Timmermans M, Foekens JA, Dorssers LC, Henzen- Logmans SC. Differential expression of estrogen, progesterone, and epidermal growth factor receptors in normal, benign, and malignant human breast tissues using dual staining immunohistochemistry. Am J Pathol 1994;144:1238-46. (Pubitemid 24172086)
    • (1994) American Journal of Pathology , vol.144 , Issue.6 , pp. 1238-1246
    • Van Agthoven, T.1    Timmermans, M.2    Foekens, J.A.3    Dorssers, L.C.J.4    Henzen-Logmans, S.C.5
  • 43
    • 0029877913 scopus 로고    scopus 로고
    • Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation
    • Bunone G, Briand PA, Miksicek RJ, Picard D. Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation. EMBO J 1996;15:2174-83. (Pubitemid 26141134)
    • (1996) EMBO Journal , vol.15 , Issue.9 , pp. 2174-2183
    • Bunone, G.1    Briand, P.-A.2    Miksicek, R.J.3    Picard, D.4
  • 44
    • 0028886694 scopus 로고
    • Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase
    • Kato S, Endoh H, Masuhiro Y, et al. Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase. Science 1995;270:1491-4.
    • (1995) Science , vol.270 , pp. 1491-1494
    • Kato, S.1    Endoh, H.2    Masuhiro, Y.3
  • 45
    • 2542620761 scopus 로고    scopus 로고
    • Human epidermal growth factor receptor 2 status modulates subcellular localization of and interaction with estrogen receptor alpha in breast cancer cells
    • DOI 10.1158/1078-0432.CCR-0740-3
    • Yang Z, Barnes CJ, Kumar R. Human epidermal growth factor receptor 2 status modulates subcellular localization of and interaction with estrogen receptor alpha in breast cancer cells. Clin Cancer Res 2004;10:3621-8. (Pubitemid 38697595)
    • (2004) Clinical Cancer Research , vol.10 , Issue.11 , pp. 3621-3628
    • Yang, Z.1    Barnes, C.J.2    Kumar, R.3
  • 46
    • 0030757687 scopus 로고    scopus 로고
    • Constitutive Raf-1 kinase activity in breast cancer cells induces both estrogen-independent growth and apoptosis
    • El-Ashry D, Miller DL, Kharbanda S, Lippman ME, Kern FG. Constitutive Raf-1 kinase activity in breast cancer cells induces both estrogen- independent growth and apoptosis. Oncogene 1997;15:423-35. (Pubitemid 27370992)
    • (1997) Oncogene , vol.15 , Issue.4 , pp. 423-435
    • El-Ashry, D.1    Miller, D.L.2    Kharbanda, S.3    Lippman, M.E.4    Kern, F.G.5
  • 47
    • 0021893220 scopus 로고
    • Transfection of v-ras(h) DNA into MCF-7 human breast cancer cells bypasses dependence on estrogen for tumorigenicity
    • Kasid A, Lippman ME, Papageorge AG, Lowy DR, Gelmann EP. Transfection of v-rasH DNA into MCF-7 human breast cancer cells bypasses dependence on estrogen for tumorigenicity. Science 1985;228:725-8. (Pubitemid 15063676)
    • (1985) Science , vol.228 , Issue.4700 , pp. 725-728
    • Kasid, A.1    Lippman, M.E.2    Papageorge, A.G.3
  • 48
    • 0028928063 scopus 로고
    • MCF-7 breast cancer cells overexpressing transfected c-erbB-2 have an in vitro growth advantage in estrogen-depleted conditions and reduced estrogen-dependence and tamoxifen-sensitivity in vivo
    • Liu Y, el-Ashry D, Chen D, Ding IY, Kern FG. MCF-7 breast cancer cells overexpressing transfected c-erbB-2 have an in vitro growth advantage in estrogen-depleted conditions and reduced estrogen-dependence and tamoxifen-sensitivity in vivo. Breast Cancer Res Treat 1995;34:97-117.
