-
1
-
-
0032999345
-
Mitogen-activated protein kinase kinase kinase 1 activates androgen receptor-dependent transcription and apoptosis in prostate cancer
-
Abreu-Martin MT, Chari A, Palladino AA, Craft NA, and Sawyers CL. Mitogen-activated protein kinase kinase ki-nase 1 activates androgen receptor-dependent transcription and apoptosis in prostate cancer. Mol Cell Biol 19: 5143-5154, 1999. (Pubitemid 29289552)
-
(1999)
Molecular and Cellular Biology
, vol.19
, Issue.7
, pp. 5143-5154
-
-
Abreu-Martin, M.T.1
Chari, A.2
Palladino, A.A.3
Craft, N.A.4
Sawyers, C.L.5
-
2
-
-
0033622470
-
Essential role of p38α MAP kinase in placental but not embryonic cardiovascular development
-
Adams RH, Porras A, Alonso G, Jones M, Vintersten K, Panelli S, Valladares A, Perez L, Klein R, and Nebreda AR. Essential role of p38α MAP kinase in placental but not embryonic cardiovascular development. Mol Cell 6: 109-116, 2000.
-
(2000)
Mol Cell
, vol.6
, pp. 109-116
-
-
Adams, R.H.1
Porras, A.2
Alonso, G.3
Jones, M.4
Vintersten, K.5
Panelli, S.6
Valladares, A.7
Perez, L.8
Klein, R.9
Nebreda, A.R.10
-
3
-
-
34248570795
-
Ubiquitin-mediated acti-vation of TAK1 and IKK
-
Adhikari A, Xu M, and Chen ZJ. Ubiquitin-mediated acti-vation of TAK1 and IKK. Oncogene 26: 3214-3226, 2007.
-
(2007)
Oncogene
, vol.26
, pp. 3214-3226
-
-
Adhikari, A.1
Xu, M.2
Chen, Z.J.3
-
4
-
-
0034610981
-
Deficiency of the stress kinase p38α results in embryonic lethality: Characterization of the kinase depen-dence of stress responses of enzyme-deficient embryonic stem cells
-
Allen M, Svensson L, Roach M, Hambor J, McNeish J, and Gabel CA. Deficiency of the stress kinase p38α results in embryonic lethality: characterization of the kinase depen-dence of stress responses of enzyme-deficient embryonic stem cells. J Exp Med 191: 859-870, 2000.
-
(2000)
J Exp Med
, vol.191
, pp. 859-870
-
-
Allen, M.1
Svensson, L.2
Roach, M.3
Hambor, J.4
McNeish, J.5
Gabel, C.A.6
-
5
-
-
49549088134
-
CEP-1347 re-duces mutant huntingtin-associated neurotoxicity and re-stores BDNF levels in R6/2 mice
-
Apostol BL, Simmons DA, Zuccato C, Illes K, Pallos J, Casale M, Conforti P, Ramos C, Roarke M, Kathuria S, Cattaneo E, Marsh JL, and Thompson LM. CEP-1347 re-duces mutant huntingtin-associated neurotoxicity and re-stores BDNF levels in R6/2 mice. Mol Cell Neurosci 39: 8-20, 2008.
-
(2008)
Mol Cell Neurosci
, vol.39
, pp. 8-20
-
-
Apostol, B.L.1
Simmons, D.A.2
Zuccato, C.3
Illes, K.4
Pallos, J.5
Casale, M.6
Conforti, P.7
Ramos, C.8
Roarke, M.9
Kathuria, S.10
Cattaneo, E.11
Marsh, J.L.12
Thompson, L.M.13
-
7
-
-
55549130760
-
Formation of stress granules inhibits apoptosis by suppressing stress-responsive MAPK pathways
-
Arimoto K, Fukuda H, Imajoh-Ohmi S, Saito H, and Ta-kekawa M. Formation of stress granules inhibits apoptosis by suppressing stress-responsive MAPK pathways. Nat Cell Biol 10: 1324-1332, 2008.
