-
1
-
-
0242499440
-
Aromatase inhibitors for breast cancer: lessons from the laboratory
-
Johnston S.R., Dowsett M. Aromatase inhibitors for breast cancer: lessons from the laboratory. Nat. Rev. Cancer 2003, 3:821-831.
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 821-831
-
-
Johnston, S.R.1
Dowsett, M.2
-
2
-
-
33846428861
-
Influences on circulating oestrogens in postmenopausal women: relationship with breast cancer
-
Kendall A., Folkerd E.J., Dowsett M. Influences on circulating oestrogens in postmenopausal women: relationship with breast cancer. J. Steroid Biochem. Mol. Biol. 2007, 103:99-109.
-
(2007)
J. Steroid Biochem. Mol. Biol.
, vol.103
, pp. 99-109
-
-
Kendall, A.1
Folkerd, E.J.2
Dowsett, M.3
-
3
-
-
0036374410
-
Aromatase and its inhibitors: significance for breast cancer therapy
-
Simpson E.R., Dowsett M. Aromatase and its inhibitors: significance for breast cancer therapy. Recent Prog. Horm. Res. 2002, 57:317-338.
-
(2002)
Recent Prog. Horm. Res.
, vol.57
, pp. 317-338
-
-
Simpson, E.R.1
Dowsett, M.2
-
4
-
-
77949908545
-
Relationship between plasma estradiol levels and estrogen-responsive gene expression in estrogen receptor-positive breast cancer in postmenopausal women
-
Dunbier A.K., Anderson H., Ghazoui Z., Folkerd E.J., A'Hern R., Crowder R.J., Hoog J., Smith I.E., Osin P., Nerurkar A., Parker J.S., Perou C.M., Ellis M.J., Dowsett M. Relationship between plasma estradiol levels and estrogen-responsive gene expression in estrogen receptor-positive breast cancer in postmenopausal women. J. Clin. Oncol. 2010, 28:1161-1167.
-
(2010)
J. Clin. Oncol.
, vol.28
, pp. 1161-1167
-
-
Dunbier, A.K.1
Anderson, H.2
Ghazoui, Z.3
Folkerd, E.J.4
A'Hern, R.5
Crowder, R.J.6
Hoog, J.7
Smith, I.E.8
Osin, P.9
Nerurkar, A.10
Parker, J.S.11
Perou, C.M.12
Ellis, M.J.13
Dowsett, M.14
-
5
-
-
33846965616
-
Prognostic value of Ki67 expression after short-term presurgical endocrine therapy for primary breast cancer
-
Dowsett M., Smith I.E., Ebbs S.R., Dixon J.M., Skene A., A'Hern R., Salter J., Detre S., Hills M., Walsh G. Prognostic value of Ki67 expression after short-term presurgical endocrine therapy for primary breast cancer. J. Natl. Cancer Inst. 2007, 99:167-170.
-
(2007)
J. Natl. Cancer Inst.
, vol.99
, pp. 167-170
-
-
Dowsett, M.1
Smith, I.E.2
Ebbs, S.R.3
Dixon, J.M.4
Skene, A.5
A'Hern, R.6
Salter, J.7
Detre, S.8
Hills, M.9
Walsh, G.10
-
6
-
-
77949752567
-
Intratumoral estrogen disposition in breast cancer
-
Haynes B.P., Straume A.H., Geisler J., A'Hern R., Helle H., Smith I.E., Lonning P.E., Dowsett M. Intratumoral estrogen disposition in breast cancer. Clin. Cancer Res. 2010, 16:1790-1801.
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 1790-1801
-
-
Haynes, B.P.1
Straume, A.H.2
Geisler, J.3
A'Hern, R.4
Helle, H.5
Smith, I.E.6
Lonning, P.E.7
Dowsett, M.8
-
7
-
-
0028853923
-
Estrogen deprivation causes estradiol hypersensitivity in human breast cancer cells
-
Masamura S., Santner S.J., Heitjan D.F., Santen R.J. Estrogen deprivation causes estradiol hypersensitivity in human breast cancer cells. J. Clin. Endocrinol. Metab. 1995, 80:2918-2925.
