Sildenafil therapy for neonatal and childhood pulmonary hypertensive vascular disease

Cardiology in the Young

Volumn 21, Issue 2, 2011, Pages 187-193

  Humpl, Tilman ^a   Reyes, Janette T ^a   Erickson, Simon ^b   Armano, Ruth ^c   Holtby, Helen ^a   Adatia, Ian ^d  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

^d UNIVERSITY OF ALBERTA   (Canada)

Author keywords

congenital cardiac disease; congenital diaphragmatic hernia; neonatal; pulmonary hypertension; Sildenafil

Indexed keywords

CREATININE; NITRIC OXIDE; SILDENAFIL; UREA; PHOSPHODIESTERASE V INHIBITOR; PIPERAZINE DERIVATIVE; PURINE DERIVATIVE; SULFONE;

ABSENCE OF SIDE EFFECTS; AGE DISTRIBUTION; ARTICLE; BLOOD PRESSURE MEASUREMENT; BLOOD PRESSURE REGULATION; CHILD; CHILDHOOD PULMONARY HYPERTENSION; CLINICAL ARTICLE; CREATININE BLOOD LEVEL; DRUG TOLERABILITY; FEMALE; HEART HEMODYNAMICS; HUMAN; INFANT; LIVER FUNCTION TEST; LUNG VASCULAR RESISTANCE; MALE; NEONATAL PULMONARY HYPERTENSION; PRESCHOOL CHILD; PULMONARY HYPERTENSION; SYSTOLIC BLOOD PRESSURE; THROMBOCYTE COUNT; TREATMENT DURATION; TREATMENT OUTCOME; UREA BLOOD LEVEL; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; ECHOCARDIOGRAPHY; ECHOGRAPHY; FOLLOW UP; HEART CATHETERIZATION; HEART RIGHT VENTRICLE FUNCTION; HEART VENTRICLE PRESSURE; LUNG WEDGE PRESSURE; NEWBORN; ORAL DRUG ADMINISTRATION; PATHOPHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; RETROSPECTIVE STUDY;

ADMINISTRATION, ORAL; CHILD, PRESCHOOL; DOSE-RESPONSE RELATIONSHIP, DRUG; ECHOCARDIOGRAPHY; FEMALE; FOLLOW-UP STUDIES; HEART CATHETERIZATION; HUMANS; HYPERTENSION, PULMONARY; INFANT; INFANT, NEWBORN; MALE; PHOSPHODIESTERASE 5 INHIBITORS; PIPERAZINES; PULMONARY WEDGE PRESSURE; PURINES; RETROSPECTIVE STUDIES; SULFONES; TREATMENT OUTCOME; VENTRICULAR FUNCTION, RIGHT; VENTRICULAR PRESSURE;

EID: 79960114914     PISSN: 10479511     EISSN: 14671107     Source Type: Journal    
DOI: 10.1017/S1047951110001745     Document Type: Article

References (20)

