메뉴 건너뛰기




Volumn 7, Issue 7, 2011, Pages 827-839

Ridaforolimus: A promising drug in the treatment of soft-tissue sarcoma and other malignancies

Author keywords

mTOR; ridaforolimus; sarcoma

Indexed keywords

2 (2 CHLORO 4 IODOANILINO) N CYCLOPROPYLMETHOXY 3,4 DIFLUOROBENZAMIDE; BEVACIZUMAB; BICALUTAMIDE; CAPECITABINE; CARBOPLATIN; CETUXIMAB; CISPLATIN; DALOTUZUMAB; DOCETAXEL; DOXORUBICIN; GEMCITABINE; IFOSFAMIDE; IMATINIB; N (2,3 DIHYDROXYPROPOXY) 3,4 DIFLUORO 2 (2 FLUORO 4 IODOANILINO)BENZAMIDE; NAVELBINE; PACLITAXEL; RIDAFOROLIMUS; TOPOTECAN; TRABECTEDIN; TRASTUZUMAB; VORINOSTAT;

EID: 79960142274     PISSN: 14796694     EISSN: 17448301     Source Type: Journal    
DOI: 10.2217/fon.11.57     Document Type: Article
Times cited : (31)

References (46)
  • 1
    • 78649347321 scopus 로고    scopus 로고
    • Targeted therapies in soft tissue sarcomas
    • Judson I. Targeted therapies in soft tissue sarcomas. Ann. Oncol. 21(Suppl. 7), VII277-VII280 (2010)
    • (2010) Ann. Oncol , vol.21 , Issue.SUPPL. 7
    • Judson, I.1
  • 2
    • 77951961590 scopus 로고    scopus 로고
    • Imatinib treatment for gastrointestinal stromal tumour (GIST
    • Lopes LF, Bacchi CE. Imatinib treatment for gastrointestinal stromal tumour (GIST). J. Cell. Mol. Med. 14(1-2), 42-50 (2010)
    • (2010) J. Cell. Mol. Med , vol.14 , Issue.1-2 , pp. 42-50
    • Lopes, L.F.1    Bacchi, C.E.2
  • 3
    • 0032985028 scopus 로고    scopus 로고
    • Modified staging system for extremity soft tissue sarcomas
    • DOI 10.1007/s10434-999-0057-9
    • Ramanathan RC, A?Hern R, Fisher C, Thomas JM. Modified staging system for extremity soft tissue sarcomas. Ann. Surg. Oncol. 6(1), 57-69 (1999) (Pubitemid 29077489)
    • (1999) Annals of Surgical Oncology , vol.6 , Issue.1 , pp. 57-69
    • Ramanathan, R.C.1    A'Hern, R.2    Fisher, C.3    Thomas, J.M.4
  • 4
    • 77950516104 scopus 로고    scopus 로고
    • MTOR signaling and drug development in cancer
    • Dancey J. mTOR signaling and drug development in cancer. Nat. Rev. Clin. Oncol. 7(4), 209-219 (2010)
    • (2010) Nat. Rev. Clin. Oncol , vol.7 , Issue.4 , pp. 209-219
    • Dancey, J.1
  • 5
    • 33751169462 scopus 로고    scopus 로고
    • A Phase II trial of AP23573, a novel mTOR inhibitor, in patients (pts) with advanced soft tissue or bone sarcoma
    • Abstract 9068
    • Chawla SP, Blay J-Y, Staddon AP et al. A Phase II trial of AP23573, a novel mTOR inhibitor, in patients (pts) with advanced soft tissue or bone sarcoma. Clin. Cancer Res. 11(24), Abstract 9068 (2005)
    • (2005) Clin. Cancer Res , vol.11 , Issue.24
    • Chawla, S.P.1    Blay, J.-Y.2    Staddon, A.P.3
  • 6
    • 84921702657 scopus 로고    scopus 로고
    • Doxorubicin-based chemotherapy for the palliative treatment of adult patients with locally advanced or metastatic soft tissue sarcoma
    • Bramwell VH, Anderson D, Charette ML. Doxorubicin-based chemotherapy for the palliative treatment of adult patients with locally advanced or metastatic soft tissue sarcoma. Cochrane Database Syst. Rev. (3), CD003293 (2003)
    • (2003) Cochrane Database Syst. Rev. , Issue.3
    • Bramwell, V.H.1    Anderson, D.2    Charette, M.L.3
  • 7
    • 34548144593 scopus 로고    scopus 로고
