Structure-based design of a new series of d-glutamic acid based inhibitors of bacterial UDP-N-acetylmuramoyl-l-alanine: D-glutamate ligase (MurD)

Journal of Medicinal Chemistry

Volumn 54, Issue 13, 2011, Pages 4600-4610

  Tomašić, Tihomir ^a   Zidar, Nace ^a   Šink, Roman ^a   Kovač, Andreja ^a   Blanot, Didier ^b   Contreras Martel, Carlos ^c,d,e   Dessen, Andréa ^c,d,e   Müller Premru, Manica ^a   Zega, Anamarija ^a   Gobec, Stanislav ^a   Kikelj, Danijel ^a   Peterlin Mašič, Lucija ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b INSTITUTE FOR INTEGRATIVE BIOLOGY OF THE CELL I2BC   (France)

^c INSTITUT DE BIOLOGIE STRUCTURALE   (France)

^d DIF   (France)

^e CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 [3 [[1 CARBOXY N [4 [(4 OXO 2 THIOXOTHIAZOLIDIN 5 YLIDENE)METHYL]PHENYL]FORMAMIDO]METHYL]BENZAMIDO]PENTANEDIOIC ACID; 2 [3 [[2 CARBOXY N [4 [(4 OXO 2 THIOXOTHIAZOLIDIN 5 YLIDENE)METHYL]PHENYL]ACETAMIDO]METHYL]BENZAMIDO]PENTANEDIOIC ACID; 2 [3 [[3 CARBOXY N [4 [(4 OXO 2 THIOXOTHIAZOLIDIN 5 YLIDENE)METHYL]PHENYL]PROPANAMIDO]METHYL]BENZAMIDO]PENTANEDIOIC ACID; ANTIINFECTIVE AGENT; BENZYLIDENE DERIVATIVE; DIMETHYL 2 [3 [[2 ETHOXY 2 OXO N [4 [(4 OXO 2 THIOXOTHIAZOLIDIN 5 YLIDENE)METHYL]PHENYL]ACETAMIDO]METHYL]BENZAMIDO]PENTANEDIOIC ACID; DIMETHYL 2 [3 [[4 METHOXY 2 OXO N [4 [(4 OXO 2 THIOXOTHIAZOLIDIN 5 YLIDENE)METHYL]PHENYL]BUTANAMIDO]METHYL]BENZAMIDO]PENTANEDIOIC ACID; GLUTAMIC ACID DERIVATIVE; LIGASE; LIGASE INHIBITOR; PROTEIN MURD; THIAZOLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENTEROCOCCUS FAECALIS; ENZYME ACTIVE SITE; ESCHERICHIA COLI; IC 50; MOLECULAR DOCKING; NONHUMAN; STAPHYLOCOCCUS AUREUS;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; GLUTAMIC ACID; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; MODELS, MOLECULAR; PEPTIDE SYNTHASES; PROTEIN BINDING; PROTEIN CONFORMATION; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79960189764     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm2002525     Document Type: Article

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