The value of echocardiography versus cardiac troponin i levels in the early detection of anthracycline cardiotoxicity in childhood acute leukemia: Prospective evaluation of a 7-year-long clinical follow-up

Pediatric Hematology and Oncology

Volumn 28, Issue 5, 2011, Pages 380-394

  Oztarhan, Kazim ^a   Guler, Serhat ^b   Aktas, Belgin ^c   Arslan, Meliha ^a   Salcioglu, Zafer ^a   Aydogan, Gonul ^a  

^a Bakirkoy Matern and Infant Hospital   (Turkey)

^b CELAL BAYAR UNIVERSITY   (Turkey)

^c ULUDAG UNIVERSITY   (Turkey)

Author keywords

ALL; anthracycline; cardiac toxicity; cardiac troponin; echocardiography

Indexed keywords

ANTHRACYCLINE; DAUNORUBICIN; DIGITALIS; DIURETIC AGENT; DOXORUBICIN; HEART ENZYME; INOTROPIC AGENT; TROPONIN I;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; CANCER CHEMOTHERAPY; CARDIOTOXICITY; CHILD; CHILDHOOD LEUKEMIA; CONGESTIVE HEART FAILURE; CONTINUOUS INFUSION; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DIASTOLIC DYSFUNCTION; DOPPLER ECHOCARDIOGRAPHY; DRUG DOSE COMPARISON; EARLY DIAGNOSIS; ECHOCARDIOGRAPHY; FEMALE; FOLLOW UP; HUMAN; LONGITUDINAL STUDY; M MODE ECHOCARDIOGRAPHY; MAJOR CLINICAL STUDY; MALE; PREDICTIVE VALUE; PRESCHOOL CHILD; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; RECEIVER OPERATING CHARACTERISTIC; SCHOOL CHILD; SENSITIVITY AND SPECIFICITY; SYSTOLE; TWO DIMENSIONAL ECHOCARDIOGRAPHY;

ANTHRACYCLINES; ANTIBIOTICS, ANTINEOPLASTIC; CHILD; CHILD, PRESCHOOL; DIASTOLE; EARLY DIAGNOSIS; ECHOCARDIOGRAPHY; FEMALE; FOLLOW-UP STUDIES; HEART; HEART FAILURE; HUMANS; INFANT; MALE; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROGNOSIS; PROSPECTIVE STUDIES; SYSTOLE; TROPONIN I;

EID: 79960138395     PISSN: 08880018     EISSN: 15210669     Source Type: Journal    
DOI: 10.3109/08880018.2011.563772     Document Type: Article

References (38)

