Ventilator-associated pneumonia as a model for approaching cost-effectiveness and infection prevention in the ICU

Current Opinion in Infectious Diseases

Volumn 24, Issue 4, 2011, Pages 385-389

  Zilberberg, Marya D ^a,b   Shorr, Andrew F ^c  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

^b EviMed Research Group LLC   (United States)

^c WASHINGTON HOSPITAL CENTER   (United States)

Author keywords

cost effectiveness; healthcare associated infections; ventilator associated pneumonia bundle

Indexed keywords

ANTIINFECTIVE AGENT; MINOCYCLINE; RIFAMPICIN;

ANTIBIOTIC PROPHYLAXIS; ANTIBIOTIC THERAPY; ARTIFICIAL VENTILATION; ASPIRATION; BACTERIAL COLONIZATION; BLEEDING; BLOOD TRANSFUSION; BODY POSITION; CATHETER INFECTION; COST EFFECTIVENESS ANALYSIS; ENDOTRACHEAL TUBE; ENTERIC FEEDING; HUMAN; HYPERGLYCEMIA; INFECTION PREVENTION; INTENSIVE CARE UNIT; INTUBATION; LENGTH OF STAY; MORBIDITY; REVIEW; SILVER IMPREGNATION; SUCTION; VENTILATOR ASSOCIATED PNEUMONIA;

COST-BENEFIT ANALYSIS; HUMANS; INFECTION CONTROL; INTENSIVE CARE UNITS; MODELS, BIOLOGICAL; MODELS, ECONOMETRIC; PNEUMONIA, VENTILATOR-ASSOCIATED;

EID: 79960250459     PISSN: 09517375     EISSN: 14736527     Source Type: Journal    
DOI: 10.1097/QCO.0b013e3283474914     Document Type: Review

References (22)

1. Institute of Medicine. To Err is Human: building a safer health system. Washington: National Academies Press; 1999.
2. Starfield B. Is US health really best in the world? JAMA 2000; 284:483-485.
3. Klevens RM, Edwards JR, Richards CL Jr, et al. Estimating healthcareassociated infections and deaths in U.S. hospitals, 2002. Public Health Rep 2007; 122:160-166.
4. Scott RD. The Direct Medical Costs of Healthcare-Associated Infections in U.S. Hospitals and the Benefits of Prevention, 2009. Division of Healthcare Quality Promotion, National Center for Preparedness, Detection, and Control of Infectious Diseases, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, February 2009.
5. Richards MJ, Edwards JR, Culver DH, Gaynes RP. Nosocomial infections in combined medical-surgical intensive care units in the United States. Infect Control Hosp Epidemiol 2000; 21:510-515. (Pubitemid 30647154)
6. Edwards JR, Peterson KD, Mu Y, et al. National Healthcare Safety Network (NHSN) report: data summary for 2006 through 2008, issued December 2009. Am J Infect Control 2009; 37:783-805.
7. Rosenthal VD, Maki DG, Salomao R, et al., International Nosocomial Infection Control Consortium. Device-associated nosocomial infections in intensive care units of 8 developing countries. Ann Intern Med 2006; 145:582-591. (Pubitemid 46780937)
8. Shorr AF, Chan CM, Zilberberg MD. Diagnostics and epidemiology in ventilator-associated pneumonia. Ther Adv Respir Dis 2011; 5:121-130.
9. Nguile-Makao M, Zahar JR, Français A, et al. Attributable mortality of ventilatorassociated pneumonia: respective impact of main characteristics at ICU admission and VAP onset using conditional logistic regression and multistate models. Intensive Care Med 2010; 36:781-789.
10. Niederman MS, Craven DE, Bonten MJ, et al. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med 2005; 171:388-416.
11. Shorr AF, O'Malley PG. Continuous subglottic suctioning for the prevention of ventilator-associated pneumonia: potential economic implications. Chest 2001; 119:228-235. (Pubitemid 32150572)
12. Shorr AF, Zilberberg MD, Kollef MH. Cost-effectiveness analysis of a silvercoated endotracheal tube to reduce the incidence of ventilator-associated pneumonia. Infect Control Hosp Epidemiol 2009; 30:759-763.
13. Van Nieuwenhoven CA, Buskens E, Bergmans DC, et al. Oral decontamination is cost-saving in the prevention of ventilator-associated pneumonia in intensive care units. Crit Care Med 2004; 32:126-130. (Pubitemid 38125573)
14. Berwick DM, Calkins DR, McCannon CJ, Hackbarth AD. The 100,000 Lives campaign: setting a goal and a deadline for improving healthcare quality. JAMA 2006; 295:324-327. (Pubitemid 43112962)
15. Zilberberg MD, Shorr AF, Kollef MH. Implementing quality improvements in the intensive care unit: ventilator bundle as an example. Crit Care Med 2009; 37:305-309.
16. Klompas M. Ventilator-associated pneumonia: is zero possible? Clin Infect Dis 2010; 51:1123-1126.
17. Bouadma L, Deslandes E, Lolom I, et al. Long-term impact of a multifaceted prevention program on ventilator-associated pneumonia in a medical intensive care unit. Clin Infect Dis 2010; 51:1115-1122.
18. Pronovost PJ, Needham DM, Berenholtz S, et al. An intervention to decrease catheter-related bloodstream infections in the ICU. N Engl J Med 2006; 355:2725-2732. (Pubitemid 46021509)
19. Berenholtz SM, Pham JC, Thompson DA, et al. Collaborative cohort study of an intervention to reduce ventilator-associated pneumonia in the intensive care unit. Infect Control Hosp Epidemiol 2011; 32:305-314.
20. Lai KK, Baker SP, Fontecchio SA. Impact of a program of intensive surveillance and interventions targeting ventilated patients in the reduction of ventilator-associated pneumonia and its cost-effectiveness. Infect Control Hosp Epidemiol 2003; 24:859-863. (Pubitemid 37516818)
21. Halton KA, Cook D, Paterson DL, et al. Cost-effectiveness of a central venous catheter care bundle. PLoS One 2010; 5:e12815.
22. Diamond GA, Kaul S. What the tortoise said to Achilles. Am J Cardiol 2010; 106:593-595.