Prognostic significance of mean platelet volume on admission in an unselected cohort of patients with non ST-segment elevation acute coronary syndrome

Thrombosis and Haemostasis

Volumn 106, Issue 1, 2011, Pages 132-140

  Taglieri, Nevio ^a   Saia, Francesco ^a   Rapezzi, Claudio ^a   Marrozzini, Cinzia ^a   Reggiani, Maria Letizia Bacchi ^a   Palmerini, Tullio ^a   Ortolani, Paolo ^a   Melandri, Giovanni ^a   Rosmini, Stefania ^a   Cinti, Laura ^a   Alessi, Laura ^a   Vagnarelli, Fabio ^a   Villani, Caterina ^a   Branzi, Angelo ^a   Marzocchi, Antonio ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Acute myocardial infarction; Platelet physiology; Risk factors

Indexed keywords

ACETYLSALICYLIC ACID; ANTITHROMBOCYTIC AGENT; CLOPIDOGREL; CREATININE; THIENOPYRIDINE DERIVATIVE; TICLOPIDINE;

ACUTE CORONARY SYNDROME; AGE; AGED; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; CORONARY STENT; CREATININE BLOOD LEVEL; DRUG ELUTING STENT; FEMALE; GENDER; HEART DEATH; HEART MUSCLE REVASCULARIZATION; HEART REINFARCTION; HIGH RISK PATIENT; HUMAN; MAJOR CLINICAL STUDY; MALE; NON ST SEGMENT ELEVATION ACUTE CORONARY SYNDROME; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; SMOKING; THROMBOCYTE COUNT; THROMBOCYTE VOLUME;

ACUTE CORONARY SYNDROME; ACUTE DISEASE; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; COHORT STUDIES; DIAGNOSTIC TESTS, ROUTINE; ELECTROCARDIOGRAPHY; ERYTHROCYTE INDICES; FEMALE; HUMANS; ITALY; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; PLATELET COUNT; PREDICTIVE VALUE OF TESTS; PROGNOSIS; RISK; SURVIVAL ANALYSIS;

EID: 79960080757     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH10-12-0821     Document Type: Article

References (36)

