Characterization of helper-dependent adenoviral vectors

Cold Spring Harbor Protocols

Volumn 6, Issue 7, 2011, Pages 867-870

  Palmer, Donna J ^a   Ng, Philip ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; ENDOTOXIN; HELPER DEPENDENT ADENOVIRUS VECTOR; UNCLASSIFIED DRUG;

ARTICLE; CLINICAL PROTOCOL; GENOMICS; INSTRUMENT STERILIZATION; MOLECULAR BIOLOGY; VIRAL CONTAMINATION; VIRUS INFECTION; VIRUS PARTICLE; VIRUS TITRATION; ADENOVIRUS; GENE VECTOR; GENETICS; GROWTH, DEVELOPMENT AND AGING; HELPER VIRUS; ISOLATION AND PURIFICATION; METHODOLOGY; VIRUS CULTURE; VIRUS LOAD;

ADENOVIRIDAE; ENDOTOXINS; GENETIC VECTORS; HELPER VIRUSES; VIRAL LOAD; VIRUS CULTIVATION;

EID: 79960035907     PISSN: None     EISSN: 15596095     Source Type: Journal    
DOI: 10.1101/pdb.prot5628     Document Type: Article

References (11)

1. Brunetti-Pierri N, Palmer DJ, Beaudet AL, Carey D, Finegold M, Ng P. 2004. Acute toxicity following high-dose systemic injection of helper-dependent adenoviral vectors into non human primates. Hum Gene Ther 15: 35-46.
2. Brunetti-Pierri N, Palmer DJ, Mane V, Finegold M, Beaudet AL, Ng P. 2005. Increased hepatic transduction with reduced systemic dissemination and proinflammatory cytokines following hydrodynamic injection of helper-dependent adenoviral vectors. Mol Ther 12: 99-106.
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4. Muruve DA, Cotter MJ, Zaiss AK, White LR, Liu Q, Chan T, Clark SA, Ross PJ, Meulenbroek RA, Maelandsmo GM, Parks RJ. 2004. Helperdependent adenovirus vectors elicit intact innate but attenuated adaptive host immune responses in vivo. J Virol 78: 5966-5972.
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7. Palmer DJ, Ng P. 2003. Improved system for helper-dependent adenoviral vector production. Mol Ther 8: 846-852.
8. Palmer DJ, Ng P. 2004. Physical and infectious titers of helperdependent adenoviral vectors: A method of direct comparison to the adenovirus reference material. Mol Ther 10: 792-798.
9. Palmer DJ, Ng P. 2005. Helper-dependent adenoviral vectors for gene therapy. Hum Gene Ther 16: 1-16.
10. Palmer DJ, Ng P. 2011. Rescue, amplification, and large-scale production of helper-dependent adenoviral vectors. Cold Spring Harb Protoc doi: 10.1101/pdb.prot5627.
11. Simek S, Byrnes A, Bauer S. 2002. FDA perspective on the use of the adenovirus reference material. BioProcessing 1: 40-42.