Biological markers of cardiac damage are not related to measures of cardiac systolic and diastolic function using cardiovascular magnetic resonance and echocardiography after an acute bout of prolonged endurance exercise

British Journal of Sports Medicine

Volumn 45, Issue 10, 2011, Pages 780-784

  Wilson, M ^a,b   O'Hanlon, R ^c   Prasad, S ^c   Oxborough, D ^d   Godfrey, R ^e   Alpendurada, F ^c   Smith, G ^c   Wong, J ^c   Basavarajaiah, S ^f   Sharma, S ^f   Nevill, A ^a   Gaze, David ^g   George, K ^h   Whyte, G ^b,h  

^a UNIVERSITY OF WOLVERHAMPTON   (United Kingdom)

^b Centre for Sports Cardiology   (United Kingdom)

^c ROYAL BROMPTON AND HAREFIELD NHS FOUNDATION TRUST   (United Kingdom)

^d UNIVERSITY OF LEEDS   (United Kingdom)

^e BRUNEL UNIVERSITY   (United Kingdom)

^f KING'S COLLEGE LONDON   (United Kingdom)

^g ST GEORGE S HOSPITAL   (United Kingdom)

^h LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; BRAIN NATRIURETIC PEPTIDE; PEPTIDE FRAGMENT; PRO BRAIN NATRIURETIC PEPTIDE (1 76); PRO-BRAIN NATRIURETIC PEPTIDE (1-76); TROPONIN I; TROPONIN T;

ADULT; ARTICLE; BODY MASS; DIASTOLE; DOPPLER ECHOCARDIOGRAPHY; ENDURANCE; HEART LEFT VENTRICLE FUNCTION; HEART STROKE VOLUME; HUMAN; MAGNETIC RESONANCE ANGIOGRAPHY; MALE; METABOLISM; MIDDLE AGED; PHYSIOLOGY; RUNNING; SYSTOLE;

ADULT; BIOLOGICAL MARKERS; BODY MASS INDEX; DIASTOLE; ECHOCARDIOGRAPHY, DOPPLER; HUMANS; MAGNETIC RESONANCE ANGIOGRAPHY; MALE; MIDDLE AGED; NATRIURETIC PEPTIDE, BRAIN; PEPTIDE FRAGMENTS; PHYSICAL ENDURANCE; RUNNING; STROKE VOLUME; SYSTOLE; TROPONIN I; TROPONIN T; VENTRICULAR FUNCTION, LEFT;

EID: 79960227694     PISSN: 03063674     EISSN: 14730480     Source Type: Journal    
DOI: 10.1136/bjsm.2009.064089     Document Type: Article

References (24)

