The immune reconstitution after an allogeneic stem cell transplant correlates with the risk of graft-versus-host disease and cytomegalovirus infection

Leukemia Research

Volumn 35, Issue 8, 2011, Pages 1124-1126

  Torelli, Giovanni F ^a   Lucarelli, Barbarella ^a   Iori, Anna P ^a   De Propris, Maria S ^a   Capobianchi, Angela ^a   Barberi, Walter ^a   Valle, Veronica ^a   Iannella, Emilia ^a   Natalino, Fiammetta ^a   Mercanti, Caterina ^a   Perrone, Salvatore ^a   Gentile, Giuseppe ^a   Guarini, Anna ^a   Foà, Robin ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Allogeneic stem cell transplant; Cytomegalovirus infection; Graft versus host disease; Natural killer cells; Regulatory T cells

Indexed keywords

IMMUNOSUPPRESSIVE AGENT;

ACUTE GRAFT VERSUS HOST DISEASE; ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOCYTIC LEUKEMIA; ALLOGENEIC STEM CELL TRANSPLANTATION; ARTICLE; CHRONIC LYMPHATIC LEUKEMIA; CHRONIC MYELOID LEUKEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; DISEASE PREDISPOSITION; FEMALE; GRAFT VERSUS HOST REACTION; HODGKIN DISEASE; HUMAN; HUMAN CELL; IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME; INFECTION RISK; MALE; MONONUCLEAR CELL; MULTIPLE MYELOMA; NATURAL KILLER CELL; OUTCOME ASSESSMENT; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; RISK ASSESSMENT; THROMBOTIC THROMBOCYTOPENIC PURPURA;

CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; FEMALE; GRAFT VS HOST DISEASE; HUMANS; KILLER CELLS, NATURAL; LEUKEMIA; LYMPHOMA; MALE; STEM CELL TRANSPLANTATION; SURVIVAL RATE; T-LYMPHOCYTES, REGULATORY; TRANSPLANTATION, HOMOLOGOUS; TREATMENT OUTCOME;

EID: 79960240709     PISSN: 01452126     EISSN: 18735835     Source Type: Journal    
DOI: 10.1016/j.leukres.2011.03.009     Document Type: Article

References (5)

1. Horowitz M.M., Gale R.P., Sondel P.M., Goldman J.M., Kersey J., Kolb H.J., et al. Graft-versus-leukemia reactions after bone marrow transplantation. Blood 1990, 75:555-562.
2. Cutler C., Giri S., Jeyapalan S., Paniagua D., Viswanathan A., Antin J.H. Acute and chronic graft-versus-host disease after allogeneic peripheral-blood stem-cell and bone marrow transplantation: a meta-analysis. J Clin Oncol 2001, 19:3685-3691.
3. Di Ianni M., Falzetti F., Carotti A., Terenzi A., Castellino F., Bonifacio E., et al. Tregs prevent GvHD and promote immune reconstitution in HLA-haploidentical transplantation. Blood 2011, doi:10.1182/blood-2010-10-311894 [e-pub ahead of print February 3].
4. Brunstein C.G., Miller J.S., Cao Q., McKenna D.H., Hippenand K.L., Curtsinger J., et al. Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics. Blood 2011, 117:1061-1070.
5. Kuijpers T.W., Baars P.A., Dantin C., van den Burg M., van Lierand R.A.W., Roosnek E. Human NK cells can control CMV infection in the absence of T cells. Blood 2008, 112:914-915.