Learning increases the survival of newborn neurons provided that learning is difficult to achieve and successful

Journal of Cognitive Neuroscience

Volumn 23, Issue 9, 2011, Pages 2159-2170

  Curlik, Daniel M ^a   Shors, Tracey J ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (3 PHOSPHONOPROPYL) 2 PIPERAZINECARBOXYLIC ACID; CYCLOSERINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CONDITIONING; DRUG EFFECT; EYELID REFLEX; HIPPOCAMPUS; LEARNING; MALE; NERVE CELL; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION;

ANALYSIS OF VARIANCE; ANIMALS; BROMODEOXYURIDINE; CELL COUNT; CELL SURVIVAL; CONDITIONING, EYELID; EXCITATORY AMINO ACID ANTAGONISTS; HIPPOCAMPUS; MALE; MAZE LEARNING; NEUROGENESIS; NEURONS; PIPERAZINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 79960126566     PISSN: 0898929X     EISSN: 15308898     Source Type: Journal    
DOI: 10.1162/jocn.2010.21597     Document Type: Article

References (40)

1. Altman, J., & Das, G. D. (1965). Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. Journal of Comparative Neurology, 124, 319-335.
2. Ambrogini, P., Cuppini, R., Cuppini, C., Ciaroni, S., Cecchini, T., Ferri, P., et al. (2000). Spatial learning affects immature granule cell survival in adult rat dentate gyrus. Neuroscience Letters, 286, 21-24.
3. Anderson, M., & Shors, T. (submitted). The effects of learning on neurogenesis: Survival versus proliferation.
4. Anderson, M. L., Sisti, H. M., Curlik, D. M., & Shors, T. J. (2010). Associative learning increases adult neurogenesis during a critical period. European Journal ofNeuroscience, 33, 175-181.
5. Burgos-Robles, A., Vidal-Gonzalez, I., Santini, E., & Quirk, G. J. (2007). Consolidation of fear extinction requires NMDA receptor-dependent bursting in the ventromedial prefrontal cortex. Neuron, 53, 871-880.
6. Cameron, H. A., & McKay, R. D. (2001). Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus. Journal of Comparative Neurology, 435, 406-417.
7. Cameron, H. A., Woolley, C. S., McEwen, B. S., & Gould, E. (1993). Differentiation of newly born neurons and glia in the dentate gyrus of the adult rat. Neuroscience, 56, 337-344.
8. Dalla, C., Bangasser, D. A., Edgecomb, C., & Shors, T. J. (2007). Neurogenesis and learning: Acquisition and asymptotic performance predict how many new cells survive in the hippocampus. Neurobiology of Learning and Memory, 88, 143-148.
9. Dalla, C., Papachristos, E. B., Whetstone, A. S., & Shors, T. J. (2009). Female rats learn trace memories better than male rats and consequently retain a greater proportion of new neurons in their hippocampi. Proceedings of the National Academy of Sciences, U.S.A., 106, 2927-2932.
10. Davis, M., Ressler, K., Rothbaum, B. O., & Richardson, R. (2006). Effects of D-cycloserine on extinction: Translation from preclinical to clinical work. Biological Psychiatry, 60, 369-375.
11. Dayer, A. G., Ford, A. A., Cleaver, K. M., Yassaee, M., & Cameron, H. A. (2003). Short-term and long-term survival of new neurons in the rat dentate gyrus. Journal of Comparative Neurology, 460, 563-572.
12. Epp, J. R., Spritzer, M. D., & Galea, L. A. (2007). Hippocampusdependent learning promotes survival of new neurons in the dentate gyrus at a specific time during cell maturation. Neuroscience, 149, 273-285.
13. Eriksson, P. S., Perfilieva, E., Bjork-Eriksson, T., Alborn, A. M., Nordborg, C., Peterson, D. A., et al. (1998). Neurogenesis in the adult human hippocampus. Nature Medicine, 4, 1313-1317.
14. Gilmartin, M. R., & McEchron, M. D. (2005). Single neurons in the dentate gyrus and CA1 of the hippocampus exhibit inverse patterns of encoding during trace fear conditioning. Behavioral Neuroscience, 119, 164-179.
15. Gould, E., Beylin, A., Tanapat, P., Reeves, A., & Shors, T. J. (1999). Learning enhances adult neurogenesis in the hippocampal formation. Nature Neuroscience, 2, 260-265.
16. Hastings, N. B., & Gould, E. (1999). Rapid extension of axons into the CA3 region by adult-generated granule cells. Journal of Comparative Neurology, 413, 146-154.
17. Henderson, G., Johnson, J. W., & Ascher, P. (1990). Competitive antagonists and partial agonists at the glycine modulatory site of the mouse N-methyl-D-aspartate receptor. Journal of Physiology, 430, 189-212.
