Estrogen sulfotransferase is expressed in subcutaneous adipose tissue of obese humans in association with TNF-α and SOCS3

Journal of Clinical Endocrinology and Metabolism

Volumn 96, Issue 7, 2011, Pages

  Ahima, Rexford S ^b   Stanley, Takara L ^a   Khor, Victor K ^b   Zanni, Markella V ^a   Grinspoon, Steven K ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; C REACTIVE PROTEIN; ESTRADIOL; ESTROGEN; ESTROGEN SULFOTRANSFERASE; INTERLEUKIN 6; LEPTIN; MESSENGER RNA; SUPPRESSOR OF CYTOKINE SIGNALING 3; TESTOSTERONE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 2;

ABDOMINAL OBESITY; ADULT; AGE; ARTICLE; BODY COMPOSITION; CLINICAL ARTICLE; COHORT ANALYSIS; CROSS-SECTIONAL STUDY; ESTRADIOL BLOOD LEVEL; ESTROGEN BLOOD LEVEL; FEMALE; GENE EXPRESSION; HORMONE BLOOD LEVEL; HUMAN; HUMAN TISSUE; INFLAMMATION; INSULIN RESISTANCE; INTRAABDOMINAL FAT; MALE; MENOPAUSE; METABOLIC SYNDROME X; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RACE DIFFERENCE; SEX DIFFERENCE; SUBCUTANEOUS FAT; TESTOSTERONE BLOOD LEVEL; TISSUE LEVEL;

ADIPONECTIN; ADULT; BODY COMPOSITION; CROSS-SECTIONAL STUDIES; FEMALE; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN RESISTANCE; LEPTIN; MALE; METABOLIC SYNDROME X; MIDDLE AGED; OBESITY; SUBCUTANEOUS FAT; SULFOTRANSFERASES; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA;

EID: 79960086104     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2010-2903     Document Type: Article

References (19)

1. Foryst-Ludwig A, Kintscher U 2010 Metabolic impact of estrogen signalling through ERα and ERβ. J Steroid Biochem Mol Biol 122:74-81
2. Miki Y, Nakata T, Suzuki T, Darnel AD, Moriya T, Kaneko C, Hidaka K, Shiotsu Y, Kusaka H, Sasano H 2002 Systemic distribution of steroid sulfatase and estrogen sulfotransferase in human adult and fetal tissues. J Clin Endocrinol Metab 87:5760-5768 (Pubitemid 36034387)
3. Tong MH, Song WC 2002 Estrogen sulfotransferase: discrete and androgen-dependent expression in the male reproductive tract and demonstration of an in vivo function in the mouse epididymis. Endocrinology 143:3144-3151 (Pubitemid 34809887)
4. Suzuki T, Miki Y, Nakata T, Shiotsu Y, Akinaga S, Inoue K, Ishida T, Kimura M, Moriya T, Sasano H 2003 Steroid sulfatase and estrogen sulfotransferase in normal human tissue and breast carcinoma. J Steroid Biochem Mol Biol 86:449-454 (Pubitemid 37412583)
5. Utsunomiya H, Ito K, Suzuki T, Kitamura T, Kaneko C, Nakata T, Niikura H, Okamura K, Yaegashi N, Sasano H 2004 Steroid sulfatase and estrogen sulfotransferase in human endometrial carcinoma. Clin Cancer Res 10:5850-5856 (Pubitemid 39180965)
6. Sato R, Suzuki T, Katayose Y, Miura K, Shiiba K, Tateno H, Miki Y, Akahira J, Kamogawa Y, Nagasaki S, Yamamoto K, Ii T, Egawa S, Evans DB, Unno M, Sasano H 2009 Steroid sulfatase and estrogen sulfotransferase in colon carcinoma: regulators of intratumoral estrogen concentrations and potent prognostic factors. Cancer Res 69:914-922
7. Khor VK, Tong MH, Qian Y, Song WC 2008 Gender-specific expression and mechanism of regulation of estrogen sulfotransferase in adipose tissues of the mouse. Endocrinology 149:5440-5448
8. Khor VK, Dhir R, Yin X, Ahima RS, Song WC 2010 Estrogen sulfotransferase regulates body fat and glucose homeostasis in female mice. Am J Physiol Endocrinol Metab 299:E657-E664
9. Stanley TL, Zanni MV, Johnsen S, Rasheed S, Makimura H, Lee H, Khor VK, Ahima RS, Grinspoon SK 2011 TNF-α antagonism with etanercept decreases glucose and increases the proportion of high molecular weight adiponectin in obese subjects with features of the metabolic syndrome. J Clin Endocrinol Metab 96:E146-E150
10. McGillicuddy FC, Chiquoine EH, Hinkle CC, Kim RJ, Shah R, Roche HM, Smyth EM, Reilly MP 2009 Interferon γ attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway. J Biol Chem 284:31936-31944
11. Mehta NN, McGillicuddy FC, Anderson PD, Hinkle CC, Shah R, Pruscino L, Tabita-Martinez J, Sellers KF, Rickels MR, Reilly MP 2010 Experimental endotoxemia induces adipose inflammation and insulin resistance in humans. Diabetes 59:172-181
12. World Health Organization 1999 Definitions, diagnosis, and classification of diabetes mellitus and its complications: report of a WHO consultation. Part 1. Diagnosis and classification of diabetes mellitus. Geneva: World Health Organization
13. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC 1985 Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412-419 (Pubitemid 15018832)
14. Dieudonné MN, Leneveu MC, Giudicelli Y, Pecquery R 2004 Evidence for functional estrogen receptors α and β in human adipose cells: regional specificities and regulation by estrogens. Am J Physiol Cell Physiol 286:C655-C661 (Pubitemid 38292672)
15. D'Eon TM, Souza SC, Aronovitz M, Obin MS, Fried SK, Greenberg AS 2005 Estrogen regulation of adiposity and fuel partitioning. Evidence of genomic and non-genomic regulation of lipogenic and oxidative pathways. J Biol Chem 280:35983-35991 (Pubitemid 41633867)
16. Nagira K, Sasaoka T, Wada T, Fukui K, Ikubo M, Hori S, Tsuneki H, Saito S, Kobayashi M 2006 Altered subcellular distribution of estrogen receptor α is implicated in estradiol-induced dual regulation of insulin signaling in 3T3-L1 adipocytes. Endocrinology 147:1020-1028 (Pubitemid 43113022)
17. Bryzgalova G, Lundholm L, Portwood N, Gustafsson JA, Khan A, Efendic S, Dahlman-Wright K 2008 Mechanisms of antidiabetogenic and body weight-lowering effects of estrogen in high-fat diet-fed mice. Am J Physiol Endocrinol Metab 295:E904-E912
18. Leiter EH, Chapman HD 1994 Obesity-induced diabetes (diabesity) in C57BL/KsJ mice produces aberrant trans-regulation of sex steroid sulfotransferase genes. J Clin Invest 93:2007-2013 (Pubitemid 24143080)
19. Nakamura Y, Miki Y, Suzuki T, Nakata T, Darnel AD, Moriya T, Tazawa C, Saito H, Ishibashi T, Takahashi S, Yamada S, Sasano H 2003 Steroid sulfatase and estrogen sulfotransferase in the atherosclerotic human aorta. Am J Pathol 163:1329-1339 (Pubitemid 37175082)