Ex Vivo T Cell Depletion of Allogeneic PBSC as Acute and Chronic GVHD Prophylaxis after Myeloablative HCT: Time to Reconsider?

Biology of Blood and Marrow Transplantation

Volumn 17, Issue 8, 2011, Pages 1112-1113

  Ho, Vincent T ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD34 ANTIGEN; CYCLOPHOSPHAMIDE; CYCLOSPORIN; METHOTREXATE; THIOTEPA; THYMOCYTE ANTIBODY;

ACUTE GRAFT VERSUS HOST DISEASE; ALLOGENEIC STEM CELL TRANSPLANTATION; CHRONIC GRAFT VERSUS HOST DISEASE; EDITORIAL; EX VIVO STUDY; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; PROPHYLAXIS; T CELL DEPLETION;

FEMALE; GRAFT VS HOST DISEASE; HEMATOLOGIC NEOPLASMS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; LEUKEMIA, MYELOID, ACUTE; LYMPHOCYTE DEPLETION; MALE; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION;

EID: 79960256723     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2011.02.005     Document Type: Editorial

References (6)

1. Mitsuyasu R.T., Champlin R.E., Gale R.P., et al. Treatment of donor bone marrow with monoclonal anti-T-cell antibody and complement for the prevention of graft-versus-host disease. A prospective, randomized, double-blind trial. Ann Intern Med 1986, 105:20-26.
2. Wagner J.E., Thompson J.S., Carter S.L., et al. Effect of graft-versus-host disease prophylaxis on 3-year disease-free survival in recipients of unrelated donor bone marrow (T-cell Depletion Trial): a multi-centre, randomised phase II-III trial. Lancet 2005, 366:733-741.
3. Finke J., Bethge W.A., Schmoor C., et al. Standard graft-versus-host disease prophylaxis with or without anti-T-cell globulin in haematopoietic cell transplantation from matched unrelated donors: a randomised, open-label, multicentre phase 3 trial. Lancet Oncol 2009, 10:855-864.
4. Kernan N.A., Collins N.H., Juliano L., et al. Clonable T lymphocytes in T cell depleted bone marrow transplants correlate with the development of graft versus host disease. Blood 1986, 68:770.
5. Jakubowski A., Small T.N., Kernan N.A., et al. T-cell depleted unrelated donor stem cell transplantation provides favorable disease-free survival for adults with hematologic malignancies. Biol Blood Marrow Transplant 2011.
6. Devine S., Carter S., Soiffer R.J., et al. Low risk of chronic graft versus host disease and relapse associated with T-cell depleted peripheral blood stem cell transplantation for acute myeloid leukemia in first remission: results of the Blood and Marrow Transplant Clinical Trials Network (BMT CTN) Protocol 0303. Biol Blood Marrow Transplant 2011.