    • (1995) Breast Cancer Res Treat , vol.34 , pp. 97-117
    • Liu, Y.1    El-Ashry, D.2    Chen, D.3    Ding, I.Y.4    Kern, F.G.5
  • 49
    • 0027973875 scopus 로고
    • Emergence of MCF-7 cells overexpressing a transfected epidermal growth factor receptor (EGFR) under estrogen-depleted conditions: Evidence for a role of EGFR in breast cancer growth and progression
    • Miller DL, el-Ashry D, Cheville AL, Liu Y, McLeskey SW, Kern FG. Emergence of MCF-7 cells overexpressing a transfected epidermal growth factor receptor (EGFR) under estrogen-depleted conditions: evidence for a role of EGFR in breast cancer growth and progression. Cell Growth Differ 1994;5:1263-74.
    • (1994) Cell Growth Differ , vol.5 , pp. 1263-1274
    • Miller, D.L.1    El-Ashry, D.2    Cheville, A.L.3    Liu, Y.4    McLeskey, S.W.5    Kern, F.G.6
  • 50
    • 32944458087 scopus 로고    scopus 로고
    • Strategies for delaying or treating in vivo acquired resistance to trastuzumab in human breast cancer xenografts
    • du Manoir JM, Francia G, Man S, Mossoba M, Medin JA, Viloria-Petit A, et al. Strategies for delaying or treating in vivo acquired resistance to trastuzumab in human breast cancer xenografts. Clin Cancer Res 2006;12:904-16.
    • (2006) Clin Cancer Res , vol.12 , pp. 904-916
    • Du Manoir, J.M.1    Francia, G.2    Man, S.3    Mossoba, M.4    Medin, J.A.5    Viloria-Petit, A.6
  • 51
    • 12144269500 scopus 로고    scopus 로고
    • Crosstalk between estrogen receptor and growth factor receptor pathways as a cause for endocrine therapy resistance in breast cancer
    • Osborne CK, Shou J, Massarweh S, Schiff R. Crosstalk between estrogen receptor and growth factor receptor pathways as a cause for endocrine therapy resistance in breast cancer. Clin Cancer Res 2005;11:865s-70s.
    • (2005) Clin Cancer Res , vol.11
    • Osborne, C.K.1    Shou, J.2    Massarweh, S.3    Schiff, R.4
  • 52
    • 34447306848 scopus 로고    scopus 로고
    • Trastuzumab: Mechanism of action, resistance and future perspectives in HER2-overexpressing breast cancer
    • DOI 10.1093/annonc/mdl475
    • Valabrega G, Montemurro F, Aglietta M. Trastuzumab: mechanism of action, resistance and future perspectives in HER2-overexpressing breast cancer. Ann Oncol 2007;18:977-84. (Pubitemid 47050487)
    • (2007) Annals of Oncology , vol.18 , Issue.6 , pp. 977-984
    • Valabrega, G.1    Montemurro, F.2    Aglietta, M.3
  • 54
    • 33750468717 scopus 로고    scopus 로고
    • Reverting estrogen-receptor-negative phenotype in HER-2- Overexpressing advanced breast cancer patients exposed to trastuzumab plus chemotherapy
    • Munzone E, Curigliano G, Rocca A, Bonizzi G, Renne G, Goldhirsch A, et al. Reverting estrogen-receptor-negative phenotype in HER-2- overexpressing advanced breast cancer patients exposed to trastuzumab plus chemotherapy. Breast Cancer Res 2006;8:R4.
    • (2006) Breast Cancer Res , vol.8
    • Munzone, E.1    Curigliano, G.2    Rocca, A.3    Bonizzi, G.4    Renne, G.5    Goldhirsch, A.6
  • 55
    • 34249011160 scopus 로고    scopus 로고
    • Trastuzumab prolongs progression- free survival in hormone-dependent and HER2-positive metastatic breast cancer
    • abstract 3
    • Mackey J, Kaufman B, Clemens M. Trastuzumab prolongs progression- free survival in hormone-dependent and HER2-positive metastatic breast cancer. Breast Cancer Res Treat 2006;100(suppl 1): abstract 3.
