Mild hypothermia as a cardioprotective approach for acute myocardial infarction: Laboratory to clinical application

Journal of Cardiovascular Pharmacology and Therapeutics

Volumn 16, Issue 2, 2011, Pages 131-139

  Hale, Sharon L ^a   Kloner, Robert A ^a,b  

^a GOOD SAMARITAN HOSPITAL   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Myocardial infarction; Therapeutic hypothermia

Indexed keywords

ADENOSINE TRIPHOSPHATE; CREATINE KINASE; CREATINE KINASE MB; CREATINE PHOSPHATE; GLYCOGEN; HEAT SHOCK PROTEIN; TISSUE PLASMINOGEN ACTIVATOR;

ACUTE HEART INFARCTION; APOPTOSIS; BODY TEMPERATURE; CATHETER; CLINICAL TRIAL (TOPIC); ECHOCARDIOGRAPHY; HEART ARREST; HEART INFARCTION PREVENTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE BLOOD FLOW; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; HEART VENTRICLE REMODELING; HIGH ENERGY PHOSPHATE; HUMAN; INDUCED HYPOTHERMIA; METABOLIC REGULATION; MICROVASCULATURE; MULTICENTER STUDY (TOPIC); NONHUMAN; PERCUTANEOUS CORONARY INTERVENTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SHIVERING; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION;

ANIMALS; BODY TEMPERATURE; CATHETERIZATION; DISEASE MODELS, ANIMAL; HUMANS; HYPOTHERMIA, INDUCED; MYOCARDIAL INFARCTION; TIME FACTORS;

EID: 79960152784     PISSN: 10742484     EISSN: 19404034     Source Type: Journal    
DOI: 10.1177/1074248410387280     Document Type: Review

References (72)