    • Adjuvant chemotherapy for localised resectable soft tissue sarcoma in adults
    • Sarcoma Meta-analysis Collaboration (SMAC
    • Adjuvant chemotherapy for localised resectable soft tissue sarcoma in adults. Sarcoma Meta-analysis Collaboration (SMAC). Cochrane Database Syst. Rev. (2), CD001419 (2000)
    • (2000) Cochrane Database Syst. Rev. , Issue.2
  • 8
    • 71049122368 scopus 로고    scopus 로고
    • Prognostic and predictive factors for outcome to first-line ifosfamide-containing chemotherapy for adult patients with advanced soft tissue sarcomas: An exploratory, retrospective analysis on large series from the European Organization for Research and Treatment of Cancer-Soft Tissue and Bone Sarcoma Group (EORTC-STBSG
    • Sleijfer S, Ouali M, van Glabbeke M et al. Prognostic and predictive factors for outcome to first-line ifosfamide-containing chemotherapy for adult patients with advanced soft tissue sarcomas: an exploratory, retrospective analysis on large series from the European Organization for Research and Treatment of Cancer-Soft Tissue and Bone Sarcoma Group (EORTC-STBSG). Eur. J. Cancer 46(1), 72-83 (2010)
    • (2010) Eur. J. Cancer , vol.46 , Issue.1 , pp. 72-83
    • Sleijfer, S.1    Ouali, M.2    Van Glabbeke, M.3
  • 9
    • 78650400907 scopus 로고    scopus 로고
    • Trabectedin in the treatment of metastatic soft tissue sarcoma: Cost-effectiveness, cost-utility and value of information
    • Soini EJ, Garcia San Andres B, Joensuu T. Trabectedin in the treatment of metastatic soft tissue sarcoma: cost-effectiveness, cost-utility and value of information. Ann. Oncol. 22(1), 215-223 (2010)
    • (2010) Ann. Oncol , vol.22 , Issue.1 , pp. 215-223
    • Soini, E.J.1    Garcia San Andres, B.2    Joensuu, T.3
  • 10
    • 33845899938 scopus 로고    scopus 로고
    • A retrospective analysis of vinorelbine chemotherapy for patients with previously treated soft-tissue sarcomas
    • Anderson SE, Keohan ML, D?Adamo DR, Maki RG. A retrospective analysis of vinorelbine chemotherapy for patients with previously treated soft-tissue sarcomas. Sarcoma 2006, 15947 (2006)
    • (2006) Sarcoma , vol.2006 , pp. 15947
    • Anderson, S.E.1    Keohan, M.L.2    Dadamo, D.R.3    Maki, R.G.4
  • 12
    • 77953915132 scopus 로고    scopus 로고
    • Update on gemcitabine and docetaxel combination therapy for primary and metastatic sarcomas
    • Hensley ML. Update on gemcitabine and docetaxel combination therapy for primary and metastatic sarcomas. Curr. Opin. Oncol. 22(4), 356-361 (2010)
    • (2010) Curr. Opin. Oncol , vol.22 , Issue.4 , pp. 356-361
    • Hensley, M.L.1
  • 15
    • 78650444420 scopus 로고    scopus 로고
    • Fatal hepatic and renal toxicity as a complication of trabectedin therapy for radiation-induced sarcoma
    • Pick AM, Nystrom KK. Fatal hepatic and renal toxicity as a complication of trabectedin therapy for radiation-induced sarcoma. J. Oncol. Pharm. Pract. 16(4), 269-272 (2010)
    • (2010) J. Oncol. Pharm. Pract , vol.16 , Issue.4 , pp. 269-272
    • Pick, A.M.1    Nystrom, K.K.2
  • 16
    • 68149096799 scopus 로고    scopus 로고
    • The pharmacology of mTOR inhibition
    • Guertin DA, Sabatini DM. The pharmacology of mTOR inhibition. Sci. Signal 2(67), PE24 (2009)