    • (2006) Breast Cancer Res Treat , vol.100 , Issue.SUPPL. 1
    • Mackey, J.1    Kaufman, B.2    Clemens, M.3
  • 56
    • 38549147013 scopus 로고    scopus 로고
    • Enhancing endocrine response with novel targeted therapies: Why have the clinical trials to date failed to deliver on the preclinical promise?
    • Johnston SR, Leary A, Martin LA, Smith IE, Dowsett M. Enhancing endocrine response with novel targeted therapies: why have the clinical trials to date failed to deliver on the preclinical promise?Cancer 2008;112:710-7.
    • (2008) Cancer , vol.112 , pp. 710-717
    • Johnston, S.R.1    Leary, A.2    Martin, L.A.3    Smith, I.E.4    Dowsett, M.5
  • 57
    • 34547523463 scopus 로고    scopus 로고
    • Small molecule signal transduction inhibitors for the treatment of solid tumors
    • DOI 10.1080/07357900701259694, PII 780907537
    • Leary A, Johnston SR. Small molecule signal transduction inhibitors for the treatment of solid tumors. Cancer Invest 2007;25:347-65. (Pubitemid 47185077)
    • (2007) Cancer Investigation , vol.25 , Issue.5 , pp. 347-365
    • Leary, A.1    Johnston, S.R.D.2
  • 58
    • 40449093012 scopus 로고    scopus 로고
    • Clinical trials update: Endocrine and biological therapy combinations in the treatment of breast cancer
    • Leary AF, Sirohi B, Johnston SR. Clinical trials update: endocrine and biological therapy combinations in the treatment of breast cancer. Breast Cancer Res 2007;9:112.
    • (2007) Breast Cancer Res , vol.9 , pp. 112
    • Leary, A.F.1    Sirohi, B.2    Johnston, S.R.3
  • 59
    • 73949105921 scopus 로고    scopus 로고
    • Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer: Results from the randomized phase III TAnDEM study
    • Kaufman B, Mackey JR, Clemens MR, Bapsy PP, Vaid A, Wardley A, et al. Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer: results from the randomized phase III TAnDEM study. J Clin Oncol 2009;27:5529-37.
    • (2009) J Clin Oncol , vol.27 , pp. 5529-5537
    • Kaufman, B.1    Mackey, J.R.2    Clemens, M.R.3    Bapsy, P.P.4    Vaid, A.5    Wardley, A.6
  • 60
    • 73149115341 scopus 로고    scopus 로고
    • Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer
    • Johnston S, Pippen J Jr, Pivot X, Lichinitser M, Sadeghi S, Dieras V, et al. Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer. J Clin Oncol 2009;27:5538-46.
    • (2009) J Clin Oncol , vol.27 , pp. 5538-5546
    • Johnston, S.1    Pippen Jr., J.2    Pivot, X.3    Lichinitser, M.4    Sadeghi, S.5    Dieras, V.6
  • 61
    • 66849136781 scopus 로고    scopus 로고
    • Phase II randomized study of neoadjuvant everolimus plus letrozole compared with placebo plus letrozole in patients with estrogen receptor-positive breast cancer
    • Baselga J, Semiglazov V, van Dam P, Manikhas A, Bellet M, Mayordomo J, et al. Phase II randomized study of neoadjuvant everolimus plus letrozole compared with placebo plus letrozole in patients with estrogen receptor-positive breast cancer. J Clin Oncol 2009;27:2630-7.
    • (2009) J Clin Oncol , vol.27 , pp. 2630-2637
    • Baselga, J.1    Semiglazov, V.2    Van Dam, P.3    Manikhas, A.4    Bellet, M.5    Mayordomo, J.6


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