Near absence of methicillin-resistance and pronounced genetic diversity among Staphylococcus epidermidis isolated from healthy persons in northern Sweden

APMIS

Volumn 119, Issue 8, 2011, Pages 505-512

  Widerström, Micael ^a,b   Wiström, Johan ^b   Ek, Elin ^b   Edebro, Helén ^b   Monsen, Tor ^b  

^a ÖSTERSUND HOSPITAL   (Sweden)

^b UMEÅ UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Community acquired infections; Genetic diversity; Molecular epidemiology; Multilocus sequence typing; Pulsed field gel electrophoresis; Staphylococcus epidermidis

Indexed keywords

CLINDAMYCIN; COTRIMOXAZOLE; FUSIDIC ACID; GENTAMICIN; METICILLIN; VANCOMYCIN;

ADOLESCENT; ADULT; AGED; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL STRAIN; BACTERIUM DETECTION; BACTERIUM EXAMINATION; BACTERIUM IDENTIFICATION; CHILD; DISEASE ASSOCIATION; FEMALE; GENE LOCUS; GENETIC VARIABILITY; GENOTYPE; HOSPITAL INFECTION; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL CARE; METHICILLIN RESISTANT STAPHYLOCOCCUS EPIDERMIDIS; MULTIDRUG RESISTANCE; NEWBORN INTENSIVE CARE; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; STAPHYLOCOCCUS HOMINIS;

ADOLESCENT; ADULT; AGED; CHILD; CHILD, PRESCHOOL; CLUSTER ANALYSIS; DNA, BACTERIAL; ELECTROPHORESIS, GEL, PULSED-FIELD; FEMALE; GENETIC VARIATION; HUMANS; MALE; METHICILLIN RESISTANCE; MICROBIAL SENSITIVITY TESTS; MIDDLE AGED; MULTILOCUS SEQUENCE TYPING; POLYMERASE CHAIN REACTION; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS EPIDERMIDIS; SWEDEN; YOUNG ADULT;

EID: 79960231846     PISSN: 09034641     EISSN: 16000463     Source Type: Journal    
DOI: 10.1111/j.1600-0463.2011.02757.x     Document Type: Article

References (33)

