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Volumn 29, Issue 4, 2011, Pages

Heart failure with preserved ejection fraction: Pathophysiology and emerging therapies

Author keywords

Diastole; Heart failure; Heart failure with preserved ejection fraction; Hypertension; Pathophysiology; Treatment

Indexed keywords

ALDOSTERONE; AMINO TERMINAL PRO BRAIN NATRIURETIC PEPTIDE; AMLODIPINE; BETA ADRENERGIC RECEPTOR; BIOLOGICAL MARKER; BRAIN NATRIURETIC PEPTIDE; CANDESARTAN; CARVEDILOL; CHLORTALIDONE; DIGOXIN; DIURETIC AGENT; DOXAZOSIN; ENALAPRIL; HYDROCHLOROTHIAZIDE; IRBESARTAN; LISINOPRIL; LOSARTAN; NEBIVOLOL; NEUROHORMONE; NITRATE; PERINDOPRIL; PHOSPHODIESTERASE V INHIBITOR; PLACEBO; PROPRANOLOL; RAMIPRIL; ROSUVASTATIN; SPIRONOLACTONE; UNINDEXED DRUG; VALSARTAN; VERAPAMIL; ANGIOTENSIN RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR;

EID: 79960259253     PISSN: 17555914     EISSN: 17555922     Source Type: Journal    
DOI: 10.1111/j.1755-5922.2010.00133.x     Document Type: Review
Times cited : (26)

References (155)
  • 2
    • 33746033433 scopus 로고    scopus 로고
    • Outcome of heart failure with preserved ejection fraction in a population-based study
    • Bhatia RS, Tu JV, Lee DS, et al. Outcome of heart failure with preserved ejection fraction in a population-based study. N Engl J Med 2006;355:260-269.
    • (2006) N Engl J Med , vol.355 , pp. 260-269
    • Bhatia, R.S.1    Tu, J.V.2    Lee, D.S.3
  • 3
    • 0041408234 scopus 로고    scopus 로고
    • Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: The CHARM-Preserved Trial
    • Yusuf S, Pfeffer MA, Swedberg K, et al. Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: The CHARM-Preserved Trial. Lancet 2003;362:777-781.
    • (2003) Lancet , vol.362 , pp. 777-781
    • Yusuf, S.1    Pfeffer, M.A.2    Swedberg, K.3
  • 5
    • 57349142933 scopus 로고    scopus 로고
    • Irbesartan in patients with heart failure and preserved ejection fraction
    • Massie BM, Carson PE, McMurray JJ, et al. Irbesartan in patients with heart failure and preserved ejection fraction. N Engl J Med 2008;359:2456-2467.
    • (2008) N Engl J Med , vol.359 , pp. 2456-2467
    • Massie, B.M.1    Carson, P.E.2    McMurray, J.J.3
  • 6
    • 0025727274 scopus 로고
    • Exercise intolerance in patients with heart failure and preserved left ventricular systolic function: Failure of the Frank-Starling mechanism
    • Kitzman DW, Higginbotham MB, Cobb FR, Sheikh KH, Sullivan MJ. Exercise intolerance in patients with heart failure and preserved left ventricular systolic function: Failure of the Frank-Starling mechanism. J Am Coll Cardiol 1991;17:1065-1072.
    • (1991) J Am Coll Cardiol , vol.17 , pp. 1065-1072
    • Kitzman, D.W.1    Higginbotham, M.B.2    Cobb, F.R.3    Sheikh, K.H.4    Sullivan, M.J.5
  • 7
    • 0035804283 scopus 로고    scopus 로고
    • The pathogenesis of acute pulmonary edema associated with hypertension
    • Gandhi SK, Powers JC, Nomeir AM, et al. The pathogenesis of acute pulmonary edema associated with hypertension. N Engl J Med 2001;344:17-22.
    • (2001) N Engl J Med , vol.344 , pp. 17-22
    • Gandhi, S.K.1    Powers, J.C.2    Nomeir, A.M.3
  • 8
    • 3843094224 scopus 로고    scopus 로고
    • Diastolic heart failure-abnormalities in active relaxation and passive stiffness of the left ventricle
    • Zile MR, Baicu CF, Gaasch WH. Diastolic heart failure-abnormalities in active relaxation and passive stiffness of the left ventricle. N Engl J Med 2004;350:1953-1959.
    • (2004) N Engl J Med , vol.350 , pp. 1953-1959
    • Zile, M.R.1    Baicu, C.F.2    Gaasch, W.H.3
  • 9
    • 42449100055 scopus 로고    scopus 로고
    • Role of left ventricular stiffness in heart failure with normal ejection fraction
    • Westermann D, Kasner M, Steendijk P, et al. Role of left ventricular stiffness in heart failure with normal ejection fraction. Circulation 2008;117:2051-2060.
    • (2008) Circulation , vol.117 , pp. 2051-2060
    • Westermann, D.1    Kasner, M.2    Steendijk, P.3
  • 10
    • 34247201690 scopus 로고    scopus 로고
    • Cardiac structure and ventricular-vascular function in persons with heart failure and preserved ejection fraction from Olmsted County, Minnesota
    • Lam CS, Roger VL, Rodeheffer RJ, et al. Cardiac structure and ventricular-vascular function in persons with heart failure and preserved ejection fraction from Olmsted County, Minnesota. Circulation 2007;115:1982-1990.
    • (2007) Circulation , vol.115 , pp. 1982-1990
    • Lam, C.S.1    Roger, V.L.2    Rodeheffer, R.J.3
  • 11
    • 0037432184 scopus 로고    scopus 로고
    • Combined ventricular systolic and arterial stiffening in patients with heart failure and preserved ejection fraction: Implications for systolic and diastolic reserve limitations
    • Kawaguchi M, Hay I, Fetics B, Kass DA. Combined ventricular systolic and arterial stiffening in patients with heart failure and preserved ejection fraction: Implications for systolic and diastolic reserve limitations. Circulation 2003;107:714-720.
    • (2003) Circulation , vol.107 , pp. 714-720
    • Kawaguchi, M.1    Hay, I.2    Fetics, B.3    Kass, D.A.4
  • 12
    • 0036153340 scopus 로고    scopus 로고
    • Left ventricular long axis function in diastolic heart failure is reduced in both diastole and systole: Time for a redefinition?
    • Yip G, Wang M, Zhang Y, Fung JW, Ho PY, Sanderson JE. Left ventricular long axis function in diastolic heart failure is reduced in both diastole and systole: Time for a redefinition? Heart 2002;87:121-125.
    • (2002) Heart , vol.87 , pp. 121-125
    • Yip, G.1    Wang, M.2    Zhang, Y.3    Fung, J.W.4    Ho, P.Y.5    Sanderson, J.E.6
  • 13
    • 0037066023 scopus 로고    scopus 로고
    • Progression of systolic abnormalities in patients with "isolated" diastolic heart failure and diastolic dysfunction
    • Yu CM, Lin H, Yang H, Kong SL, Zhang Q, Lee SW. Progression of systolic abnormalities in patients with "isolated" diastolic heart failure and diastolic dysfunction. Circulation 2002;105:1195-1201.
    • (2002) Circulation , vol.105 , pp. 1195-1201
    • Yu, C.M.1    Lin, H.2    Yang, H.3    Kong, S.L.4    Zhang, Q.5    Lee, S.W.6
  • 14
    • 0036145166 scopus 로고    scopus 로고
    • Diastolic heart failure" or heart failure caused by subtle left ventricular systolic dysfunction?
    • Petrie MC, Caruana L, Berry C, McMurray JJ. Diastolic heart failure" or heart failure caused by subtle left ventricular systolic dysfunction? Heart 2002;87:29-31.
    • (2002) Heart , vol.87 , pp. 29-31
    • Petrie, M.C.1    Caruana, L.2    Berry, C.3    McMurray, J.J.4
  • 15
    • 33750995868 scopus 로고    scopus 로고
    • Impaired chronotropic and vasodilator reserves limit exercise capacity in patients with heart failure and a preserved ejection fraction
    • Borlaug BA, Melenovsky V, Russell SD, Kessler K, Pacak K, Becker LC, Kass DA. Impaired chronotropic and vasodilator reserves limit exercise capacity in patients with heart failure and a preserved ejection fraction. Circulation 2006;114:2138-2147.
    • (2006) Circulation , vol.114 , pp. 2138-2147
    • Borlaug, B.A.1    Melenovsky, V.2    Russell, S.D.3    Kessler, K.4    Pacak, K.5    Becker, L.C.6    Kass, D.A.7
  • 16
    • 16244402639 scopus 로고    scopus 로고
    • Left heart failure with a normal ejection fraction: Identification of different pathophysiologic mechanisms
    • Maurer MS, King DL, El-Khoury Rumbarger L, Packer M, Burkhoff D. Left heart failure with a normal ejection fraction: Identification of different pathophysiologic mechanisms. J Card Fail 2005; 11:177-187.
    • (2005) J Card Fail , vol.11 , pp. 177-187
    • Maurer, M.S.1    King, D.L.2    El-Khoury Rumbarger, L.3    Packer, M.4    Burkhoff, D.5
  • 17
    • 33846083280 scopus 로고    scopus 로고
    • Cardiovascular features of heart failure with preserved ejection fraction versus nonfailing hypertensive left ventricular hypertrophy in the urban Baltimore community: The role of atrial remodeling/dysfunction
    • Melenovsky V, Borlaug BA, Rosen B, et al. Cardiovascular features of heart failure with preserved ejection fraction versus nonfailing hypertensive left ventricular hypertrophy in the urban Baltimore community: The role of atrial remodeling/dysfunction. J Am Coll Cardiol 2007;49:198-207.
