Bioequivalence evaluation of a triamterene-hydrochlorothiazide generic product: A new bioequivalence index for fixed-dose combinations

Regulatory Toxicology and Pharmacology

Volumn 59, Issue 1, 2011, Pages 149-156

  Hamidi, Mehrdad ^a,b   Shahbazi, Mohammad Ali ^b   Azimi, Kourosh ^b  

^a ZANJAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Bioequivalence; Fixed dose combinations; HPLC UV; Hydrochlorothiazide; Liquid liquid extraction; Triamterene

Indexed keywords

HYDROCHLOROTHIAZIDE PLUS TRIAMTERENE; ANTIHYPERTENSIVE AGENT; GENERIC DRUG; HYDROCHLOROTHIAZIDE; TRIAMTERENE;

ADULT; AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG ELIMINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE; TIME TO MAXIMUM PLASMA CONCENTRATION; ULTRAVIOLET RADIATION; BIOAVAILABILITY; BLOOD; CHEMISTRY; CLINICAL TRIAL; CONFIDENCE INTERVAL; CONTROLLED CLINICAL TRIAL; DRUG COMBINATION; IRAN; METHODOLOGY; ORAL DRUG ADMINISTRATION; PHARMACOKINETICS; REFERENCE VALUE; SENSITIVITY AND SPECIFICITY;

ADMINISTRATION, ORAL; ADULT; ANTIHYPERTENSIVE AGENTS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CONFIDENCE INTERVALS; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; DRUG COMBINATIONS; DRUGS, GENERIC; HUMANS; HYDROCHLOROTHIAZIDE; IRAN; MALE; REFERENCE VALUES; SENSITIVITY AND SPECIFICITY; THERAPEUTIC EQUIVALENCY; TRIAMTERENE;

EID: 79960080761     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2010.12.006     Document Type: Article

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