    • (2009) Sci. Signal , vol.2 , Issue.67
    • Guertin, D.A.1    Sabatini, D.M.2
  • 17
    • 79960129086 scopus 로고    scopus 로고
    • Structure-based design of AP23573, a phosphorus-containing analog of rapamycin for anti-tumor therapy
    • Abstract 2476
    • Metcalf CA 3rd, Bohacek R, Rozamus LW et al. Structure-based design of AP23573, a phosphorus-containing analog of rapamycin for anti-tumor therapy. AACR Meeting Abstracts 45, Abstract 2476 (2004)
    • (2004) AACR Meeting Abstracts , vol.45
    • Bohacek, R.1    Rozamus, L.W.2
  • 19
    • 63149129641 scopus 로고    scopus 로고
    • A Phase i trial to determine the safety, tolerability, and maximum tolerated dose of deforolimus in patients with advanced malignancies
    • Hartford CM, Desai AA, Janisch L et al. A Phase I trial to determine the safety, tolerability, and maximum tolerated dose of deforolimus in patients with advanced malignancies. Clin. Cancer Res. 15(4), 1428-1434 (2009
    • (2009) Clin. Cancer Res , vol.15 , Issue.4 , pp. 1428-1434
    • Hartford, C.M.1    Desai, A.A.2    Janisch, L.3
  • 20
    • 72849129290 scopus 로고    scopus 로고
    • Pharmacokinetics of oral deforolimus (AP23573, MK-8669
    • Abstract 14555
    • Fetterly GJ, Mita MM, Britten CD et al. Pharmacokinetics of oral deforolimus (AP23573, MK-8669). ASCO Meeting Abstracts 26(Suppl. 15), Abstract 14555 (2008
    • (2008) ASCO Meeting Abstracts , vol.26 , Issue.SUPPL. 15
    • Fetterly, G.J.1    Mita, M.M.2    Britten, C.D.3
  • 21
    • 3142514248 scopus 로고    scopus 로고
    • Broad anti-tumor activity of AP23573, an mTOR inhibitor in clinical development
    • Abstract 882
    • Clackson T, Metcalf CA, Rivera VM et al. Broad anti-tumor activity of AP23573, an mTOR inhibitor in clinical development. Proc. Am. Soc. Clin. Oncol. 22, Abstract 882 (2003)
    • (2003) Proc. Am. Soc. Clin. Oncol , vol.22
    • Clackson, T.1    Metcalf, C.A.2    Rivera, V.M.3
  • 22
    • 79960126202 scopus 로고    scopus 로고
    • Anti-tumor activity of the mTOR inhibitor deforolimus (AP23573; MK-8669) in sarcoma and endometrial cancer models and exploration of molecular correlates of sensitivity
    • Abstract 1482
    • Squillace R, Miller D, Clapham D et al. Anti-tumor activity of the mTOR inhibitor deforolimus (AP23573; MK-8669) in sarcoma and endometrial cancer models and exploration of molecular correlates of sensitivity. AACR Meeting Abstracts 2008(Annual Meeting), Abstract 1482 (2008)
    • (2008) AACR Meeting Abstracts 2008 (Annual Meeting)
    • Squillace, R.1    Miller, D.2    Clapham, D.3
  • 25
    • 12844258508 scopus 로고    scopus 로고
    • Anti-proliferative activity of the mTOR inhibitor AP23573 in combination with cytotoxic and targeted agents
    • Abstract 3887
    • Rivera VM, Tang H, Metcalf CA 3rd et al. Anti-proliferative activity of the mTOR inhibitor AP23573 in combination with cytotoxic and targeted agents. Proc. Am. Assoc. Cancer Res. 45, Abstract 3887 (2004)
    • (2004) Proc. Am. Assoc. Cancer Res , vol.45
    • Rivera, V.M.1    Tang, H.2
  • 26
    • 36349006801 scopus 로고    scopus 로고
    • Chemosensitization by dual pharmacological inhibition of MEK and mTOR signaling pathways in human non-small cell lung cancer (NSCLC
    • Abstract 4867
