Steroid-free maintenance of islet allografts using mycophenolate mofetil and cyclosporine in the nonhuman primate

Annals of Transplantation

Volumn 16, Issue 2, 2011, Pages 88-97

  Buss, Jill L ^a   Essig, Elizabeth ^a   Osei, Kwame ^a   Brodsky, Sergey ^a   Hadley, Gregg ^a   Rajab, Amer ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

Cyclosporine; Immunosuppression; Islet transplantation; Mycophenolate mofetil; Non human primate

Indexed keywords

CYCLOSPORIN; CYCLOSPORIN A; GLUCOSE; INSULIN; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; STEROID; THYMOCYTE ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DIET RESTRICTION; FOLLOW UP; GLUCOSE BLOOD LEVEL; GRAFT RECIPIENT; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNOSUPPRESSIVE TREATMENT; INSULIN BLOOD LEVEL; INTRAVENOUS GLUCOSE TOLERANCE TEST; KIDNEY TRANSPLANTATION; MACACA FASCICULARIS; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PANCREAS ISLET TRANSPLANTATION; PANCREAS RESECTION; PORTAL VEIN; PRIMATE; SHORT COURSE THERAPY; TREATMENT DURATION;

EID: 79960091025     PISSN: 14259524     EISSN: None     Source Type: Journal    
DOI: 10.12659/AOT.881870     Document Type: Article

References (21)

1. Atkinson MA, Maclaren NK: The pathogenesis of insulin-dependent diabetes mellitus. N Engl J Med, 1994; 331: 1428-36
2. Scharp DW, Lacy PE, Santiago JV et al: Insulin independence after islet transplantation into type 1 diabetic patient. Diabetes, 1990; 39: 515-18
3. Fiorina P, Shapiro AM, Ricordi C, Secchi A: The clinical impact of islet transplantation. Am. J. Transplant, 2008; 8: 1990-97
4. Boker A, Rothenberg L, Hernandez C et al: Human islet transplantation: update. World J Surg, 2001; 25: 481-86
5. Rajab A, Pelletier RP, Ferguson RM et al: Steroidfree maintenance immunosuppression with rapamune and low-dose neoral in pancreas transplant recipients. Transplantation, 2007; 84: 1131-37
6. Shapiro J: Eighty years after insulin: parallels with modern islet transplantation. CMAJ, 2002; 167: 1398-400
7. Davalli AM, Ogawa Y, Ricordi C et al: A selective decrease in the beta cell mass of human islets transplanted into diabetic nude mice. Transplantation, 1995; 59: 817-20
8. Nir T, Melton DA, Dor Y: Recovery from diabetes in mice by beta cell regeneration. J Clin Invest, 2007; 117: 2553-61
9. Meier-Kriesch HU, Li S et al: Immunosuppression: evolution in practice and trends. Am J Transplant, 2006; 6: 1111-31
10. th ed. Washington, DC: National Academy Press; 1996
11. Linetsky E, Bottino R, Lehmann R et al: Improved human islet isolation using a new enzyme blend, liberase. Diabetes, 1997; 46: 1120-23
12. Ricordi C, Lacy PE, Finke EH et al: Automated method for isolation of human pancreatic islets. Diabetes, 1988; 37: 413-20
13. Latif ZA, Noel J, Alejandro R: A simple method of staining fresh or cultured islets. Transplantation, 1988; 45: 827-30
14. Elkhammas EA, Henry ML, Ferguson RM et al: Simultaneous pancreas-kidney transplantation: overview of the ohio state experience. Yonsei Med J, 2004; 45: 1095-1100
15. Bonnefoy-Berard N, Vincent C, Revillard JP: Antibodies against functional leukocyte surface molecules in polyclonal antilymphocyte and antithymocyte globulins. Transplantation, 1991; 51: 669-73
16. Bellin MD, Kandaswamy R, Parkey J et al: Prolonged insulin independence after islet allotransplants in recipients with type 1 diabetes. Am J Transplant, 2008; 8: 2463-70
17. Menger MD, Vajkoczy P, Leiderer R et al: Influence of experimental hyperglycemia on microvascular blood perfusion of pancreatic islet isografts. J Clin Invest, 1992; 90: 1361-69
18. Malinowski M, Pratschke J, Lock J et al: Effect of tacrolimus dosing on glucose metabolism in an experimental rat model. Ann Transplant, 2010; 15: 60-65
19. Chien YS, Chen YT, Chuang CH et al: Incidence and risk factors of new-onset diabetes mellitus after renal transplantation. Transplant Proc, 2008; 40: 2409-11
20. Luan FL, Steffick DE, Ojo AO: New-onset diabetes mellitus in kidney transplant recipients discharged on steroid-free immunosuppression. Transplantation, 2011; 91: 334-41
21. Matthews DR, Hosker JP, Rudenski AS et al: Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia, 1985; 28: 412-19