-
(2008)
Nat Cell Biol
, vol.10
, pp. 1324-1332
-
-
Arimoto, K.1
Fukuda, H.2
Imajoh-Ohmi, S.3
Saito, H.4
Ta-Kekawa, M.5
-
8
-
-
1142309730
-
Protein kinase activation and myocardial ischemia/reperfusion injury
-
DOI 10.1016/j.cardiores.2003.09.031
-
Armstrong SC. Protein kinase activation and myocardial is-chemia/reperfusion injury. Cardiovasc Res 61: 427-436, 2004. (Pubitemid 38210149)
-
(2004)
Cardiovascular Research
, vol.61
, Issue.3
, pp. 427-436
-
-
Armstrong, S.C.1
-
9
-
-
33847082012
-
Sustained JNK signaling by proteolytically processed HPK1 mediates IL-3 independent survival dur-ing monocytic differentiation
-
Arnold R, Frey CR, Muller W, Brenner D, Krammer PH, and Kiefer F. Sustained JNK signaling by proteolytically processed HPK1 mediates IL-3 independent survival dur-ing monocytic differentiation. Cell Death Differ 14: 568-575, 2007.
-
(2007)
Cell Death Differ
, vol.14
, pp. 568-575
-
-
Arnold, R.1
Frey, C.R.2
Muller, W.3
Brenner, D.4
Krammer, P.H.5
Kiefer, F.6
-
10
-
-
0035805496
-
Caspase-mediated cleavage of hematopoietic progenitor kinase 1 (HPK1) converts an activator of NF?B into an in-hibitor of NF?B
-
Arnold R, Liou J, Drexler HC, Weiss A, and Kiefer F. Caspase-mediated cleavage of hematopoietic progenitor kinase 1 (HPK1) converts an activator of NF?B into an in-hibitor of NF?B. J Biol Chem 276: 14675-14684, 2001.
-
(2001)
J Biol Chem
, vol.276
, pp. 14675-14684
-
-
Arnold, R.1
Liou, J.2
Drexler, H.C.3
Weiss, A.4
Kiefer, F.5
-
11
-
-
41149153993
-
Protein kinase D in the cardiovascular system: Emerging roles in health and disease
-
DOI 10.1161/CIRCRESAHA.107.168211, PII 0000301220080201000008
-
Avkiran M, Rowland AJ, Cuello F, and Haworth RS. Pro-tein kinase D in the cardiovascular system: emerging roles in health and disease. Circ Res 102: 157-163, 2008. (Pubitemid 351651119)
-
(2008)
Circulation Research
, vol.102
, Issue.2
, pp. 157-163
-
-
Avkiran, M.1
Rowland, A.J.2
Cuello, F.3
Haworth, R.S.4
-
12
-
-
0141750434
-
Identification of modulators of TRAIL-induced apoptosis via RNAi-based phenotypic screening
-
DOI 10.1016/S1097-2765(03)00348-4
-
Aza-Blanc P, Cooper CL, Wagner K, Batalov S, Deveraux QL, and Cooke MP. Identification of modulators of TRAIL-induced apoptosis via RNAi-based phenotypic screening. Mol Cell 12: 627-637, 2003. (Pubitemid 37222485)
-
(2003)
Molecular Cell
, vol.12
, Issue.3
, pp. 627-637
-
-
Aza-Blanc, P.1
Cooper, C.L.2
Wagner, K.3
Batalov, S.4
Deveraux, Q.L.5
Cooke, M.P.6
-
13
-
-
0346462998
-
P21-activated kinase-1 signaling mediates cyclin D1 expression in mammary epithelial and cancer cells
-
DOI 10.1074/jbc.M309937200
-
Balasenthil S, Sahin AA, Barnes CJ, Wang RA, Pestell RG, Vadlamudi RK, and Kumar R p21-activated kinase-1 sig-naling mediates cyclin D1 expression in mammary epithe-lial and cancer cells. J Biol Chem 279: 1422-1428, 2004. (Pubitemid 38082670)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.2
, pp. 1422-1428
-
-
Balasenthil, S.1
Sahin, A.A.2
Barnes, C.J.3
Wang, R.-A.4
Pestell, R.G.5
Vadlamudi, R.K.6
Kumar, R.7
-
14
-
-
27944461325
-
Generation and characterization of p38β (MAPK11) gene-targeted mice
-
DOI 10.1128/MCB.25.23.10454-10464.2005
-
Beardmore VA, Hinton HJ, Eftychi C, Apostolaki M, Ar-maka M, Darragh J, McIlrath J, Carr JM, Armit LJ, Clacher C, Malone L, Kollias G, and Arthur JS. Generation and characterization of p38?S (MAPK11) gene-targeted mice. Mol Cell Biol 25: 10454-10464, 2005. (Pubitemid 41681967)
-
(2005)
Molecular and Cellular Biology
, vol.25
