The effects of supplemental zinc and honey on wound healing in rats

Iranian Journal of Basic Medical Sciences

Volumn 14, Issue 4, 2011, Pages 391-398

  Sazegar, Ghasem ^a   Hosseini, Seyed Reza Attarzadeh ^b   Behravan, Effat ^c  

^a MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b FERDOWSI UNIVERSITY OF MASHHAD   (Iran)

^c MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Honey; Spectrophotometry; Tensile strength; Wound healing; Zinc sulfate

Indexed keywords

COLLAGEN FIBER; ZINC SULFATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BACTERIAL GROWTH; CONTROLLED STUDY; DRUG EFFECT; EPITHELIZATION; HISTOLOGY; HONEY; NONHUMAN; RAT; REVASCULARIZATION; SKIN; TENSILE STRENGTH; VITAMIN SUPPLEMENTATION; WOUND HEALING;

ANIMALIA; BACTERIA (MICROORGANISMS); RATTUS;

EID: 79960156650     PISSN: 20083866     EISSN: 20083874     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Storm-Versloot MN, Vos CG, Ubbink DT, Vermeulen H., Topical silver for preventing wound infection. Cochrane Database of Systematic Reviews, 2010; 3:006478.
2. O'Meara SM, Cullum NA, Majid M, Sheldon TA. Systematic review of antimicrobial agents used for chronic wounds. Br J Surg 2001; 88:4-21.
3. O'Meara, S, Ovington, L. Antibiotics and antiseptics for venous leg ulcers (Protocol for a Cochrane Review). The Cochrane Library, John Wiley & Sons Ltd, 2002; 2.
4. Roberts PR, Black KW, Santamauro JT, Zaloga GP. Dietary peptides improve wound healing following surgery. Nutrition 1998; 14: 266-269.
5. Hema SD, Shankar KM, Bhushan P. Wound healing activity of topical application forms based on Ayurveda.* eCAM 2009; 10:1-10.
6. Govindarajan R, Madhavan V, Rao CV, Shirwaikar A, Mehrotra S, Pushpagandan P. Healing potential of Anogeissus latifolia for dermal wounds in rats. Acta Pharm 2004; 54:331-338.
7. Rozaini MZ, Zuki ABZ, Noordin M, Norimah Y, Hakim AN. The effects of different types of honey on tensile strength evaluation of burn wound tissue healing. Int J Appl Res Vet Med 2004; 2:2.
8. Alvarez OM, Gilbreath RL. Effect of dietary thiamine on intermolecular collagen cross-linking during wound repair: a mechanical and biochemical assessment. J Trauma 1982; 22:20-4.
9. Aprahamian M, Dentinger A, Stock-Damge C, Kouassi JC, Grenier JF. Effects of supplemental pantothenic acid on wound healing: experimental study in rabbit. Am J Clin Nutr 1985; 41:578-589.
10. Vaxman F, Olender S, Lambert A, Nisand G, Aprahamian M, Bruch JF, et al. Effect of pantothenic acid and ascorbic acid supplementation on human skin wound healing process. A double-blind, prospective and randomized trial. Eur Surg Res 1995; 27:158-166.
11. Mazzotta C, Balestrazzi A, Traversi C, Baiocchi S, Caporossi T, Tommasi C, Caporossi A. Treatment of progressive keratoconus by riboflavin-UVA-induced cross-linking of corneal collagen: ultrastructural analysis by Heidelberg Retinal Tomograph II in vivo confocal microscopy in humans. Cornea 2007; 26:390-397.
12. Levine M. New concepts in the biology and biochemistry of ascorbic acid. N Engl J Med 1986; 314:892-902.
13. Ringsdorf WM Jr, Cheraskin E. Vitamin C and human wound healing. Oral Surg Oral Med Oral Pathol 1982; 53:231-6.
14. Hunt TK. Vitamin A and wound healing. J Am Acad Dermatol 1986; 15:817-21.
15. Sobol SE, Keswani S, Parvadia JK, Crombleholme T, Potsic WP. Effect of corticosteroid-antibiotic agents on granulation tissue in a murine model. Arch Otolaryngol Head Neck Surg 2005; 131:330-335.
16. Ehrlich HP, Hunt TK. Effect of cortisone and vitamin A on wound healing. Ann Surg 1968;167:324.
17. MacKay DJ, Miller AL. Nutritional support for wound healing. Altern Med Rev 2003; 8:359-377
18. Jaarin K, Gapor MT, Nafeeza MI, Fauzee AM. Effect of various doses of palm vitamin E and tocopherol on aspirin-induced gastric lesions in rats. Int J Exp Pathol 2002; 83:295-302.