    • Legrier M-E, D?Silva S, Yan H-G, Horwitz SB, McDaid HM. Chemosensitization by dual pharmacological inhibition of MEK and mTOR signaling pathways in human non-small cell lung cancer (NSCLC). AACR Meeting Abstracts 47, Abstract 4867 (2006)
    • (2006) AACR Meeting Abstracts , vol.47
    • Legrier, M.-E.1    Dsilva, S.2    Yan, H.-G.3    Horwitz, S.B.4    McDaid, H.M.5
  • 27
    • 66249119078 scopus 로고    scopus 로고
    • Combined MEK and mTOR suppression is synergistic in human NSCLC and is mediated via inhibition of protein translation
    • Abstract 10615
    • McDaid HM, Legrier M, Yang CH et al. Combined MEK and mTOR suppression is synergistic in human NSCLC and is mediated via inhibition of protein translation. J. Clin. Oncol. 25(Suppl. 18), Abstract 10615 (2007)
    • (2007) J. Clin. Oncol , vol.25 , Issue.SUPPL. 18
    • McDaid, H.M.1    Legrier, M.2    Ch, Y.3
  • 28
    • 79960110254 scopus 로고    scopus 로고
    • Combination treatment with the anti-IGF1R antibody MK-0646 and the mTOR inhibitor deforolimus leads to more effective PI3K pathway targeting and anti-tumor activity
    • Abstract 2809
    • Sathyanarayanan S, Jha S, Klinghoffer R et al. Combination treatment with the anti-IGF1R antibody MK-0646 and the mTOR inhibitor deforolimus leads to more effective PI3K pathway targeting and anti-tumor activity. AACR Meeting Abstracts 2009(2 Annual Meeting), Abstract 2809 (2009)
    • (2009) AACR Meeting Abstracts 2009(2 Annual Meeting)
    • Sathyanarayanan, S.1    Jha, S.2    Klinghoffer, R.3
  • 29
    • 51449089221 scopus 로고    scopus 로고
    • Deforolimus trial 106-A Phase i trial evaluating 7 regimens of oral deforolimus (AP23573, MK-8669
    • Abstract 3509
    • Mita MM, Britten CD, Poplin E et al. Deforolimus trial 106-A Phase I trial evaluating 7 regimens of oral deforolimus (AP23573, MK-8669). ASCO Meeting Abstracts 26(Suppl. 15), Abstract 3509 (2008)
    • (2008) ASCO Meeting Abstracts , vol.26 , Issue.SUPPL. 15
    • Mita, M.M.1    Britten, C.D.2    Poplin, E.3
  • 30
    • 73849119080 scopus 로고    scopus 로고
    • Phase Ib study of weekly mammalian target of rapamycin inhibitor ridaforolimus (AP23573; MK-8669) with weekly paclitaxel
    • Sessa C, Tosi D, Vigano L et al. Phase Ib study of weekly mammalian target of rapamycin inhibitor ridaforolimus (AP23573; MK-8669) with weekly paclitaxel. Ann. Oncol. 21(6), 1315-1322 (2010)
    • (2010) Ann. Oncol , vol.21 , Issue.6 , pp. 1315-1322
    • Sessa, C.1    Tosi, D.2    Vigano, L.3
  • 31
    • 78049513393 scopus 로고    scopus 로고
    • Phase Ib study of the mTOR inhibitor ridaforolimus with capecitabine
    • Perotti A, Locatelli A, Sessa C et al. Phase Ib study of the mTOR inhibitor ridaforolimus with capecitabine. J. Clin. Oncol. 28(30), 4554-4561 (2010
    • (2010) J. Clin. Oncol , vol.28 , Issue.30 , pp. 4554-4561
    • Perotti, A.1    Locatelli, A.2    Sessa, C.3
  • 32
    • 79960149312 scopus 로고    scopus 로고
    • Phase i trial of oral deforolimus in combination with bevacizumab in patients with advanced solid tumours
    • Abstract 1256
    • Nemunaitis J, Hochster HS, Lustgarten S, Turner CD, Haluska F, Mita MM. Phase I trial of oral deforolimus in combination with bevacizumab in patients with advanced solid tumours. Eur. J. Cancer Suppl. 7(2), Abstract 1256 (2009)