1. Abendschein DR, Tacker WA Jr, Babbs CF. Protection of ischemic myocardium by whole-body hypothermia after coronary artery occlusion in dogs. Am Heart J. 1978;96(6):7722-7780.
2. Voorhees WD 3rd, Abendchein DR, Tacker WA Jr. Effect of whole-body hypothermia on myocardial blood flow and infarct salvage during coronary artery occlusion in dogs. Am Heart J. 1984;107(5 pt 1):945-949. (Pubitemid 14100849)
3. Meerbaum SM, Haendchen RV, Corday E, et al. Hypothermic coronary venous phased retroperfusion: a closed-chest treatment of acute regional myocardial ischemia. Circulation. 1982;65(7): 1435-1445. (Pubitemid 12123638)
4. Wakida Y, Haendchen RV, Kobayashi S, Nordlander R, Corday E. Percutaneous cooling of ischemic myocardium by hypothermic retroperfusion of autologous arterial blood: effects on regional myocardial temperature distribution and infarct size. J Am Coll Cardiol. 1991;18(1):293-300.
5. Haendchen RV, Corday E, Meerbaum S, Povzhitkov M, Rit J, Fishbein MC. Prevention of ischemic injury and early reperfusion derangements by hypothermia retroperfusion. J Am Coll Cardiol. 1983;1(4):1067-1080. (Pubitemid 13107527)
6. Hale SL, Kloner RA. Myocardial temperature in acute myocardial infarction: protecting ischemic myocardium with mild regional hypothermia in rabbits. Am J Physiol. 1997;273(1 pt 2): H220-H227.
7. Chien GL, Wolff RA, Davis RF, van Winkle DM. "Normothermic range" temperature affects myocardial infarct size. Cardiovasc Res. 1994;28(7):1014-1017.
8. Duncker DJ, Klassen CL, Ishibashi Y, Herrlinger SH, Pavek TJ, Bache RJ. Effect of temperature on myocardial infarction in swine. Am J Physiol. 1996;270(4 pt 2):H1189-H1199.
9. McClanahan TB, Mertz TE, Martin BJ, et al. Pentostatin reduces infarct size in pigs only when combined with mild hypothermia [abstract]. Circulation. 1994;90(suppl 1):1-478.
10. Schwartz LM, Verbinski SG, Vander Heide RS, Reimer KA. Epicardial temperature is a major predictor of infarct size in dogs. J Mol Cell Cardiol. 1997;29(6): 1577-1583. (Pubitemid 27270228)
11. Miki R, Liu GS, Cohen MV, Downey JM. Mild hypothermia reduces infarct size in the beating rabbit heart: a practical intervention for acute myocardial infarction? Basic Res Cardiol. 1998;93(5):372-383. (Pubitemid 28499457)
12. Dae MW, Gao DW, Sessler DI, Chair K, Stillson CA. Effect of endovascular cooling on myocardial temperature, infarct size and cardiac output in human-sized pigs. Am J Physiol. 2001;282(5): H1584-H1591. (Pubitemid 34654823)
13. Hale SL, Dave RH, Kloner RA. Regional hypothermia reduces myocardial necrosis even when instituted after the onset of ischemia. Basic Res Cardiol. 1997;92(5):351-357. (Pubitemid 28014561)
14. Kanemoto S, Matsubara M, Noma M, et al. Mild hypothermia to limit myocardial ischemia-reperfusion injury: importance of timing. Ann Thorac Surg. 2009;87(1):157-163.
15. Hale SL, Kloner RA. Myocardial temperature reduction attenuates necrosis after prolonged ischemia in rabbits. Cardiovasc Res. 1998;40(3):502-507. (Pubitemid 28557290)
16. Maeng M, Mortensen UM, Kristensen J, Kristiansen SB, Andersen HR. Hypothermia during reperfusion does not reduce myocardial infarct size in pigs. Basic Res Cardiol. 2006;101(1): 61-68. (Pubitemid 43323433)
17. Otake H, Shite J, Paredes OL, et al. Catheter-based transcoronary myocardial hypothermia attenuates arrhythmia and myocardial necrosis in pigs with acute myocardial infarction. J Am Coll Cardiol. 2007;49(2):250-260. (Pubitemid 46054394)
18. Götberg M, Olivecrona GK, Engblom H, et al. Rapid shortduration hypothermia with cold saline and endovascular cooling before reperfusion reduces microvascular obstruction and myocardial infarct size. BMC Cardiovasc Disord. 2008 Apr 10;8:7. http://www.biomedcentral.com/1471-2261/8/7. Accessed May 18, 2010.