1. Middleton N, Shave R, George K, et al. Left ventricular function immediately following prolonged exercise: a meta-analysis. Med Sci Sports Exerc 2006; 38 : 681 - 7.
2. Shave R, George KP, Atkinson G, et al. Exercise-induced cardiac troponin Trelease: a meta-analysis. Med Sci Sports Exerc 2007; 39 : 2099 - 106. (Pubitemid 350211502)
3. George K, Shave R, Warburton D, et al. Exercise and the heart: can you have too much of a good thing? Med Sci Sports Exerc 2008; 40 : 1390 - 2.
4. Bellenger N G, Francis JM, Davies CL, et al. Establishment and performance of a magnetic resonance cardiac function clinic. J Cardiovasc Magn Reson 2000; 2 : 15 - 22. (Pubitemid 30183732)
5. Bellenger N G, Grothues F, Smith GC, et al. Quantifi cation of right and left ventricular function by cardiovascular magnetic resonance. Herz 2000; 25 : 392 - 9. (Pubitemid 30470078)
6. Scharhag J, Urhausen A, Schneider G, et al. Reproducibility and clinical signifi cance of exercise-induced increases in cardiac troponins and N-terminal pro brain natriuretic peptide in endurance athletes. Eur J Cardiovasc Prev Rehabil 2006; 13 : 388 - 97. (Pubitemid 44318650)
7. Möhlenkamp S, Lehmann N, Breuckmann F, et al.; Marathon Study Investigators; Heinz Nixdorf Recall Study Investigators Running: the risk of coronary events: Prevalence and prognostic relevance of coronary atherosclerosis in marathon runners. Eur Heart J 2008; 29 : 1903 - 10.
8. George K, Oxborough D, Forster J, et al. Mitral annular myocardial velocity assessment of segmental left ventricular diastolic function after prolonged exercise in humans. J Physiol (Lond) 2005; 569 : 305 - 13. (Pubitemid 41701393)
9. Middleton N, George K, Whyte G, et al. Cardiac troponin Trelease is stimulated by endurance exercise in healthy humans. J Am Coll Cardiol 2008; 52 : 1813 - 4.
10. Neilan TG, Januzzi JL, Lee-Lewandrowski E, et al. Myocardial injury and ventricular dysfunction related to training levels among nonelite participants in the Boston marathon. Circulation 2006; 114 : 2325 - 33. (Pubitemid 44847449)
11. Neilan TG, Yoerger DM, Douglas PS, et al. Persistent and reversible cardiac dysfunction among amateur marathon runners. Eur Heart J 2006; 27 : 1079 - 84.
12. Scharhag J, George K, Shave R, et al. Exercise-associated increases in cardiac biomarkers. Med Sci Sports Exerc 2008; 40 : 1408 - 15.
13. Michielsen E C, Wodzig WK, Van Dieijen-Visser MP. Cardiac troponin Trelease after prolonged strenuous exercise. Sports Med 2008; 38 : 425 - 35. (Pubitemid 351550539)
14. Shave RE, Whyte GP, George K, et al. Prolonged exercise should be considered alongside typical symptoms of acute myocardial infarction when evaluating increases in cardiac troponin T. Heart 2005; 91 : 1219 - 20. (Pubitemid 41192409)
15. George K, Whyte G, Stephenson C, et al. Postexercise left ventricular function and cTnT in recreational marathon runners. Med Sci Sports Exerc 2004; 36 : 1709 - 15. (Pubitemid 39332288)
16. Rifai N, Douglas PS, O'Toole M, et al. Cardiac troponin T and I, echocardiographic [correction of electrocardiographic] wall motion analyses, and ejection fractions in athletes participating in the Hawaii Ironman Triathlon. Am J Cardiol 1999; 83 : 1085 - 9. (Pubitemid 29162796)
17. Thompson P D, Apple FS, Wu A. Marathoner's heart? Circulation 2006; 114 : 2306 - 8. (Pubitemid 44847445)
18. Cerqueira MD, Weissman NJ, Dilsizian V, et al.; American Heart Association Writing Group on Myocardial Segmentation and Registration for Cardiac Imaging. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart: a statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Circulation 2002; 105 : 539 - 42. (Pubitemid 34262671)
19. Whyte G, George K, Shave R, et al. Impact of marathon running on cardiac structure and function in recreational runners. Clin Sci 2005; 108 : 73 - 80. (Pubitemid 40052287)
20. Koller A. Exercise-induced increases in cardiac troponins and prothrombotic markers. Med Sci Sports Exerc 2003; 35 : 444 - 8. (Pubitemid 36284713)
21. Dawson E A, Whyte G P, Black M A, et al. Changes in vascular and cardiac function after prolonged strenuous exercise in humans. J Appl Physiol 2008; 105 : 1562 - 8.
22. Scharhag J, Herrmann M, Urhausen A, et al. Independent elevations of N-terminal pro-brain natriuretic peptide and cardiac troponins in endurance athletes after prolonged strenuous exercise. Am Heart J 2005; 150 : 1128 - 34. (Pubitemid 41773512)
23. Neilan T G, Ton-Nu TT, Jassal DS, et al. Myocardial adaptation to short-term high-intensity exercise in highly trained athletes. J Am Soc Echocardiogr 2006; 19 : 1280 - 5. (Pubitemid 44416178)
24. Scott JM, Esch BT, Shave R, et al. Cardiovascular consequences of completing a 160-km ultramarathon. Med Sci Sports Exerc 2009; 41 : 26 - 34.