, Issue.23
, pp. 10454-10464
-
-
Beardmore, V.A.1
Hinton, H.J.2
Eftychi, C.3
Apostolaki, M.4
Armaka, M.5
Darragh, J.6
McIlrath, J.7
Carr, J.M.8
Armit, L.J.9
Clacher, C.10
Malone, L.11
Kollias, G.12
Arthur, J.S.C.13
-
15
-
-
0032979438
-
Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation
-
DOI 10.1038/6854
-
Behrens A, Sibilia M, and Wagner EF. Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation. Nat Genet 21: 326-329,1999. (Pubitemid 29124945)
-
(1999)
Nature Genetics
, vol.21
, Issue.3
, pp. 326-329
-
-
Behrens, A.1
Sibilia, M.2
Wagner, E.F.3
-
16
-
-
33746359639
-
The death-associated protein kinases: Structure, function, and beyond
-
DOI 10.1146/annurev.biochem.75.103004.142615
-
Bialik S and Kimchi A. The death-associated protein ki-nases: structure, function, and beyond. Annu Rev Biochem 75: 189-210, 2006. (Pubitemid 44118031)
-
(2006)
Annual Review of Biochemistry
, vol.75
, pp. 189-210
-
-
Bialik, S.1
Kimchi, A.2
-
17
-
-
0037179867
-
MEKK1-induced apoptosis requires TRAIL death receptor activation and is inhibited by AKT/PKB through inhibition of MEKK1 cleavage
-
DOI 10.1038/sj.onc.1205819
-
Bild AH, Mendoza FJ, Gibson EM, Huang M, Villanueva J, Garrington TP, Jove R, Johnson GL, and Gibson SB. MEKK1-induced apoptosis requires TRAIL death receptor activation and is inhibited by AKT/PKB through inhibition of MEKK1 cleavage. Oncogene 21: 6649-6656, 2002. (Pubitemid 35177044)
-
(2002)
Oncogene
, vol.21
, Issue.43
, pp. 6649-6656
-
-
Bild, A.H.1
Mendoza, F.J.2
Gibson, E.M.3
Huang, M.4
Villanueva, J.5
Garrington, T.P.6
Jove, R.7
Johnson, G.L.8
Gibson, S.B.9
-
18
-
-
57649130592
-
Protein kinase D is a positive regulator of Bit1 apoptotic function
-
Biliran H, Jan Y, Chen R, Pasquale EB, and Ruoslahti E. Protein kinase D is a positive regulator of Bit1 apoptotic function. J Biol Chem 283: 28029-28037, 2008.
-
(2008)
J Biol Chem
, vol.283
, pp. 28029-28037
-
-
Biliran, H.1
Jan, Y.2
Chen, R.3
Pasquale, E.B.4
Ruoslahti, E.5
-
19
-
-
42449148304
-
Mice lacking both mixed-lineage kinase genes Mlk1 and Mlk2 retain a wild type phenotype
-
Bisson N, Tremblay M, Robinson F, Kaplan DR, Trusko SP, and Moss T. Mice lacking both mixed-lineage kinase genes Mlk1 and Mlk2 retain a wild type phenotype. Cell Cycle 7: 909-916, 2008. (Pubitemid 351573786)
-
(2008)
Cell Cycle
, vol.7
, Issue.7
, pp. 909-916
-
-
Bisson, N.1
Tremblay, M.2
Robinson, F.3
Kaplan, D.R.4
Trusko, S.P.5
Moss, T.6
-
20
-
-
0029913172
-
Taxol-induced apoptosis and phosphoryla-tion of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway
-
Blagosklonny MV, Schulte T, Nguyen P, Trepel J, and Neckers LM. Taxol-induced apoptosis and phosphoryla-tion of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway. Cancer Res 56: 1851-1854, 1996.
-
(1996)
Cancer Res
, vol.56
, pp. 1851-1854
-
-
Blagosklonny, M.V.1
Schulte, T.2
Nguyen, P.3
Trepel, J.4
Neckers, L.M.5
-
21
-
-
0036132855
-
Tyrosine phosphorylation of protein kinase Cδ is essential for its apoptotic effect in response to etoposide
-
DOI 10.1128/MCB.22.1.182-195.2002
-
Blass M, Kronfeld I, Kazimirsky G, Blumberg PM, and Brodie C. Tyrosine phosphorylation of protein kinase Cδ is essential for its apoptotic effect in response to etoposide. Mol Cell Biol 22: 182-195, 2002 (Pubitemid 33144267)
-
(2002)
Molecular and Cellular Biology
, vol.22
, Issue.1
, pp. 182-195
-
-
Blass, M.1
Kronfeld, I.2
Kazimirsky, G.3
Blumberg, P.M.4
Brodie, C.5
-
22
-
-
38149078120
-
Inhibitors of c-Jun N-terminal kinases: JuNK no more?