19. Tenaud I, Sainte-Marie I, Jumbou O, Litoux P, Dréno B. In vitro modulation of keratinocyte wound healing integrins by zinc, copper and manganese. Br J Dermatol 1999; 140:26-34.
20. Pereira CE, Felcman J. Correlation between five minerals and the healing effect of Brazilian medicinal plants. Biol Trace Elem Res 1998; 65:251-259.
21. Carlisle EM. Silicon as an essential trace element in animal nutrition. Ciba Found Symp 1986; 121:123-139.
22. Jiang Y, Ding G, Lu S. Behavior of dermal fibroblasts on microdot arrays yields insight into wound healing mechanisms. Mol Biol Rep. 2011 Jan; 38:387-94.
23. 2 laser system in porcine model. Laryngoscope 2006; 116:6:1002-1006.
24. Sandstead HH. Understanding zinc: Recent observations and interpretations. J Lab Clin Med 1994; 124:322-327.
25. Liszewski RF. The effect of zinc on wound healing: a collective review. J Am Osteopath Assoc 1981; 81:104-106.
26. Lansdown ABG. Zinc in the healing wound. Lancet 1996; 347:706-707.
27. Ågren MS. Zinc in wound repair. Arch Dermatol 1999; 135:1273-1234.
28. Ebrahimi A, Hoseini A, Sazegar G. The Effects of zinc sulfate in wound healing of incision wounds in rat. Shahid Beheshti Journal of the Faculty of Medicine 1996; 20:1:4-13.
29. Ågren MS. Studies on zinc in wound healing. Acta Derm Venereol Suppl 1990; 154:1-36.
30. Greenway SE, Filler LE, Greenway FL.Topical insulin in wound healing: a randomised, double-blind, placebo-controlled trial. J Wound Care 1999; 8:526-528.
31. Sesta G, Persanooddo L, Nisi F, Ricci L. Effects of artificial sugar feeding on sugar composition of royal jelly. Apiacta. 2006; 41:60-70.
32. Molan PC. The evidence supporting the use honey as a wound dressing. Int J Low Exterm Wounds 2006; 40-54.
33. Subrahmanyam M. Topical application of honey in treatment of burns. Br J Surg 1991; 78:497-498.
34. Subrahmanyam M. Honey impregnated gauze versus polyurethane film (op site R) in the treatment of burnsa prospective randomized study. Br J Surg 1993; 46:322-323.
35. Bergman A, Yanai J, Weiss J, Bell D, David MP. Acceleration of wound healing by topicalapplication of honey: an animal model. Am J Surg 1983; 145:374-376.
36. Yilmaz N, Nisbet O, Nisbet C, Ceylan G, Hoşgör F, Dede OD. Biochemical evaluation of the therapeutic effectiveness of honey in oral mucosal ulcers. Bosn J Basic Med Sci 2009; 9:290-295.
37. Cooper RA, Molan PC, Harding KG. Antibacterial activity of honey against strains of Staphylococcus aurous from infected wounds. J R Soc Med 1999; 92:283-285.
38. Tan HT, Rahman RA, Gan SH, Halim AS, Hassan SA, Sulaiman SA, et al. The antibacterial properties of Malaysian tualang honey against wound and enteric microorganisms in comparison to manuka honey. BMC Complement Altern Med 2009; 34.[abstract]
39. Glade MJ. Polysulfated glycosaminoglycan accelerates net synthesis of collagen and glycosaminoglycans by arthritic equine cartilage tissues and chondrocytes. Am J Vet Res 1990; 51:779-785.
40. Fosmire GJ. Zinc toxicity. Am J Clinical Nutr 1990; 51:225-227.
41. Muscará MN, McKnight W, Asfaha S, Wallace JL. Wound collagen deposition in rats: effects of an NONSAID and a selective COX-2 inhibitor. Br J Pharmacol 2000; 129:681-686.
42. Parasad AS. Zinc: an overview. Nutrition 1995; II(suppl):93-99.
43. Levenson SM, Demetriou AA. Wound healing: biochemical and clinical aspect. Philadelphia: WB Saunders; 1992.p.248-273.
44. Ågren MS, Franzen L. Influence of zinc deficiency on breaking strength of 3-week-old skin incisions in the rat. Acta Chir Scand 1990; 156:667-670.
45. Senapati A, Thompson PH. Zinc deficiency and the prolonged accumulation of zinc in wounds. Br J Surg 1985; 72:7:583-584.
46. Dunford C, Cooper R, Molan P. Using honey as a dressing for infected skin lesions. Nurs Times 2000; 96:7-9.