Impact of leukocytosis on thrombotic risk and survival in 532 patients with essential thrombocythemia: A retrospective study

Annals of Hematology

Volumn 90, Issue 8, 2011, Pages 933-938

  Palandri, Francesca ^a   Polverelli, Nicola ^a   Catani, Lucia ^a   Ottaviani, Emanuela ^a   Baccarani, Michele ^a   Vianelli, Nicola ^a,b  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b L and A Seràgnoli Hematology and Oncological Sciences Institute   (Italy)

Author keywords

Essential thrombocythemia; Leukocytosis; Survival; Thrombotic risk

Indexed keywords

HEMOGLOBIN;

ADOLESCENT; ADULT; AGED; AGING; ARTICLE; FEMALE; GENE MUTATION; HEMOGLOBIN BLOOD LEVEL; HIGH RISK PATIENT; HUMAN; LEUKOCYTE COUNT; LEUKOCYTOSIS; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; PROGNOSIS; RETROSPECTIVE STUDY; RISK ASSESSMENT; RISK FACTOR; SURVIVAL; THROMBOCYTHEMIA; THROMBOSIS;

ADOLESCENT; ADULT; AGE FACTORS; AGED; FEMALE; HEMOGLOBINS; HUMANS; LEUKOCYTE COUNT; LEUKOCYTOSIS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; RISK FACTORS; SURVIVAL ANALYSIS; THROMBOCYTHEMIA, ESSENTIAL; THROMBOSIS; YOUNG ADULT;

EID: 79960238893     PISSN: 09395555     EISSN: 14320584     Source Type: Journal    
DOI: 10.1007/s00277-010-1154-3     Document Type: Article

References (22)

