Dermal infiltrates of cutaneous T-cell lymphomas with epidermotropism but not other cutaneous lymphomas are abundant with langerin + dendritic cells

Journal of the European Academy of Dermatology and Venereology

Volumn 25, Issue 8, 2011, Pages 922-927

  Der Petrossian, M ^a   Valencak, J ^a   Jonak, C ^a   Klosner, G ^a   Dani, T ^a   Mullauer L ^b   Pehamberger, H ^a   Knobler, R ^a   Trautinger, F ^c  

^a Universitatsklinik fur Dermatologie   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c Karl Landsteiner Institute of Dermatological Research   (Austria)

Author keywords

CD20; CD3; cutaneous lymphomas; immunofluorescence; langerhans cell; langerin

Indexed keywords

CD20 ANTIGEN; CD3 ANTIGEN; LANGERIN; MONOCLONAL ANTIBODY;

ADULT; ARTICLE; B CELL LYMPHOMA; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CUTANEOUS B CELL LYMPHOMA; CUTANEOUS T CELL LYMPHOMA; DENDRITIC CELL; DISEASE ASSOCIATION; EPIDERMIS; EPIDERMOTROPISM; FEMALE; HUMAN; LARGE CELL LYMPHOMA; LYMPHOMATOID PAPULOSIS; MAJOR CLINICAL STUDY; MALE; MYCOSIS FUNGOIDES; PANNICULITIS; PRIORITY JOURNAL; SKIN FUNCTION; SKIN INFILTRATE; STAINING; T LYMPHOCYTE;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD; ANTIGENS, CD20; ANTIGENS, CD3; DENDRITIC CELLS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LECTINS, C-TYPE; LYMPHOMA, B-CELL; LYMPHOMA, T-CELL, CUTANEOUS; MALE; MANNOSE-BINDING LECTINS; MIDDLE AGED; SKIN NEOPLASMS; YOUNG ADULT;

EID: 79960232965     PISSN: 09269959     EISSN: 14683083     Source Type: Journal    
DOI: 10.1111/j.1468-3083.2010.03882.x     Document Type: Article

References (27)

