Resting cardiac energy metabolism is inversely associated with heart rate in healthy young adult men

American Heart Journal

Volumn 162, Issue 1, 2011, Pages 136-141

  Fragasso, Gabriele ^a   De Cobelli, Francesco ^a   Spoladore, Roberto ^a   Esposito, Antonio ^a   Salerno, Anna ^a   Calori, Giliola ^a   Montanaro, Claudia ^a   Maranta, Francesco ^a   Lattuada, Guido ^b,c   Margonato, Alberto ^a   Del Maschio, Alessandro ^a   Perseghin, Gianluca ^b,c  

^a VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^b SAN RAFFAELE HOSPITAL   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CHOLESTEROL; CREATINE PHOSPHATE; CREATININE; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; TRIACYLGLYCEROL;

ADULT; ARTICLE; BODY MASS; CHOLESTEROL BLOOD LEVEL; CREATININE BLOOD LEVEL; DIASTOLIC BLOOD PRESSURE; ENERGY METABOLISM; GLUCOSE BLOOD LEVEL; HEART MUSCLE METABOLISM; HEART RATE; HUMAN; IN VIVO STUDY; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MALE; NORMAL HUMAN; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL;

ADENOSINE TRIPHOSPHATE; ADULT; ENERGY METABOLISM; HEART RATE; HEART VENTRICLES; HUMANS; MAGNETIC RESONANCE IMAGING, CINE; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MYOCARDIUM; PHOSPHOCREATINE; PROSPECTIVE STUDIES; REFERENCE VALUES; REST; VENTRICULAR FUNCTION, LEFT;

EID: 79960152080     PISSN: 00028703     EISSN: 10976744     Source Type: Journal    
DOI: 10.1016/j.ahj.2011.04.012     Document Type: Article

References (37)