    • (2007) J Am Coll Cardiol , vol.49 , pp. 198-207
    • Melenovsky, V.1    Borlaug, B.A.2    Rosen, B.3
  • 18
    • 33847316480 scopus 로고    scopus 로고
    • Ventricular structure and function in hypertensive participants with heart failure and a normal ejection fraction: The Cardiovascular Health Study
    • Maurer MS, Burkhoff D, Fried LP, Gottdiener J, King DL, Kitzman DW. Ventricular structure and function in hypertensive participants with heart failure and a normal ejection fraction: The Cardiovascular Health Study. J Am Coll Cardiol 2007;49:972-981.
    • (2007) J Am Coll Cardiol , vol.49 , pp. 972-981
    • Maurer, M.S.1    Burkhoff, D.2    Fried, L.P.3    Gottdiener, J.4    King, D.L.5    Kitzman, D.W.6
  • 19
    • 48049092842 scopus 로고    scopus 로고
    • Left ventricular abnormal response during dynamic exercise in patients with heart failure and preserved left ventricular ejection fraction at rest
    • Ennezat PV, Lefetz Y, Marechaux S, et al. Left ventricular abnormal response during dynamic exercise in patients with heart failure and preserved left ventricular ejection fraction at rest. J Card Fail 2008;14:475-480.
    • (2008) J Card Fail , vol.14 , pp. 475-480
    • Ennezat, P.V.1    Lefetz, Y.2    Marechaux, S.3
  • 20
    • 44449100711 scopus 로고    scopus 로고
    • Preserved left ventricular twist and circumferential deformation, but depressed longitudinal and radial deformation in patients with diastolic heart failure
    • Wang J, Khoury DS, Yue Y, Torre-Amione G, Nagueh SF. Preserved left ventricular twist and circumferential deformation, but depressed longitudinal and radial deformation in patients with diastolic heart failure. Eur Heart J 2008;29:1283-1289.
    • (2008) Eur Heart J , vol.29 , pp. 1283-1289
    • Wang, J.1    Khoury, D.S.2    Yue, Y.3    Torre-Amione, G.4    Nagueh, S.F.5
  • 22
    • 67650538295 scopus 로고    scopus 로고
    • Contractility and ventricular systolic stiffening in hypertensive heart disease insights into the pathogenesis of heart failure with preserved ejection fraction
    • Borlaug BA, Lam CS, Roger VL, Rodeheffer RJ, Redfield MM. Contractility and ventricular systolic stiffening in hypertensive heart disease insights into the pathogenesis of heart failure with preserved ejection fraction. J Am Coll Cardiol 2009;54:410-418.
    • (2009) J Am Coll Cardiol , vol.54 , pp. 410-418
    • Borlaug, B.A.1    Lam, C.S.2    Roger, V.L.3    Rodeheffer, R.J.4    Redfield, M.M.5
  • 23
    • 67449092157 scopus 로고    scopus 로고
    • The pathophysiology of heart failure with normal ejection fraction: Exercise echocardiography reveals complex abnormalities of both systolic and diastolic ventricular function involving torsion, untwist, and longitudinal motion
    • Tan YT, Wenzelburger F, Lee E, et al. The pathophysiology of heart failure with normal ejection fraction: Exercise echocardiography reveals complex abnormalities of both systolic and diastolic ventricular function involving torsion, untwist, and longitudinal motion. J Am Coll Cardiol 2009;54:36-46.
    • (2009) J Am Coll Cardiol , vol.54 , pp. 36-46
    • Tan, Y.T.1    Wenzelburger, F.2    Lee, E.3
  • 24
    • 67650547206 scopus 로고    scopus 로고
    • Heart failure with preserved ejection fraction is characterized by dynamic impairment of active relaxation and contraction of the left ventricle on exercise and associated with myocardial energy deficiency
    • Phan TT, Abozguia K, Nallur Shivu G, et al. Heart failure with preserved ejection fraction is characterized by dynamic impairment of active relaxation and contraction of the left ventricle on exercise and associated with myocardial energy deficiency. J Am Coll Cardiol 2009;54:402-409.
    • (2009) J Am Coll Cardiol , vol.54 , pp. 402-409
    • Phan, T.T.1    Abozguia, K.2    Nallur Shivu, G.3
  • 25
    • 33749991812 scopus 로고    scopus 로고
    • Mechanisms of diastolic dysfunction in heart failure
    • Borlaug BA, Kass DA. Mechanisms of diastolic dysfunction in heart failure. Trends Cardiovasc Med 2006;16:273-279.
    • (2006) Trends Cardiovasc Med , vol.16 , pp. 273-279
    • Borlaug, B.A.1    Kass, D.A.2
  • 26
    • 11144354091 scopus 로고    scopus 로고
    • Hospitalization for heart failure in the presence of a normal left ventricular ejection fraction: Results of the New York Heart Failure Registry
    • Klapholz M, Maurer M, Lowe AM, et al. Hospitalization for heart failure in the presence of a normal left ventricular ejection fraction: Results of the New York Heart Failure Registry. J Am Coll Cardiol 2004;43:1432-1438.
    • (2004) J Am Coll Cardiol , vol.43 , pp. 1432-1438
    • Klapholz, M.1    Maurer, M.2    Lowe, A.M.3
  • 27
    • 65549145093 scopus 로고    scopus 로고
    • Focused update incorporated into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults: A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: Developed in collaboration with the International Society for Heart and Lung Transplantation
    • 2009;:.
    • Hunt SA, Abraham WT, Chin MH, et al. 2009 Focused update incorporated into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults: A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: Developed in collaboration with the International Society for Heart and Lung Transplantation. Circulation 2009;119:e391-e479.
    • (2009) Circulation , vol.119
    • Hunt, S.A.1    Abraham, W.T.2    Chin, M.H.3
  • 28
    • 0037432199 scopus 로고    scopus 로고
    • Heart failure with a normal ejection fraction: Is it really a disorder of diastolic function?
    • Burkhoff D, Maurer MS, Packer M. Heart failure with a normal ejection fraction: Is it really a disorder of diastolic function? Circulation 2003;107:656-658.
    • (2003) Circulation , vol.107 , pp. 656-658
    • Burkhoff, D.1    Maurer, M.S.2    Packer, M.3
  • 29
    • 33846186415 scopus 로고    scopus 로고
    • Heart failure-associated alterations in troponin I phosphorylation impair ventricular relaxation-after load and force-frequency responses and systolic function
    • Bilchick KC, Duncan JG, Ravi R, et al. Heart failure-associated alterations in troponin I phosphorylation impair ventricular relaxation-after load and force-frequency responses and systolic function. Am J Physiol Heart Circ Physiol 2006;292:H318-H325.
    • (2006) Am J Physiol Heart Circ Physiol , vol.292
    • Bilchick, K.C.1    Duncan, J.G.2    Ravi, R.3
  • 32
    • 0033178717 scopus 로고    scopus 로고
    • Afterload induced changes in myocardial relaxation: A mechanism for diastolic dysfunction
    • Leite-Moreira AF, Correia-Pinto J, Gillebert TC. Afterload induced changes in myocardial relaxation: A mechanism for diastolic dysfunction. Cardiovasc Res 1999;43:344-353.
    • (1999) Cardiovasc Res , vol.43 , pp. 344-353
    • Leite-Moreira, A.F.1    Correia-Pinto, J.2    Gillebert, T.C.3
  • 33
    • 34548185475 scopus 로고    scopus 로고
    • Acute and chronic ventricular-arterial coupling in systole and diastole. Insights from an elderly hypertensive model
    • Shapiro BP, Lam CS, Patel JB, et al. Acute and chronic ventricular-arterial coupling in systole and diastole. Insights from an elderly hypertensive model. Hypertension 2007;50:503-511.
    • (2007) Hypertension , vol.50 , pp. 503-511
    • Shapiro, B.P.1    Lam, C.S.2    Patel, J.B.3
  • 34
    • 34250689098 scopus 로고    scopus 로고
    • Effect of angiotensin receptor blockade and antihypertensive drugs on diastolic function in patients with hypertension and diastolic dysfunction: A randomised trial
    • Solomon SD, Janardhanan R, Verma A, et al. Effect of angiotensin receptor blockade and antihypertensive drugs on diastolic function in patients with hypertension and diastolic dysfunction: A randomised trial. Lancet 2007;369:2079-2087.
    • (2007) Lancet , vol.369 , pp. 2079-2087
    • Solomon, S.D.1    Janardhanan, R.2    Verma, A.3
  • 35
    • 39649112375 scopus 로고    scopus 로고
    • The cardiac cycle and the physiologic basis of left ventricular contraction, ejection, relaxation, and filling
    • Fukuta H, Little WC. The cardiac cycle and the physiologic basis of left ventricular contraction, ejection, relaxation, and filling. Heart Fail Clin 2008;4:1-11.
    • (2008) Heart Fail Clin , vol.4 , pp. 1-11
    • Fukuta, H.1    Little, W.C.2
  • 36
    • 0023481279 scopus 로고
    • Comparative influence of load versus inotropic states on indexes of ventricular contractility: Experimental and theoretical analysis based on pressure-volume relationships
    • Kass DA, Maughan WL, Guo ZM, Kono A, Sunagawa K, Sagawa K. Comparative influence of load versus inotropic states on indexes of ventricular contractility: Experimental and theoretical analysis based on pressure-volume relationships. Circulation 1987;76:1422-1436.
