Allogeneic Hematopoietic Stem Cell Transplantation in Leukocyte Adhesion Deficiency Type 1: A Single Center Experience

Biology of Blood and Marrow Transplantation

Volumn 17, Issue 8, 2011, Pages 1245-1249

  Al Dhekri, Hasan ^a   Al Mousa, Hamoud ^a   Ayas, Mouhab ^a   Al Muhsen, Saleh ^a,b   Al Ghonaium, Abdulaziz ^a   Al Ghanam, Ghanam ^a   Al Saud, Bandar ^a   Arnaout, Rand ^a   Al Seraihy, Amal ^a   Al Ahmari, Ali ^a   Al Jefri, Abdullah ^a   Al Mahr, Mohammed ^a   El Solh, Hassan ^a  

^a KING FAISAL SPECIALIST HOSPITAL AND RESEARCH CENTER   (Saudi Arabia)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Cyclosporine A; Matched related donor; Mismatched related donor; Primary immunodeficiency disease; Unrelated cord blood

Indexed keywords

ALEMTUZUMAB; BUSULFAN; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; ETOPOSIDE; HLA ANTIGEN; IMMUNOGLOBULIN; METHOTREXATE; PREDNISONE; THYMOCYTE ANTIBODY;

ADD ON THERAPY; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; BONE MARROW; CHILD; CLINICAL ARTICLE; DONOR; ENGRAFTMENT; EVENT FREE SURVIVAL; FEMALE; FOLLOW UP; GRAFT RECIPIENT; GRAFT VERSUS HOST REACTION; HUMAN; IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME; IMMUNOSUPPRESSIVE TREATMENT; INFANT; LEUKOCYTE ADHESION DEFICIENCY; LEUKOCYTE ADHESION DEFICIENCY TYPE 1; MALE; OVERALL SURVIVAL; PRESCHOOL CHILD; RETROSPECTIVE STUDY; SURVIVAL RATE; TREATMENT DURATION; UMBILICAL CORD BLOOD; WHOLE BODY RADIATION;

CHIMERISM; CYCLOSPORINE; FEMALE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INFANT; INFANT, NEWBORN; LEUKOCYTE-ADHESION DEFICIENCY SYNDROME; MALE; RETROSPECTIVE STUDIES; TISSUE DONORS; TRANSPLANTATION CONDITIONING; TRANSPLANTATION, HOMOLOGOUS; TREATMENT OUTCOME;

EID: 79960273078     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2010.12.714     Document Type: Article

References (19)

1. Fischer A., Lisowska-Grospierre B., Anderson D.C., et al. Leukocyte adhesion deficiency: molecular basis and functional consequences. Immunodefic Rev 1988, 1:39-54.
2. Kishimoto T.K., Hollander N., Roberts T.M., et al. Heterogeneous mutations in the beta subunit common to the LFA-1, Mac-1, and p150, 95 glycoproteins cause leukocyte adhesion deficiency. Cell 1987, 50:193-202.
3. Roos D., Meischl C., de Boer M., et al. Genetic analysis of patients with leukocyte adhesion deficiency: genomic sequencing reveals otherwise undetectable mutations. Exp Hematol 2002, 30:252-261.
4. Anderson D.C., Schmalsteig F.C., Finegold M.J., et al. The severe and moderate phenotypes of heritable Mac-1, LFA-1 deficiency: their quantitative definition and relation to leukocyte dysfunction and clinical features. J Infect Dis 1985, 152:668-689.
5. Anderson D.C., Springer T.A. Leukocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1, and P150, 95 glycoprotein. Annu Rev Med 1987, 38:175-194.
6. LeDiest F., Blanche S., Keable H., et al. Successful HLA non-identical bone marrow transplantation in three patients with leukocyte adhesion deficiency. Blood 1989, 74:512-518.
7. Fischer A., Landais P., Friedrich W. Bone marrow transplantation (BMT) in Europe for primary immunodeficiencies other than severe combined immunodeficiency. Blood 1994, 83:1149-1154.
8. Farinha N.J., Duval M., Wagner E., et al. Unrelated bone marrow transplantation for leukocyte adhesion deficiency. Bone Marrow Transplant 2002, 30:979-981.
9. Thomas C., Le Deist F., Cavazzana-Calvo M., et al. Results of allogeneic bone marrow transplantation in patients with leukocyte adhesion deficiency. Blood 1995, 86:1629-1635.
10. Qasim W., Cavazzana-Calvo M., Davies E.G., et al. Allogeneic hematopoietic stem cell transplantation for leukocyte adhesion deficiency. Pediatrics 2009, 123:836-840.
11. Starý J., Bartůnková J., Kobylka P., et al. Successful HLA-identical sibling cord blood transplantation in a 6-year-old boy with leukocyte adhesion deficiency syndrome. Bone Marrow Transplant 1996, 18:249-252.
12. Glucksberg H., Storb R., Fefer A., et al. Clinical manifestations of GVHD in human recipients of marrow from HLA-matched sibling donors. Transplantation 1974, 18:295-299.
13. Atkinson K., Horowitz M.M., Gale R.P., et al. Consensus among bone marrow transplanters for diagnosis, grading and treatment of chronic graft-versus-host-disease. Bone Marrow Transplant 1989, 4:247-254.
14. Suliaman F.A., Harfi H. High incidence of severe combined immune deficiency in the Eastern Province of Saudi Arabia. Pediatr Asthma Allergy Immunol 2006, 19:14-18.
15. Suliaman F.A., Sheikh S., Almuhsen S., et al. Epidemiology of chronic granulomatous disease of childhood in Eastern Province, Saudi Arabia. Pediatr Asthma Allergy Immunol 2009, 22:21-26.
16. Al-Herz W. Primary immunodeficiency disorders in Kuwait: first report from Kuwait National Primary Immunodeficiency Registry (2004-2006). J Clin Immunol 2008, 28:186-193.
17. El Mouzan M.I., Al Salloum A.A., Al Herbish A.S., et al. Consanguinity and major genetic disorders in Saudi children: a community-based cross-sectional study. Ann Saudi Med 2008, 28:169-173.
18. Creevy K.E., Bauer T.R., Tuschong L.M., et al. Mixed chimeric hematopoietic stem cell transplant reverses the disease phenotype in canine leukocyte adhesion deficiency. Vet Immunol Immunopathol 2003, 95:113-121.
19. Bauer T.R., Creevy K.E., Gu Y.C., et al. Very low levels of donor CD18+ neutrophils following allogeneic hematopoietic stem cell transplantation reverse the disease phenotype in canine leukocyte adhesion deficiency. Blood 2004, 103:3582-3589.