-
(1995)
J. Clin. Endocrinol. Metab.
, vol.80
, pp. 2918-2925
-
-
Masamura, S.1
Santner, S.J.2
Heitjan, D.F.3
Santen, R.J.4
-
8
-
-
0036702132
-
Molecular changes associated with the acquisition of oestrogen hypersensitivity in MCF-7 breast cancer cells on long-term oestrogen deprivation
-
Chan C.M., Martin L.A., Johnston S.R., Ali S., Dowsett M. Molecular changes associated with the acquisition of oestrogen hypersensitivity in MCF-7 breast cancer cells on long-term oestrogen deprivation. J. Steroid Biochem. Mol. Biol. 2002, 81:333-341.
-
(2002)
J. Steroid Biochem. Mol. Biol.
, vol.81
, pp. 333-341
-
-
Chan, C.M.1
Martin, L.A.2
Johnston, S.R.3
Ali, S.4
Dowsett, M.5
-
9
-
-
0042232592
-
Enhanced estrogen receptor (ER) alpha ERBB2, and MAPK signal transduction pathways operate during the adaptation of MCF-7 cells to long term estrogen deprivation
-
Martin L.A., Farmer I., Johnston S.R., Ali S., Marshall C., Dowsett M. Enhanced estrogen receptor (ER) alpha ERBB2, and MAPK signal transduction pathways operate during the adaptation of MCF-7 cells to long term estrogen deprivation. J. Biol. Chem. 2003, 278:30458-30468.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 30458-30468
-
-
Martin, L.A.1
Farmer, I.2
Johnston, S.R.3
Ali, S.4
Marshall, C.5
Dowsett, M.6
-
10
-
-
29144494969
-
The anti-oestrogen ICI 182,780, but not tamoxifen, inhibits the growth of MCF-7 breast cancer cells refractory to long-term oestrogen deprivation through down-regulation of oestrogen receptor and IGF signalling
-
Martin L.A., Pancholi S., Chan C.M., Farmer I., Kimberley C., Dowsett M., Johnston S.R. The anti-oestrogen ICI 182,780, but not tamoxifen, inhibits the growth of MCF-7 breast cancer cells refractory to long-term oestrogen deprivation through down-regulation of oestrogen receptor and IGF signalling. Endocr. Relat. Cancer 2005, 12:1017-1036.
-
(2005)
Endocr. Relat. Cancer
, vol.12
, pp. 1017-1036
-
-
Martin, L.A.1
Pancholi, S.2
Chan, C.M.3
Farmer, I.4
Kimberley, C.5
Dowsett, M.6
Johnston, S.R.7
-
11
-
-
0026722827
-
Aromatization inhibition alone or in combination with GnRH agonists for the treatment of premenopausal breast cancer patients
-
Dowsett M., Stein R.C., Coombes R.C. Aromatization inhibition alone or in combination with GnRH agonists for the treatment of premenopausal breast cancer patients. J. Steroid Biochem. Mol. Biol. 1992, 43:155-159.
-
(1992)
J. Steroid Biochem. Mol. Biol.
, vol.43
, pp. 155-159
-
-
Dowsett, M.1
Stein, R.C.2
Coombes, R.C.3
-
12
-
-
0035930095
-
Effect of long-term estrogen deprivation on apoptotic responses of breast cancer cells to 17beta-estradiol
-
Song R.X., Mor G., Naftolin F., McPherson R.A., Song J., Zhang Z., Yue W., Wang J., Santen R.J. Effect of long-term estrogen deprivation on apoptotic responses of breast cancer cells to 17beta-estradiol. J. Natl. Cancer Inst. 2001, 93:1714-1723.