    • (1987) Circulation , vol.76 , pp. 1422-1436
    • Kass, D.A.1    Maughan, W.L.2    Guo, Z.M.3    Kono, A.4    Sunagawa, K.5    Sagawa, K.6
  • 37
    • 33645014333 scopus 로고    scopus 로고
    • Contractile behavior of the left ventricle in diastolic heart failure: With emphasis on regional systolic function
    • Aurigemma GP, Zile MR, Gaasch WH. Contractile behavior of the left ventricle in diastolic heart failure: With emphasis on regional systolic function. Circulation 2006;113:296-304.
    • (2006) Circulation , vol.113 , pp. 296-304
    • Aurigemma, G.P.1    Zile, M.R.2    Gaasch, W.H.3
  • 38
    • 18444374462 scopus 로고    scopus 로고
    • Left ventricular systolic performance, function, and contractility in patients with diastolic heart failure
    • Baicu CF, Zile MR, Aurigemma GP, Gaasch WH. Left ventricular systolic performance, function, and contractility in patients with diastolic heart failure. Circulation 2005;111:2306-2312.
    • (2005) Circulation , vol.111 , pp. 2306-2312
    • Baicu, C.F.1    Zile, M.R.2    Aurigemma, G.P.3    Gaasch, W.H.4
  • 39
    • 39649106311 scopus 로고    scopus 로고
    • Ventricular-vascular interaction in heart failure
    • Borlaug BA, Kass DA. Ventricular-vascular interaction in heart failure. Heart Fail Clin 2008;4:23-36.
    • (2008) Heart Fail Clin , vol.4 , pp. 23-36
    • Borlaug, B.A.1    Kass, D.A.2
  • 40
    • 58649123999 scopus 로고    scopus 로고
    • Cardiovascular reserve function in heart failure with preserved ejection fraction: Systolic versus diastolic determinants
    • Borlaug BA, Lam CSP, Olson TP, Flood KS, Johnson BD, Redfield MM. Cardiovascular reserve function in heart failure with preserved ejection fraction: Systolic versus diastolic determinants. Circulation (abs) 2008;118:S1022.
    • (2008) Circulation (abs) , vol.118
    • Borlaug, B.A.1    Lam, C.S.P.2    Olson, T.P.3    Flood, K.S.4    Johnson, B.D.5    Redfield, M.M.6
  • 41
    • 33749181093 scopus 로고    scopus 로고
    • Chronotropic incompetence and its contribution to exercise intolerance in older heart failure patients
    • Brubaker PH, Joo KC, Stewart KP, Fray B, Moore B, Kitzman DW. Chronotropic incompetence and its contribution to exercise intolerance in older heart failure patients. J Cardiopulm Rehabil 2006;26:86-89.
    • (2006) J Cardiopulm Rehabil , vol.26 , pp. 86-89
    • Brubaker, P.H.1    Joo, K.C.2    Stewart, K.P.3    Fray, B.4    Moore, B.5    Kitzman, D.W.6
  • 43
    • 0024347775 scopus 로고
    • Impaired chronotropic response to exercise in patients with congestive heart failure. Role of postsynaptic beta-adrenergic desensitization
    • Colucci WS, Ribeiro JP, Rocco MB, et al. Impaired chronotropic response to exercise in patients with congestive heart failure. Role of postsynaptic beta-adrenergic desensitization. Circulation 1989;80:314-323.
    • (1989) Circulation , vol.80 , pp. 314-323
    • Colucci, W.S.1    Ribeiro, J.P.2    Rocco, M.B.3
  • 44
    • 14044251380 scopus 로고    scopus 로고
    • Effects of candesartan on cardiac sympathetic nerve activity in patients with congestive heart failure and preserved left ventricular ejection fraction
    • Kasama S, Toyama T, Kumakura H, Takayama Y, Ichikawa S, Suzuki T, Kurabayashi M. Effects of candesartan on cardiac sympathetic nerve activity in patients with congestive heart failure and preserved left ventricular ejection fraction. J Am Coll Cardiol 2005;45:661-667.
    • (2005) J Am Coll Cardiol , vol.45 , pp. 661-667
    • Kasama, S.1    Toyama, T.2    Kumakura, H.3    Takayama, Y.4    Ichikawa, S.5    Suzuki, T.6    Kurabayashi, M.7
  • 45
    • 79960283578 scopus 로고    scopus 로고
    • Impaired heart rate recovery and chronotropic incompetence in patients with heart failure with preserved ejection fraction
    • Nov 16 [Epub ahead of print]. doi:.
    • Phan TT, Nallur Shivu G, Abozguia K, et al. Impaired heart rate recovery and chronotropic incompetence in patients with heart failure with preserved ejection fraction. Circ Heart Fail 2009 Nov 16 [Epub ahead of print]. doi:.
    • (2009) Circ Heart Fail
    • Phan, T.T.1    Nallur Shivu, G.2    Abozguia, K.3
  • 46
    • 33748668461 scopus 로고    scopus 로고
    • Altered creatine kinase adenosine triphosphate kinetics in failing hypertrophied human myocardium
    • Smith CS, Bottomley PA, Schulman SP, Gerstenblith G, Weiss RG. Altered creatine kinase adenosine triphosphate kinetics in failing hypertrophied human myocardium. Circulation 2006;114:1151-1158.
    • (2006) Circulation , vol.114 , pp. 1151-1158
    • Smith, C.S.1    Bottomley, P.A.2    Schulman, S.P.3    Gerstenblith, G.4    Weiss, R.G.5
  • 47
    • 0027372973 scopus 로고
    • Diminished contractile response to increased heart rate in intact human left ventricular hypertrophy. Systolic versus diastolic determinants
    • Liu CP, Ting CT, Lawrence W, Maughan WL, Chang MS, Kass DA. Diminished contractile response to increased heart rate in intact human left ventricular hypertrophy. Systolic versus diastolic determinants. Circulation 1993;88:1893-1906.
    • (1993) Circulation , vol.88 , pp. 1893-1906
    • Liu, C.P.1    Ting, C.T.2    Lawrence, W.3    Maughan, W.L.4    Chang, M.S.5    Kass, D.A.6
  • 48
    • 0027190019 scopus 로고
    • Impaired acetylcholine-mediated vasodilation in patients with congestive heart failure. Role of endothelium-derived vasodilating and vasoconstricting factors
    • Katz SD, Schwarz M, Yuen J, LeJemtel TH. Impaired acetylcholine-mediated vasodilation in patients with congestive heart failure. Role of endothelium-derived vasodilating and vasoconstricting factors. Circulation 1993;88:55-61.
    • (1993) Circulation , vol.88 , pp. 55-61
    • Katz, S.D.1    Schwarz, M.2    Yuen, J.3    LeJemtel, T.H.4
  • 49
    • 33847726656 scopus 로고    scopus 로고
    • Leg flow-mediated arterial dilation in elderly patients with heart failure and normal left ventricular ejection fraction
    • Hundley WG, Bayram E, Hamilton CA, et al. Leg flow-mediated arterial dilation in elderly patients with heart failure and normal left ventricular ejection fraction. Am J Physiol Heart Circ Physiol 2007;292:H1427-H1434.
    • (2007) Am J Physiol Heart Circ Physiol , vol.292
    • Hundley, W.G.1    Bayram, E.2    Hamilton, C.A.3
  • 50
    • 79960210410 scopus 로고    scopus 로고
    • Does endothelial dysfunction contribute to exercise limitation in heart failure with preserved ejection fraction?
    • Borlaug BA, Olson TP, Lam CS, Flood KS, Johnson BD, Redfield MM, Lerman A. Does endothelial dysfunction contribute to exercise limitation in heart failure with preserved ejection fraction?. J Am Coll Cardiol 2009; 53(10 Suppl A):A144-A197.
    • (2009) J Am Coll Cardiol , vol.53 , Issue.10 SUPPL. A
    • Borlaug, B.A.1    Olson, T.P.2    Lam, C.S.3    Flood, K.S.4    Johnson, B.D.5    Redfield, M.M.6    Lerman, A.7
  • 51
    • 0032211093 scopus 로고    scopus 로고
    • Coupled systolic-ventricular and vascular stiffening with age: Implications for pressure regulation and cardiac reserve in the elderly
    • Chen CH, Nakayama M, Nevo E, Fetics BJ, Maughan WL, Kass DA. Coupled systolic-ventricular and vascular stiffening with age: Implications for pressure regulation and cardiac reserve in the elderly. J Am Coll Cardiol 1998;32:1221-1227.
    • (1998) J Am Coll Cardiol , vol.32 , pp. 1221-1227
    • Chen, C.H.1    Nakayama, M.2    Nevo, E.3    Fetics, B.J.4    Maughan, W.L.5    Kass, D.A.6
  • 52
    • 0034847365 scopus 로고    scopus 로고
    • Cardiac cycle-dependent changes in aortic area and distensibility are reduced in older patients with isolated diastolic heart failure and correlate with exercise intolerance
    • Hundley WG, Kitzman DW, Morgan TM, et al. Cardiac cycle-dependent changes in aortic area and distensibility are reduced in older patients with isolated diastolic heart failure and correlate with exercise intolerance. J Am Coll Cardiol 2001;38:796-802.
    • (2001) J Am Coll Cardiol , vol.38 , pp. 796-802
    • Hundley, W.G.1    Kitzman, D.W.2    Morgan, T.M.3
  • 53
    • 4444227057 scopus 로고    scopus 로고
    • Mechanisms of heart failure with well preserved ejection fraction in dogs following limited coronary microembolization
    • He KL, Dickstein M, Sabbah HN, et al. Mechanisms of heart failure with well preserved ejection fraction in dogs following limited coronary microembolization. Cardiovasc Res 2004;64:72-83.
