Understanding cargo specificity in intraflagellar transport

EMBO Journal

Volumn 30, Issue 13, 2011, Pages 2518-2519

  Parker, David S ^a   Katsanis, Nicholas ^a  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CARRIER PROTEIN; CELL PROTEIN; INVERSIN; PROTEIN B9D2; PROTEIN FLEER; PROTEIN IFT88; UNCLASSIFIED DRUG;

ARTICLE; AXONEME; BIOGENESIS; CELL ORGANELLE; CELL SPECIFICITY; CELL TRANSPORT; CELL TYPE; CILIARY MOTILITY; FLAGELLUM; INTRAFLAGELLAR TRANSPORT; KINETOSOME; MICROTUBULE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; ZEBRA FISH;

ANIMALS; AXONEME; BIOLOGICAL TRANSPORT; COMPREHENSION; FLAGELLA; MODELS, BIOLOGICAL; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY; ZEBRAFISH;

EID: 79960033848     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2011.196     Document Type: Article

References (13)

1. Badano JL, Mitsuma N, Beales PL, Katsanis N (2006) The ciliopa-thies: an emerging class of human genetic disorders. Annu Rev Genomics Hum Genet 7: 125-148 (Pubitemid 44627925)
2. Das G, Jenny A, Klein TJ, Eaton S, Mlodzik M (2004) Diego interacts with Prickle and Strabismus/Van Gogh to localize planar cell polarity complexes. Development 131: 4467-4476 (Pubitemid 39409688)
3. Gerdes JM, Davis EE, Katsanis N (2009) The vertebrate primary cilium in development, homeostasis, and disease. Cell 137: 32-45
4. Otto EA, Schermer B, Obara T, O'Toole JF, Hiller KS, Mueller AM, Ruf RG, Hoefele J, Beekmann F, Landau D, Foreman JW, Goodship JA, Strachan T, Kispert A, Wolf MT, Gagnadoux MF, Nivet H, Antignac C, Walz G, Drummond IA et al (2003) Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination. Nat Genet 34: 413-420 (Pubitemid 36935334)
5. Pedersen LB, Rosenbaum JL (2008) Intraflagellar transport (IFT) role in ciliary assembly, resorption and signalling. Curr Top Dev Biol 85: 23-61
6. Phillips CL, Miller KJ, Filson AJ, Nurnberger J, Clendenon JL, Cook GW, Dunn KW, Overbeek PA, Gattone II VH, Bacallao RL (2004) Renal cysts of inv/inv mice resemble early infantile nephro-nophthisis. J Am Soc Nephrol 15: 1744-1755 (Pubitemid 38822053)
7. Ross AJ, May-Simera H, Eichers ER, Kai M, Hill J, Jagger DJ, Leitch CC, Chapple JP, Munro PM, Fisher S, Tan PL, Phillips HM, Leroux MR, Henderson DJ, Murdoch JN, Copp AJ, Eliot MM, Lupski JR, Kemp DT, Dollfus H et al (2005) Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates. Nat Genet 37: 1135-1140 (Pubitemid 41486669)
8. Silverman MA, Leroux MR (2009) Intraflagellar transport and the generation of dynamic, structurally and functionally diverse cilia. Trends Cell Biol 19: 306-316
9. Simons M, Gloy J, Ganner A, Bullerkotte A, Bashkurov M, Kronig C, Schermer B, Benzing T, Cabello OA, Jenny A, Mlodzik M, Polok B, Driever W, Obara T, Walz G (2005) Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways. Nat Genet 37: 537-543 (Pubitemid 40617284)
10. Town T, Breunig JJ, Sarkisian MR, Spilianakis C, Ayoub AE, Liu X, Ferrandino AF, Gallagher AR, Li MO, Rakic P, Flavell RA (2008) The stumpy gene is required for mammalian ciliogenesis. Proc Natl Acad Sci USA 105 : 2853-2858 (Pubitemid 351723633)
11. Watanabe D, Saijoh Y, Nonaka S, Sasaki G, Ikawa Y, Yokoyama T, Hamada H (2003) The left-right determinant inversin is a component of node monocilia and other 9+0 cilia. Development 130: 1725-1734 (Pubitemid 36575901)
12. Williams CL, Winkelbauer ME, Schafer JC, Michaud EJ, Yoder BK (2008) Functional redundancy of the B9 proteins and nephro-cystins in Caenorhabditis elegans ciliogenesis. Mol Biol Cell 19: 2154-2168
13. Zhao C, Malicki J (2011) Nephrocystins and MKS proteins interact with IFT particle and facilitate transport of selected ciliary cargos. EMBO J 30: 2532-2544