-
(2001)
J. Natl. Cancer Inst.
, vol.93
, pp. 1714-1723
-
-
Song, R.X.1
Mor, G.2
Naftolin, F.3
McPherson, R.A.4
Song, J.5
Zhang, Z.6
Yue, W.7
Wang, J.8
Santen, R.J.9
-
13
-
-
79960239633
-
Biomarker changes associated with the development of resistance to aromatase inhibitors (AIs) in ER-positive breast cancer
-
Arnedos M., Drury S., Afentakis M., Hills M., Salter J., Smith I.E., Dowsett M. Biomarker changes associated with the development of resistance to aromatase inhibitors (AIs) in ER-positive breast cancer. J. Clin. Oncol. 2010, 28.
-
(2010)
J. Clin. Oncol.
, pp. 28
-
-
Arnedos, M.1
Drury, S.2
Afentakis, M.3
Hills, M.4
Salter, J.5
Smith, I.E.6
Dowsett, M.7
-
14
-
-
77649173208
-
Lapatinib restores hormone sensitivity with differential effects on estrogen receptor signaling in cell models of human epidermal growth factor receptor 2-negative breast cancer with acquired endocrine resistance
-
Leary A.F., Drury S., Detre S., Pancholi S., Lykkesfeldt A.E., Martin L.A., Dowsett M., Johnston S.R. Lapatinib restores hormone sensitivity with differential effects on estrogen receptor signaling in cell models of human epidermal growth factor receptor 2-negative breast cancer with acquired endocrine resistance. Clin. Cancer Res. 2010, 16:1486-1497.
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 1486-1497
-
-
Leary, A.F.1
Drury, S.2
Detre, S.3
Pancholi, S.4
Lykkesfeldt, A.E.5
Martin, L.A.6
Dowsett, M.7
Johnston, S.R.8
-
15
-
-
77949754385
-
Phase II, randomized trial to compare anastrozole combined with gefitinib or placebo in postmenopausal women with hormone receptor-positive metastatic breast cancer
-
Cristofanilli M., Valero V., Mangalik A., Royce M., Rabinowitz I., Arena F.P., Kroener J.F., Curcio E., Watkins C., Bacus S., Cora E.M., Anderson E., Magill P.J. Phase II, randomized trial to compare anastrozole combined with gefitinib or placebo in postmenopausal women with hormone receptor-positive metastatic breast cancer. Clin. Cancer Res. 2010, 16:1904-1914.
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 1904-1914
-
-
Cristofanilli, M.1
Valero, V.2
Mangalik, A.3
Royce, M.4
Rabinowitz, I.5
Arena, F.P.6
Kroener, J.F.7
Curcio, E.8
Watkins, C.9
Bacus, S.10
Cora, E.M.11
Anderson, E.12
Magill, P.J.13
-
16
-
-
33748527362
-
A phase II and biologic correlative study investigating anastrozole (A) in combination with gefitinib (G) in postmenopausal patients with estrogen receptor positive (ER) metastatic breast carcinoma (MBC) who have previously failed hormonal therapy
-
Mita M., Bono J., Mita A. A phase II and biologic correlative study investigating anastrozole (A) in combination with gefitinib (G) in postmenopausal patients with estrogen receptor positive (ER) metastatic breast carcinoma (MBC) who have previously failed hormonal therapy. Breast Cancer Res. Treat. 2005, 94(Suppl. 1):1117.
-
(2005)
Breast Cancer Res. Treat.
, vol.94
, Issue.SUPPL. 1
, pp. 1117
-
-
Mita, M.1
Bono, J.2
Mita, A.3
-
17
-
-
73949105921
-
Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer: results from the randomized phase III TAnDEM study
-
Kaufman B., Mackey J.R., Clemens M.R., Bapsy P.P., Vaid A., Wardley A., Tjulandin S., Jahn M., Lehle M., Feyereislova A., Revil C., Jones A. Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer: results from the randomized phase III TAnDEM study. J. Clin. Oncol. 2009, 27:5529-5537.
