Insights into the cellular trafficking of splice redirecting oligonucleotides complexed with chemically modified cell-penetrating peptides

Journal of Controlled Release

Volumn 153, Issue 2, 2011, Pages 163-172

  Said Hassane, Fatouma ^a   Abes, Rachida ^a   El Andaloussi, Samir ^b,c   Lehto, Taavi ^c   Sillard, Rannar ^b   Langel, Ülo ^b,c   Lebleu, Bernard ^a  

^a UNIVERSITÉ DE MONTPELLIER   (France)

^b UNIVERSITY OF TARTU   (Estonia)

^c STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

Cell penetrating peptides; Endocytosis; Endosomal escape; Oligonucleotides delivery; Splicing redirection

Indexed keywords

CELL INTERNALIZATION; CELL UPTAKE; CELL-PENETRATING PEPTIDE; CHEMICALLY MODIFIED; ENDOCYTIC ROUTE; ENDOCYTIC VESICLES; ENDOCYTOSIS; ENDOSOMAL ESCAPE; FUNCTIONAL ASSAYS; IN-VITRO; IN-VIVO; INTRACELLULAR VESICLES; MEMBRANE POTENTIALS; MICROMOLAR CONCENTRATION; MURINE MODEL; MUSCULAR DYSTROPHY; NON-COVALENT COMPLEXES;

MOLECULAR BIOLOGY; OLIGONUCLEOTIDES; PEPTIDES; STEARIC ACID;

CELLS;

OLIGONUCLEOTIDE; PEPTIDE DERIVATIVE; SMALL INTERFERING RNA; STEARIC ACID;

ARTICLE; CELL TRANSPORT; CONTROLLED STUDY; DRUG CONJUGATION; DRUG TRANSPORT; ENDOCYTOSIS; FLUORESCENCE ACTIVATED CELL SORTER; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; CELL MEMBRANE PERMEABILITY; CELL-PENETRATING PEPTIDES; CLATHRIN; ENDOCYTOSIS; HELA CELLS; HUMANS; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDES, ANTISENSE; RNA SPLICING;

EID: 79960104928     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2011.04.013     Document Type: Article

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