Treatment of first tonic - Clonic seizure does not affect mortality: Long-term follow-up of a randomised clinical trial

Journal of Neurology, Neurosurgery and Psychiatry

Volumn 82, Issue 8, 2011, Pages 924-927

  Leone, Maurizio A ^a,b   Vallalta, Roberto ^b   Solari, Alessandra ^c   Beghi, Ettore ^b  

^a MAGGIORE DELLA CARITÀ HOSPITAL   (Italy)

^b MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^c DEPARTMENT OF NEUROSURGERY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT;

ADOLESCENT; ADULT; AGE; ARTICLE; CHILD; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; EEG ABNORMALITY; EPILEPSY; FAMILY HISTORY; FEMALE; FOLLOW UP; HUMAN; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MORTALITY; NEUROLOGIC EXAMINATION; NUCLEAR MAGNETIC RESONANCE IMAGING; PERINATAL PERIOD; PRENATAL PERIOD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECURRENT DISEASE; REMISSION; RISK ASSESSMENT; SEX; SURVIVAL RATE; TONIC CLONIC SEIZURE;

EID: 79960139070     PISSN: 00223050     EISSN: 1468330X     Source Type: Journal    
DOI: 10.1136/jnnp.2010.240069     Document Type: Article

References (12)

1. First Seizure Trial Group. Randomized clinical trial on the efficacy of antiepileptic drugs in reducing the risk of relapse after a first unprovoked tonic-clonic seizure. Neurology 1993;43:478-83.
2. Leone MA, Solari A, Beghi E; FIRST Group. Treatment of the first tonic-clonic seizure does not affect long-term remission of epilepsy. Neurology 2006;67:2227-9. (Pubitemid 46035483)
3. Marson A, Jacoby A, Johnson A, et al; Medical Research Council MESS Study Group. Immediate versus deferred antiepileptic drug treatment for early epilepsy and single seizures: a randomised controlled trial. Lancet 2005;365:2007-13.
4. Forsgren L, Hauser WA, Olafsson E, et al. Mortality of epilepsy in developed countries: a review. Epilepsia 2005;46(Suppl 11):18-27. (Pubitemid 44922032)
5. Sillanpää M, Shinnar S. Long-term mortality in childhood-onset epilepsy. N Engl J Med 2010;363:2522-9.
6. Musicco M, Beghi E, Solari A, et al; First Seizure Trial Group (FIRST Group). Treatment of first tonic-clonic seizure does not improve the prognosis of epilepsy. Neurology 1997;49:991-8.
7. SAS Institute. SUGI Supplemental Library User's Guide. Version 8 Edition. Cary, NC: SAS Institute, 1999-2001.
8. Loiseau J, Picot MC, Loiseau P. Short-term mortality after a first epileptic seizure: a population-based study. Epilepsia 1999;40:1388-92. (Pubitemid 29471338)
9. Hauser WA, Annegers JF, Elveback LR. Mortality in patients with epilepsy. Epilepsia 1980;21:399-412. (Pubitemid 10054081)
10. Neligan A, Bell GS, Shorvon SD, et al. Temporal trends in the mortality of people with epilepsy: a review. Epilepsia 2010;51:2241-6.
11. Lakatos E. Designing complex group sequential survival trials. Statistics in Medicine 2002;21:1969-89. (Pubitemid 34752618)
12. Fisher RS, van Emde Boas W, Blume W, et al. Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia 2005;46:470-2. (Pubitemid 40470667)