It is time to remove the 'benign' from the essential tremor label

Parkinsonism and Related Disorders

Volumn 17, Issue 7, 2011, Pages 516-520

  Louis, Elan D ^a,b,c   Okun, Michael S ^d,e  

^a Columbia University ^*  (United States)

^b Taub Institute for Research on Alzheimer's Disease and the Aging Brain and the Gertrude H Sergievsky Center   (United States)

^c NONE   (United States)

^d UNIVERSITY OF FLORIDA   (United States)

^e UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Benign; Clinical; Cognition; Essential tremor; Gait

Indexed keywords

BALANCE DISORDER; COGNITIVE DEFECT; COMORBIDITY; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; DISEASE COURSE; ESSENTIAL TREMOR; GAIT DISORDER; HEARING IMPAIRMENT; HUMAN; MORTALITY; PHYSICAL DISABILITY; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT;

COGNITION DISORDERS; COMORBIDITY; ESSENTIAL TREMOR; GAIT DISORDERS, NEUROLOGIC; HEARING LOSS; HUMANS; MENTAL DISORDERS;

EID: 79960283481     PISSN: 13538020     EISSN: 18735126     Source Type: Journal    
DOI: 10.1016/j.parkreldis.2011.03.012     Document Type: Review

References (50)

1. Louis E.D., Broussolle E., Goetz C.G., Krack P., Kaufmann P., Mazzoni P. Historical underpinnings of the term essential tremor in the late 19th century. Neurology 2008, 71:856-859.
2. Davis C.H., Kunkle E.C. Benign essential (heredofamilial) tremor. AMA Arch Intern Med 1951, 87:808-816.
3. Lacritz L.H., Dewey R., Giller C., Cullum C.M. Cognitive functioning in individuals with " benign" essential tremor. J Int Neuropsychol Soc 2002, 8:125-129.
4. George M.S., Lydiard R.B. Social phobia secondary to physical disability. A review of benign essential tremor (BET) and stuttering. Psychosomatics 1994, 35:520-523.
5. Benito-Leon J. Essential tremor: from a monosymptomatic disorder to a more complex entity. Neuroepidemiology 2008, 31:191-192.
6. Gasparini M., Bonifati V., Fabrizio E., Fabbrini G., Brusa L., Lenzi G.L., et al. Frontal lobe dysfunction in essential tremor: a preliminary study. J Neurol 2001, 248:399-402.
7. Lombardi W.J., Woolston D.J., Roberts J.W., Gross R.E. Cognitive deficits in patients with essential tremor. Neurology 2001, 57:785-790.
8. Benito-Leon J., Louis E.D., Bermejo-Pareja F. Population-based case-control study of cognitive function in essential tremor. Neurology 2006, 66:69-74.
9. Higginson C.I., Wheelock V.L., Levine D., King D.S., Pappas C.T., Sigvardt K.A. Cognitive deficits in essential tremor consistent with frontosubcortical dysfunction. J Clin Exp Neuropsychol 2008, 1-6.
10. Troster A.I., Woods S.P., Fields J.A., Lyons K.E., Pahwa R., Higginson C.I., et al. Neuropsychological deficits in essential tremor: an expression of cerebello-thalamo-cortical pathophysiology?. Eur J Neurol 2002, 9:143-151.
11. Sahin H.A., Terzi M., Ucak S., Yapici O., Basoglu T., Onar M. Frontal functions in young patients with essential tremor: a case comparison study. J Neuropsychiatry Clin Neurosci 2006, 18:64-72.
12. Frisina P.G., Tse W., Halbig T.D., Libow L.S. The pattern of cognitive-functional decline in elderly essential tremor patients: an exploratory-comparative study with Parkinson's and Alzheimer's disease patients. J Am Med Dir Assoc 2009, 10:238-242.
13. Louis E.D., Benito-Leon J., Vega-Quiroga S., Bermejo-Pareja F. Faster rate of cognitive decline in essential tremor cases than controls: a prospective study. Eur J Neurol 2010, 17:1291-1297.
14. Thawani S.P., Schupf N., Louis E.D. Essential tremor is associated with dementia: prospective population-based study in New York. Neurology 2009, 73:621-625.
15. Bermejo-Pareja F., Louis E.D., Benito-Leon J. Risk of incident dementia in essential tremor: a population-based study. Mov Disord 2007, 22:1573-1580.
16. Louis E.D., Benito-Leon J., Vega-Quiroga S., Bermejo-Pareja F. Cognitive and motor functional activity in non-demented community-dwelling essential tremor cases. J Neurol Neurosurg Psychiatr 2001, 81:997-1001.
17. Louis E.D. Functional correlates of lower cognitive test scores in essential tremor. Mov Disord 2010, 25:481-485.
18. Tan E.K., Fook-Chong S., Lum S.Y., Gabriel C., Koh K.K., Prakash K.M., et al. Non-motor manifestations in essential tremor: use of a validated instrument to evaluate a wide spectrum of symptoms. Parkinsonism Relat Disord 2005, 11:375-380.
19. Dogu O., Louis E.D., Sevim S., Kaleagasi H., Aral M. Clinical characteristics of essential tremor in Mersin, Turkey - a population-based door-to-door study. J Neurol 2005, 252:570-574.
20. Louis E.D., Benito-Leon J., Bermejo-Pareja F. Self-reported depression and anti-depressant medication use in essential tremor: cross-sectional and prospective analyses in a population-based study. Eur J Neurol 2007, 14:1138-1146.
21. Miller K.M., Okun M.S., Fernandez H.F., Jacobson C.E., Rodriguez R.L., Bowers D. Depression symptoms in movement disorders: comparing Parkinson's disease, dystonia, and essential tremor. Mov Disord 2007, 22:666-672.
