Thalassaemia: The long road from the bedside through the laboratory to the community

Transfusion Medicine

Volumn 21, Issue 4, 2011, Pages 218-223

  Weatherall, D J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GLOBIN; DNA; HEMOGLOBIN; HEMOGLOBIN F;

ALPHA THALASSEMIA; ARTICLE; BLOOD TRANSFUSION; COMMUNITY CARE; DNA DETERMINATION; GENE MUTATION; GENETIC REGULATION; GENETIC VARIABILITY; HEALTH PROGRAM; HEALTH SERVICE; HEMOGLOBIN SYNTHESIS; HUMAN; LABORATORY TEST; MENTAL DEFICIENCY; MORTALITY; PRENATAL DIAGNOSIS; SICKLE CELL ANEMIA; THALASSEMIA; X CHROMOSOME;

BIOMEDICAL RESEARCH; HISTORY, 20TH CENTURY; HISTORY, 21ST CENTURY; HUMANS; THALASSEMIA;

EID: 79960149454     PISSN: 09587578     EISSN: 13653148     Source Type: Journal    
DOI: 10.1111/j.1365-3148.2011.01090.x     Document Type: Article

References (12)

1. Allen, S.J., O'Donnell, A., Alexander, N.D.E., Alpers, M.P., Peto, T.E.A., Clegg, J.B. & Weatherall, D.J. (1997) α-thalassemia protects children against disease due to malaria and other infections. Proceedings of the National Academy of Sciences, USA, 94, 14736-14741.
2. Alter, B.P. (1990) Antenatal diagnosis. Summary of results. Annals of the New York Academy of Sciences, 612, 237.
3. Haldane, J.B.S. (1949) The rate of mutation of human genes. Proceedings of the VIII International Congress Genetics, Hereditas, 35, 267-273.
4. Modell, B. & Darlison, M. (2008) Global epidemiology of haemoglobin disorders and derived service indicators. Bulletin of the World Health Organisation, 86, 480-487.
5. O'Donnell, A., Premawardhena, A., Arambepola, M. et al. (2009) Interaction of malaria with a common form of severe thalassemia in an Asian population. Proceedings of the National Academy Science USA, 106, 18716-18721.
6. Weatherall, D.J. (2001) Phenotype-genotype relationships in monogenic disease: lessons from the thalassaemias. Nature Reviews Genetics, 2, 245-255.
7. Weatherall, D.J. (2010) The inherited diseases of hemoglobin are an emerging global health burden. Blood, 115, 4331-4336.
8. Weatherall, D.J. & Clegg, J.B. (1975) The α chain termination mutants and their relationship to thalassaemia. Philosophical Transactions for the Royal Society, London (B), 271, 411-455.
9. Weatherall, D.J. & Clegg, J.B. (2001) The Thalassaemia Syndromes (4th edn). Blackwell Science, Oxford.
10. Weatherall, D.J., Clegg, J.B. & Naughton, M.A. (1965) Globin synthesis in thalassemia: an in vitro study. Nature, 208, 1061-1065.
11. Weatherall, D.J., Higgs, D.R., Bunch, C. et al. (1981) Hemoglobin H disease and mental retardation. A new syndrome or a remarkable coincidence? New England Journal of Medicine, 305, 607-612.
12. WHO. (2002) Genomics and World Health. WHO, Geneva.