MiR-9 downregulates CDX2 expression in gastric cancer cells

International Journal of Cancer

Volumn 129, Issue 11, 2011, Pages 2611-2620

  Rotkrua, Pichayanoot ^a   Akiyama, Yoshimitsu ^a   Hashimoto, Yutaka ^a   Otsubo, Takeshi ^a   Yuasa, Yasuhito ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

CDX2; gastric cancer; microRNA; miR 9

Indexed keywords

MICRORNA; MICRORNA 9; TRANSCRIPTION FACTOR CDX2; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ARTICLE; BINDING SITE; CANCER CELL; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL STRAIN HEK293; CONTROLLED STUDY; DOWN REGULATION; GENE; GROWTH INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; MUC2 GENE; P21 GENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOMACH CANCER; TFF3 GENE;

3' UNTRANSLATED REGIONS; BLOTTING, WESTERN; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; DNA METHYLATION; DOWN-REGULATION; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, NEOPLASTIC; HOMEODOMAIN PROTEINS; HUMANS; LUCIFERASES; MICRORNAS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STOMACH NEOPLASMS;

EID: 79960108916     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.25923     Document Type: Article

References (44)

1. Garcia M, Jemal A, Ward EM, Center MM, Hao Y, Siegel RL, Thun MJ,. Global cancer facts & figures 2007. Atlanta (GA): American Cancer Society, 2007: 1-50.
2. Lauren P,. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification. Acta Pathol Microbiol Scand 1965; 64: 31-49.
3. Becker KF, Atkinson MJ, Reich U, Becker I, Nekarda H, Siewert JR, Hofler H,. E-cadherin gene mutations provide clues to diffuse type gastric carcinomas. Cancer Res 1994; 54: 3845-52. (Pubitemid 24241205)
4. Tamura G, Yin J, Wang S, Fleisher AS, Zou T, Abraham JM, Kong D, Smolinski KN, Wilson KT, James SP, Silverberg SG, Nishizuka S, et al. E-Cadherin gene promoter hypermethylation in primary human gastric carcinomas. J Natl Cancer Inst 2000; 92: 569-73. (Pubitemid 30212319)
5. Yuasa Y,. Control of gut differentiation and intestinal-type gastric carcinogenesis. Nat Rev Cancer 2003; 3: 592-600. (Pubitemid 37328831)
6. Silberg DG, Swain GP, Suh ER, Traber PG,. Cdx1 and cdx2 expression during intestinal development. Gastroenterology 2000; 119: 961-71.
7. Bai YQ, Yamamoto H, Akiyama Y, Tanaka H, Takizawa T, Koike M, Kenji Yagi O, Saitoh K, Takeshita K, Iwai T, Yuasa Y,. Ectopic expression of homeodomain protein CDX2 in intestinal metaplasia and carcinomas of the stomach. Cancer Lett 2002; 176: 47-55. (Pubitemid 34085069)
8. Silberg DG, Sullivan J, Kang E, Swain GP, Moffett J, Sund NJ, Sackett SD, Kaestner KH,. Cdx2 ectopic expression induces gastric intestinal metaplasia in transgenic mice. Gastroenterology 2002; 122: 689-96. (Pubitemid 34173821)
9. Mutoh H, Sakurai S, Satoh K, Tamada K, Kita H, Osawa H, Tomiyama T, Sato Y, Yamamoto H, Isoda N, Yoshida T, Ido K, et al. Development of gastric carcinoma from intestinal metaplasia in Cdx2-transgenic mice. Cancer Res 2004; 64: 7740-47. (Pubitemid 39446905)
10. Busuttil RA, Boussioutas A,. Intestinal metaplasia: a premalignant lesion involved in gastric carcinogenesis. J Gastroenterol Hepatol 2009; 24: 193-201.