1. Davi G, Patrono C. Platelet activation and atherothrombosis. N Engl J Med 2007; 357: 2482-2494.
2. Angiolillo DJ, et al. Impact of platelet reactivity on cardiovascular outcomes in patients with type 2 diabetes mellitus and coronary artery disease. J Am Coll Cardiol 2007; 50: 1541-1547.
3. Breet NJ, et al. Comparison of platelet function tests in predicting clinical outcome in patients undergoing coronary stent implantation. J Am Med Assoc 2010; 303: 754-762.
4. Frere C, et al. ADP-induced platelet aggregation and platelet reactivity index VASP are good predictive markers for clinical outcomes in non-ST elevation acute coronary syndrome. Thromb Haemost 2007; 98: 838-843.
5. Gurbel PA, et al. Platelet reactivity in patients and recurrent events post-stenting: results of the PREPARE POST-STENTING Study. J Am Coll Cardiol 2005; 46: 1820-1826.
6. Boos CJ, Lip GY. Assessment of mean platelet volume in coronary artery disease - what does it mean? Thromb Res 2007; 120: 11-13.
7. Bath PM, Butterworth RJ. Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibrinolysis 1996; 7: 157-161.
8. Kamath S, et al. Platelet activation: assessment and quantification. Eur Heart J 2001; 22: 1561-1571.
9. Karpatkin S. Heterogeneity of human platelets. VI. Correlation of platelet function with platelet volume. Blood 1978; 51: 307-316.
10. Martin JF, et al. The biological significance of platelet volume: its relationship to bleeding time, platelet thromboxane B2 production and megakaryocyte nuclear DNA concentration. Thromb Res 1983; 32: 443-460.
11. Elsenberg EH, et al. The influence of clinical characteristics, laboratory and inflammatory markers on 'high on-treatment platelet reactivity' as measured with different platelet function tests. Thromb Haemost 2009; 102: 719-727.
12. Martin JF, et al. Influence of platelet size on outcome after myocardial infarction. Lancet 1991; 338: 1409-1411.
13. Pabon Osuna P, et al. The effect of the mean platelet volume on the short-term prognosis of acute myocardial infarct. Rev Esp Cardiol 1998; 51: 816-822.
14. Huczek Z, et al. Mean platelet volume on admission predicts impaired reperfusion and long-term mortality in acute myocardial infarction treated with primary percutaneous coronary intervention. J Am Coll Cardiol 2005; 46: 284-290.
15. Estevez-Loureiro R, et al. Mean platelet volume predicts patency of the infarct-related artery before mechanical reperfusion and short-term mortality in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Thromb Res 2009; 124: 536-540.
16. Kushner FG, et al. 2009 Focused Updates: ACC/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction (updating the 2004 Guideline and 2007 Focused Update) and ACC/AHA/SCAI Guidelines on Percutaneous Coronary Intervention (updating the 2005 Guideline and 2007 Focused Update): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation 2009; 120: 2271-2306.
17. Chan MY, et al. Long-term mortality of patients undergoing cardiac catheterization for ST-elevation and non-ST-elevation myocardial infarction. Circulation 2009; 119: 3110-3117.
18. Cutlip DE, et al. Clinical end points in coronary stent trials: a case for standardized definitions. Circulation 2007; 115: 2344-2351.
19. Goncalves SC, et al. Usefulness of Mean Platelet Volume as a Biomarker for Long- Term Outcomes After Percutaneous Coronary Intervention. Am J Cardiol 2011; 107: 204-209.
20. Guthikonda S, et al. Role of reticulated platelets and platelet size heterogeneity on platelet activity after dual antiplatelet therapy with aspirin and clopidogrel in patients with stable coronary artery disease. J Am Coll Cardiol 2008; 52: 743-749.
21. Cesari F, et al. Relationship between high platelet turnover and platelet function in high-risk patients with coronary artery disease on dual antiplatelet therapy. Thromb Haemost 2008; 99: 930-935.
22. Huczek Z, et al. Baseline platelet size is increased in patients with acute coronary syndromes developing early stent thrombosis and predicts future residual platelet reactivity. A case-control study. Thromb Res 2010; 125: 406-412.
23. Martin JF, Penington DG. The relationship between the age and density of circulating 51-Cr labelled platelets in the sub-human primate. Thromb Res 1983; 30: 157-164.
24. Hoffman R. Regulation of megakaryocytopoiesis. Blood 1989; 74: 1196-1212.
25. Kaushansky K. Thrombopoietin: the primary regulator of megakaryocyte and platelet production. Thromb Haemost 1995; 74: 521-525.
26. Erne P, et al. Mean platelet volume and size distribution and their sensitivity to agonists in patients with coronary artery disease and congestive heart failure. Thromb Haemost 1988; 59: 259-263.
27. Brown AS, et al. Megakaryocyte ploidy and platelet changes in human diabetes and atherosclerosis. Arterioscler Thromb Vasc Biol 1997; 17: 802-807.
28. Pizzulli L, et al. Changes in platelet size and count in unstable angina compared to stable angina or non-cardiac chest pain. Eur Heart J 1998; 19: 80-84.
29. Kario K, et al. Cigarette smoking increases the mean platelet volume in elderly patients with risk factors for atherosclerosis. Clin Lab Haematol 1992; 14: 281-287.
30. Nadar S, et al. Platelet morphology and plasma indices of platelet activation in essential hypertension: effects of amlodipine-based antihypertensive therapy. Ann Med 2004; 36: 552-557.
31. Papanas N, et al. Mean platelet volume in patients with type 2 diabetes mellitus. Platelets 2004; 15: 475-478.
32. Pathansali R, et al. Altered megakaryocyte-platelet haemostatic axis in hypercholesterolaemia. Platelets 2001; 12: 292-297.
33. Klovaite J, et al. High platelet volume and increased risk of myocardial infarction: 39,531 participants from the general population. J Thromb Haemost 2011; 9: 49-56.
34. Chung I, Lip GY. Platelets and heart failure. Eur Heart J 2006; 27: 2623-2631.
35. Endler G, et al. Mean platelet volume is an independent risk factor for myocardial infarction but not for coronary artery disease. Br J Haematol 2002; 117: 399-404.
36. De Luca G, et al. Mean platelet volume and the extent of coronary artery disease: results from a large prospective study. Atherosclerosis 2009; 206: 292-297.