    • (2004) Cardiovasc Res , vol.64 , pp. 72-83
    • He, K.L.1    Dickstein, M.2    Sabbah, H.N.3
  • 54
    • 29244481128 scopus 로고    scopus 로고
    • Left atrial volume, geometry, and function in systolic and diastolic heart failure of persons ≥ 65 years of age (the cardiovascular health study)
    • Gottdiener JS, Kitzman DW, Aurigemma GP, Arnold AM, Manolio TA. Left atrial volume, geometry, and function in systolic and diastolic heart failure of persons ≥ 65 years of age (the cardiovascular health study). Am J Cardiol 2006;97:83-89.
    • (2006) Am J Cardiol , vol.97 , pp. 83-89
    • Gottdiener, J.S.1    Kitzman, D.W.2    Aurigemma, G.P.3    Arnold, A.M.4    Manolio, T.A.5
  • 55
    • 34948848595 scopus 로고    scopus 로고
    • Impact of atrial fibrillation in heart failure with normal ejection fraction: A clinical and echocardiographic study
    • Fung JW, Sanderson JE, Yip GW, Zhang Q, Yu CM. Impact of atrial fibrillation in heart failure with normal ejection fraction: A clinical and echocardiographic study. J Card Fail 2007;13:649-655.
    • (2007) J Card Fail , vol.13 , pp. 649-655
    • Fung, J.W.1    Sanderson, J.E.2    Yip, G.W.3    Zhang, Q.4    Yu, C.M.5
  • 57
    • 33845902228 scopus 로고    scopus 로고
    • Systolic and diastolic dyssynchrony in patients with diastolic heart failure and the effect of medical therapy
    • Wang J, Kurrelmeyer KM, Torre-Amione G, Nagueh SF. Systolic and diastolic dyssynchrony in patients with diastolic heart failure and the effect of medical therapy. J Am Coll Cardiol 2007;49:88-96.
    • (2007) J Am Coll Cardiol , vol.49 , pp. 88-96
    • Wang, J.1    Kurrelmeyer, K.M.2    Torre-Amione, G.3    Nagueh, S.F.4
  • 58
    • 33845909967 scopus 로고    scopus 로고
    • Diastolic and systolic asynchrony in patients with diastolic heart failure: A common but ignored condition
    • Yu CM, Zhang Q, Yip GW, Lee PW, Kum LC, Lam YY, Fung JW. Diastolic and systolic asynchrony in patients with diastolic heart failure: A common but ignored condition. J Am Coll Cardiol 2007;49:97-105.
    • (2007) J Am Coll Cardiol , vol.49 , pp. 97-105
    • Yu, C.M.1    Zhang, Q.2    Yip, G.W.3    Lee, P.W.4    Kum, L.C.5    Lam, Y.Y.6    Fung, J.W.7
  • 59
    • 33846330126 scopus 로고    scopus 로고
    • Unexplained pulmonary hypertension in elderly patients
    • Shapiro BP, McGoon MD, Redfield MM. Unexplained pulmonary hypertension in elderly patients. Chest 2007;131:94-100.
    • (2007) Chest , vol.131 , pp. 94-100
    • Shapiro, B.P.1    McGoon, M.D.2    Redfield, M.M.3
  • 60
    • 72649099929 scopus 로고    scopus 로고
    • Caveat Medicus! Pulmonary hypertension in the elderly: A word of caution
    • Boilson BA, Schiger JA, Borlaug BA. Caveat Medicus! Pulmonary hypertension in the elderly: A word of caution. Eur J Heart Fail 2010;12:89-93.
    • (2010) Eur J Heart Fail , vol.12 , pp. 89-93
    • Boilson, B.A.1    Schiger, J.A.2    Borlaug, B.A.3
  • 61
    • 78650067846 scopus 로고    scopus 로고
    • A phase 2 randomized, double-blind, placebo-controlled exploratory efficacy study of Sitaxsentan sodium to improve impaired exercise tolerance in subjects with diastolic heart failure
    • Zile MR, Barst RJ, Bourge R, Redfield MM, Little WC. A phase 2 randomized, double-blind, placebo-controlled exploratory efficacy study of Sitaxsentan sodium to improve impaired exercise tolerance in subjects with diastolic heart failure. J Card Fail (abs) 2009;15(6 Suppl 1):S63.
    • (2009) J Card Fail (abs) , vol.15 , Issue.6 SUPPL. 1
    • Zile, M.R.1    Barst, R.J.2    Bourge, R.3    Redfield, M.M.4    Little, W.C.5
  • 62
    • 79960255070 scopus 로고    scopus 로고
    • Evaluating the effectiveness of sildenafil at improving health outcomes and exercise ability in people with diastolic heart failure (The RELAX Study). Available from:. NCT00763867 [Accessed 20 November 2009].
    • Redfield MM, Lee KL, Braunwald E. Evaluating the effectiveness of sildenafil at improving health outcomes and exercise ability in people with diastolic heart failure (The RELAX Study). Available from: 2008; NCT00763867 [Accessed 20 November 2009].
    • (2008)
    • Redfield, M.M.1    Lee, K.L.2    Braunwald, E.3
  • 63
    • 37449010748 scopus 로고    scopus 로고
    • An epidemic of dyssynchrony: But what does it mean?
    • Kass DA. An epidemic of dyssynchrony: But what does it mean? J Am Coll Cardiol 2008;51:12-17.
    • (2008) J Am Coll Cardiol , vol.51 , pp. 12-17
    • Kass, D.A.1
  • 64
    • 33847103071 scopus 로고    scopus 로고
    • Why does chronic heart failure cause breathlessness and fatigue?
    • Witte KK, Clark AL. Why does chronic heart failure cause breathlessness and fatigue? Prog Cardiovasc Dis 2007;49:366-384.
    • (2007) Prog Cardiovasc Dis , vol.49 , pp. 366-384
    • Witte, K.K.1    Clark, A.L.2
  • 65
    • 0030297870 scopus 로고    scopus 로고
    • Exercise limitation in chronic heart failure: Central role of the periphery
    • Clark AL, Poole-Wilson PA, Coats AJ. Exercise limitation in chronic heart failure: Central role of the periphery. J Am Coll Cardiol 1996;28:1092-1102.
    • (1996) J Am Coll Cardiol , vol.28 , pp. 1092-1102
    • Clark, A.L.1    Poole-Wilson, P.A.2    Coats, A.J.3
  • 66
    • 36148948551 scopus 로고    scopus 로고
    • Long-term use of sildenafil in the therapeutic management of heart failure
    • Guazzi M, Samaja M, Arena R, Vicenzi M, Guazzi MD. Long-term use of sildenafil in the therapeutic management of heart failure. J Am Coll Cardiol 2007;50:2136-2144.
    • (2007) J Am Coll Cardiol , vol.50 , pp. 2136-2144
    • Guazzi, M.1    Samaja, M.2    Arena, R.3    Vicenzi, M.4    Guazzi, M.D.5
  • 67
    • 33846486188 scopus 로고    scopus 로고
    • Chronic kidney disease associated mortality in diastolic versus systolic heart failure: A propensity matched study
    • Ahmed A, Rich MW, Sanders PW, et al. Chronic kidney disease associated mortality in diastolic versus systolic heart failure: A propensity matched study. Am J Cardiol 2007;99:393-398.
    • (2007) Am J Cardiol , vol.99 , pp. 393-398
    • Ahmed, A.1    Rich, M.W.2    Sanders, P.W.3
  • 68
    • 54549122617 scopus 로고    scopus 로고
    • Comparison of blood volume characteristics in anemic patients with low versus preserved left ventricular ejection fractions
    • Abramov D, Cohen RS, Katz SD, Mancini D, Maurer MS. Comparison of blood volume characteristics in anemic patients with low versus preserved left ventricular ejection fractions. Am J Cardiol 2008;102:1069-1072.
    • (2008) Am J Cardiol , vol.102 , pp. 1069-1072
    • Abramov, D.1    Cohen, R.S.2    Katz, S.D.3    Mancini, D.4    Maurer, M.S.5
  • 69
    • 31344463012 scopus 로고    scopus 로고
    • Anemia in patients with heart failure and preserved systolic function
    • Felker GM, Shaw LK, Stough WG, O'Connor CM. Anemia in patients with heart failure and preserved systolic function. Am Heart J 2006;151:457-462.
    • (2006) Am Heart J , vol.151 , pp. 457-462
    • Felker, G.M.1    Shaw, L.K.2    Stough, W.G.3    O'Connor, C.M.4
  • 71
    • 34548486562 scopus 로고    scopus 로고
    • Comparison of the effect of anemia on in-hospital mortality in patients with versus without preserved left ventricular ejection fraction
    • Latado AL, Passos LC, Darze ES, Lopes AA. Comparison of the effect of anemia on in-hospital mortality in patients with versus without preserved left ventricular ejection fraction. Am J Cardiol 2006;98:1631-1634.
    • (2006) Am J Cardiol , vol.98 , pp. 1631-1634
    • Latado, A.L.1    Passos, L.C.2    Darze, E.S.3    Lopes, A.A.4
  • 73
    • 0034702499 scopus 로고    scopus 로고
    • Do patients with suspected heart failure and preserved left ventricular systolic function suffer from "diastolic heart failure" or from misdiagnosis? A prospective descriptive study
    • Caruana L, Petrie MC, Davie AP, McMurray JJ. Do patients with suspected heart failure and preserved left ventricular systolic function suffer from "diastolic heart failure" or from misdiagnosis? A prospective descriptive study. BMJ 2000;321:215-218.
    • (2000) BMJ , vol.321 , pp. 215-218
    • Caruana, L.1    Petrie, M.C.2    Davie, A.P.3    McMurray, J.J.4
  • 75
    • 34548068568 scopus 로고    scopus 로고
    • Prognosis in heart failure with a normal ejection fraction
    • Cleland JG, Taylor J, Tendera M. Prognosis in heart failure with a normal ejection fraction. N Engl J Med 2007;357:829-830.