11. Liu Q, Teh M, Ito K, Shah N, Ito Y, Yeoh KG,. CDX2 expression is progressively decreased in human gastric intestinal metaplasia, dysplasia and cancer. Mod Pathol 2007; 20: 1286-97. (Pubitemid 350126854)
12. Park DY, Srivastava A, Kim GH, Mino-Kenudson M, Deshpande V, Zukerberg LR, Song GA, Lauwers GY,. CDX2 expression in the intestinal-type gastric epithelial neoplasia: frequency and significance. Mod Pathol 2010; 23: 54-61.
13. Seno H, Oshima M, Taniguchi MA, Usami K, Ishikawa TO, Chiba T, Taketo MM,. CDX2 expression in the stomach with intestinal metaplasia and intestinal-type cancer: prognostic implications. Int J Oncol 2002; 21: 769-74.
14. Lorentz O, Cadoret A, Duluc I, Capeau J, Gespach C, Cherqui G, Freund JN,. Downregulation of the colon tumour-suppressor homeobox gene Cdx-2 by oncogenic ras. Oncogene 1999; 18: 87-92. (Pubitemid 29060582)
15. Kawai H, Tomii K, Toyooka S, Yano M, Murakami M, Tsukuda K, Shimizu N,. Promoter methylation downregulates CDX2 expression in colorectal carcinomas. Oncol Rep 2005; 13: 547-51.
16. Yuasa Y, Nagasaki H, Akiyama Y, Sakai H, Nakajima T, Ohkura Y, Takizawa T, Koike M, Tani M, Iwai T, Sugihara K, Imai K, et al. Relationship between CDX2 gene methylation and dietary factors in gastric cancer patients. Carcinogenesis 2005; 26: 193-200. (Pubitemid 40207715)
17. Song JH, Kim CJ, Cho YG, Chae JS, Cao Z, Nam SW, Lee JY, Park WS,. Genetic alterations of the Cdx2 gene in gastric cancer. APMIS 2008; 116: 74-80. (Pubitemid 351191104)
18. Bartel DP,. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004; 116: 281-97.
19. Kloosterman WP, Plasterk RH,. The diverse functions of microRNAs in animal development and disease. Dev Cell 2006; 11: 441-50. (Pubitemid 44430905)
20. Esquela-Kerscher A, Slack FJ,. Oncomirs-microRNAs with a role in cancer. Nat Rev Cancer 2006; 6: 259-69.
21. Li Z, Zhan W, Wang Z, Zhu B, He Y, Peng J, Cai S, Ma J,. Inhibition of PRL-3 gene expression in gastric cancer cell line SGC7901 via microRNA suppressed reduces peritoneal metastasis. Biochem Biophys Res Commun 2006; 348: 229-37. (Pubitemid 44163504)
22. Petrocca F, Visone R, Onelli MR, Shah MH, Nicoloso MS, de Martino I, Iliopoulos D, Pilozzi E, Liu CG, Negrini M, Cavazzini L, Volinia S, et al. E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer. Cancer Cell 2008; 13: 272-86. (Pubitemid 351318375)
23. Hashimoto Y, Akiyama Y, Otsubo T, Shimada S, Yuasa Y,. Involvement of epigenetically silenced microRNA-181c in gastric carcinogenesis. Carcinogenesis 2010; 31: 777-84.
24. Tsukamoto Y, Nakada C, Noguchi T, Tanigawa M, Nguyen LT, Uchida T, Hijiya N, Matsuura K, Fujioka T, Seto M, Moriyama M,. MicroRNA-375 is downregulated in gastric carcinomas and regulates cell survival by targeting PDK1 and 14-3-3zeta. Cancer Res 2010; 70: 2339-49.
25. Wada R, Akiyama Y, Hashimoto Y, Fukamachi H, Yuasa Y,. miR-212 is downregulated and suppresses methyl-CpG-binding protein MeCP2 in human gastric cancer. Int J Cancer 2010; 127: 1106-14.
26. Japanese Gastric Cancer Association,. Japanese Classification of Gastric Carcinoma-2nd English Edition. Gastric Cancer 1998; 1: 10-24.
27. Abramoff MD, Magelhaes PJ, Ram SJ,. "Image Processing with ImageJ". Biophotonics Int 2004; 11: 36-42.
28. Yamamoto H, Bai YQ, Yuasa Y,. Homeodomain protein CDX2 regulates goblet-specific MUC2 gene expression. Biochem Biophys Res Commun 2003; 300: 813-8. (Pubitemid 36259834)
