Pathology consultation on drug-induced hemolytic anemia

American Journal of Clinical Pathology

Volumn 136, Issue 1, 2011, Pages 7-12

  Pierce, Arand ^a   Nester, Theresa ^a,b  

^a PUGET SOUND BLOOD CENTER   (United States)

^b UNIVERSITY OF WASHINGTON MEDICAL CENTER   (United States)

Author keywords

Cephalosporins; Drug induced immune hemolytic anemia; Hemolytic anemia; Pathology consultation

Indexed keywords

ANTIBIOTIC AGENT; BETA LACTAMASE INHIBITOR; CEFALOTIN; CEFOTETAN; CEFTRIAXONE; FLUDARABINE; METHYLDOPA; NONSTEROID ANTIINFLAMMATORY AGENT; PENICILLIN G; PIPERACILLIN; PLATINUM DERIVATIVE; PROBENECID; QUINIDINE; QUININE; STEROID;

ARTICLE; AUTOIMMUNE HEMOLYTIC ANEMIA; CHRONIC LYMPHATIC LEUKEMIA; COOMBS TEST; DRUG INDUCED IMMUNE HEMOLYTIC ANEMIA; DRUG MEGADOSE; ERYTHROCYTE TRANSFUSION; HEMOLYSIS; HUMAN; IN VITRO STUDY; PRIORITY JOURNAL; SINGLE DRUG DOSE;

ANEMIA, HEMOLYTIC, AUTOIMMUNE; ANTI-BACTERIAL AGENTS; AUTOANTIBODIES; CEPHALOSPORINS; HUMANS;

EID: 79960143603     PISSN: 00029173     EISSN: 19437722     Source Type: Journal    
DOI: 10.1309/AJCPBVLJZH6W6RQM     Document Type: Article

References (33)