    • (2007) N Engl J Med , vol.357 , pp. 829-830
    • Cleland, J.G.1    Taylor, J.2    Tendera, M.3
  • 76
    • 44349182588 scopus 로고    scopus 로고
    • Perception of symptoms is out of proportion to cardiac pathology in patients with "diastolic heart failure
    • Ingle L, Cleland JG, Clark AL. Perception of symptoms is out of proportion to cardiac pathology in patients with "diastolic heart failure. Heart 2008;94:748-753.
    • (2008) Heart , vol.94 , pp. 748-753
    • Ingle, L.1    Cleland, J.G.2    Clark, A.L.3
  • 78
    • 27544455785 scopus 로고    scopus 로고
    • The role of NT-proBNP in the diagnostics of isolated diastolic dysfunction: Correlation with echocardiographic and invasive measurements
    • Tschope C, Kasner M, Westermann D, Gaub R, Poller WC, Schultheiss HP. The role of NT-proBNP in the diagnostics of isolated diastolic dysfunction: Correlation with echocardiographic and invasive measurements. Eur Heart J 2005;26:2277-2284.
    • (2005) Eur Heart J , vol.26 , pp. 2277-2284
    • Tschope, C.1    Kasner, M.2    Westermann, D.3    Gaub, R.4    Poller, W.C.5    Schultheiss, H.P.6
  • 79
    • 32644436929 scopus 로고    scopus 로고
    • B-type natriuretic peptide strongly reflects diastolic wall stress in patients with chronic heart failure: Comparison between systolic and diastolic heart failure
    • Iwanaga Y, Nishi I, Furuichi S, et al. B-type natriuretic peptide strongly reflects diastolic wall stress in patients with chronic heart failure: Comparison between systolic and diastolic heart failure. J Am Coll Cardiol 2006;47:742-748.
    • (2006) J Am Coll Cardiol , vol.47 , pp. 742-748
    • Iwanaga, Y.1    Nishi, I.2    Furuichi, S.3
  • 82
    • 47849087223 scopus 로고    scopus 로고
    • Heart failure with preserved ejection fraction: Treat now by treating comorbidities
    • Shah SJ, Gheorghiade M. Heart failure with preserved ejection fraction: Treat now by treating comorbidities. JAMA 2008;300:431-433.
    • (2008) JAMA , vol.300 , pp. 431-433
    • Shah, S.J.1    Gheorghiade, M.2
  • 83
    • 0038642326 scopus 로고    scopus 로고
    • A meta-analysis of the effects of treatment on left ventricular mass in essential hypertension
    • Klingbeil AU, Schneider M, Martus P, Messerli FH, Schmieder RE. A meta-analysis of the effects of treatment on left ventricular mass in essential hypertension. Am J Med 2003;115:41-46.
    • (2003) Am J Med , vol.115 , pp. 41-46
    • Klingbeil, A.U.1    Schneider, M.2    Martus, P.3    Messerli, F.H.4    Schmieder, R.E.5
  • 84
    • 33746178479 scopus 로고    scopus 로고
    • Effect of losartan and hydrochlorothiazide on exercise tolerance in exertional hypertension and left ventricular diastolic dysfunction
    • Little WC, Zile MR, Klein A, Appleton CP, Kitzman DW, Wesley-Farrington DJ. Effect of losartan and hydrochlorothiazide on exercise tolerance in exertional hypertension and left ventricular diastolic dysfunction. Am J Cardiol 2006;98:383-385.
    • (2006) Am J Cardiol , vol.98 , pp. 383-385
    • Little, W.C.1    Zile, M.R.2    Klein, A.3    Appleton, C.P.4    Kitzman, D.W.5    Wesley-Farrington, D.J.6
  • 85
    • 0027472287 scopus 로고
    • Effect of enalapril on congestive heart failure treated with diuretics in elderly patients with prior myocardial infarction and normal left ventricular ejection fraction
    • Aronow WS, Kronzon I. Effect of enalapril on congestive heart failure treated with diuretics in elderly patients with prior myocardial infarction and normal left ventricular ejection fraction. Am J Cardiol 1993;71:602-604.
    • (1993) Am J Cardiol , vol.71 , pp. 602-604
    • Aronow, W.S.1    Kronzon, I.2
  • 86
    • 23944473132 scopus 로고    scopus 로고
    • Therapy for diastolic heart failure
    • Little WC, Brucks S. Therapy for diastolic heart failure. Prog Cardiovasc Dis 2005;47:380-388.
    • (2005) Prog Cardiovasc Dis , vol.47 , pp. 380-388
    • Little, W.C.1    Brucks, S.2
  • 87
    • 1342284053 scopus 로고    scopus 로고
    • Effect of carvedilol on diastolic function in patients with diastolic heart failure and preserved systolic function. Results of the Swedish Doppler-echocardiographic study (SWEDIC)
    • Bergstrom A, Andersson B, Edner M, Nylander E, Persson H, Dahlstrom U. Effect of carvedilol on diastolic function in patients with diastolic heart failure and preserved systolic function. Results of the Swedish Doppler-echocardiographic study (SWEDIC). Eur J Heart Fail 2004;6:453-461.
    • (2004) Eur J Heart Fail , vol.6 , pp. 453-461
    • Bergstrom, A.1    Andersson, B.2    Edner, M.3    Nylander, E.4    Persson, H.5    Dahlstrom, U.6
  • 88
    • 33847320614 scopus 로고    scopus 로고
    • Prescription of beta-blockers in patients with advanced heart failure and preserved left ventricular ejection fraction. Clinical implications and survival
    • Dobre D, van Veldhuisen DJ, DeJongste MJ, et al. Prescription of beta-blockers in patients with advanced heart failure and preserved left ventricular ejection fraction. Clinical implications and survival. Eur J Heart Fail 2007;9:280-286.
    • (2007) Eur J Heart Fail , vol.9 , pp. 280-286
    • Dobre, D.1    van Veldhuisen, D.J.2    DeJongste, M.J.3
  • 89
  • 90
    • 58149097941 scopus 로고    scopus 로고
    • Clinical effectiveness of beta-blockers in heart failure: Findings from the OPTIMIZE-HF (Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure) Registry
    • Hernandez AF, Hammill BG, O'Connor CM, Schulman KA, Curtis LH, Fonarow GC. Clinical effectiveness of beta-blockers in heart failure: Findings from the OPTIMIZE-HF (Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure) Registry. J Am Coll Cardiol 2009;53:184-192.
    • (2009) J Am Coll Cardiol , vol.53 , pp. 184-192
    • Hernandez, A.F.1    Hammill, B.G.2    O'Connor, C.M.3    Schulman, K.A.4    Curtis, L.H.5    Fonarow, G.C.6
  • 91
    • 0030853984 scopus 로고    scopus 로고
    • Effect of propranolol versus no propranolol on total mortality plus nonfatal myocardial infarction in older patients with prior myocardial infarction, congestive heart failure, and left ventricular ejection fraction ≥ 40% treated with diuretics plus angiotensin-converting enzyme inhibitors
    • Aronow WS, Ahn C, Kronzon I. Effect of propranolol versus no propranolol on total mortality plus nonfatal myocardial infarction in older patients with prior myocardial infarction, congestive heart failure, and left ventricular ejection fraction ≥ 40% treated with diuretics plus angiotensin-converting enzyme inhibitors. Am J Cardiol 1997;80:207-209.
    • (1997) Am J Cardiol , vol.80 , pp. 207-209
    • Aronow, W.S.1    Ahn, C.2    Kronzon, I.3
  • 92
    • 13544258730 scopus 로고    scopus 로고
    • Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS)
    • Flather MD, Shibata MC, Coats AJ, et al. Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS). Eur Heart J 2005;26:215-225.
    • (2005) Eur Heart J , vol.26 , pp. 215-225
    • Flather, M.D.1    Shibata, M.C.2    Coats, A.J.3
  • 93
    • 33645237084 scopus 로고    scopus 로고
    • Effects of nebivolol in elderly heart failure patients with or without systolic left ventricular dysfunction: Results of the SENIORS echocardiographic substudy
    • Ghio S, Magrini G, Serio A, et al. Effects of nebivolol in elderly heart failure patients with or without systolic left ventricular dysfunction: Results of the SENIORS echocardiographic substudy. Eur Heart J 2006;27:562-568.
    • (2006) Eur Heart J , vol.27 , pp. 562-568
    • Ghio, S.1    Magrini, G.2    Serio, A.3
  • 94
    • 66149123458 scopus 로고    scopus 로고
    • Beta-blockade with nebivolol in elderly heart failure patients with impaired and preserved left ventricular ejection fraction: Data From SENIORS (Study of Effects of Nebivolol Intervention on Outcomes and Rehospitalization in Seniors With Heart Failure)
    • van Veldhuisen DJ, Cohen-Solal A, Bohm M, et al. Beta-blockade with nebivolol in elderly heart failure patients with impaired and preserved left ventricular ejection fraction: Data From SENIORS (Study of Effects of Nebivolol Intervention on Outcomes and Rehospitalization in Seniors With Heart Failure). J Am Coll Cardiol 2009;53:2150-2158.
    • (2009) J Am Coll Cardiol , vol.53 , pp. 2150-2158
    • van Veldhuisen, D.J.1    Cohen-Solal, A.2    Bohm, M.3
  • 95
    • 58649109169 scopus 로고    scopus 로고
    • Treatment of heart failure with preserved ejection fraction
    • Borlaug BA. Treatment of heart failure with preserved ejection fraction. Curr Treat Options Cardiovasc Med 2009;11:79-87.