1. Blatt J, Copeland DR, Bleyer WA. Late effects of childhood cancer and its treatment. In: Pizzo PA, Poplack DG, eds. Principles and Practice of Pediatric Oncology. Philadelphia: Lippincot-Raven; 1997:1303-1329.
2. Marina N. Long-term survivors of childhood cancer. The medical consequences of cure. Pediatric Clin North Am. 1997;44:1021-1042. (Pubitemid 27368677)
3. Steinherz LJ, Steinherz PG, Tan C, et al. Cardiac toxicity 4 to 20 years after completing anthracycline therapy. JAMA. 1991;266:1672-1677.
4. Steinherz LJ, Steinherz PG, Tan C. Cardiac failure and dysrhythmias 6-19 years after anthracycline theraphy: a series of 15 patients. Md Pediatr Oncol. 1995;24:352-361.
5. Wouters KA, Kremer LCM, Miller TL, et al. Protecting against anthracycline-induced myocardial damage: a review of the most promising strategies. Br J Haematol. 2005;131:561-578. (Pubitemid 43899624)
6. van Dalen EC, Caron HN, Kremer LC. Prevention of anthracycline-induced cardiotoxicity in children: the evidence. Eur J Cancer. 2007;43:1134-1140. (Pubitemid 46590739)
7. Von Hoff DD, Rozencweig M, Layard M, et al. Daunomycin-induced cardiotoxicity in children and adults. A review of 110 cases. Am JMed. 1977;62:200-208. (Pubitemid 8042834)
8. Mertens AC, Yasui Y, Neglia JP, et al. Late mortality experience in five-year survivors of childhood and adolescent cancer: the Childhood Cancer Survivor Study. J Clin Oncol. 2001;19:3163-3172. (Pubitemid 32591432)
9. Bryant J, Picot J, Baxter L, et al. Use of cardiac markers to assess the toxic effects of anthracyclines given to children with cancer: a systematic review [review]. Eur J Cancer. 2007;43:1959-1966. (Pubitemid 47299200)
10. Meinardi MT, Van Der Graaf WT, van Veldhuisen DJ, et al. Detection of anthracycline-induced cardiotoxicity [review]. Cancer Treat Rev. 1999;25:237-247.
11. Bertinchant J.P, Polge A, Juan JM, et al. Evaluation of cardiac Troponin I and T levels as markers of myocardial damage in doxorubicine-induced cardiomyopathy rats, and their relationship with echocardiographic and histological findigs. Clin Chim Acta. 2003;329:39-51. (Pubitemid 36183480)
12. Kismet E, Varan A, Ayabakan C, et al. Serum troponin T levels and echocardiographic evaluation in children with doxorubicine. Pediatr Blood Cancer. 2004;42:220-224. (Pubitemid 38235071)
13. Cardinale D, Sandri MT, Martinoni A, et al. Myocardial injury revealed by plasma troponin I in breast cancer treated with high-dose chemotheraphy. Ann Oncol. 2002;13:710-715. (Pubitemid 34567376)
14. Gerhard W, Katus H, Ravkilde J, et al. S-Troponin T in suspected ischemic myocardial injury compared with mass and catalytic concentrations of S-creatine kinase isoenzyme MB. Clin Chem. 1991;37:1405-1411. (Pubitemid 21925981)
15. Ohman EM, Armstrong PW, Christenson RH, et al. GUSTO lla Investigators, Cardiac troponin T levels for risk stratification in acute myocardial ischemia. N Engl J Med. 1996;335:1333-1341. (Pubitemid 26360451)
16. Lipschultz SE, Rifai N, Sallan SE, et al. Predictive value of cardiac troponin T in pediatric patients at risk formyocardial injury. Circulation. 1997;96:2641-2648. (Pubitemid 27451357)
17. Shan K, Linchoff MA, Young JB. Anthracycline-induced cardiotoxicity. Ann Intern Med. 1996;125:47-58.
18. Hridina R, Gersl V, Klimtova I. Anthracycline-induced cardiotoxicity. Acta Med (Hradec Kravole). 2000;43:75-82.
19. Childrens Oncology Group. Long-Term Follow-Up Guidelines. Version 3.0. Available at:http://www.childrensoncologygroup.org/disc/le/pdf/LTFUGuidelines. pdf. Accessed October 2008.
20. Silverman NH. Quantative methods to enhance morphological information using M-Mode, Doppler and cross-sectional ultrasound. In: Silverman NH, ed. Pediatric Echocardiography. Baltimore, London: Williams-Wilkins; 1993:35-36.
21. Teicholz LE, Kreulen T, Hermen MV, Gorlin R. Problems in echocardiographic volume determinations: echocardiographic-angiographic correlations in the presence and absence of asynergy. Am J Cardiol. 1976;37:7-12.
22. Quinonos MA. Doppler assessment of left ventricular diastolic function. In: Nanda NC, ed. Doppler Echocardiography. 2 ed. Philadelphia, London: Lea-Febiger; 1993:197-215.
23. Granadier E, Lima CD, Allen HD, et al. Normal intracardiac and great vessel Doppler flow velocities in infants and children. J AmColl Cardiol. 1984;4:343-350. (Pubitemid 14053563)
24. Parish MD, Boucek RJ, Burger J, et al. Exercise radionuclide ventriculography in children: normal values for exercise variables and right and left ventricular function. Br Heart J. 1985;54:509-516. (Pubitemid 16206883)
25. Tezer Kutluk. Epidemiology of childhood cancers. Klin Gelisim. 2007;2:5-12.
26. Lightfoot JT, Roman E. Causes of childhood leukemia and lymphoma. Toxicol Appl Pharmacol. 2004;199:104-117.
27. Biner B. Echocardiography and Cardiac Troponin T in the Diagnosis of Early and Late Anthracycline Toxicity in Acute Leukemia of Childhood [unpublishedmasters thesis]. Istanbul:Department of Pediatrics, Istanbul Faculty ofMedicine, Istanbul University; 2000.
28. Kremer LC, Bastiaansen BA,Offringa M, et al. Troponin T in the first 24 hours after the administration of chemotherapy and the detection ofmyocardial damage in children. Eur J Cancer. 2002;38:686-689. (Pubitemid 34251392)
29. Eichhorn EJ, Bristow MR. Medical therapy can improve the biological properties of the chronically failing heart. A new era in the treatment of heart failure. Circulation. 1996;94:2285-2296. (Pubitemid 26360526)
30. Steinherz LJ, Graham T, Hurwitz R. Guidelines for cardiac monitoring of children during and after anthracycline theraphy: report of the Cardiology Committee of the Children Cancer Study Group. Pediatrics. 1992;89:943-949.
31. Goorin AM, Borow KM, Goldman A, et al. Congestive heart failure due to adriamycin cardiotoxicity: its natural history in children. Cancer. 1981;47:2810-2816. (Pubitemid 11066873)
32. Misson E, Calzolari C, Pau B. High circulating levels of circulating troponin I in human congestive heart failure. J AmColl Cardiol. 1996;27(Suppl A):338A.
33. La Vecchia L, Mezzana G, Ometto R, et al. Detectable serum troponin I in patients with heart failure of nonmyocardial ischemic origin. Am J Cardiol. 1997;80:88-89.
34. Von Hoff DD, Rozencweig M, Basa P, et al. Risk factors for doxorubicin-induced congestive heart failure. Ann InternMed. 1979;91:710-717. (Pubitemid 10218041)
35. Lipschultz SE, Colan SD, Gelber RD, et al. Late Cardiac effects of doxorubicin theraphy for acute lymphoblastic leukemia in childhood.N Engl J Med. 1991;324:808-815.
36. De Wolf D, Suys B, Maurus R, et al. Dobutamine stress echocardiography in the evaluation of late anthracycline cardiotoxicity in childhood cancer survivors. Pediatr Res. 1996;39:504-512. (Pubitemid 26070846)
37. Bristow MA, Mason JW, Billingham ME, Daniels JR. Doxorubicine cardiomyopathy: phonocardiography, endomyocardial biopsy and cardiac catheterization.Ann InternMed. 1978;88:168-175. (Pubitemid 8282147)
38. BuLock FA, Mott MG, Oakhill A, Martin RP. Left ventricular diastolic filling paterns associated with progressive antracyhcline-inducedmyocardial damage: a prospective study. Pediatric Cardiol. 1999;20:252-263. (Pubitemid 29279628)