1. Petz LD, Garratty G. Immune Hemolytic Anemias. 2nd ed. Philadelphia, PA: Churchill Livingstone; 2004.
2. Snapper I, Marks D, Schwartz L, et al. Hemolytic anemia secondary to mesantoin. Ann Intern Med. 1953;39:619-623.
3. Garratty G. Drug-induced immune hemolytic anemia. Hematology Am Soc Hematol Educ Program. 2009:73-79.
4. Garratty G. Problems associated with passively transfused blood group alloantibodies. Am J Clin Pathol. 1998;109:769-777. (Pubitemid 28247280)
5. Larsson LG, Welsh VJ, Ladd DJ. Acute intravascular hemolysis secondary to out-of-group platelet transfusion. Transfusion. 2000;40:902-906.
6. Robertson VM, Dickson LG, Romond EH, et al. Positive antiglobulin tests due to intravenous immunoglobulin in patients who received bone marrow transplant. Transfusion. 1987;27:28-31. (Pubitemid 17036551)
7. Ukita M, Takahashi A, Nunotani T, et al. IgG subclasses of anti-A and anti-B antibodies bound to the cord red cells in ABO incompatible pregnancies. Vox Sang. 1989;56:181-186. (Pubitemid 19095014)
8. Huh YO, Liu FJ, Rogge K, et al. Positive direct antiglobulin test and high serum immunoglobulin G values. Am J Clin Pathol. 1988;90:197-200.
9. Heddle NM, Kelton JG, Turchyn KL, et al. Hypergammaglobulinemia can be associated with a positive direct antiglobulin test, a nonreactive eluate, and no evidence of hemolysis. Transfusion. 1988;28:29-33.
10. Johnson ST. Warm autoantibody or drug-dependent antibody? That is the question! Immunohematology. 2007;23:161-164.
11. Johnson ST. Drug-induced immune hemolytic anemia. Transfus Apher Sci. 2009;40:205-207.
12. Garratty G, Arndt PA. An update on drug-induced immune hemolytic anemia. Immunohematology. 2007;23:105-119. (Pubitemid 350287626)
13. Johnson ST, Fueger JT, Gottschall JL. One center's experience: the serology and drugs associated with drug-induced hemolytic anemia: a new paradigm. Transfusion. 2007;47:697-702. (Pubitemid 46449631)
14. Arndt PA, Leger RM, Garratty G. Serology of antibodies to second- and third-generation cephalosporins associated with immune hemolytic anemia and/or positive direct antiglobulin tests. Transfusion. 1999;39:1239-1246.
15. Garratty G. Immune hemolytic anemia associated with drug therapy. Blood Rev. 2010;24:143-150.
16. Johnson ST, Weitekamp LA, Sauer DE, et al. Piperacillin-dependent antibody with relative e specificity reacting with drug treated red cells and untreated red cells in the presence of drug [abstract]. Transfusion. 1994;34(suppl):70S.
17. Johnson ST, Fueger JT, Sauer DE, et al. Drug-induced hemolytic anemia associated with Zosyn, serologically presenting as warm autoimmune hemolytic anemia and detected best in the presence of drug [abstract]. Transfusion. 2006;46(suppl):127A.
18. Bandara M, Seder DB, Garratty G, et al. Piperacillin-induced immune hemolytic anemia in an adult with cystic fibrosis. Case Report Med. 2010;2010:161454. doi:10.1155/2010/161454.
19. Arndt PA, Leger RM, Garratty G. Serological characteristics of anti-piperacillin in seventeen patients with drug-induced immune hemolytic anemia [abstract]. Transfusion. 2010;50(suppl):37S.
20. Mayer B, Yürek S, Salama A. Piperacillin-induced immune hemolysis: new cases and a concise review of the literature. Transfusion. 2010;50:1135-1138.
21. Leger RM. Positive DAT in immune mediated hemolysis. In: Roback JD, Combs MR, Grossman BJ, et al, eds. AABB Technical Manual. Bethesda, MD: AABB Press; 2008:499-524.
22. Garratty G. Target antigens for red-cell-bound autoantibodies. In: Nance SJ, ed. Clinical and Basic Science Aspects of Immunohematology. Arlington, VA: AABB Press; 1991:33-72.
23. Viraraghavan R, Chakravarti AG, Soreth J. Cefotetan-induced haemolytic anaemia: a review of 85 cases. Adverse Drug React Toxicol Rev. 2002;21:101-107. (Pubitemid 34711965)
24. Leger RM, Arndt PA, Garratty G. Serological studies of piperacillin antibodies. Transfusion. 2008;48:2429-2434.
25. Arndt P, Garratty G. Is severe immune hemolytic anemia, following a single dose of cefotetan, associated with the presence of "naturally- occurring" anti-cefotetan [abstract]? Transfusion. 2001;41(suppl):24S.
26. Seltsam A, Salama A. Ceftriaxone-induced hemolysis: two case reports and a concise review of the literature. Intensive Care Med. 2000;26:1390-1394.
27. Murphy WG, Kelton JG. Methyldopa-induced autoantibodies against red blood cells. Blood Rev. 1988;2:36-42.
28. Hoffman PC. Immune hemolytic anemia: selected topics. Hematology Am Soc Hematol Educ Program. 2009:80-86.
29. Borthakur G, O'Brien S, Wierda WG, et al. Immune anaemias in patients with chronic lymphocytic leukaemia treated with fludarabine, cyclophosphamide and rituximab: incidence and predictors. Br J Haematol. 2007;136:800-805. (Pubitemid 46348418)
30. Garratty G, Arndt PA. Positive direct antiglobulin tests and haemolytic anaemia following therapy with betalactamase inhibitor containing drugs may be associated with nonimmunologic adsorption of protein onto red blood cells. Br J Haematol. 1998;100:777-783. (Pubitemid 28126115)
31. Broadberry RE, Farren TW, Bevin SV, et al. Tazobactam-induced haemolytic anaemia, possibly caused by non-immunological adsorption of IgG onto patient's red cells. Transfus Med. 2004;14:53-57. (Pubitemid 38477760)
32. Arndt P, Garratty G, Isaak E, et al. Positive direct and indirect antiglobulin tests associated with oxaliplatin can be due to drug antibody and/or drug-induced nonimmunologic protein adsorption. Transfusion. 2009;49:711-718.
33. Judd WJ, Johnson ST, Storry JR. Judd's Methods in Immunohematology. 3rd ed. Bethesda, MD: AABB Press; 2008.