-
(2009)
J. Clin. Oncol.
, vol.27
, pp. 5529-5537
-
-
Kaufman, B.1
Mackey, J.R.2
Clemens, M.R.3
Bapsy, P.P.4
Vaid, A.5
Wardley, A.6
Tjulandin, S.7
Jahn, M.8
Lehle, M.9
Feyereislova, A.10
Revil, C.11
Jones, A.12
-
18
-
-
73149115341
-
Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer
-
Johnston S., Pippen J., Pivot X., Lichinitser M., Sadeghi S., Dieras V., Gomez H.L., Romieu G., Manikhas A., Kennedy M.J., Press M.F., Maltzman J., Florance A., O'Rourke L., Oliva C., Stein S., Pegram M. Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer. J. Clin. Oncol. 2009, 27:5538-5546.
-
(2009)
J. Clin. Oncol.
, vol.27
, pp. 5538-5546
-
-
Johnston, S.1
Pippen, J.2
Pivot, X.3
Lichinitser, M.4
Sadeghi, S.5
Dieras, V.6
Gomez, H.L.7
Romieu, G.8
Manikhas, A.9
Kennedy, M.J.10
Press, M.F.11
Maltzman, J.12
Florance, A.13
O'Rourke, L.14
Oliva, C.15
Stein, S.16
Pegram, M.17
-
19
-
-
20244374413
-
Biomarker changes during neoadjuvant anastrozole, tamoxifen, or the combination: influence of hormonal status and HER-2 in breast cancer-a study from the IMPACT trialists
-
Dowsett M., Ebbs S.R., Dixon J.M., Skene A., Griffith C., Boeddinghaus I., Salter J., Detre S., Hills M., Ashley S., Francis S., Walsh G., Smith I.E. Biomarker changes during neoadjuvant anastrozole, tamoxifen, or the combination: influence of hormonal status and HER-2 in breast cancer-a study from the IMPACT trialists. J. Clin. Oncol. 2005, 23:2477-2492.
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 2477-2492
-
-
Dowsett, M.1
Ebbs, S.R.2
Dixon, J.M.3
Skene, A.4
Griffith, C.5
Boeddinghaus, I.6
Salter, J.7
Detre, S.8
Hills, M.9
Ashley, S.10
Francis, S.11
Walsh, G.12
Smith, I.E.13
-
20
-
-
24644490871
-
Neoadjuvant treatment of postmenopausal breast cancer with anastrozole, tamoxifen, or both in combination: the Immediate Preoperative Anastrozole, Tamoxifen, or Combined with Tamoxifen (IMPACT) multicenter double-blind randomized trial
-
Smith I.E., Dowsett M., Ebbs S.R., Dixon J.M., Skene A., Blohmer J.U., Ashley S.E., Francis S., Boeddinghaus I., Walsh G. Neoadjuvant treatment of postmenopausal breast cancer with anastrozole, tamoxifen, or both in combination: the Immediate Preoperative Anastrozole, Tamoxifen, or Combined with Tamoxifen (IMPACT) multicenter double-blind randomized trial. J. Clin. Oncol. 2005, 23:5108-5116.
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 5108-5116
-
-
Smith, I.E.1
Dowsett, M.2
Ebbs, S.R.3
Dixon, J.M.4
Skene, A.5
Blohmer, J.U.6
Ashley, S.E.7
Francis, S.8
Boeddinghaus, I.9
Walsh, G.10
-
21
-
-
0037157603
-
Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: first results of the ATAC randomised trial
-
Baum M., Budzar A.U., Cuzick J., Forbes J., Houghton J.H., Klijn J.G., Sahmoud T. Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: first results of the ATAC randomised trial. Lancet 2002, 359:2131-2139.
