Lack of association between genetic variations in the KALRN region and ischemic stroke

Clinical Biochemistry

Volumn 44, Issue 12, 2011, Pages 1018-1020

  Olsson, Sandra ^a   Jood, Katarina ^a   Melander, Olle ^b   Sjögren, Marketa ^b   Norrving, Bo ^c   Nilsson, Michael ^a   Lindgren, Arne ^c   Jern, Christina ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b LUND UNIVERSITY   (Sweden)

^c LUND UNIVERSITY   (Sweden)

Author keywords

Genetics; Ischemic stroke; Kalirin; RhoGEF; Single nucleotide polymorphism

Indexed keywords

KALIRIN; PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BRAIN ISCHEMIA; CARDIOVASCULAR RISK; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DIABETES MELLITUS; DISEASE REGISTRY; GENE FREQUENCY; GENE REPLICATION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROMOTER REGION; RECURRENT DISEASE; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; SWEDEN;

AGED; BRAIN ISCHEMIA; CASE-CONTROL STUDIES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN-SERINE-THREONINE KINASES; RISK FACTORS; STROKE; SWEDEN;

EID: 79960289731     PISSN: 00099120     EISSN: 18732933     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2011.05.025     Document Type: Article

References (8)

1. Hauser E.R., Crossman D.C., Granger C.B., Haines J.L., Jones C.J., Mooser V., et al. A genomewide scan for early-onset coronary artery disease in 438 families: the GENECARD Study. Am J Hum Genet 2004, 75:436-447.
2. Wang L., Hauser E.R., Shah S.H., Pericak-Vance M.A., Haynes C., Crosslin D., et al. Peakwide mapping on chromosome 3q13 identifies the kalirin gene as a novel candidate gene for coronary artery disease. Am J Hum Genet 2007, 80:650-663.
3. Krug T., Manso H., Gouveia L., Sobral J., Xavier J.M., Albergaria I., et al. Kalirin: a novel genetic risk factor for ischemic stroke. Hum Genet 2010, 127:513-523.
4. Jood K., Ladenvall C., Rosengren A., Blomstrand C., Jern C. Family history in ischemic stroke before 70years of age: the Sahlgrenska Academy Study on Ischemic Stroke. Stroke 2005, 36:1383-1387.
5. Olsson S., Melander O., Jood K., Smith J.G., Lövkvist H., Sjögren M., et al. Genetic variant on chromosome 12p13 does not show association to ischemic stroke in 3 Swedish case-control studies. Stroke 2011, 42:214-216.
6. Li C., Engström G., Hedblad B., Berglund G., Janzon L. Risk factors for stroke in subjects with normal blood pressure: a prospective cohort study. Stroke 2005, 36:234-238.
7. Hallström B., Jönsson A.C., Nerbrand C., Petersen B., Norrving B., Lindgren A. Lund Stroke Register: hospitalization pattern and yield of different screening methods for first-ever stroke. Acta Neurol Scand 2007, 115:49-54.
8. Horne B.D., Hauser E.R., Wang L., Muhlestein J.B., Anderson J.L., Carlquist J.F., et al. Validation study of genetic associations with coronary artery disease on chromosome 3q13-21 and potential effect modification by smoking. Ann Hum Genet 2009, 73:551-558.