'A low risk is still a risk': Exploring women's attitudes towards genetic testing for breast cancer susceptibility in order to target disease prevention

Public Health Genomics

Volumn 14, Issue 4-5, 2011, Pages 238-247

  Henneman, L ^a   Timmermans, D R ^a   Bouwman, C M ^a   Cornel, M C ^a   Meijers Heijboer, H ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Attitudes; Breast cancer; Cancer prevention; Genetic susceptibility testing; Low penetrance alleles

Indexed keywords

ADULT; AGED; ARTICLE; ATTITUDE TO HEALTH; BREAST CANCER; CANCER PREVENTION; CANCER SUSCEPTIBILITY; FAMILY HISTORY; FEMALE; FINANCIAL MANAGEMENT; GENETIC RISK; GENETIC SCREENING; GENETIC SUSCEPTIBILITY; HEALTH CARE ACCESS; HEALTH PROGRAM; HUMAN; HUMAN EXPERIMENT; MAMMOGRAPHY; MEDICAL INFORMATION; PATIENT AUTONOMY; PRIORITY JOURNAL; RISK ASSESSMENT; SOCIAL DISCRIMINATION;

ADULT; AGED; ATTITUDE TO HEALTH; BREAST NEOPLASMS; FEMALE; FOCUS GROUPS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MIDDLE AGED; RISK ASSESSMENT; WOMEN;

EID: 79960133976     PISSN: 16624246     EISSN: 16628063     Source Type: Journal    
DOI: 10.1159/000276543     Document Type: Article

References (33)