29. Livak KJ, Schmittgen TD,. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001; 25: 402-8. (Pubitemid 34164012)
30. Bai YQ, Miyake S, Iwai T, Yuasa Y,. CDX2, a homeobox transcription factor, upregulates transcription of the p21/WAF1/CIP1 gene. Oncogene 2003; 22: 7942-9. (Pubitemid 37175859)
31. Mesquita P, Jonckheere N, Almeida R, Ducourouble MP, Serpa J, Silva E, Pigny P, Silva FS, Reis C, Silberg D, Van Seuningen I, David L,. Human MUC2 mucin gene is transcriptionally regulated by Cdx homeodomain proteins in gastrointestinal carcinoma cell lines. J Biol Chem 2003; 278: 51549-56. (Pubitemid 38020398)
32. Shimada T, Koike T, Yamagata M, Yoneda M, Hiraishi H,. Regulation of TFF3 expression by homeodomain protein CDX2. Regul Pept 2007; 140: 81-7. (Pubitemid 46275061)
33. Suh E, Traber PG,. An intestine-specific homeobox gene regulates proliferation and differentiation. Mol Cell Biol 1996; 16: 619-25. (Pubitemid 26029101)
34. Yang W, Velcich A, Lozonschi I, Liang J, Nicholas C, Zhuang M, Bancroft L, Augenlicht LH,. Inactivation of p21WAF1/cip1 enhances intestinal tumor formation in Muc2-/- mice. Am J Pathol 2005; 166: 1239-46. (Pubitemid 40524446)
35. Taupin D, Podolsky DK,. Trefoil factors: initiators of mucosal healing. Nat Rev Mol Cell Biol 2003; 4: 721-32. (Pubitemid 37082187)
36. Takahashi K, Hirano F, Matsumoto K, Aso K, Haneda M,. Homeobox gene CDX2 inhibits human pancreatic cancer cell proliferation by down-regulating cyclin D1 transcriptional activity. Pancreas 2009; 38: 49-57.
37. Chawengsaksophak K, James R, Hammond VE, Kontgen F, Beck F,. Homeosis and intestinal tumours in Cdx2 mutant mice. Nature 1997; 386: 84-7. (Pubitemid 27130925)
38. Gao N, White P, Kaestner KH,. Establishment of intestinal identity and epithelial-mesenchymal signaling by Cdx2. Dev Cell 2009; 16: 588-99.
39. Myatt SS, Wang J, Monteiro LJ, Christian M, Ho KK, Fusi L, Dina RE, Brosens JJ, Ghaem-Maghami S, Lam EW,. Definition of microRNAs that repress expression of the tumor suppressor gene FOXO1 in endometrial cancer. Cancer Res 2010; 70: 367-77.
40. Iorio MV, Ferracin M, Liu CG, Veronese A, Spizzo R, Sabbioni S, Magri E, Pedriali M, Fabbri M, Campiglio M, Menard S, Palazzo JP, et al. MicroRNA gene expression deregulation in human breast cancer. Cancer Res 2005; 65: 7065-70. (Pubitemid 41161233)
41. Sun Y, Wu J, Wu SH, Thakur A, Bollig A, Huang Y, Liao DJ,. Expression profile of microRNAs in c-Myc induced mouse mammary tumors. Breast Cancer Res Treat 2009; 118: 185-96.
42. Ma L, Young J, Prabhala H, Pan E, Mestdagh P, Muth D, Teruya-Feldstein J, Reinhardt F, Onder TT, Valastyan S, Westermann F, Speleman F, et al. miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Nat Cell Biol 2010; 12: 247-56.
43. Lehmann U, Hasemeier B, Christgen M, Muller M, Romermann D, Langer F, Kreipe H,. Epigenetic inactivation of microRNA gene hsa-mir-9-1 in human breast cancer. J Pathol 2008; 214: 17-24.
44. Lujambio A, Calin GA, Villanueva A, Ropero S, Sanchez-Cespedes M, Blanco D, Montuenga LM, Rossi S, Nicoloso MS, Faller WJ, Gallagher WM, Eccles SA, et al. A microRNA DNA methylation signature for human cancer metastasis. Proc Natl Acad Sci USA 2008; 105: 13556-61.