    • (2009) Eur. J. Cancer Suppl , vol.7 , Issue.2
    • Nemunaitis, J.1    Hochster, H.S.2    Lustgarten, S.3    Turner, C.D.4    Haluska, F.5    Mita, M.M.6
  • 33
    • 84655175180 scopus 로고    scopus 로고
    • Ridaforolimus (AP23573; MK-8669) in combination with trastuzumab for patients with HER2-positive trastuzumab-refractory metastatic breast cancer: A multicenter Phase 2 clinical trial
    • San Antonio, TX, USA. 10-13 December
    • Yardley D, Seiler M, Ray-Coquard I et al. Ridaforolimus (AP23573; MK-8669) in combination with trastuzumab for patients with HER2-positive trastuzumab-refractory metastatic breast cancer: a multicenter Phase 2 clinical trial. Presented at: The 32nd Annual CTRC-AACR San Antonio Breast Cancer Symposium. San Antonio, TX, USA, 10-13 December 2009
    • (2009) The 32nd Annual CTRC-AACR San Antonio Breast Cancer Symposium
    • Yardley, D.1    Seiler, M.2    Ray-Coquard, I.3
  • 34
    • 33645650328 scopus 로고    scopus 로고
    • A Phase II study of AP23573 (an mTOR inhibitor) in patients (pts) with advanced sarcomas
    • Abstract 9068
    • Chawla SP, Sankhala KK, Chua V et al. A Phase II study of AP23573 (an mTOR inhibitor) in patients (pts) with advanced sarcomas. ASCO Meeting Abstracts 23(Suppl. 16), Abstract 9068 (2005)
    • (2005) ASCO Meeting Abstracts , vol.23 , Issue.SUPPL. 16
    • Chawla, S.P.1    Sankhala, K.K.2    Chua, V.3
  • 35
    • 37149033966 scopus 로고    scopus 로고
    • Survival results with AP23573, a novel mTOR inhibitor, in patients (pts) with advanced soft tissue or bone sarcomas: Update of Phase II trial
    • Abstract 10076
    • Chawla SP, Tolcher AW, Staddon AP et al. Survival results with AP23573, a novel mTOR inhibitor, in patients (pts) with advanced soft tissue or bone sarcomas: update of Phase II trial. ASCO Meeting Abstracts 25(Suppl. 18), Abstract 10076 (2007)
    • (2007) ASCO Meeting Abstracts , vol.25 , Issue.SUPPL. 18
    • Chawla, S.P.1    Tolcher, A.W.2    Staddon, A.P.3
  • 36
    • 33750238350 scopus 로고    scopus 로고
    • Updated results of a Phase II trial of AP23573, a novel mTOR inhibitor, in patients (pts) with advanced soft tissue or bone sarcomas
    • Abstract 9505
    • Chawla SP, Tolcher AW, Staddon AP et al. Updated results of a Phase II trial of AP23573, a novel mTOR inhibitor, in patients (pts) with advanced soft tissue or bone sarcomas. ASCO Meeting Abstracts 24(Suppl. 18), Abstract 9505 (2006)
    • (2006) ASCO Meeting Abstracts , vol.24 , Issue.SUPPL. 18
    • Chawla, S.P.1    Tolcher, A.W.2    Staddon, A.P.3
  • 37
    • 79960136636 scopus 로고    scopus 로고
    • For the AP23573 Sarcoma Study Group: Early response evaluation of therapy with AP23573 (an mTOR inhibitor) in sarcoma using [18F]2-fluoro-2-deoxy-d- glucose (FDG) positron emission tomography (PET) scan
    • Abstract 9028
    • Sankhala KK, Chawla SP, Iagaru A et al.; for the AP23573 Sarcoma Study Group: Early response evaluation of therapy with AP23573 (an mTOR inhibitor) in sarcoma using [18F]2-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET) scan. ASCO Meeting Abstracts 23(Suppl. 16), Abstract 9028 (2005)