    • (2009) Curr Treat Options Cardiovasc Med , vol.11 , pp. 79-87
    • Borlaug, B.A.1
  • 96
    • 57749189570 scopus 로고    scopus 로고
    • Heart failure with preserved and reduced left ventricular ejection fraction in the antihypertensive and lipid-lowering treatment to prevent heart attack trial
    • Davis BR, Kostis JB, Simpson LM, et al. Heart failure with preserved and reduced left ventricular ejection fraction in the antihypertensive and lipid-lowering treatment to prevent heart attack trial. Circulation 2008;118:2259-2267.
    • (2008) Circulation , vol.118 , pp. 2259-2267
    • Davis, B.R.1    Kostis, J.B.2    Simpson, L.M.3
  • 97
    • 42549149364 scopus 로고    scopus 로고
    • The Hong Kong diastolic heart failure study: A randomised controlled trial of diuretics, irbesartan and ramipril on quality of life, exercise capacity, left ventricular global and regional function in heart failure with a normal ejection fraction
    • Yip GW, Wang M, Wang T, et al. The Hong Kong diastolic heart failure study: A randomised controlled trial of diuretics, irbesartan and ramipril on quality of life, exercise capacity, left ventricular global and regional function in heart failure with a normal ejection fraction. Heart 2008;94:573-580.
    • (2008) Heart , vol.94 , pp. 573-580
    • Yip, G.W.1    Wang, M.2    Wang, T.3
  • 98
    • 0033566889 scopus 로고    scopus 로고
    • NO and cardiac diastolic function
    • Paulus WJ, Shah AM. NO and cardiac diastolic function. Cardiovasc Res 1999;43:595-606.
    • (1999) Cardiovasc Res , vol.43 , pp. 595-606
    • Paulus, W.J.1    Shah, A.M.2
  • 99
    • 60749101278 scopus 로고    scopus 로고
    • Invasive hemodynamic assessment in heart failure
    • Borlaug BA, Kass DA. Invasive hemodynamic assessment in heart failure. Heart Fail Clin 2009;5:217-228.
    • (2009) Heart Fail Clin , vol.5 , pp. 217-228
    • Borlaug, B.A.1    Kass, D.A.2
  • 101
    • 67349149420 scopus 로고    scopus 로고
    • Cyclic GMP signaling in cardiovascular pathophysiology and therapeutics
    • Tsai EJ, Kass DA. Cyclic GMP signaling in cardiovascular pathophysiology and therapeutics. Pharmacol Ther 2009;122:216-238.
    • (2009) Pharmacol Ther , vol.122 , pp. 216-238
    • Tsai, E.J.1    Kass, D.A.2
  • 102
    • 0025129567 scopus 로고
    • Usefulness of verapamil for congestive heart failure associated with abnormal left ventricular diastolic filling and normal left ventricular systolic performance
    • Setaro JF, Zaret BL, Schulman DS, Black HR, Soufer R. Usefulness of verapamil for congestive heart failure associated with abnormal left ventricular diastolic filling and normal left ventricular systolic performance. Am J Cardiol 1990;66:981-986.
    • (1990) Am J Cardiol , vol.66 , pp. 981-986
    • Setaro, J.F.1    Zaret, B.L.2    Schulman, D.S.3    Black, H.R.4    Soufer, R.5
  • 103
    • 0036156549 scopus 로고    scopus 로고
    • Effect of verapamil in elderly patients with left ventricular diastolic dysfunction as a cause of congestive heart failure
    • Hung MJ, Cherng WJ, Kuo LT, Wang CH. Effect of verapamil in elderly patients with left ventricular diastolic dysfunction as a cause of congestive heart failure. Int J Clin Prac 2002;56:57-62.
    • (2002) Int J Clin Prac , vol.56 , pp. 57-62
    • Hung, M.J.1    Cherng, W.J.2    Kuo, L.T.3    Wang, C.H.4
  • 104
    • 0033133505 scopus 로고    scopus 로고
    • Verapamil acutely reduces ventricular-vascular stiffening and improves aerobic exercise performance in elderly individuals
    • Chen CH, Nakayama M, Talbot M, et al. Verapamil acutely reduces ventricular-vascular stiffening and improves aerobic exercise performance in elderly individuals. J Am Coll Cardiol 1999;33:1602-1609.
    • (1999) J Am Coll Cardiol , vol.33 , pp. 1602-1609
    • Chen, C.H.1    Nakayama, M.2    Talbot, M.3
  • 105
    • 85047676796 scopus 로고
    • Aldosterone and cardiac fibrosis: In vitro studies
    • Fullerton MJ, Funder JW. Aldosterone and cardiac fibrosis: In vitro studies. Cardiovasc Res 1994;28:1863-1867.
    • (1994) Cardiovasc Res , vol.28 , pp. 1863-1867
    • Fullerton, M.J.1    Funder, J.W.2
  • 106
    • 3543099842 scopus 로고    scopus 로고
    • Effect of aldosterone antagonism on myocardial dysfunction in hypertensive patients with diastolic heart failure
    • Mottram PM, Haluska B, Leano R, Cowley D, Stowasser M, Marwick TH. Effect of aldosterone antagonism on myocardial dysfunction in hypertensive patients with diastolic heart failure. Circulation 2004;110:558-565.
    • (2004) Circulation , vol.110 , pp. 558-565
    • Mottram, P.M.1    Haluska, B.2    Leano, R.3    Cowley, D.4    Stowasser, M.5    Marwick, T.H.6
  • 107
    • 3042520870 scopus 로고    scopus 로고
    • Digoxin in the management of cardiovascular disorders
    • Gheorghiade M, Adams KF Jr., Colucci WS. Digoxin in the management of cardiovascular disorders. Circulation 2004;109:2959-2964.
    • (2004) Circulation , vol.109 , pp. 2959-2964
    • Gheorghiade, M.1    Adams Jr., K.F.2    Colucci, W.S.3
  • 108
    • 33745446787 scopus 로고    scopus 로고
    • Effects of digoxin on morbidity and mortality in diastolic heart failure: The ancillary digitalis investigation group trial
    • Ahmed A, Rich MW, Fleg JL, et al. Effects of digoxin on morbidity and mortality in diastolic heart failure: The ancillary digitalis investigation group trial. Circulation 2006;114:397-403.
    • (2006) Circulation , vol.114 , pp. 397-403
    • Ahmed, A.1    Rich, M.W.2    Fleg, J.L.3
  • 109
    • 22544443085 scopus 로고    scopus 로고
    • Statin therapy may be associated with lower mortality in patients with diastolic heart failure: A preliminary report
    • Fukuta H, Sane DC, Brucks S, Little WC. Statin therapy may be associated with lower mortality in patients with diastolic heart failure: A preliminary report. Circulation 2005;112:357-363.
    • (2005) Circulation , vol.112 , pp. 357-363
    • Fukuta, H.1    Sane, D.C.2    Brucks, S.3    Little, W.C.4
  • 110
    • 53049095795 scopus 로고    scopus 로고
    • Effect of rosuvastatin in patients with chronic heart failure (the GISSI-HF trial): A randomised, double-blind, placebo-controlled trial
    • Tavazzi L, Maggioni AP, Marchioli R, et al. Effect of rosuvastatin in patients with chronic heart failure (the GISSI-HF trial): A randomised, double-blind, placebo-controlled trial. Lancet 2008;372:1231-1239.
    • (2008) Lancet , vol.372 , pp. 1231-1239
    • Tavazzi, L.1    Maggioni, A.P.2    Marchioli, R.3
  • 111
    • 0025057337 scopus 로고
    • Influence of coronary occlusion during PTCA on end-systolic and end-diastolic pressure-volume relations in humans
    • Kass DA, Midei M, Brinker J, Maughan WL. Influence of coronary occlusion during PTCA on end-systolic and end-diastolic pressure-volume relations in humans. Circulation 1990;81:447-460.
    • (1990) Circulation , vol.81 , pp. 447-460
    • Kass, D.A.1    Midei, M.2    Brinker, J.3    Maughan, W.L.4
  • 112
    • 0037086097 scopus 로고    scopus 로고
    • Coronary artery disease in patients with heart failure and preserved systolic function
    • Choudhury L, Gheorghiade M, Bonow RO. Coronary artery disease in patients with heart failure and preserved systolic function. Am J Cardiol 2002;89:719-722.
    • (2002) Am J Cardiol , vol.89 , pp. 719-722
    • Choudhury, L.1    Gheorghiade, M.2    Bonow, R.O.3
  • 113
    • 0033832849 scopus 로고    scopus 로고
    • Flash pulmonary edema: Association with hypertension and reoccurrence despite coronary revascularization
    • Kramer K, Kirkman P, Kitzman D, Little WC. Flash pulmonary edema: Association with hypertension and reoccurrence despite coronary revascularization. Am Heart J 2000;140:451-455.
    • (2000) Am Heart J , vol.140 , pp. 451-455
    • Kramer, K.1    Kirkman, P.2    Kitzman, D.3    Little, W.C.4
  • 114
    • 51549103844 scopus 로고    scopus 로고
    • Clinical trials update from Heart Rhythm 2008 and Heart Failure 2008: ATHENA, URGENT, INH study, HEART and CK-1827452
    • Coletta AP, Cleland JG, Cullington D, Clark AL. Clinical trials update from Heart Rhythm 2008 and Heart Failure 2008: ATHENA, URGENT, INH study, HEART and CK-1827452. Eur J Heart Fail 2008;10:917-920.