18. Hofmann, S. G., Meuret, A. E., Smits, J. A., Simon, N. M., Pollack, M. H., Eisenmenger, K., et al. (2006). Augmentation of exposure therapy with D-cycloserine for social anxiety disorder. Archives of General Psychiatry, 63, 298-304.
19. Hood, W. F., Compton, R. P., & Monahan, J. B. (1989). D-Cycloserine: A ligand for the N-methyl-D-aspartate coupled glycine receptor has partial agonist characteristics. Neuroscience Letters, 98, 91-95.
20. Kaplan, M. S., & Hinds, J. W. (1977). Neurogenesis in the adult rat: Electron microscopic analysis of light radioautographs. Science, 197, 1092-1094.
21. Kornack, D. R., & Rakic, P. (1999). Continuation of neurogenesis in the hippocampus of the adult macaque monkey. Proceedings of the National Academy of Sciences, U.S.A., 96, 5768-5773.
22. Ledgerwood, L., Richardson, R., & Cranney, J. (2003). Effects of D-cycloserine on extinction of conditioned freezing. Behavioral Neuroscience, 117, 341-349.
23. Leuner, B., Falduto, J., & Shors, T. J. (2003). Associative memory formation increases the observation of dendritic spines in the hippocampus. Journal of Neuroscience, 23, 659-665.
24. Leuner, B., Mendolia-Loffredo, S., Kozorovitskiy, Y., Samburg, D., Gould, E., & Shors, T. J. (2004). Learning enhances the survival of new neurons beyond the time when the hippocampus is required for memory. Journal of Neuroscience, 24, 7477-7481.
25. Markakis, E. A., & Gage, F. H. (1999). Adult-generated neurons in the dentate gyrus send axonal projections to field CA3 and are surrounded by synaptic vesicles. Journal of Comparative Neurology, 406, 449-460.
26. Miller, M. W., & Nowakowski, R. S. (1988). Use of bromodeoxyuridine-immunohistochemistry to examine the proliferation, migration and time of origin of cells in the central nervous system. Brain Research, 457, 44-52.
27. Moyer, J. R., Jr., Thompson, L. T., & Disterhoft, J. F. (1996). Trace eyeblink conditioning increases CA1 excitability in a transient and learning-specific manner. Journal of Neuroscience, 16, 5536-5546.
28. Moyer, J. R., Jr., Thompson, L. T., & Disterhoft, J. F. (2000). Increased excitability of aged rabbit CA1 neurons after trace eyeblink conditioning. Journal of Neuroscience, 20, 5476-5482.
29. Nokia, M. S., Penttonen, M., Korhonen, T., & Wikgren, J. (2008). Hippocampal theta (3-8 Hz) activity during classical eyeblink conditioning in rabbits. Neurobiology of Learning and Memory, 90, 62-70.
30. Onur, O. A., Schlaepfer, T. E., Kukolja, J., Bauer, A., Jeung, H., Patin, A., et al. (2010). The N-methyl-D-aspartate receptor co-agonist D-cycloserine facilitates declarative learning and hippocampal activity in humans. Biological Psychiatry, 67, 1205-1211.
31. Rouaud, E., & Billard, J. M. (2003). D-Cycloserine facilitates synaptic plasticity but impairs glutamatergic neurotransmission in rat hippocampal slices. British Journal of Pharmacology, 140, 1051-1056.
32. Servatius, R. J., & Shors, T. J. (1996). Early acquisition, but not retention, of the classically conditioned eyeblink response is N-methyl-D-aspartate (NMDA) receptor dependent. Behavioral Neuroscience, 110, 1040-1048.
33. Shors, T. J. (2008). From stem cells to grandmother cells: How neurogenesis relates to learning and memory. Cell Stem Cell, 3, 253-258.
34. Shors, T. J. (2009). Saving new brain cells. Scientific American, 300, 46-52, 54.
35. Sisti, H. M., Glass, A. L., & Shors, T. J. (2007). Neurogenesis and the spacing effect: Learning over time enhances memory and the survival of new neurons. Learning and Memory, 14, 368-375.
36. Tashiro, A., Zhao, C., & Gage, F. H. (2006). Retrovirus-mediated single-cell gene knockout technique in adult newborn neurons in vivo. Nature Protocols, 1, 3049-3055.
37. Thompson, L. T., & Disterhoft, J. F. (1997). Age- and dosedependent facilitation of associative eyeblink conditioning by D-cycloserine in rabbits. Behavioral Neuroscience, 111, 1303-1312.
38. Thompson, L. T., Moskal, J. R., & Disterhoft, J. F. (1992). Hippocampus-dependent learning facilitated by a monoclonal antibody or D-cycloserine. Nature, 359, 638-641.
39. Waddell, J., Mallimo, E., & Shors, T. (2010). D-Cycloserine reverses the detrimental effects of stress on learning in females and enhances retention in males. Neurobiology of Learning and Memory, 93, 31-36.
40. Waddell, J., & Shors, T. J. (2008). Neurogenesis, learning and associative strength. European Journal of Neuroscience, 27, 3020-3028.