1. Rowden G, Phillips TM, Lewis MG, Wilkinson RD,. Target role of Langerhans cells in mycosis fungoides: transmission and immuno-electron microscopic studies. J Cutan Pathol 1979; 6: 364-382. (Pubitemid 10248831)
2. Jimbow K, Chiba M, Horikoshi T,. Electron microscopic identification of Langerhans cells in the dermal infiltrates of mycosis fungoides. J Invest Dermatol 1982; 78: 102-107. (Pubitemid 12165737)
3. Matejka M, Konrad K,. Epidermal Langerhans cells in mycosis fungoides and Sézary syndrome. Wien Klin Wochenschr 1983; 95: 847-852. (Pubitemid 14200469)
4. Braverman IM, Klein S, Grant A,. Electron microscopic and immunolabeling studies of the lesional and normal skin of patients with mycosis fungoides treated by total body electron beam irradiation. J Am Acad Dermatol 1987; 16: 61-74. (Pubitemid 17001981)
5. -) increased in the dermis of plaque lesions of mycosis fungoides. J Am Acad Dermatol 1991; 25: 491-499.
6. Chu A, Berger CL, Kung P, Edelson RL,. In situ identification of Langerhans cells in dermal infiltrate of cutaneous T cell lymphoma. J Am Acad Dermatol 1982; 6: 350-354. (Pubitemid 12183581)
7. McMillan EM, Beeman K, Wasik R, Everett MA,. Demonstration of OKT 6-reactive cells in mycosis fungoides. J Am Acad Dermatol 1982; 6: 880-887. (Pubitemid 12155258)
8. Fivenson DP, Nickoloff BJ,. Distinctive dendritic cell subsets expressing factor XIIIa, CD1a, CD1b and CD1c in mycosis fungoides and psoriasis. J Cutan Pathol 1995; 22: 223-228.
9. Goteri G, Filosa A, Mannello B, et al. Density of neoplastic lymphoid infiltrate, CD8+ T cells, and CD1a+ dendritic cells in mycosis fungoides. J Clin Pathol 2003; 56: 453-459.
10. Pigozzi B, Bordignon M, Belloni Fortina A, et al. Expression of the CD1a molecule in B- and T-lymphoproliferative skin conditions. Oncol Rep 2006; 15: 347-351.
11. Thomas JA, Janossy G, Graham-Brown RA, et al. The relationship between T lymphocyte subsets and Ia-like antigen positive nonlymphoid cells in early stages of cutaneous T cell lymphoma. J Invest Dermatol 1982; 78: 169-176. (Pubitemid 12165752)
12. Bani D, Pimpinelli N, Moretti S, Giannotti B,. Langerhans cells and mycosis fungoides-a critical overview of their pathogenic role in the disease. Clin Exp Dermatol 1990; 15: 7-12. (Pubitemid 20033875)
13. Meissner K, Löning T, Rehpenning W,. Epidermal Langerhans cells and prognosis of patients with mycosis fungoides and Sézary syndrome. In Vivo 1993; 7: 277-280. (Pubitemid 23205706)
14. Lüftl M, Feng A, Licha E, Schuler G,. Dendritic cells and apoptosis in mycosis fungoides. Br J Dermatol 2002; 147: 1171-1179. (Pubitemid 36963024)
15. Berger CL, Hanlon D, Kanada D, et al. The growth of cutaneous T-cell lymphoma is stimulated by immature dendritic cells. Blood 2002; 99: 2929-2939. (Pubitemid 34525383)
16. Wilcox RA, Wada DA, Ziesmer SC, et al. Monocytes promote tumor cell survival in T-cell lymphoproliferative disorders and are impaired in their ability to differentiate into mature dendritic cells. Blood 2009; 114: 2936-2944.
17. + dendritic cells survey the skin in the steady state. J Exp Med 2007; 204: 3133-3146.
18. + dendritic cells. J Exp Med 2007; 204: 3147-3156.
19. + dendritic cells that develop and function independently of epidermal Langerhans cells. J Exp Med 2007; 204: 3119-3131.
20. Kaplan DH, Kissenpfennig A, Clausen BE,. Insights into Langerhans cell function from Langerhans cell ablation models. Eur J Immunol 2008; 38: 2369-2376.
21. Schmuth M, Sideroff A, Danner B, et al. Reduced number of CD1a+ cells in cutaneous B-cell lymphoma. Am J Clin Pathol 2001; 116: 72-78.
22. Carbonelle A, Martin-Garcia N, Ortonne N, et al. Study of the reactive dendritic cells in small B-cell lymphoproliferations of the skin. Virchows Arch 2007; 450: 441-447. (Pubitemid 46466387)
23. Willemze R, Jaffe ES, Burg G, et al. WHO-EORTC classification for cutaneous lymphomas. Blood 2005; 105: 3768-3785. (Pubitemid 40656118)
24. Senff NJ, Noordijk EM, Kim YH, et al. European Organization for Research and Treatment of Cancer and International Society for Cutaneous Lymphoma consensus recommendations for the management of cutaneous B-cell lymphomas. Blood 2008; 112: 1600-1609.
25. Bunn PA Jr, Lamberg SI,. Report of the Committee on Staging and Classification of Cutaneous T-Cell Lymphomas. Cancer Treat Rep 1979; 63: 725-728. (Pubitemid 9217604)
26. Olsen E, Vonderheid E, Pimpinelli N, et al. Revisions to the staging and classification of mycosis fungoides and Sézary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the cutaneous lymphoma task force of the European Organization of Research and Treatment of Cancer (EORTC). Blood 2007; 110: 1713-1722. (Pubitemid 47443880)
27. Valladeau J, Ravel O, Dezutter-Dambuyant C, et al. Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunitiy 2000; 12: 71-81. (Pubitemid 30069216)