-
Bogoyevitch MA and Arthur PG. Inhibitors of c-Jun N-terminal kinases: JuNK no more? Biochim Biophys Acta 1784: 76-93, 2008.
-
(2008)
Biochim Biophys Acta
, vol.1784
, pp. 76-93
-
-
Bogoyevitch, M.A.1
Arthur, P.G.2
-
23
-
-
0742306509
-
Improvement of embryonic dopaminergic neurone survival in culture and after grafting into the striatum of hemiparkinsonian rats by CEP-1347
-
DOI 10.1046/j.1471-4159.2003.02198.x
-
Boll JB, Geist MA, Kaminski Schierle GS, Petersen K, Leist M, and Vaudano E. Improvement of embryonic dopami-nergic neurone survival in culture and after grafting into the striatum of hemiparkinsonian rats by CEP-1347 J Neurochem 88: 698-707, 2004. (Pubitemid 38145557)
-
(2004)
Journal of Neurochemistry
, vol.88
, Issue.3
, pp. 698-707
-
-
Boll, J.B.1
Geist, M.A.2
Kaminski Schierle, G.S.3
Petersen, K.4
Leist, M.5
Vaudano, E.6
-
24
-
-
0035019371
-
CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Aβ-induced cortical neuron apoptosis
-
DOI 10.1046/j.1471-4159.2001.00294.x
-
Bozyczko-Coyne D, O'Kane TM, Wu ZL, Dobrzanski P, Murthy S, Vaught JL, and Scott RW. CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Aß-induced cortical neuron apoptosis. J Neurochem 77: 849-863, 2001. (Pubitemid 32466782)
-
(2001)
Journal of Neurochemistry
, vol.77
, Issue.3
, pp. 849-863
-
-
Bozyczko-Coyne, D.1
O'Kane, T.M.2
Wu, Z.-L.3
Dobrzanski, P.4
Murthy, S.5
Vaught, J.L.6
Scott, R.W.7
-
25
-
-
0041660960
-
Mechanism of p38 MAP kinase activation in vivo
-
DOI 10.1101/gad.1107303
-
Brancho D, Tanaka N, Jaeschke A, Ventura JJ, Kelkar N, Tanaka Y, Kyuuma M, Takeshita T, Flavell RA, and Davis RJ. Mechanism of p38 MAP kinase activation in vivo. Genes Dev 17: 1969-1978, 2003. (Pubitemid 36999324)
-
(2003)
Genes and Development
, vol.17
, Issue.16
, pp. 1969-1978
-
-
Brancho, D.1
Tanaka, N.2
Jaeschke, A.3
Ventura, J.-J.4
Kelkar, N.5
Tanaka, Y.6
Kyuuma, M.7
Takeshita, T.8
Flavell, R.A.9
Davis, R.J.10
-
26
-
-
17644373073
-
Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades
-
DOI 10.1128/MCB.25.9.3670-3681.2005
-
Brancho D, Ventura JJ, Jaeschke A, Doran B, Flavell RA, and Davis RJ. Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades. Mol Cell Biol 25: 3670-3681, 2005. (Pubitemid 40559573)
-
(2005)
Molecular and Cellular Biology
, vol.25
, Issue.9
, pp. 3670-3681
-
-
Brancho, D.1
Ventura, J.-J.2
Jaeschke, A.3
Doran, B.4
Flavell, R.A.5
Davis, R.J.6
-
27
-
-
37049019709
-
Caspase-cleaved HPK1 induces CD95L-independent activation-induced cell death in T and B lymphocytes
-
DOI 10.1182/blood-2007-01-071167
-
Brenner D, Golks A, Becker M, Muller W, Frey CR, Novak R, Melamed D, Kiefer F, Krammer PH, and Arnold R Caspase-cleaved HPK1 induces CD95L-independent activation-induced cell death in T and B lymphocytes. Blood 110: 3968-3977, 2007. (Pubitemid 350248452)
-
(2007)
Blood
, vol.110
, Issue.12
, pp. 3968-3977
-
-
Brenner, D.1
Golks, A.2
Becker, M.3
Muller, W.4
Frey, C.R.5
Novak, R.6
Melamed, D.7
Kiefer, F.8
Krammer, P.H.9
Arnold, R.10