22. Louis E.D., Barnes L., Albert S.M., Cote L., Schneier F.R., Pullman S.L., et al. Correlates of functional disability in essential tremor. Mov Disord 2001, 16:914-920.
23. Schneier F.R., Barnes L.F., Albert S.M., Louis E.D. Characteristics of social phobia among persons with essential tremor. J Clin Psychiatry 2001, 62:367-372.
24. Louis E.D. Essential tremor as a neuropsychiatric disorder. J Neurol Sci 2010, 289:144-148.
25. Deep-brain stimulation of the subthalamic nucleus or the pars interna of the globus pallidus in Parkinson's disease. N Engl J Med 2001, 345:956-963. Group DiPS.
26. Singer C., Sanchez-Ramos J., Weiner W.J. Gait abnormality in essential tremor. Mov Disord 1994, 9:193-196.
27. Hubble J.P., Busenbark K.L., Pahwa R., Lyons K., Koller W.C. Clinical expression of essential tremor: effects of gender and age. Mov Disord 1997, 12:969-972.
28. Stolze H., Petersen G., Raethjen J., Wenzelburger R., Deuschl G. The gait disorder of advanced essential tremor. Brain 2001, 124:2278-2286.
29. Louis E.D., Rios E., Rao A.K. Tandem gait performance in essential tremor: clinical correlates and association with midline tremors. Mov Disord 2010, 25:1633-1638.
30. Parisi S.L., Heroux M.E., Culham E.G., Norman K.E. Functional mobility and postural control in essential tremor. Arch Phys Med Rehabil 2006, 87:1357-1364.
31. Benito-Leon J.L.E., Bermejo-Pareja F. Reported hearing impairment in essential tremor: a population-based case-control study. Neuroepidemiology 2007, 29:213-217.
32. Ondo W.G., Sutton L., Dat Vuong K., Lai D., Jankovic J. Hearing impairment in essential tremor. Neurology 2003, 61:1093-1097.
33. Chaudhuri K.R., Buxton-Thomas M., Dhawan V., Peng R., Meilak C., Brooks D.J. Long duration asymmetrical postural tremor is likely to predict development of Parkinson's disease and not essential tremor: clinical follow up study of 13 cases. J Neurol Neurosurg Psychiatr 2005, 76:115-117.
34. Yahr M.D., Orosz D., Purohit D.P. Co-occurrence of essential tremor and Parkinson's disease: clinical study of a large kindred with autopsy findings. Parkinsonism Relat Disord 2003, 9:225-231.
35. Minen M.T., Louis E.D. Emergence of Parkinson's disease in essential tremor: a study of the clinical correlates in 53 patients. Mov Disord 2008, 23:1602-1605.
36. Shahed J., Jankovic J. Exploring the relationship between essential tremor and Parkinson's disease. Parkinsonism Relat Disord 2007, 13:67-76.
37. Tan E.K., Lee S.S., Fook-Chong S., Lum S.Y. Evidence of increased odds of essential tremor in Parkinson's disease. Mov Disord 2008, 23:993-997.
38. Benito-Leon J., Louis E.D., Bermejo-Pareja F. Risk of incident Parkinson's disease and parkinsonism in essential tremor: a population based study. J Neurol Neurosurg Psychiatr 2009, 80:423-425.
39. Benito-Leon J., Louis E.D., Bermejo-Pareja F. Elderly-onset essential tremor is associated with dementia. Neurology 2006, 66:1500-1505.
40. Putzke J.D., Whaley N.R., Baba Y., Wszolek Z.K., Uitti R.J. Essential tremor: predictors of disease progression in a clinical cohort. J Neurol Neurosurg Psychiatr 2006, 77:1235-1237.
41. Louis ED, Agnew A, Gillman A, Gerbin M, Viner AS. Estimating annual rate of decline: prospective, longitudinal data on arm tremor severity in two groups of essential tremor cases. J Neurology Neurosurg Psychiatr, 2011 Mar 24. [Epub ahead of print].
42. Cohen O., Pullman S., Jurewicz E., Watner D., Louis E.D. Rest tremor in patients with essential tremor: prevalence, clinical correlates, and electrophysiologic characteristics. Arch Neurol 2003, 60:405-410.
43. Leegwater-Kim J., Louis E.D., Pullman S.L., Floyd A.G., Borden S., Moskowitz C.B., et al. Intention tremor of the head in patients with essential tremor. Mov Disord 2006, 21:2001-2005.
44. Critchley M. Observations of essential (heredofamilial) tremor. Brain 1949, 72:113-139.
45. Bain P.G., Findley L.J., Thompson P.D., Gresty M.A., Rothwell J.C., Harding A.E., et al. A study of hereditary essential tremor. Brain 1994, 117:805-824.
46. Louis E.D., Ford B., Wendt K.J., Cameron G. Clinical characteristics of essential tremor: data from a community-based study. Mov Disord 1998, 13:803-808.
47. Louis E.D., Benito-Leon J., Bermejo-Pareja F. Philadelphia Geriatric Morale Scale in essential tremor: a population-based study in three Spanish communities. Mov Disord 2008, 23:1435-1440.
48. Louis E.D., Ferreira J.J. How common is the most common adult movement disorder? Update on the worldwide prevalence of essential tremor. Mov Disord 2010, 25:534-541.
49. Rajput A.H., Offord K.P., Beard C.M., Kurland L.T. Essential tremor in Rochester, Minnesota: a 45-year study. J Neurol Neurosurg Psychiatr 1984, 47:466-470.
50. Louis E.D., Benito-Leon J., Ottman R., Bermejo-Pareja F. A population-based study of mortality in essential tremor. Neurology 2007, 69:1982-1989.