19. Van den Doel MA, Gho BC, Duval SY, Schoemaker RG, Duncker DJ, Verdouw PD. Hypothermia extends the cardioprotection by ischaemic preconditioning to coronary artery occlusions of longer duration. Cardiovasc Res. 1998:37(1); 76-81. (Pubitemid 28122618)
20. Hale SL, Kloner RA. Ischemic preconditioning and myocardial hypothermia in rabbits with prolonged coronary artery occlusion. Am J Physiol. 1999;246(6 pt 2):H2029-H2034. (Pubitemid 29323488)
21. Dote K, Wolff RA, Van Winkle DM. Hypothermia increases the threshold for ischemic preconditioning. J Thorac Cardiovasc Surg. 1998;116(2):319-326. (Pubitemid 28367100)
22. Olivecrona GK, Gotberg M, Harnek J, Van der Pals J, Erlinge D. Mild hypothermia reduces cardiac post-ischemic reactive hyperemia. BMC Cardiovascular Disorders 2001. http://www. biomedcentral.com/1471-2261/7/5. Accessed May 18, 2010.
23. Lauri T, Leskinen M, Timisjarvi J. Effects of surface-induced hypothermia and rewarming on canine cardiac contractionrelaxation cycle. Int J Circumpolar Health. 1997;56(1-2):40-48.
24. Tissier R, Couvreur N, Ghaleh B, et al. Rapid cooling preserves the ischaemic myocardium against mitochondrial damage and left ventricular dysfunction. Cardiovasc Res. 2009;83(2): 345-353.
25. Kloner RA, Ganote CE, Jennings RB. The "no-reflow" phenomenon following temporary coronary artery occlusion in the dog. J Clin Invest. 1974;54(6):1496-1508.
26. Ambrosio G, Weisman HF, Mannisi JA, Becker LC. Progressive impairment of regional myocardial perfusion after initial restoration of postischemic blood flow. Circulation. 1989;80(6): 1846-1861. (Pubitemid 20031716)
27. Hale SL, Dae MW, Kloner RA. Hypothermia during reperfusion limits 'no-reflow' injury in a rabbit model of acute myocardial infarction. Cardiovasc Res. 2003;59(3): 715-722. (Pubitemid 38368688)
28. Hamamoto H, Leshnower BG, Parish LM, et al. Regional heterogeneity of myocardial reperfusion injury: effect of mild hypothermia. Ann Thorac Surg. 2009;87(1):164-171.
29. Wakida Y, Nordlander R, Kodayashi S, Kar S, Haendchen R. Corday E. Short-term synchronized retroperfusion before reperfusion reduces infarct size after prolonged ischemia in dogs. Circulation. 1993;88(5 pt 1):2370-2380. (Pubitemid 23326117)
30. Hamamoto H, Sakamoto H, Bradley G, et al. Very mild hypothermia during ischemia and reperfusion improved postinfarction remodeling. Ann Thorac Surg. 2009;87:172-177.
31. Polderman KH. Mechanisms of action, physiological effects and complications of hypothermia. Crit Care Med. 2009;37(7 suppl): S186-S202.
32. Ning XH, Xu CS, Song YC, et al. Hypothermia preserves function and signaling for mitochondrial biogenesis during subsequent ischemia. Am J Physiol. 1998;274(3 pt 2):H786-H793.
33. Eidelman Y, Glat PM, Pachter HL, Cabrera R, Rosenberg C. The effects of topical hypothermia and steroids and ATP levels in an in vivo liver ischemia model. J Trauma. 1994;37(4):677-681. (Pubitemid 24338121)
34. Simkhovich BZ, Hale SL, Kloner RA. Metabolic mechanism by which mild regional hypothermia preserves ischemic tissue. J Cardiovasc Pharmacol Ther. 2004;9(2):83-90. (Pubitemid 39071593)
35. Zar HA, Tanigawa K, Kim YM, Lancaster JR Jr. Mild therapeutic hypothermia for postischemic vasoconstriction in the perfused rat liver. Anesthesiology. 1999;90(4):1103-1111. (Pubitemid 29159769)
36. Ning XH, Chen SH, Xu CS, et al. Hypothermic protection of the ischemic heart via alterations in apoptotic pathways as assessed by gene array analysis. J Appl Physiol. 2002;92(5):2200-2207.
37. Meybohm P, Gruenewald M, Albrecht M, et al. Hypothermia and postconditioning after cardiopulmonary resuscitation reduce cardiac dysfunction by modulating inflammation, apoptosis and remodeling. PLoS One. 2009;4(10):e7588.