    • (2008) Eur J Heart Fail , vol.10 , pp. 917-920
    • Coletta, A.P.1    Cleland, J.G.2    Cullington, D.3    Clark, A.L.4
  • 115
    • 36048937641 scopus 로고    scopus 로고
    • The rationale and design of the Surgical Treatment for Ischemic Heart Failure (STICH) trial
    • Velazquez EJ, Lee KL, O'Connor CM, et al. The rationale and design of the Surgical Treatment for Ischemic Heart Failure (STICH) trial. J Thorac Cardiovas Surg 2007;134:1540-1547.
    • (2007) J Thorac Cardiovas Surg , vol.134 , pp. 1540-1547
    • Velazquez, E.J.1    Lee, K.L.2    O'Connor, C.M.3
  • 116
    • 0036981233 scopus 로고    scopus 로고
    • Clinical benefit of renal artery angioplasty with stenting for the control of recurrent and refractory congestive heart failure
    • Gray BH, Olin JW, Childs MB, Sullivan TM, Bacharach JM. Clinical benefit of renal artery angioplasty with stenting for the control of recurrent and refractory congestive heart failure. Vasc Med (London, England) 2002;7:275-279.
    • (2002) Vasc Med (London, England) , vol.7 , pp. 275-279
    • Gray, B.H.1    Olin, J.W.2    Childs, M.B.3    Sullivan, T.M.4    Bacharach, J.M.5
  • 117
    • 70449650655 scopus 로고    scopus 로고
    • Revascularization versus medical therapy for renal-artery stenosis
    • Wheatley K, Ives N, Gray R, et al. Revascularization versus medical therapy for renal-artery stenosis. N Engl J Med 2009;361:1953-1962.
    • (2009) N Engl J Med , vol.361 , pp. 1953-1962
    • Wheatley, K.1    Ives, N.2    Gray, R.3
  • 118
    • 0023808940 scopus 로고
    • Recurrent pulmonary oedema in hypertension due to bilateral renal artery stenosis: Treatment by angioplasty or surgical revascularisation
    • Pickering TG, Herman L, Devereux RB, et al. Recurrent pulmonary oedema in hypertension due to bilateral renal artery stenosis: Treatment by angioplasty or surgical revascularisation. Lancet 1988;2:551-552.
    • (1988) Lancet , vol.2 , pp. 551-552
    • Pickering, T.G.1    Herman, L.2    Devereux, R.B.3
  • 119
    • 0037032384 scopus 로고    scopus 로고
    • Pathophysiological characterization of isolated diastolic heart failure in comparison to systolic heart failure
    • Kitzman DW, Little WC, Brubaker PH, et al. Pathophysiological characterization of isolated diastolic heart failure in comparison to systolic heart failure. JAMA 2002;288:2144-2150.
    • (2002) JAMA , vol.288 , pp. 2144-2150
    • Kitzman, D.W.1    Little, W.C.2    Brubaker, P.H.3
  • 120
    • 64249125022 scopus 로고    scopus 로고
    • Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial
    • O'Connor CM, Whellan DJ, Lee KL, et al. Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial. JAMA 2009;301:1439-1450.
    • (2009) JAMA , vol.301 , pp. 1439-1450
    • O'Connor, C.M.1    Whellan, D.J.2    Lee, K.L.3
  • 121
    • 79960277924 scopus 로고    scopus 로고
    • Leipzig Exercise Intervention in Chronic Heart Failure and Aging (LEICA). Available from:. NCT00176319 [Accessed 20 November 2009].
    • Hambrecht RP, Gielen S, Adams V. Leipzig Exercise Intervention in Chronic Heart Failure and Aging (LEICA). Available from:. 2005;NCT00176319 [Accessed 20 November 2009].
    • (2005)
    • Hambrecht, R.P.1    Gielen, S.2    Adams, V.3
  • 122
    • 79960209528 scopus 로고    scopus 로고
    • Exercise Intolerance in Elderly Patients With Diastolic Heart Failure (SECRET). Available from:. NCT00959660 [Accessed 20 November 2009].
    • Kitzman D. Exercise Intolerance in Elderly Patients With Diastolic Heart Failure (SECRET). Available from:. 2009;NCT00959660 [Accessed 20 November 2009].
    • (2009)
    • Kitzman, D.1
  • 123
    • 4644272249 scopus 로고    scopus 로고
    • Effect of aging and physical activity on left ventricular compliance
    • Arbab-Zadeh A, Dijk E, Prasad A, et al. Effect of aging and physical activity on left ventricular compliance. Circulation 2004;110:1799-1805.
    • (2004) Circulation , vol.110 , pp. 1799-1805
    • Arbab-Zadeh, A.1    Dijk, E.2    Prasad, A.3
  • 124
    • 33744935757 scopus 로고    scopus 로고
    • Does fitness level modulate the cardiovascular hemodynamic response to exercise?
    • Stickland MK, Welsh RC, Petersen SR, et al. Does fitness level modulate the cardiovascular hemodynamic response to exercise? J Appl Physiol 2006;100:1895-1901.
    • (2006) J Appl Physiol , vol.100 , pp. 1895-1901
    • Stickland, M.K.1    Welsh, R.C.2    Petersen, S.R.3
  • 125
    • 0035838376 scopus 로고    scopus 로고
    • Exercise training attenuates age-associated diastolic dysfunction in rats
    • Brenner DA, Apstein CS, Saupe KW. Exercise training attenuates age-associated diastolic dysfunction in rats. Circulation 2001;104:221-226.
    • (2001) Circulation , vol.104 , pp. 221-226
    • Brenner, D.A.1    Apstein, C.S.2    Saupe, K.W.3
  • 126
    • 34249872424 scopus 로고    scopus 로고
    • The effects of aging and physical activity on Doppler measures of diastolic function
    • Prasad A, Popovic ZB, Arbab-Zadeh A, et al. The effects of aging and physical activity on Doppler measures of diastolic function. Am J Cardiol 2007;99:1629-1636.
    • (2007) Am J Cardiol , vol.99 , pp. 1629-1636
    • Prasad, A.1    Popovic, Z.B.2    Arbab-Zadeh, A.3
  • 127
    • 76449089924 scopus 로고    scopus 로고
    • Diastolic function in healthy humans: Non-invasive assessment and the impact of acute and chronic exercise
    • George KP, Naylor LH, Whyte GP, Shave RE, Oxborough D, Green DJ. Diastolic function in healthy humans: Non-invasive assessment and the impact of acute and chronic exercise. Eur J Appl Physiol 2010;108:1-14.
    • (2010) Eur J Appl Physiol , vol.108 , pp. 1-14
    • George, K.P.1    Naylor, L.H.2    Whyte, G.P.3    Shave, R.E.4    Oxborough, D.5    Green, D.J.6
  • 128
    • 79960223162 scopus 로고    scopus 로고
    • Anemia in Heart Failure With a Preserved Ejection Fraction (HFPEF). Available from:. NCT00286182 [Accessed 20 November 2009].
    • Maurer M. Anemia in Heart Failure With a Preserved Ejection Fraction (HFPEF). Available from:. 2006;NCT00286182 [Accessed 20 November 2009].
    • (2006)
    • Maurer, M.1
  • 129
    • 27444439573 scopus 로고    scopus 로고
    • Sildenafil inhibits beta-adrenergic-stimulated cardiac contractility in humans
    • Borlaug BA, Melenovsky V, Marhin T, Fitzgerald P, Kass DA. Sildenafil inhibits beta-adrenergic-stimulated cardiac contractility in humans. Circulation 2005;112:2642-2649.
    • (2005) Circulation , vol.112 , pp. 2642-2649
    • Borlaug, B.A.1    Melenovsky, V.2    Marhin, T.3    Fitzgerald, P.4    Kass, D.A.5
  • 131
    • 20044363270 scopus 로고    scopus 로고
    • Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy
    • Takimoto E, Champion HC, Li M, et al. Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy. Nat Med 2005;11:214-222.
    • (2005) Nat Med , vol.11 , pp. 214-222
    • Takimoto, E.1    Champion, H.C.2    Li, M.3
  • 132
    • 0033858827 scopus 로고    scopus 로고
    • Acute type 5 phosphodiesterase inhibition with sildenafil enhances flow-mediated vasodilation in patients with chronic heart failure
    • Katz SD, Balidemaj K, Homma S, Wu H, Wang J, Maybaum S. Acute type 5 phosphodiesterase inhibition with sildenafil enhances flow-mediated vasodilation in patients with chronic heart failure. J Am Coll Cardiol 2000;36:845-851.
    • (2000) J Am Coll Cardiol , vol.36 , pp. 845-851
    • Katz, S.D.1    Balidemaj, K.2    Homma, S.3    Wu, H.4    Wang, J.5    Maybaum, S.6
  • 133
    • 33846099444 scopus 로고    scopus 로고
    • Sildenafil improves exercise hemodynamics and oxygen uptake in patients with systolic heart failure
    • Lewis GD, Lachmann J, Camuso J, et al. Sildenafil improves exercise hemodynamics and oxygen uptake in patients with systolic heart failure. Circulation 2007;115:59-66.
    • (2007) Circulation , vol.115 , pp. 59-66
    • Lewis, G.D.1    Lachmann, J.2    Camuso, J.3
  • 134
    • 33847785230 scopus 로고    scopus 로고
    • Heart failure: A state of brain natriuretic peptide deficiency or resistance or both!
    • Chen HH. Heart failure: A state of brain natriuretic peptide deficiency or resistance or both! J Am Coll Cardiol 2007;49:1089-1091.
    • (2007) J Am Coll Cardiol , vol.49 , pp. 1089-1091
    • Chen, H.H.1
  • 135
    • 0035818917 scopus 로고    scopus 로고
    • Aldosterone in congestive heart failure
    • Weber KT. Aldosterone in congestive heart failure. N Engl J Med 2001;345:1689-1697.