1. Shapiro S, Coleman EA, Broeders M, Codd M, De Koning H, Fracheboud J, Moss S, Paci E, Stachenko S, Ballard-Barbash R: Breast cancer screening programmes in 22 countries: current policies, administration and guidelines. Int J Epidemiol 1998; 27: 735-742. (Pubitemid 28504958)
2. Pharoah PDP, Antoniou A, Bobrow M, Zimmern RL, Easton DF, Ponder BAJ: Polygenic susceptibility to breast cancer and implications for prevention. Nat Genet 2002; 31: 33-36.
3. Pharoah PDP, Antoniou AC, Easton DF, Ponder BAJ: Polygenes, risk prediction, and targeted prevention of breast cancer. N Engl J Med 2008; 358: 2796-2803. (Pubitemid 351930854)
4. Turnbull C, Rahman N: Genetic predisposition to breast cancer: past, present, and future. Annu Rev Genomics Hum Genet 2008; 9: 321-345.
5. Lynge E, Olsen AH, Fracheboud J, Patnick J: Reporting of performance indicators of mammography screening in Europe. Eur J Cancer Prev 2003; 12: 213-222. (Pubitemid 36686748)
6. Irwig L, McCaffery K, Salkeld G, Bossuyt P: Screening and choice - informed choice for screening: implications for evaluation. Br Med J 2006; 332: 1148-1150. (Pubitemid 44480884)
7. Jepson RG, Hewison J, Thompson AG, Weller D: How should we measure informed choice? The case of cancer screening. J Med Ethics 2005; 31: 192-196. (Pubitemid 40542127)
8. Silverman E, Woloshin S, Schwartz LM, Byram SJ, Welch HG, Fischhoff B: Women's views on breast cancer risk and screening mammography: a qualitative interview study. Med Dec Making 2001; 21: 231-240. (Pubitemid 32452767)
9. Webster P, Austoker J: Women's knowledge about breast cancer risk and their views of the purpose and implications of breast screening - a questionnaire survey. J Public Health 2006; 28: 197-202. (Pubitemid 44418596)
10. Lerman C, Seay J, Balshem A, Audrain J: Interest in genetic testing among first-degree relatives of breast-cancer patients. Am J Med Genet 1995; 57: 385-392.
11. Chaliki H, Loader S, Levenkron JC, Logan-Young W, Hall WJ, Rowley PT: Women's receptivity to testing for a genetic susceptibility to breast-cancer. Am J Public Health 1995; 85: 1133-1135.
12. Ulrich CM, Kristal AR, White E, Hunt JR, Durfy SJ, Potter JD: Genetic testing for cancer risk: a population survey on attitudes and intention. Community Genet 1998; 1: 213-222.
13. Press NA, Yasui Y, Reynolds S, Durfy SJ, Burke W: Women's interest in genetic testing for breast cancer susceptibility may be based on unrealistic expectations. Am J Med Genet 2001; 99: 99-110. (Pubitemid 32204778)
14. Gwyn K, Vernon SW, Conoley PM: Intention to pursue genetic testing for breast cancer among women due for screening mammography. Cancer Epidemiol Biomarkers Prev 2003; 12: 96-102. (Pubitemid 36193998)
15. Tambor ES, Rimer BK, Strigo TS: Genetic testing for breast cancer susceptibility: awareness and interest among women in the general population. Am J Med Genet 1997; 68: 43-49. (Pubitemid 27023839)
16. Durfy SJ, Bowen DJ, McTiernan A, Sporleder J, Burke W: Attitudes and interest in genetic testing for breast and ovarian cancer susceptibility in diverse groups of women in western Washington. Cancer Epidemiol Biomarkers Prev 1999; 8: 369-375. (Pubitemid 29193892)
17. Vuckovic N, Harris EL, Valanis B, Stewart B: Consumer knowledge and opinions of genetic testing for breast cancer risk. Am J Obstet Gynecol 2003; 189:S48-S53. (Pubitemid 37372576)
18. Jernstrom H: Polygenes: risk prediction, and targeted prevention of breast cancer. N Engl J Med 2008; 359: 1407.
19. Tessaro I, Borstelmann N, Regan K, Rimer BK, Winer E: Genetic testing for susceptibility to breast cancer: findings from women's focus groups. J Womens Health 1997; 6: 317-327.
20. Lewis MJ, Peterson SK: Perceptions of genetic testing for cancer predisposition among Ashkenazi Jewish women. Community Genet 2007; 10: 72-81. (Pubitemid 46474695)
21. Lodder L, Frets PG, Trijsburg RW, Meijers-Heijboer EJ, Klijn JG, Duivenvoorden HJ, Tibben A, Wagner A, Van der Meer C, Van den Ouweland A, Niermeijer M: Psychological impact of receiving a BRCA1/BRCA2 test result. Am J Med Genet 2001; 98: 15-24. (Pubitemid 32041846)
22. Watson M, Foster C, Eeles R, Eccles D, Ashley S, Davidson R, Mackay J, Morrison PJ, Hopwood P, Evans DGR and Psychosocial Study Collaborators: Psychosocial impact of breast/ovarian ( BRCA1/2 ) cancer-predictive genetic testing in a UK multi-centre clinical cohort. Br J Cancer 2004; 91: 1787-1794. (Pubitemid 39664966)
23. Gotzsche PC, Hartling OJ, Nielsen M, Brodersen J, Jorgensen KJ: Breast screening: the facts - or maybe not. Br Med J 2009; 338: b86.
24. Osterlie W, Solbjor M, Skolbekken JA, Hofvind S, Saetnan AR, Forsmo S: Challenges of informed choice in organised screening. J Med Ethics 2008; 34:e5.
25. Feero WG, Guttmacher AE, Collins FS: The genome gets personal - almost. JAMA 2008; 299: 1351-1352. (Pubitemid 351439081)
26. Khoury MJ, Gwinn M, Yoon PW, Dowling N, Moore CA, Bradley L: The continuum of translation research in genomic medicine: how can we accelerate the appropriate integration of human genome discoveries into health care and disease prevention? Genet Med 2007; 9: 665-674. (Pubitemid 350287151)
27. Rogowski WH, Grosse SD, Khoury MJ: Challenges of translating genetic tests into clinical and public health practice. Nat Rev Genet 2009; 10: 489-495.
28. Warner E, Messersmith H, Causer P, Eisen A, Shumak R, Plewes D: Systematic review: using magnetic resonance imaging to screen women at high risk for breast cancer. Ann Intern Med 2008; 148: 671-679. (Pubitemid 351669112)
29. Van Dijk S, Otten W, Van Asperen CJ, Timmermans DR, Tibben A, Zoeteweij MW, Silberg S, Breuning MH, Kievit J: Feeling at risk: how women interpret their familial breast cancer risk. Am J Med Genet A 2004; 131: 42-49. (Pubitemid 39434793)
30. Van den Berg M, Timmermans DR, Knol DL, Van Eijk JT, De Smit DJ, Van Vugt JM, Van der Wal G: Understanding pregnant women's decision making concerning prenatal screening. Health Psychol 2008; 27: 430-437.
31. Lerman C, Biesecker B, Benkendorf JL, Kerner J, Gomez-Caminero A, Hughes C, Reed MM: Controlled trial of pretest education approaches to enhance informed decision-making for BRCA1 gene testing. J Natl Cancer Inst 1997; 89: 148-157. (Pubitemid 27034791)
32. Meijers-Heijboer EJ, Verhoog LC, Brekelmans CT, Seynaeve C, Tilanus-Linthorst MM, Wagner A, Dukel L, Devilee P, Van den Ouweland AM, Van Geel AN, Klijn JG: Presymptomatic DNA testing and prophylactic surgery in families with a BRCA1 or BRCA2 mutation. Lancet 2000; 355: 2015-2020. (Pubitemid 30339238)
33. Lerman C, Narod S, Schulman K, Hughes C, Gomez-Caminero A, Bonney G, Gold K, Trock B, Main D, Lynch J, Fulmore C, Snyder C, Lemon SJ, Conway T, Tonin P, Lenoir G, Lynch H: BRCA1 testing in families with hereditary breast-ovarian cancer. A prospective study of patient decision making and outcomes. JAMA 1996; 275: 1885-1892. (Pubitemid 26196448)