38. Huang CH, Chen HW, Tsai MS, et al. Antiapoptotic cardioprotective effect of hypothermia treatment against oxidative stress injuries. Acad Emerg Med. 2009;16(9):872-880.
39. Xu L, Yenari MA, Steinberg GK, Giffard RG. Mild hypothermia reduces apoptosis of mouse neurons in vitro early in the cascade. J Cereb Blood Flow Metab. 2002;22(1):21-28. (Pubitemid 34038379)
40. Huet O, Kinirons B, Dupic L, et al. Induced mild hypothermia reduces mortality during acute inflammation in rats. Acta Anaesthesiol Scand. 2007;51 (9): 1211-1216. (Pubitemid 47389687)
41. Deng H, Han HS, Cheng D, Sim GH, Yenari MA. Mild hypothermia inhibits inflammation after experimental stroke and brain inflammation. Stroke. 2003;34(10):2495-2501. (Pubitemid 37221971)
42. Harris SB, Darwin MG, Russell SR, O'Farrell JM, Fletcher M, Wowk B. Rapid (0.5 degrees C/min) minimally invasive induction of hypothermia using cold perfluorochemical lung lavage in dogs. Resuscitation. 2001 50(2): 189-204. (Pubitemid 32823458)
43. Tissier R, Couvreur N, Ghaleh B, et al. Rapid cooling preserves the ischaemic myocardium against mitochondrial damage and left ventricular dysfunction. Cardiovasc Res. 2009;83(2): 345-353.
44. Tissier R, Hamanaka K, Kuno A, Parker JC, Cohen MV, Downey JM. Total liquid ventilation provides ultra-fast cardioprotective cooling. J Am Coll Cardiol. 2007;49(5):601-605. (Pubitemid 46177438)
45. Dave RH, Hale SL, Kloner RA. Hypothermic, closed circuit pericardioperfusion: a potential cardioprotective technique in acute regional ischemia. J Am Coll Cardiol. 1998;31(7): 1667-1671. (Pubitemid 28273313)
46. Dixon SR, Whitbourn RJ, Dae MW, et al. Induction of mild systemic hypothermia with endovascular cooling during primary percutaneous coronary intervention for acute myocardial infarction. J Am Coll Cardiol. 2002;40(11):1928-1934. (Pubitemid 35425362)
47. O'Neill WW, on behalf of the COOL-MI Investigators. A prospective, randomized trial of mild hypothermia during PCI treatment of ST elevation MI. Presented at Transcatheter Cardiovascular Therapeutics 2003, Washington, DC, September 2003.
48. Grines CL, on behalf of the ICE-IT Investigators. Intravascular cooling adjunctive to percutaneous coronary intervention for acute myocardial infarction. Presented at the 16th Annual Transcatheter Cardiovascular Therapeutics, Washington DC, September 27-October 1, 2004.
49. Kandsari DE, Chu A, Brodie BR, et al. Feasibility of endovascular cooling as an adjunct to primary percutaneous coronary intervention (results of the LOWTEMP pilot study). Am J Cardiol. 2004; 93(5):636-639. (Pubitemid 38293078)
50. Ly HQ, Denault A, Dupris J, et al. A pilot study: the Noninvasive Surface Cooling Thermoregulatory Study for Mild Hypothermia Induction in Acute Myocardial Infarction (the NICAMI Study). Am Heart J. 2005;150(5):933.
51. Wolfram S, Pierau C, Radke PW, Schunkert H, Kurowski V. Mild therapeutic hypothermia in patients after out-of-hospital cardiac arrest due to acute ST-segment elevation myocardial infarction undergoing immediate percutaneous coronary intervention. Crit Care Med. 2008;36(6): 1780-1786.
52. Koreny M, Sterz F, Uray T, et al. Effect of cooling after human cardiac arrest on myocardial infarct size. Resuscitation. 2009; 80(1):56-60.
53. Polderman KH, Herold I. Therapeutic hypothermia and controlled normothermia in the intensive care unit: practical considerations, side effects, and cooling methods. Crit Care Med. 2009;37(3): 1101-1120.
54. Mokhtarani M, Mahgoub A, Morioka N, et al. Buspirone and meperidine synergistically reduce the shivering threshold. Anesth Analg. 2001 ;93(5): 1233-1239. (Pubitemid 33021023)
