Innovative high-performance liquid chromatography method development for the screening of 19 antimalarial drugs based on a generic approach, using design of experiments, independent component analysis and design space

Journal of Chromatography A

Volumn 1218, Issue 31, 2011, Pages 5205-5215

  Debrus, B ^a   Lebrun, P ^a   Kindenge, J Mbinze ^a,b   Lecomte, F ^a   Ceccato, A ^c   Caliaro, G ^c   Mbay, J Mavar Tayey ^b   Boulanger, B ^d   Marini, R D ^a   Rozet, E ^a   Hubert, Ph ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b UNIVERSITY OF KINSHASA   (Congo)

^c Odyssea Pharma ^*  (Belgium)

^d Arlenda SA   (Belgium)

Author keywords

Antimalarial drugs; Counterfeit; Design of experiments; Design space; Independent component analysis; Quality by design

Indexed keywords

ANTIMALARIAL DRUG; COUNTERFEIT; DESIGN SPACE; INDEPENDENT COMPONENTS; QUALITY BY DESIGN;

COMPUTER SIMULATION; CRIME; DESIGN; DESIGN OF EXPERIMENTS; EXPERIMENTS; LIQUID CHROMATOGRAPHY; MATHEMATICAL MODELS; MONTE CARLO METHODS; OPTIMIZATION; QUALITY CONTROL; RISK MANAGEMENT;

INDEPENDENT COMPONENT ANALYSIS;

AMODIAQUINE; ANTIMALARIAL AGENT; ARTEETHER; ARTEMETHER; ARTEMISININ; ARTESUNATE; ATOVAQUONE; BENFLUMETOL; CHLOROQUINE; CINCHONINE; DIHYDROARTEMISININ; HALOFANTRINE; MEFLOQUINE; PIPERAQUINE; PRIMAQUINE; PROGUANIL; PYRIMETHAMINE; QUININE; SULFADOXINE; SULFALENE;

ARTICLE; DESIGN OF EXPERIMENT; DESIGN SPACE; DRUG SCREENING; DRUG STRUCTURE; FACTORIAL DESIGN; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INDEPENDENT COMPONENT ANALYSIS; MATHEMATICAL MODEL; METHODOLOGY; MONTE CARLO METHOD; PH; PRIORITY JOURNAL; SEPARATION TECHNIQUE; TEMPERATURE;

ANTIMALARIALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG EVALUATION, PRECLINICAL; DRUGS, GENERIC; RESEARCH DESIGN;

EID: 79960134350     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2011.05.102     Document Type: Article

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