    • (2001) N Engl J Med , vol.345 , pp. 1689-1697
    • Weber, K.T.1
  • 136
    • 79960273584 scopus 로고    scopus 로고
    • Aldosterone Antagonist Therapy for Adults With Heart Failure and Preserved Systolic Function (TOPCAT). Available from:. NCT00094302 [Accessed 20 November 2009].
    • Li R. Aldosterone Antagonist Therapy for Adults With Heart Failure and Preserved Systolic Function (TOPCAT). Available from:. 2004;NCT00094302 [Accessed 20 November 2009].
    • (2004)
    • Li, R.1
  • 137
    • 27644489210 scopus 로고    scopus 로고
    • Rho-kinase inhibition in the therapy of cardiovascular disease
    • Lai A, Frishman WH. Rho-kinase inhibition in the therapy of cardiovascular disease. Cardiol Rev 2005;13:285-292.
    • (2005) Cardiol Rev , vol.13 , pp. 285-292
    • Lai, A.1    Frishman, W.H.2
  • 138
    • 79960241238 scopus 로고    scopus 로고
    • Restoration of Chronotropic Competence in Heart Failure Patients With Normal Ejection Fraction (RESET). Available from:. NCT00670111 [Accessed 20 November 2009].
    • Kass DA. Restoration of Chronotropic Competence in Heart Failure Patients With Normal Ejection Fraction (RESET). Available from:. 2008;NCT00670111 [Accessed 20 November 2009].
    • (2008)
    • Kass, D.A.1
  • 139
    • 79960286985 scopus 로고    scopus 로고
    • If Channel Blockade With Ivabradine in Patients With Diastolic Heart Failure. Available from:. NCT00757055 [Accessed 20 November 2009].
    • McCaffrey DJ, McDonald K. If Channel Blockade With Ivabradine in Patients With Diastolic Heart Failure. Available from:. 2008;NCT00757055 [Accessed 20 November 2009].
    • (2008)
    • McCaffrey, D.J.1    McDonald, K.2
  • 140
    • 53749090260 scopus 로고    scopus 로고
    • Parasympathetic nervous system and heart failure: Pathophysiology and potential implications for therapy
    • Olshansky B, Sabbah HN, Hauptman PJ, Colucci WS. Parasympathetic nervous system and heart failure: Pathophysiology and potential implications for therapy. Circulation 2008;118:863-871.
    • (2008) Circulation , vol.118 , pp. 863-871
    • Olshansky, B.1    Sabbah, H.N.2    Hauptman, P.J.3    Colucci, W.S.4
  • 141
    • 0037177171 scopus 로고    scopus 로고
    • New concepts in diastolic dysfunction and diastolic heart failure. Part II. Causal mechanisms and treatment
    • Zile MR, Brutsaert DL. New concepts in diastolic dysfunction and diastolic heart failure. Part II. Causal mechanisms and treatment. Circulation 2002;105:1503-1508.
    • (2002) Circulation , vol.105 , pp. 1503-1508
    • Zile, M.R.1    Brutsaert, D.L.2
  • 142
    • 0035970120 scopus 로고    scopus 로고
    • A cross-link breaker has sustained effects on arterial and ventricular properties in older rhesus monkeys
    • Vaitkevicius PV, Lane M, Spurgeon H, et al. A cross-link breaker has sustained effects on arterial and ventricular properties in older rhesus monkeys. Proc Natl Acad Sci U S A 2001;98:1171-1175.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 1171-1175
    • Vaitkevicius, P.V.1    Lane, M.2    Spurgeon, H.3
  • 144
    • 16244371321 scopus 로고    scopus 로고
    • The effect of alagebrium chloride (ALT-711), a novel glucose cross-link breaker, in the treatment of elderly patients with diastolic heart failure
    • Little WC, Zile MR, Kitzman DW, Hundley WG, O'Brien TX, Degroof RC. The effect of alagebrium chloride (ALT-711), a novel glucose cross-link breaker, in the treatment of elderly patients with diastolic heart failure. J Card Fail 2005;11:191-195.
    • (2005) J Card Fail , vol.11 , pp. 191-195
    • Little, W.C.1    Zile, M.R.2    Kitzman, D.W.3    Hundley, W.G.4    O'Brien, T.X.5    Degroof, R.C.6
  • 145
    • 0036645337 scopus 로고    scopus 로고
    • Transforming growth factor-beta function blocking prevents myocardial fibrosis and diastolic dysfunction in pressure-overloaded rats
    • Kuwahara F, Kai H, Tokuda K, Kai M, Takeshita A, Egashira K, Imaizumi T. Transforming growth factor-beta function blocking prevents myocardial fibrosis and diastolic dysfunction in pressure-overloaded rats. Circulation 2002;106:130-135.
    • (2002) Circulation , vol.106 , pp. 130-135
    • Kuwahara, F.1    Kai, H.2    Tokuda, K.3    Kai, M.4    Takeshita, A.5    Egashira, K.6    Imaizumi, T.7
  • 146
    • 35748974863 scopus 로고    scopus 로고
    • Myocardial matrix remodeling and the matrix metalloproteinases: Influence on cardiac form and function
    • Spinale FG. Myocardial matrix remodeling and the matrix metalloproteinases: Influence on cardiac form and function. Physiol Rev 2007;87:1285-1342.
    • (2007) Physiol Rev , vol.87 , pp. 1285-1342
    • Spinale, F.G.1
  • 147
    • 1242342244 scopus 로고    scopus 로고
    • The giant protein titin: A major player in myocardial mechanics, signaling, and disease
    • Granzier HL, Labeit S. The giant protein titin: A major player in myocardial mechanics, signaling, and disease. Circ Res 2004;94:284-295.
    • (2004) Circ Res , vol.94 , pp. 284-295
    • Granzier, H.L.1    Labeit, S.2
  • 149
    • 33646171304 scopus 로고    scopus 로고
    • Myocardial structure and function differ in systolic and diastolic heart failure
    • van Heerebeek L, Borbely A, Niessen HW, et al. Myocardial structure and function differ in systolic and diastolic heart failure. Circulation 2006;113:1966-1973.
    • (2006) Circulation , vol.113 , pp. 1966-1973
    • van Heerebeek, L.1    Borbely, A.2    Niessen, H.W.3
  • 150
    • 79960280680 scopus 로고    scopus 로고
    • Perhexiline Therapy in Heart Failure With Preserved Ejection Fraction Syndrome. Available from:; NCT00839228 [Accessed 20 November 2009].
    • Frenneaux M. Perhexiline Therapy in Heart Failure With Preserved Ejection Fraction Syndrome. Available from:. 2009;NCT00839228 [Accessed 20 November 2009].
    • (2009)
    • Frenneaux, M.1
  • 151
    • 0033520357 scopus 로고    scopus 로고
    • Intravenous allopurinol decreases myocardial oxygen consumption and increases mechanical efficiency in dogs with pacing-induced heart failure
    • Ekelund UE, Harrison RW, Shokek O, et al. Intravenous allopurinol decreases myocardial oxygen consumption and increases mechanical efficiency in dogs with pacing-induced heart failure. Circ Res 1999;85:437-445.
    • (1999) Circ Res , vol.85 , pp. 437-445
    • Ekelund, U.E.1    Harrison, R.W.2    Shokek, O.3
  • 152
    • 44649122196 scopus 로고    scopus 로고
    • Impact of oxypurinol in patients with symptomatic heart failure. Results of the OPT-CHF study
    • Hare JM, Mangal B, Brown J, et al. Impact of oxypurinol in patients with symptomatic heart failure. Results of the OPT-CHF study. J Am Coll Cardiol 2008;51:2301-2309.
    • (2008) J Am Coll Cardiol , vol.51 , pp. 2301-2309
    • Hare, J.M.1    Mangal, B.2    Brown, J.3
  • 153
    • 47649122637 scopus 로고    scopus 로고
    • Reversal of cardiac hypertrophy and fibrosis from pressure overload by tetrahydrobiopterin: Efficacy of recoupling nitric oxide synthase as a therapeutic strategy
    • Moens AL, Takimoto E, Tocchetti CG, et al. Reversal of cardiac hypertrophy and fibrosis from pressure overload by tetrahydrobiopterin: Efficacy of recoupling nitric oxide synthase as a therapeutic strategy. Circulation 2008;117:2626-2636.
    • (2008) Circulation , vol.117 , pp. 2626-2636
    • Moens, A.L.1    Takimoto, E.2    Tocchetti, C.G.3
  • 154
    • 34548748213 scopus 로고    scopus 로고
    • Therapeutic potential of tetrahydrobiopterin for treating vascular and cardiac disease
    • Moens AL, Kass DA. Therapeutic potential of tetrahydrobiopterin for treating vascular and cardiac disease. J Cardiovas Pharmacol 2007;50:238-246.
    • (2007) J Cardiovas Pharmacol , vol.50 , pp. 238-246
    • Moens, A.L.1    Kass, D.A.2
  • 155
    • 45549105581 scopus 로고    scopus 로고
    • Ranolazine improves diastolic dysfunction in isolated myocardium from failing human hearts-role of late sodium current and intracellular ion accumulation
    • Sossalla S, Wagner S, Rasenack EC, et al. Ranolazine improves diastolic dysfunction in isolated myocardium from failing human hearts-role of late sodium current and intracellular ion accumulation. J Mol Cell Cardiol 2008;45:32-43.
    • (2008) J Mol Cell Cardiol , vol.45 , pp. 32-43
    • Sossalla, S.1    Wagner, S.2    Rasenack, E.C.3


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