1. Claesson C, Nilsson LE, Kronvall G, Walder M, Sorberg M. Antimicrobial activity of tigecycline and comparative agents against clinical isolates of staphylococci and enterococci from ICUs and general hospital wards at three Swedish university hospitals. Scand J Infect Dis 2009;41:171-81.
2. Claesson C, Hallgren A, Nilsson M, Svensson E, Hanberger H, Nilsson LE. Susceptibility of staphylococci and enterococci to antimicrobial agents at different ward levels in four north European countries. Scand J Infect Dis 2007;39:1002-12.
3. Li M, Wang X, Gao Q, Lu Y. Molecular characterization of Staphylococcus epidermidis strains isolated from a teaching hospital in Shanghai, China. J Med Microbiol 2009;58:456-61.
4. Klingenberg C, Ronnestad A, Anderson AS, Abrahamsen TG, Zorman J, Villaruz A, et al. Persistent strains of coagulase-negative staphylococci in a neonatal intensive care unit: virulence factors and invasiveness. Clin Microbiol Infect 2007;13:1100-11.
5. Agvald-Ohman C, Lund B, Hjelmqvist H, Hedin G, Struwe J, Edlund C. ICU stay promotes enrichment and dissemination of multiresistant coagulase-negative staphylococcal strains. Scand J Infect Dis 2006;38:441-7.
6. Chu VH, Woods CW, Miro JM, Hoen B, Cabell CH, Pappas PA, et al. Emergence of coagulase-negative staphylococci as a cause of native valve endocarditis. Clin Infect Dis 2008;46:232-42.
7. Kozitskaya S, Olson ME, Fey PD, Witte W, Ohlsen K, Ziebuhr W. Clonal analysis of Staphylococcus epidermidis isolates carrying or lacking biofilm-mediating genes by multilocus sequence typing. J Clin Microbiol 2005;43:4751-7.
8. Cimiotti JP, Wu F, Della-Latta P, Nesin M, Larson E. Emergence of resistant staphylococci on the hands of new graduate nurses. Infect Control Hosp Epidemiol 2004;25:431-5.
9. Klingenberg C, Glad GT, Olsvik R, Flaegstad T. Rapid PCR detection of the methicillin resistance gene, mecA, on the hands of medical and non-medical personnel and healthy children and on surfaces in a neonatal intensive care unit. Scand J Infect Dis 2001;33:494-7.
10. Miragaia M, Couto I, de Lencastre H. Genetic diversity among methicillin-resistant Staphylococcus epidermidis (MRSE). Microb Drug Resist 2005;11:83-93.
11. Lang S, Livesley MA, Lambert PA, Elliott J, Elliott TS. The genomic diversity of coagulase-negative staphylococci associated with nosocomial infections. J Hosp Infect 1999;43:187-93.
12. Zingg W, Demartines N, Imhof A, Senn G, Ruef C. Rapid colonization with methicillin-resistant coagulase-negative staphylococci after surgery. World J Surg 2009;33:2058-62.
13. Widerstrom M, Monsen T, Karlsson C, Edebro H, Johansson A, Wistrom J. Clonality among multidrug-resistant hospital-associated Staphylococcus epidermidis in northern Europe. Scand J Infect Dis 2009;41:642-9.
14. Monsen T, Karlsson C, Wistrom J. Spread of clones of multidrug-resistant, coagulase-negative staphylococci within a university hospital. Infect Control Hosp Epidemiol 2005;26:76-80.
15. Aires De Sousa M, Santos Sanches I, Ferro ML, De Lencastre H. Epidemiological study of staphylococcal colonization and cross-infection in two West African Hospitals. Microb Drug Resist 2000;6:133-41.
16. Milisavljevic V, Wu F, Cimmotti J, Haas J, Della-Latta P, Larson E, et al. Genetic relatedness of Staphylococcus epidermidis from infected infants and staff in the neonatal intensive care unit. Am J Infect Control 2005;33:341-7.
17. Jamaluddin TZ, Kuwahara-Arai K, Hisata K, Terasawa M, Cui L, Baba T, et al. Extreme genetic diversity of methicillin-resistant Staphylococcus epidermidis strains disseminated among healthy Japanese children. J Clin Microbiol 2008;46:3778-83.
18. Silva FR, Mattos EM, Coimbra MV, Ferreira-Carvalho BT, Figueiredo AM. Isolation and molecular characterization of methicillin-resistant coagulase-negative staphylococci from nasal flora of healthy humans at three community institutions in Rio de Janeiro City. Epidemiol Infect 2001;127:57-62.
19. Widerstrom M, Monsen T, Karlsson C, Wistrom J. Molecular epidemiology of meticillin-resistant coagulase-negative staphylococci in a Swedish county hospital: evidence of intra- and interhospital clonal spread. J Hosp Infect 2006;64:177-83.
20. Milisavljevic V, Tran LP, Batmalle C, Bootsma HJ. Benzyl alcohol and ethanol can enhance the pathogenic potential of clinical Staphylococcus epidermidis strains. Am J Infect Control 2008;36:552-8.
21. Murray PR, Bannerman TL, Peacock SJ. Staphylococcus, Micrococcus, and other catalase-positive cocci. In: Murray PR, editor. Manual of Clinical Microbiology. Washington, D.C: ASM Press, 2007: 390-411.
22. Monsen T, Ronnmark M, Olofsson C, Wistrom J. An inexpensive and reliable method for routine identification of staphylococcal species. Eur J Clin Microbiol Infect Dis 1998;17:327-35.
23. Brakstad OG, Maeland JA, Tveten Y. Multiplex polymerase chain reaction for detection of genes for Staphylococcus aureus thermonuclease and methicillin resistance and correlation with oxacillin resistance. APMIS 1993;101:681-8.
24. Tenover FC, Arbeit RD, Goering RV, Mickelsen PA, Murray BE, Persing DH, et al. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J Clin Microbiol 1995;33:2233-9.
25. Johansson A, Koskiniemi S, Gottfridsson P, Wistrom J, Monsen T. Multiple-locus variable-number tandem repeat analysis for typing of Staphylococcus epidermidis. J Clin Microbiol 2006;44:260-5.
26. Thomas JC, Vargas MR, Miragaia M, Peacock SJ, Archer GL, Enright MC. Improved multilocus sequence typing scheme for Staphylococcus epidermidis. J Clin Microbiol 2007;45:616-9.
27. Miragaia M, Thomas JC, Couto I, Enright MC, de Lencastre H. Inferring a population structure for Staphylococcus epidermidis from multilocus sequence typing data. J Bacteriol 2007;189:2540-52.
28. Ibrahem S, Salmenlinna S, Lyytikainen O, Vaara M, Vuopio-Varkila J. Molecular characterization of methicillin-resistant Staphylococcus epidermidis strains from bacteraemic patients. Clin Microbiol Infect 2008;14:1020-7.
29. Schoenfelder SM, Lange C, Eckart M, Hennig S, Kozytska S, Ziebuhr W. Success through diversity - how Staphylococcus epidermidis establishes as a nosocomial pathogen. Int J Med Microbiol 2010;300:380-6.
30. Monk AB, Boundy S, Chu VH, Bettinger JC, Robles JR, Fowler VG Jr, et al. Analysis of the genotype and virulence of Staphylococcus epidermidis isolates from patients with infective endocarditis. Infect Immun 2008;76:5127-32.
31. Cuevas O, Cercenado E, Vindel A, Guinea J, Sanchez-Conde M, Sanchez-Somolinos M, et al. Evolution of the antimicrobial resistance of Staphylococcus spp. in Spain: five nationwide prevalence studies, 1986 to 2002. Antimicrob Agents Chemother 2004;48:4240-5.
32. Levy SB, Marshall B. Antibacterial resistance worldwide: causes, challenges and responses. Nat Med 2004;10:S122-9.
33. Larson EL, McGinley KJ, Foglia AR, Talbot GH, Leyden JJ. Composition and antimicrobic resistance of skin flora in hospitalized and healthy adults. J Clin Microbiol 1986;23:604-8.