55. Tveita T, Mortensen E, Hevrøy O, Refsum H, Ytrehus K. Experimental hypothermia: effects of core cooling and rewarming on hemodynamics, coronary blood flow, and myocardial metabolism in dogs. Anesth Analg. 1994;79(2):212-218. (Pubitemid 24240853)
56. Tveita T, Skandfer M, Refsum H, Ytrehus K. Experimental hypothermia and rewarming: changes in mechanical function and metabolism of rat heart. J Appl Physiol. 1996;80(1):291-297. (Pubitemid 26034875)
57. Pattison CW, Dimitri WR, Williams BT. Persistent conduction disturbances following coronary artery bypass surgery: cold cardioplegia vs. intermittent ischaemic arrest (32 degrees C). Scand J Thorac Cardiovasc Surg. 2001 ;25(2): 151-154.
58. Mouritzen CV, Andersen MN. Mechanisms of ventricular fibrillation during hypothermia. J Thorac Cardiovasc Surg. 1966;5: 585-589.
59. Frank SM, Satitpunwhycha P, Bruce SR, Herscovitch P, Goldstein DS. Increased myocardial perfusion and sympathoadrenal activation during mild core hypothermia in awake humans. Clin Sci (Lond). 2003;104(5):503-508. (Pubitemid 36628146)
60. Shaw GJ, Dhamija A, Holland CK, et al. Temperature dependence of tPA thrombolysis in an in-vitro clot model. Acad Emerg Med. 2003;10:438-439.
61. Holzer M, Behringer W. Therapeutic hypothermia after cardiac arrest and myocardial infarction. Best Pract Res Clin Anaesthesiol. 2008;22(4):711-728.
62. Holzer M, Sterz F. Hypothermia After Cardiac Arrest Study Group. Therapeutic hypothermia after cardiopulmonary resuscitation. Expert Rev Cardiovasc Ther. 2003;1(2):317-325.
63. Sterz F, Holzer M, Roine R, et al. Hypothermia after cardiac arrest: a treatment that works. Curr Opin Crit Care. 2003;9(3):205-210. (Pubitemid 36667816)
64. Froehler MT, Ovbiagele B. Therapeutic hypothermia for acute ischemic stroke. Expert Rev Cardiovasc Ther. 2010;8(4): 593-603.
65. van der Worp HB, Macleod MR, Kollmar R; European Stroke Research Network for Hypothermia (EuroHYP). Therapeutic hypothermia for acute ischemic stroke: ready to start large randomized trials? J Cereb Blood Flow Metab. 2010;30(6): 1079-1093.
66. Linares G, Mayer SA. Hypothermia for the treatment of ischemic and hemorrhagic stroke. Crit Care Med. 2009;37(7 suppl): S243-S249.
67. Meloni BP, Campbell K, Zhu H, Knuckey NW. In search of clinical neuroprotection after brain ischemia: the case for mild hypothermia (35 degrees C) and magnesium. Stroke. 2009; 40(6):2236-2240.
68. Lyden PD, Krieger D, Yenari M, Dietrich WD. Therapeutic hypothermia for acute stroke. Int J Stroke. 2006;1(1):9-19. ClinicalTRials.gov. Can hypothermia be incorporated into primary angioplasty for heart attack, http:// clinicaltrials.gov/ct2/show/NCT00763828?term=hypothermia+AND+myocardial+infarct- ion&rank=l. Accessed April 5, 2010. (Pubitemid 43740667)
69. ClinicalTrials.gov. Adjunctive mild hypothermia therapy to primary percutaneous coronary intervention in patients with acute myocardial infarction complicated with shock: a feasibility study. http://clinicaltrials.gov/ct2/show/ NCT00846222?term=hypothermia+AND+myocardial+infarction&rank=2. Accessed April 5, 2010.
70. ClinicalTrials.gov. Cool MI II. Cooling as an adjunctive therapy to percutaneous intervention in patients with acute myocardial infarction. http://clinicaltrials.gov/ct2/show/NCT00248196?term= hypothermia+AND+myocardial+infarction&rank=3. Accessed April 5, 2010.
71. McFalls EO, Ward HB, Moritz TE, et al. Coronary-artery revascularization before elective major vascular surgery. N Engl J Med. 2004;351(27):2795-2804. (Pubitemid 40051903)
72. ClinicalTrials.gov. Examine the effects of maintaining body core temperature during CABGs. http://clinicaltrials.gov/ct2/show/NCT00791050?term= hypothermia+AND+myocardial+infarct-ion&rank=4. Accessed April 5, 2010.