-
(2002)
Lancet
, vol.359
, pp. 2131-2139
-
-
Baum, M.1
Budzar, A.U.2
Cuzick, J.3
Forbes, J.4
Houghton, J.H.5
Klijn, J.G.6
Sahmoud, T.7
-
22
-
-
0142181118
-
Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early-stage breast cancer: results of the ATAC (Arimidex Tamoxifen Alone or in Combination) trial efficacy and safety update analyses
-
Baum M., Buzdar A., Cuzick J., Forbes J., Houghton J., Howell A., Sahmoud T. Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early-stage breast cancer: results of the ATAC (Arimidex Tamoxifen Alone or in Combination) trial efficacy and safety update analyses. Cancer 2003, 98:1802-1810.
-
(2003)
Cancer
, vol.98
, pp. 1802-1810
-
-
Baum, M.1
Buzdar, A.2
Cuzick, J.3
Forbes, J.4
Houghton, J.5
Howell, A.6
Sahmoud, T.7
-
23
-
-
34548445351
-
Molecular response to aromatase inhibitor treatment in primary breast cancer
-
Mackay A., Urruticoechea A., Dixon J.M., Dexter T., Fenwick K., Ashworth A., Drury S., Larionov A., Young O., White S., Miller W.R., Evans D.B., Dowsett M. Molecular response to aromatase inhibitor treatment in primary breast cancer. Breast Cancer Res. 2007, 9:R37.
-
(2007)
Breast Cancer Res.
, vol.9
-
-
Mackay, A.1
Urruticoechea, A.2
Dixon, J.M.3
Dexter, T.4
Fenwick, K.5
Ashworth, A.6
Drury, S.7
Larionov, A.8
Young, O.9
White, S.10
Miller, W.R.11
Evans, D.B.12
Dowsett, M.13
-
24
-
-
63049137792
-
Gene expression profiles differentiating between breast cancers clinically responsive or resistant to letrozole
-
Miller W.R., Larionov A., Renshaw L., Anderson T.J., Walker J.R., Krause A., Sing T., Evans D.B., Dixon J.M. Gene expression profiles differentiating between breast cancers clinically responsive or resistant to letrozole. J. Clin. Oncol. 2009, 27:1382-1387.
-
(2009)
J. Clin. Oncol.
, vol.27
, pp. 1382-1387
-
-
Miller, W.R.1
Larionov, A.2
Renshaw, L.3
Anderson, T.J.4
Walker, J.R.5
Krause, A.6
Sing, T.7
Evans, D.B.8
Dixon, J.M.9
-
25
-
-
34648858600
-
Changes in breast cancer transcriptional profiles after treatment with the aromatase inhibitor, letrozole
-
Miller W.R., Larionov A.A., Renshaw L., Anderson T.J., White S., Murray J., Murray E., Hampton G., Walker J.R., Ho S., Krause A., Evans D.B., Dixon J.M. Changes in breast cancer transcriptional profiles after treatment with the aromatase inhibitor, letrozole. Pharmacogenet. Genomics 2007, 17:813-826.
-
(2007)
Pharmacogenet. Genomics
, vol.17
, pp. 813-826
-
-
Miller, W.R.1
Larionov, A.A.2
Renshaw, L.3
Anderson, T.J.4
White, S.5
Murray, J.6
Murray, E.7
Hampton, G.8
Walker, J.R.9
Ho, S.10
Krause, A.11
Evans, D.B.12
Dixon, J.M.13
-
26
-
-
79960221944
-
Early acquired resistance to endocrine therapy: extending the neoadjuvant model
-
Anderson H., A'Hern R., Salter J., Hills M., Detre S., Larionov A., Skene A., Miller W.R., Dixon J.M., Smith I.E., Dowsett M. Early acquired resistance to endocrine therapy: extending the neoadjuvant model. Cancer Res. 2010, 69:2005.
-
(2010)
Cancer Res.