1. W.B. Kannel, C. Kannel, and R.S. Paffenbarger Jr Heart rate and cardiovascular mortality: the Framingham Study Am Heart J 113 1987 1489 1494 (Pubitemid 17092823)
2. C.R. Cole, E.H. Blackstone, and F.J. Pashkow Heart-rate recovery immediately after exercise as a predictor of mortality N Engl J Med 341 1999 1351 1357 (Pubitemid 29503574)
3. F. Seccareccia, F. Pannozzo, and F. Dima Heart rate as a predictor of mortality: the MATISS project Am J Public Health 91 2001 1258 1263 (Pubitemid 32708866)
4. A. Diaz, M.G. Bourassa, and M.C. Guertin Long-term prognostic value of resting heart rate in patients with suspected or proven coronary artery disease Eur Heart J 26 2005 967 974 (Pubitemid 40695027)
5. X. Jouven, J.P. Empana, and P.J. Schwartz Heart-rate profile during exercise as a predictor of sudden death N Engl J Med 352 2005 1951 1958 (Pubitemid 40638365)
6. G. Grassi, S. Vailati, and G. Bertinieri Heart rate as marker of sympathetic activity J Hypertens 16 1998 1635 1639 (Pubitemid 28515490)
7. G. Grassi, F. Arenare, and F. Quarti-Trevano Heart rate, sympathetic cardiovascular influences, and the metabolic syndrome Prog Cardiovasc Dis 52 2009 31 37
8. F.M. Bengel, P. Ueberfuhr, and S.I. Ziegler Non-invasive assessment of the effect of cardiac sympathetic innervation on metabolism of the human heart Eur J Nucl Med 27 2000 1650 1657
9. P. Arner, E. Kriegholm, and P. Engfeldt Adrenergic regulation of lipolysis in situ at rest and during exercise J Clin Invest 85 1990 893 898 (Pubitemid 20087493)
10. G.X. Zhang, S. Kimura, and A. Nishiyama Cardiac oxidative stress in acute and chronic isoproterenol-infused rats Cardiovasc Res 65 2005 230 238 (Pubitemid 40038496)
11. R.S. Balaban, H.L. Kantor, and L.A. Katz Relation between work and phosphate metabolite in the in vivo paced mammalian heart Science 232 1986 1121 1123 (Pubitemid 16050798)
12. T. Wallimann, M. Wyss, and D. Brdiczka Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the "PCr circuit" for cellular energy homeostasis Biochem J 281 1992 21 40
13. P.A. Bottomley Noninvasive study of high-energy phosphate metabolism in human heart by depth-resolved 31P NMR spectroscopy Science 229 1985 769 772 (Pubitemid 15049822)
14. P.A. Bottomley, R.G. Weiss, and C.J. Hardy Myocardial high-energy phosphate metabolism and allograft rejection in patients with heart transplants Radiology 181 1991 67 75
15. A. De Roos, J. Doornbos, and P.R. Luyten Cardiac metabolism in patients with dilated and hypertrophic cardiomyopathy: assessment with proton-decoupled P-31 MR spectroscopy J Magn Reson Imaging 2 1992 711 719
16. S. Neubauer, T. Krahe, and R. Schindler 31P magnetic resonance spectroscopy in dilated cardiomyopathy and coronary artery disease Circulation 86 1992 1810 1818
17. M.A. Conway, J. Allis, and R. Ouwerkerk Detection of low PCr to ATP ratio in failing hypertrophied myocardium by 31P magnetic resonance spectroscopy Lancet 338 1991 973 976
18. T. Yabe, K. Mitsunami, and M. Okada Detection of myocardial ischemia by 31P magnetic resonance spectroscopy during handgrip exercise Circulation 89 1994 1709 1716
19. M.A. Conway, P.A. Bottomley, and R. Ouwerkerk Mitral regurgitation: impaired systolic function, eccentric hypertrophy, and increased severity are linked to lower phosphocreatine/ATP ratios in humans Circulation 97 1998 1716 1723 (Pubitemid 28211421)
20. L. Nascimben, J.S. Ingwall, and P. Pauletto The creatine kinase system in failing and nonfailing human myocardium Circulation 94 1996 1894 1901 (Pubitemid 26349302)
21. G. Fragasso, G. Perseghin, and F. De Cobelli Effects of metabolic modulation by trimetazidine on left ventricular function and phosphocreatine/adenosine triphosphate ratio in patients with heart failure Eur Heart J 27 2006 942 948
22. G. Perseghin, G. Natali, and F. De Cobelli Abnormal left ventricular energy metabolism in obese men with preserved systolic and diastolic functions is associated with insulin resistance Diabetes Care 30 2007 1520 1527
23. G. Perseghin, G. Lattuada, and F. De Cobelli Left ventricular energy metabolism is impaired and the intrapericardial and mediastinal fat is increased in young, non-diabetic men with newly found fatty liver Hepatology 47 2008 51 58 (Pubitemid 351171041)
24. G. Perseghin, P. Fiorina, and F. De Cobelli Cross-sectional assessment of the effect of kidney and kidney-pancreas transplantation on resting left ventricular energy metabolism in type 1 diabetic-uremic patients: a 31P-MRS study J Am Coll Cardiol 46 2005 1085 1092 (Pubitemid 41316519)
25. H.J. Lamb, H.P. Beyerbacht, and R. Ouwerkerk Metabolic response of normal human myocardium to high dose atropine-dobutamine stress studied by 31P-NMR spectroscopy Circulation 96 1997 2969 2977 (Pubitemid 27500097)
26. H.J. Lamb, J. Doornbos, and J.A. den Hollander Reproducibility of human cardiac 31P-NMR spectroscopy NMR Biomed 9 1996 217 227
27. T.M. Wallace, J.C. Levy, and D.R. Matthews Use and abuse of HOMA modeling Diabetes Care 27 2004 1487 1495 (Pubitemid 38680001)
28. P. Palatini, L. Thijs, and J.A. Staessen Predictive value of clinic and ambulatory heart rate for mortality in elderly subjects with systolic hypertension Arch Intern Med 162 2002 2313 2321 (Pubitemid 35332514)
29. P. Lechat, J.S. Hulot, and S. Escolano Heart rate and cardiac rhythm relationships with bisoprolol benefit in chronic heart failure in CIBIS II Trial Circulation 103 2001 1428 1433 (Pubitemid 32220636)
30. A.R. Dyer, V. Persky, and J. Stamler Heart rate as a prognostic factor for coronary heart disease and mortality findings in three Chicago epidemiological studies Am J Epidemiol 112 1980 736 749 (Pubitemid 11130662)
31. R.F. Gillum, D.M. Makuc, and J.J. Feldman Pulse rate, coronary heart disease, and death: the NHANES I Epidemiologic Follow-Up Study Am Heart J 121 1991 171 177
32. G. Perseghin, F. De Cobelli, and A. Esposito Effect of the sporting discipline on the right and left ventricular morphology and function of elite male track runners; a magnetic resonance imaging and 31P-spectroscopy study Am Heart J 154 2007 937 942 (Pubitemid 47632492)
33. G. Perseghin, F. De Cobelli, and A. Esposito Left ventricular function and energy metabolism in middle-aged men undergoing long lasting sustained aerobic oxidative training Heart 95 2009 630 635
34. G. Nallur Shivu, T.T. Phan, and K. Abozguia Relationship between coronary microvascular dysfunction and cardiac energetics impairment in type 1 diabetes mellitus Circulation 121 2010 1209 1215
35. M. Scheuermann-Freestone, P.L. Madsen, and D. Manners Abnormal cardiac and skeletal muscle energy metabolism in patients with type 2 diabetes Circulation 107 2003 3040 3046 (Pubitemid 36758977)
36. R.G. Weiss, P.A. Bottomley, and C.J. Hardy Regional myocardial metabolism of high-energy phosphates during isometric exercise in patients with coronary artery disease N Engl J Med 323 1990 1593 1600
37. M.A. Conway, J.D. Bristow, and M.J. Blackledge Cardiac metabolism during exercise in healthy volunteers measured by 31P magnetic resonance spectroscopy Br Heart J 65 1991 25 30