Reduced pericellular sensitivity to IGF-I in fibroblasts from girls with Turner syndrome: A mechanism to impair clinical responses to GH

Pediatric Research

Volumn 70, Issue 1, 2011, Pages 25-30

  Westwood, Melissa ^a   Tajbakhsh, Shahin H ^a   Siddals, Kirk W ^a   Whatmore, Andrew J ^a   Clayton, Peter E ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN BINDING PROTEIN 4; SOMATOMEDIN C;

ARTICLE; BIOAVAILABILITY; CELL ISOLATION; CELL TYPE; CHEMOSENSITIVITY; CLINICAL ARTICLE; CONTROLLED STUDY; CULTURE MEDIUM; FEMALE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SKIN FIBROBLAST; TREATMENT RESPONSE; TURNER SYNDROME;

ANALYSIS OF VARIANCE; CELLS, CULTURED; FEMALE; FIBROBLASTS; GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 2; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 4; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 5; INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS; INSULIN-LIKE GROWTH FACTOR I; JANUS KINASE 2; PHOSPHORYLATION; SKIN; TIME FACTORS; TURNER SYNDROME;

EID: 79960214297     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1203/PDR.0b013e31821b570b     Document Type: Article

References (29)

1. Saenger P 1996 Turner's syndrome. N Engl J Med 335:1749-1754 (Pubitemid 26399351)
2. Rochiccioli P, David M, Malpuech G, Colle M, Limal JM, Battin J, Mariani R, Sultan C, Nivelon JL, Simonin G, Bost M, Chatelain P, Bertrand AM, Freycon R, Bouquier JJ, Pierron P 1994 Study of final height in Turner's syndrome: ethnic and genetic influences. Acta Paediatr 83:305-308 (Pubitemid 24121139)
3. Zadik Z, Landau H, Chen M, Altman Y, Lieberman E 1992 Assessment of growth hormone (GH) axis in Turner's syndrome using 24-hour integrated concentrations of GH, insulin-like growth factor-I, plasma GH-binding activity, GH binding to IM9 cells, and GH response to pharmacological stimulation. J Clin Endocrinol Metab 75:412-416
4. Lanes R, Brito S, Suniaga M, Moncada G, Borges M 1990 Growth hormone secretion in pubertal age patients with Turner's syndrome. J Clin Endocrinol Metab 71:770-772 (Pubitemid 20286082)
5. Wit JM, Massarano AA, Kamp GA, Hindmarsh PC, van Es A, Brook CG, Preece MA, Matthews DR 1992 Growth hormone secretion in patients with Turner's syndrome as determined by time series analysis. Acta Endocrinol (Copenh) 127:7-12
6. Massa G, Bouillon R, Vanderschueren-Lodeweyckx M 1992 Serum growth hormone (GH)-binding protein and insulin-like growth factor-I levels in Turner's syndrome before and during treatment with recombinant human GH and ethinyl estradiol. J Clin Endocrinol Metab 75:1298-1302
7. Baxter L, Bryant J, Cave CB, Milne R 2007 Recombinant growth hormone for children and adolescents with Turner syndrome. Cochrane Database Syst Rev 1:CD003887
8. Ranke MB, Lindberg A, Ferrandez-Longas A, Darendeliler F, Albertsson-Wikland K, Dunger D, Cutfield WS, Tauber M, Wilton P, Wollmann HA, Reiter EO 2007 Major determinants of height development in Turner syndrome (TS) patients treated with GH: analysis of 987 patients from KIGS. Pediatr Res 61:105-110 (Pubitemid 46352325)
9. Hochberg Z, Aviram M, Rubin D, Pollack S 1997 Decreased sensitivity to insulinlike growth factor I in Turner's syndrome: a study of monocytes and T lymphocytes. Eur J Clin Invest 27:543-547
10. Barreca A, Larizza D, Damonte G, Arvigo M, Ponzani P, Cesarone A, Lo CF, Severi F, Giordano G, Minuto F 1997 Insulin-like growth factors (IGF-I and IGF-II) and IGF-binding protein-3 production by fibroblasts of patients with Turner's syndrome in culture. J Clin Endocrinol Metab 82:1041-1046 (Pubitemid 27166639)
11. Freeth JS, Ayling RM, Whatmore AJ, Towner P, Price DA, Norman MR, Clayton PE 1997 Human skin fibroblasts as a model of growth hormone (GH) action in GH receptor-positive Laron's syndrome. Endocrinology 138:55-61 (Pubitemid 27009405)
12. Westwood M, Gibson JM, Pennells LA, White A 1999 Modification of plasma insulin-like growth factors and binding proteins during oral contraceptive use and the normal menstrual cycle. Am J Obstet Gynecol 180:530-536 (Pubitemid 29149122)
13. Gravholt CH, Frystyk J, Flyvbjerg A, Orskov H, Christiansen JS 2001 Reduced free IGF-I and increased IGFBP-3 proteolysis in Turner syndrome: modulation by female sex steroids. Am J Physiol Endocrinol Metab 280:E308-E314