, vol.69
, pp. 2005
-
-
Anderson, H.1
A'Hern, R.2
Salter, J.3
Hills, M.4
Detre, S.5
Larionov, A.6
Skene, A.7
Miller, W.R.8
Dixon, J.M.9
Smith, I.E.10
Dowsett, M.11
-
27
-
-
34548537574
-
A phase II placebo-controlled trial of neoadjuvant anastrozole alone or with gefitinib in early breast cancer
-
Smith I.E., Walsh G., Skene A., Llombart A., Mayordomo J.I., Detre S., Salter J., Clark E., Magill P., Dowsett M. A phase II placebo-controlled trial of neoadjuvant anastrozole alone or with gefitinib in early breast cancer. J. Clin. Oncol. 2007, 25:3816-3822.
-
(2007)
J. Clin. Oncol.
, vol.25
, pp. 3816-3822
-
-
Smith, I.E.1
Walsh, G.2
Skene, A.3
Llombart, A.4
Mayordomo, J.I.5
Detre, S.6
Salter, J.7
Clark, E.8
Magill, P.9
Dowsett, M.10
-
28
-
-
0029877913
-
Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation
-
Bunone G., Briand P.A., Miksicek R.J., Picard D. Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation. EMBO J. 1996, 15:2174-2183.
-
(1996)
EMBO J.
, vol.15
, pp. 2174-2183
-
-
Bunone, G.1
Briand, P.A.2
Miksicek, R.J.3
Picard, D.4
-
29
-
-
0031594574
-
Pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167
-
Joel P.B., Smith J., Sturgill T.W., Fisher T.L., Blenis J., Lannigan D.A. pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167. Mol. Cell. Biol. 1998, 18:1978-1984.
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 1978-1984
-
-
Joel, P.B.1
Smith, J.2
Sturgill, T.W.3
Fisher, T.L.4
Blenis, J.5
Lannigan, D.A.6
-
30
-
-
0034667395
-
Inhibition of HER2/neu (erbB-2) and mitogen-activated protein kinases enhances tamoxifen action against HER2-overexpressing, tamoxifen-resistant breast cancer cells
-
Kurokawa H., Lenferink A.E., Simpson J.F., Pisacane P.I., Sliwkowski M.X., Forbes J.T., Arteaga C.L. Inhibition of HER2/neu (erbB-2) and mitogen-activated protein kinases enhances tamoxifen action against HER2-overexpressing, tamoxifen-resistant breast cancer cells. Cancer Res. 2000, 60:5887-5894.
-
(2000)
Cancer Res.
, vol.60
, pp. 5887-5894
-
-
Kurokawa, H.1
Lenferink, A.E.2
Simpson, J.F.3
Pisacane, P.I.4
Sliwkowski, M.X.5
Forbes, J.T.6
Arteaga, C.L.7
-
31
-
-
0000631273
-
The signal-dependent coactivator CBP is a nuclear target for pp90RSK
-
Nakajima T., Fukamizu A., Takahashi J., Gage F.H., Fisher T., Blenis J., Montminy M.R. The signal-dependent coactivator CBP is a nuclear target for pp90RSK. Cell 1996, 86:465-474.
-
(1996)
Cell
, vol.86
, pp. 465-474
-
-
Nakajima, T.1
Fukamizu, A.2
Takahashi, J.3
Gage, F.H.4
Fisher, T.5
Blenis, J.6
Montminy, M.R.7
-
32
-
-
0029786690
-
CREB binding protein acts synergistically with steroid receptor coactivator-1 to enhance steroid receptor-dependent transcription
-
Smith C.L., Onate S.A., Tsai M.J., O'Malley B.W. CREB binding protein acts synergistically with steroid receptor coactivator-1 to enhance steroid receptor-dependent transcription. Proc. Natl. Acad. Sci. U.S.A. 1996, 93:8884-8888.
-
(1996)
Proc. Natl. Acad. Sci. U.S.A.
, vol.93
, pp. 8884-8888
-
-
Smith, C.L.1
Onate, S.A.2
Tsai, M.J.3
O'Malley, B.W.4
|