1. CN Harrison 2005 Essential thrombocythaemia: challenges and evidence-based management Br J Haematol 130 153 165 16029444 10.1111/j.1365-2141.2005.05543.x (Pubitemid 41602516)
2. T Barbui G Barosi A Grossi, et al. 2004 Practice guidelines for the therapy of essential thrombocythemia. A statement from the Italian Society of Hematology, the Italian Society of Experimental Hematology and the Italian Group for Bone Marrow Transplantation Haematologica 89 2 215 232 15003898 1:CAS:528:DC%2BD2cXotlSrt7Y%3D (Pubitemid 38796497)
3. F Palandri L Catani N Testoni, et al. 2009 Long-term follow-up of 386 consecutive patients with essential thrombocythemia: safety of cytoreductive therapy Am J Hematol 84 4 215 220 19208420 10.1002/ajh.21360
4. F Passamonti E Rumi L Arcaini, et al. 2008 Prognostic factors for thrombosis, myelofibrosis, and leukemia in essential thrombocythemia: a study of 605 patients Haematologica 93 11 1645 1651 18790799 10.3324/haematol.13346
5. A Tefferi M Elliott 2007 Thrombosis in myeloproliferative disorders: prevalence, prognostic factors, and the role of leukocytes and JAK2V617F Semin Thromb Hemost 33 4 313 320 17525888 10.1055/s-2007-976165 1:CAS:528: DC%2BD2sXntlOns7Y%3D (Pubitemid 46878103)
6. AM Vannucchi E Antonioli P Guglielmelli, et al. 2007 Clinical profile of homozygous JAK2 617V>F mutation in patients with polycythemia vera or essential thrombocythemia Blood 110 3 840 846 17379742 10.1182/blood-2006-12- 064287 1:CAS:528:DC%2BD2sXos1CqsL4%3D (Pubitemid 47267419)
7. V De Stefano T Za E Rossi, et al. 2010 Leukocytosis is a risk factor for recurrent arterial thrombosis in young patients with polycythemia vera and essential thrombocythemia Am J Hematol 85 2 97 100 20052743
8. F Lussana S Caberlon C Pagani, et al. 2009 Association of V617F Jak2 mutation with the risk of thrombosis among patients with essential thrombocythaemia or idiopathic myelofibrosis: a systematic review Thromb Res 124 4 409 417 19299003 10.1016/j.thromres.2009.02.004 1:CAS:528:DC%2BD1MXhtVOju77K
9. M Marchetti A Falanga 2008 Leukocytosis, JAK2V617F mutation, and hemostasis in myeloproliferative disorders Pathophysiol Haemost Thromb 36 3-4 148 159 19176988
10. A Tefferi N Gangat A Wolanskyj 2007 The interaction between leukocytosis and other risk factors for thrombosis in essential thrombocythemia Blood 109 9 4105 17449801 10.1182/blood-2007-01-066985 1:CAS:528:DC%2BD2sXkvFChsr8%3D (Pubitemid 46641767)
11. F Girodon F Dutrillaux J Broséus, et al. 2010 Leukocytosis is associated with poor survival but not with increased risk of thrombosis in essential thrombocythemia: a population-based study of 311 patients Leukemia 24 4 900 903 20130601 10.1038/leu.2010.5 1:STN:280:DC%2BC3c3lslGjtQ%3D%3D
12. A Carobbio G Finazzi V Guerini, et al. 2007 Leukocytosis is a risk factor for thrombosis in essential thrombocythemia: interaction with treatment, standard risk factors, and Jak2 mutation status Blood 109 6 2310 2313 17110452 10.1182/blood-2006-09-046342 1:CAS:528:DC%2BD2sXnslygsr0%3D (Pubitemid 46425868)
13. A Carobbio E Antonioli P Guglielmelli, et al. 2008 Leukocytosis and risk stratification assessment in essential thrombocythemia J Clin Oncol 26 16 2732 2736 18443353 10.1200/JCO.2007.15.3569 1:CAS:528:DC%2BD1cXnvVOhsbc%3D
14. AP Wolanskyj SM Schwager RF McClure, et al. 2006 Essential thrombocythemia beyond the first decade: life expectancy, long-term complication rates, and prognostic factors Mayo Clin Proc 81 2 159 166 16471068 10.4065/81.2.159 (Pubitemid 43205767)
15. S Murphy P Peterson H Iland, et al. 1997 Experience of the Polycythemia Vera Study Group with essential thrombocythemia: a final report on diagnostic criteria, survival, and leukemic transition by treatment Semin Hematol 34 1 29 39 9025160 1:STN:280:DyaK2s7nslKmsg%3D%3D (Pubitemid 27063140)
16. JW Vardiman NL Harris RD Brunning 2002 The World Health Organization (WHO) classification of the myeloid neoplasms Blood 100 7 2292 2302 12239137 10.1182/blood-2002-04-1199 1:CAS:528:DC%2BD38XnvVGisrY%3D
17. JM Bennett D Catovsky MT Daniel, et al. 1985 Proposed revised criteria for the classification of acute myeloid leukemia. A report of the French-American-British Cooperative Group Ann Intern Med 103 4 620 625 3862359 1:STN:280:DyaL2MzgsFaitg%3D%3D
18. G Barosi A Ambrosetti C Finelli, et al. 1999 The Italian consensus conference on diagnostic criteria for myelofibrosis with myeloid metaplasia Br J Haematol 104 4 730 737 10192432 10.1046/j.1365-2141.1999.01262.x 1:STN:280:DyaK1M3gs1Kmsg%3D%3D (Pubitemid 29143490)
19. H Quentmeier RA MacLeod M Zaborski, et al. 2006 JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders Leukemia 20 3 471 476 16408098 10.1038/sj.leu.2404081 1:CAS:528:DC%2BD28Xhs1Kjtbo%3D (Pubitemid 43291746)
20. F Passamonti E Rumi C Pascutto M Cazzola M Lazzarino 2009 Increase in leukocyte count over time predicts thrombosis in patients with low-risk essential thrombocythemia J Thromb Haemost 7 9 1587 1589 19566793 10.1111/j.1538-7836.2009.03531.x 1:STN:280:DC%2BD1MrotFCgsA%3D%3D
21. N Gangat AP Wolanskyj RF McClure, et al. 2007 Risk stratification for survival and leukemic transformation in essential thrombocythemia: a single institutional study of 605 patients Leukemia 21 270 276 17170720 10.1038/sj.leu.2404500 1:STN:280:DC%2BD2s%2Fks1ejtA%3D%3D (Pubitemid 46158119)
22. A Tefferi JW Vardiman 2008 Classification and diagnosis of myeloproliferative neoplasms: the 2008 World Health Organization criteria and point-of-care diagnostic algorithms Leukemia 22 14 22 17882280 10.1038/sj.leu.2404955 1:CAS:528:DC%2BD1cXmsV2jtA%3D%3D