14. Yakar S, Liu J-L, Stannard B, Butler A, Accili D, Sauer B, LeRoith D 1999 Normal growth and development in the adsence of hepatic insulin-like growth factor I. Proc Natl Acad Sci U S A 96:7324-7329 (Pubitemid 29299660)
15. Batch JA, Mercuri FA, Edmondson SR, Werther GA 1994 Localization of messenger ribonucleic acid for insulin-like growth factor binding proteins in human skin by in situ hybridization. J Clin Endocrinol Metab 79:1444-1449
16. Neely EK, Rosenfeld RG 1992 Insulin-like growth factors (IGFs) reduce IGF-binding protein-4 (IGFBP-4) concentration and stimulate IGFBP-3 independently of IGF receptors in human fibroblasts and epidermal cells. Endocrinology 130:985-993
17. Kamp GA, Ouwens DM, Hoogerbrugge CM, Zwinderman AH, Maassen JA, Wit JM 2002 Skin fibroblasts of children with idiopathic short stature show an increased mitogenic response to IGF-I and secrete more IGFBP-3. Clin Endocrinol (Oxf) 56:439-447 (Pubitemid 34429618)
18. Gargosky SE, Wilson KF, Fielder PJ, Vaccarello MA, Guevara-Aguirre J, Diamond FB, Baxter RC, Rosenbloom AL, Rosenfeld RG 1993 The composition and distribution of insulin-like growth factors (IGFs) and IGF-binding proteins (IGFBPs) in the serum of growth hormone receptor-deficient patients: effects of IGF-I therapy on IGFBP-3. J Clin Endocrinol Metab 77:1683-1689 (Pubitemid 24000935)
19. Hansen LH, Wang X, Kopchick JJ, Bouchelouche P, Nielsen JH, Galsgaard ED, Billestrup N 1996 Identification of tyrosine residues in the intracellular domain of the growth hormone receptor required for transcriptional signaling and Stat5 activation. J Biol Chem 271:12669-12673 (Pubitemid 26160943)
20. Silva CM, Kloth MT, Whatmore AJ, Freeth JS, Anderson N, Laughlin KK, Huynh T, Woodall AJ, Clayton PE 2002 GH and epidermal growth factor signaling in normal and Laron syndrome fibroblasts. Endocrinology 143:2610-2617 (Pubitemid 34701324)
21. Freeth JS, Silva CM, Whatmore AJ, Clayton PE 1998 Activation of the signal transducers and activators of transcription signaling pathway by growth hormone (GH) in skin fibroblasts from normal and GH binding protein-positive Laron Syndrome children. Endocrinology 139:20-28 (Pubitemid 28166286)
22. Kofoed EM, Hwa V, Little B, Woods KA, Buckway CK, Tsubaki J, Pratt KL, Bezrodnik L, Jasper H, Tepper A, Heinrich JJ, Rosenfeld RG 2003 Growth hormone insensitivity associated with a STAT5b mutation. N Engl J Med 349:1139-1147 (Pubitemid 37122326)
23. Abuzzahab MJ, Schneider A, Goddard A, Grigorescu F, Lautier C, Keller E, Kiess W, Klammt J, Kratzsch J, Osgood D, Pfaffle R, Raile K, Seidel B, Smith RJ, Chernausek SD 2003 IGF-I receptor mutations resulting in intrauterine and postnatal growth retardation. N Engl J Med 349:2211-2222 (Pubitemid 37485137)
24. Conover CA 1990 Regulation of insulin-like growth factor (IGF)-binding protein synthesis by insulin and IGF-I in cultured bovine fibroblasts. Endocrinology 126:3139-3145 (Pubitemid 20216572)
25. Donnelly MJ, Holly JM 1996 Rhe role of IGFBP-3 in the regulation of IGFBP-4 proteolysis. J Endocrinol 149:R1-R7
26. Jørgensen JO, Blum WF, Møller N, Ranke MB, Christiansen JS 1991 Short-term changes in serum insulin-like growth factors (IGF) and IGF binding protein 3 after different modes of intravenous growth hormone (GH) exposure in GH-deficient patients. J Clin Endocrinol Metab 72:582-587 (Pubitemid 21921734)
27. Villafuerte BC, Zhang WN, Phillips LS 1996 Insulin and insulin-like growth factor-I regulate hepatic insulin-like growth factor binding protein-3 by different mechanisms. Mol Endocrinol 10:622-630 (Pubitemid 26176270)
28. de Ridder MA, Stijnen T, Hokken-Koelega AC 2008 Prediction model for adult height of small for gestational age children at the start of growth hormone treatment. J Clin Endocrinol Metab 93:477-483 (Pubitemid 351240819)
29. Camacho-Hubner C, Busby WH Jr, McCusker RH, Wright G, Clemmons DR 1992 Identification of the forms of insulin-like growth factor-binding proteins produced by human fibroblasts and the mechanisms that regulate their secretion. J Biol Chem 267:11949-11956