    • (2005) ASCO Meeting Abstracts , vol.23 , Issue.SUPPL. 16
    • Sankhala, K.K.1    Chawla, S.P.2    Iagaru, A.3
  • 38
    • 0032757213 scopus 로고    scopus 로고
    • 18F]- fluorodeoxyglucose and positron emission tomography: Review and 1999 EORTC recommendations
    • DOI 10.1016/S0959-8049(99)00229-4, PII S0959804999002294
    • Young H, Baum R, Cremerius U et al. Measurement of clinical and subclinical tumour response using [18F]-fluorodeoxyglucose and positron emission tomography: review and 1999 EORTC recommendations. European Organization for Research and Treatment of Cancer (EORTC) PETStudy Group. Eur. J. Cancer 35(13), 1773-1782 (1999) (Pubitemid 29512308)
    • (1999) European Journal of Cancer , vol.35 , Issue.13 , pp. 1773-1782
    • Young, H.1    Baum, R.2    Cremerius, U.3    Herholz, K.4    Hoekstra, O.5    Lammertsma, A.A.6    Pruim, J.7    Price, P.8
  • 39
    • 79960148410 scopus 로고    scopus 로고
    • Details matter to ridaforolimus story
    • Flanagan M. Details matter to ridaforolimus story. Biocentury 19(5), 6-7 (2011)
    • (2011) Biocentury , vol.19 , Issue.5 , pp. 6-7
    • Flanagan, M.1
  • 40
    • 37149010753 scopus 로고    scopus 로고
    • A Phase II trial of the mTOR inhibitor AP23573 as a single agent in advanced endometrial cancer
    • Abstract 5516
    • Colombo N, McMeekin S, Schwartz P et al. A Phase II trial of the mTOR inhibitor AP23573 as a single agent in advanced endometrial cancer. ASCO Meeting Abstracts 25(Suppl. 18), Abstract 5516 (2007)
    • (2007) ASCO Meeting Abstracts , vol.25 , Issue.SUPPL. 18
    • Colombo, N.1    McMeekin, S.2    Schwartz, P.3
  • 41
    • 51449096670 scopus 로고    scopus 로고
    • A Phase 2 clinical trial of deforolimus (AP23573, MK-8669), a novel mammalian target of rapamycin inhibitor, in patients with relapsed or refractory hematologic malignancies
    • Rizzieri DA, Feldman E, Dipersio JF et al. A Phase 2 clinical trial of deforolimus (AP23573, MK-8669), a novel mammalian target of rapamycin inhibitor, in patients with relapsed or refractory hematologic malignancies. Clin. Cancer Res. 14(9), 2756-2762 (2008
    • (2008) Clin. Cancer Res , vol.14 , Issue.9 , pp. 2756-2762
    • Rizzieri, D.A.1    Feldman, E.2    Dipersio, J.F.3
  • 42
    • 74549192779 scopus 로고    scopus 로고
    • Preliminary characterization of oral lesions associated with inhibitors of mammalian target of rapamycin in cancer patients
    • Sonis S, Treister N, Chawla S, Demetri G, Haluska F. Preliminary characterization of oral lesions associated with inhibitors of mammalian target of rapamycin in cancer patients. Cancer 116, 210-215 (2009
    • (2009) Cancer , vol.116 , pp. 210-215
    • Sonis, S.1    Treister, N.2    Chawla, S.3    Demetri, G.4    Haluska, F.5
  • 43
    • 79953176993 scopus 로고    scopus 로고
    • Ridaforolimus
    • Ridaforolimus. Drugs R D 10(3), 165-178 (2010
    • (2010) Drugs R D , vol.10 , Issue.3 , pp. 165-178
  • 44
    • 79951575730 scopus 로고    scopus 로고
    • American Cancer Society
    • American Cancer Society. Cancer Facts and Figures 2010 www.cancer.org/acs/groups/content/@ epidemiologysurveilance/documents/ document/acspc-026238.pdf
    • (2010) Cancer Facts and Figures


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.