Corneal cross-linking and safety issues

Open Ophthalmology Journal

Volumn 5, Issue , 2011, Pages 14-16

  Spoerl, Eberhard ^a   Hoyer, Anne ^a   Pillunat, Lutz E ^a   Raiskup, Frederik ^a  

^a UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

Author keywords

Biomechanics; Cornea; Cross linking; Keratoconus; Ultraviolet light

Indexed keywords

ALCOHOL; COLLAGEN; GLUTARALDEHYDE; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; RIBOFLAVIN; SINGLET OXYGEN;

ARTICLE; CORNEA DISEASE; CORNEA ENDOTHELIUM; CORNEA STROMA; CORNEAL COLLAGEN CROSS LINKING; ENDOTHELIUM CELL; HUMAN; ILLUMINATION; KERATOCONUS; LENS; LIGHT ABSORPTION; LIGHT EMITTING DIODE; MINIMALLY INVASIVE PROCEDURE; PHOTOCHEMISTRY; PHOTOOXIDATION; PRIORITY JOURNAL; RETINA; ULTRAVIOLET A RADIATION; ULTRAVIOLET RADIATION;

EID: 79960107291     PISSN: None     EISSN: 18743641     Source Type: Journal    
DOI: 10.2174/1874364101105010014     Document Type: Article

References (27)

1. Spoerl E, Huhle M, Seiler T. Induction of cross-links in corneal tissue. Exp Eye Res 1998; 66: 97-103.
2. Spoerl E, Seiler T. Techniques for stiffening the cornea. J Refract Surg 1999; 15: 711-3.
3. Spörl E, Schreiber J, Hellmund K, Seiler T, Knuschke P. Studies on the stabilization of the cornea in rabbits. Ophthalmologe 2000; 97: 203-6.
4. Wollensak G, Spörl E, Reber F, Pillunat L, Funk R. Corneal endothelial cytotoxicity of riboflavin/UVA treatment in vitro. Ophthalmic Res 2003; 35: 324-8.
5. Wollensak G, Spoerl E, Wilsch M, Seiler T. Endothelial cell damage after riboflavin-ultraviolet-A treatment in the rabbit. J Cataract Refract Surg 2003; 29: 1786-90.
6. Wollensak G, Spoerl E, Wilsch M, Seiler T. Keratocyte apoptosis after collagen cross-linking using riboflavin/UVA treatment. Cornea 2004; 23: 43-49.
7. Wollensak G, Spoerl E, Reber F, Seiler T. Keratocyte cytotoxicity of riboflavin/UVA-treatment in vitro. Eye 2004; 18: 718-722.
8. Wollensak G. Histological changes in human cornea after cross-linking with riboflavin and ultraviolet A. Acta Opthalmol 2010; 88(2): e17-8.
9. Wollensak G, Spoerl E, Seiler T. Riboflavin/ultraviolet-A-induced collagen cross-linking for the treatment of keratoconus. Am J Ophthalmol 2003; 135: 620-27.
10. Spörl E, Raiskup-Wolf F, Pillunat LE. Biophysical principles of collagen cross-linking. Klin Monatsbl Augenheilkd 2008; 225: 131-7.
11. [11] Spoerl E, Mrochen M, Sliney D, Trokel S, Seiler T. Safety of UVA-riboflavin cross-linking of the cornea. Cornea 2007; 26: 385-9.
12. Baiocchi S, Mazzotta C, Cerretani D, Caporossi T, Caporossi A. Corneal cross-linking: riboflavin concentration in corneal stroma exposed with and without epithelium. J Cataract Refract Surg 2009; 35: 893-9.
13. Hayes S, O'Brart DP, Lamdin LS, et al. Effect of complete epithelial debridement before riboflavin-ultraviolet-A corneal collagen crosslinking therapy. J Cataract Refract Surg 2008; 34: 657-61.
14. Kampik D, Ralla B, Keller S, Hirschberg M, Friedl P, Geerling G. Influence of corneal collagen crosslinking with riboflavin and ultraviolet-a irradiation on excimer laser surgery. Invest Ophthalmol Vis Sci 2010; 51: 3929-34.
15. Koller T, Seiler T. Therapeutic cross-linking of the cornea using riboflavin/UVA. Klin Monatsbl Augenheilkd 2007; 224: 700-6.
16. Matthes R. Guidelines on limits of exposure to ultraviolet radiation of wavelengths between 180 nm and 400 nm (incoherent optical radiation). Health Physics 2004; 87: 171-186.
17. Andreassen TT, Simonsen AH, Oxlund H. Biomechanical properties of keratoconus and normal corneas. Exp Eye Res 1980; 31: 435-41.
18. Mazzotta C, Balestrazzi A, Traversi C, et al. Treatment of progressive keratoconus by riboflavin-UVA-induced cross-linking of corneal collagen: ultrastructural analysis by Heidelberg Retinal Tomograph II in vivo confocal microscopy in humans. Cornea 2007; 26: 390-7.
19. Mazzotta C, Traversi C, Baiocchi S, et al. Corneal healing after riboflavin ultraviolet-A collagen cross-linking determined by confocal laser scanning microscopy in vivo: early and late modifications. Am J Ophthalmol 2008; 146: 527-33.
20. McKegney M, Taggart I, Grant MH. The influence of crosslinking agents and diamines on the pore size, morphology and the biological stability of collagen sponges and their effect on cell penetration through the sponge matrix. J Mater Sci Mater Med 2001; 12: 833-44.
21. Köhler A. Gedanken zu einem neuen Beleuchtungsverfahren für mikrophotographische Zwecke. Germany: Zeitschrift für wissenschaftliche Mikroskopie 1893.
22. Semchishen VA, Mrochen M, Seminogov VN, Panchenko VY, Seiler T. Light beam shaping and homogenization (LSBH) by irregular microlens structure for medical applications. SPIE Proc 1998; 3251: 28-33.
23. Bueller M, Spoerl E, Seiler T, Mrochen M. UV collagen cross-linking of the cornea - safety aspects and design of a UV illumination system. Progress in Biomedical optics and Imaging -Proc SPIE 2008; 6844: 1-11
24. Caporossi A, Baiocchi S, Mazzotta C, et al. Parasurgical therapy for keratoconus by riboflavin-ultraviolet type A rays induced cross-linking of cerneal collagen: preliminary refractive results in an Italian study. J Cataract Refract Surg 2006; 32: 837-45.
25. Mazzotta C, Traversi C, Baiocchi S, et al. Conservative treatment of keratoconus by riboflavin-uva-induced cross-linking of corneal collagen: qualitative investigation. Eur J Ophthalmol 2006; 16: 530-5.
26. Wittig-Silva C, Whiting M, Lamoureux E, Lindsay RG, Sullivan LJ, Snibson GR. A randomized controlled trial of corneal collagen cross-linking in progressive keratoconus: preliminary results. J Refract Surg 2008; 24: S720-5.
27. Vinciguerra P, Albè E, Trazza S, et al. Refractive, topographic, tomographic, and aberrometric analysis of keratoconic eyes undergoing corneal cross-linking. Ophthalmology 2009; 116: 369-78.