1. Adatia I. Recent advances in pulmonary vascular disease. Curr Opin Pediatr 2002; 14: 292-297. (Pubitemid 34478516)
2. Khemani E, McElhinney DB, Rhein L, et al. Pulmonary artery hypertension in formerly premature infants with bronchopulmonary dysplasia: clinical features and outcomes in the surfactant era. Pediatrics 2007; 120: 1260-1269. (Pubitemid 350223677)
3. Ghofrani HA, Pepke-Zaba J, Barbera JA, et al. Nitric oxide pathway and phosphodiesterase inhibitors in pulmonary arterial hypertension. J Am Coll Cardiol 2004; 43: 68S-72S. (Pubitemid 38759720)
4. Humpl T, Reyes JT, Holtby H, Stephens D, Adatia I. Beneficial effect of oral sildenafil therapy on childhood pulmonary arterial hypertension: twelve-month clinical trial of a singledrug, open-label, pilot study. Circulation 2005; 111: 3274-3280. (Pubitemid 40875000)
5. Sastry BK, Narasimhan C, Reddy NK, Raju BS. Clinical efficacy of sildenafil in primary pulmonary hypertension: a randomized, placebo-controlled, double-blind, crossover study. J Am Coll Cardiol 2004; 43: 1149-1153. (Pubitemid 38452588)
6. Michelakis ED, TymchakW, Noga M, et al. Long-term treatment with oral sildenafil is safe and improves functional capacity and hemodynamics in patients with pulmonary arterial hypertension. Circulation 2003; 108: 2066-2069. (Pubitemid 37337580)
7. Mourani PM, Sontag MK, Ivy DD, Abman SH. Effects of longterm sildenafil treatment for pulmonary hypertension in infants with chronic lung disease. J Pediatr 2009; 154: 379-384.
8. Steinhorn RH, Kinsella JP, Pierce C, et al. Intravenous sildenafil in the treatment of neonates with persistent pulmonary hypertension. J Pediatr 2009; 155: 841-847; e841.
9. Schulze-Neick I, Hartenstein P, Li J, et al. Intravenous sildenafil is a potent pulmonary vasodilator in children with congenital heart disease. Circulation 2003; 108 Suppl 1: II167-II173. (Pubitemid 37099949)
10. Stocker C, Penny DJ, Brizard CP, Cochrane AD, Soto R, Shekerdemian LS. Intravenous sildenafil and inhaled nitric oxide: a randomised trial in infants after cardiac surgery. Intensive Care Med 2003; 29: 1996-2003. (Pubitemid 37487135)
11. Noori S, Friedlich P, Wong P, Garingo A, Seri I. Cardiovascular effects of sildenafil in neonates and infants with congenital diaphragmatic hernia and pulmonary hypertension. Neonatology 2007; 91: 92-100.
12. Galie N, Torbicki A, Barst R, et al. Guidelines on diagnosis and treatment of pulmonary arterial hypertension. The Task Force on Diagnosis and Treatment of Pulmonary Arterial Hypertension of the European Society of Cardiology. Eur Heart J 2004; 25: 2243-2278.
13. Grunig E, Weissmann S, Ehlken N, et al. Stress Doppler echocardiography in relatives of patients with idiopathic and familial pulmonary arterial hypertension: results of a multicenter European analysis of pulmonary artery pressure response to exercise and hypoxia. Circulation 2009; 119: 1747-1757.
14. Adatia I. Improving the outcome of childhood pulmonary arterial hypertension: the effect of bosentan in the setting of a dedicated pulmonary hypertension clinic. J Am Coll Cardiol 2005; 46: 705-706. (Pubitemid 41132701)
15. Adatia I. Pulmonary veno-occlusive disease. In: Freedom RM, Yoo S-J, Mikailian H and Williams WG (eds). The Natural and Modified History of Congenital Heart Disease. Futura, New York, 2004; 513.
16. Atz AM, Adatia I, Wessel DL. Rebound pulmonary hypertension after inhalation of nitric oxide. Ann Thorac Surg 1996; 62: 1759-1764. (Pubitemid 26421112)
17. Miller OI, Tang SF, Keech A, Celermajer DS. Rebound pulmonary hypertension on withdrawal from inhaled nitric oxide. Lancet 1995; 346: 51-52.
18. Namachivayam P, Theilen U, Butt WW, Cooper SM, Penny DJ, Shekerdemian LS. Sildenafil prevents rebound pulmonary hypertension after withdrawal of nitric oxide in children. Am J Respir Crit Care Med 2006; 174: 1042-1047. (Pubitemid 44684454)
19. Cordell WH, Maturi RK, Costigan TM, et al. Retinal effects of 6 months of daily use of tadalafil or sildenafil. Arch Ophthalmol 2009; 127: 367-373.
20. Keller RL, Moore P, Teitel D, Hawgood S, McQuitty J, Fineman JR. Abnormal vascular tone in infants and children with lung hypoplasia: findings from cardiac catheterization and the response to chronic therapy. Pediatr Crit Care Med 2006; 7: 589-594. (Pubitemid 44715302)