-
28
-
-
3843146318
-
Protein kinase C δ mediates cerebral reperfusion injury In Vivo
-
DOI 10.1523/JNEUROSCI.4474-03.2004
-
Bright R, Raval AP, Dembner JM, Perez-Pinzon MA, Steinberg GK, Yenari MA, and Mochly-Rosen D. Protein kinase Cδ mediates cerebral reperfusion injury in vivo. J Neurosci 24: 6880-6888, 2004. (Pubitemid 39045444)
-
(2004)
Journal of Neuroscience
, vol.24
, Issue.31
, pp. 6880-6888
-
-
Bright, R.1
Raval, A.P.2
Dembner, J.M.3
Perez-Pinzon, M.A.4
Steinberg, G.K.5
Yenari, M.A.6
Mochly-Rosen, D.7
-
29
-
-
0033485261
-
Phosphorylation of human p53 by p38 kinase coordinates N-terminal phos-phorylation and apoptosis in response to UV radiation
-
Bulavin DV, Saito S, Hollander MC, Sakaguchi K, Ander-son CW, Appella E, and Fornace AJ, Jr. Phosphorylation of human p53 by p38 kinase coordinates N-terminal phos-phorylation and apoptosis in response to UV radiation EMBO J 18: 6845-6854, 1999.
-
(1999)
EMBO J
, vol.18
, pp. 6845-6854
-
-
Bulavin, D.V.1
Saito, S.2
Hollander, M.C.3
Sakaguchi, K.4
Ander-Son, C.W.5
Appella, E.6
Fornace Jr., A.J.7
-
30
-
-
73649089980
-
ERK and cell death: Mecha-nisms of ERK-induced cell death\apoptosis, autophagy and senescence
-
Cagnol S and Chambard JC. ERK and cell death: mecha-nisms of ERK-induced cell death\apoptosis, autophagy and senescence. FEBS J 277: 2-21, 2010.
-
(2010)
FEBS J
, vol.277
, pp. 2-21
-
-
Cagnol, S.1
Chambard, J.C.2
-
31
-
-
77956659871
-
And Ciriolo MR p38(MAPK)/p53 signalling axis mediates neuronal apo-ptosis in response to tetrahydrobiopterin-induced oxidative stress and glucose uptake inhibition: Implication for neu-rodegeneration
-
Cardaci S, Filomeni G, Rotilio G, and Ciriolo MR p38(MAPK)/p53 signalling axis mediates neuronal apo-ptosis in response to tetrahydrobiopterin-induced oxidative stress and glucose uptake inhibition: implication for neu-rodegeneration. Biochem J 430: 439-451, 2010.
-
(2010)
Biochem J
, vol.430
, pp. 439-451
-
-
Cardaci, S.1
Filomeni, G.2
Rotilio, G.3
-
32
-
-
0030755579
-
The regulation of anoikis: MEKK-1 activation requires cleavage by caspases
-
DOI 10.1016/S0092-8674(00)80339-6
-
Cardone MH, Salvesen GS, Widmann C, Johnson G, and Frisch SM. The regulation of anoikis: MEKK-1 acti-vation requires cleavage by caspases. Cell 90: 315-323, 1997. (Pubitemid 27329716)
-
(1997)
Cell
, vol.90
, Issue.2
, pp. 315-323
-
-
Cardone, M.H.1
Salvesen, G.S.2
Widmann, C.3
Johnson, G.4
Frisch, S.M.5
-
33
-
-
33748796617
-
V-Src-dependent down-regulation of the Ste20-like kinase SLK by casein kinase II
-
DOI 10.1074/jbc.M605665200
-
Chaar Z, O'Reilly P, Gelman I, and Sabourin LA. v-Src-dependent down-regulation of the Ste20-like kinase SLK by casein kinase II. J Biol Chem 281: 28193-28199, 2006. (Pubitemid 44414533)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.38
, pp. 28193-28199
-
-
Chaar, Z.1
O'Reilly, P.2
Gelman, I.3
Sabourin, L.A.4
-
34
-
-
16444373346
-
The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1
-
DOI 10.1038/sj.onc.1208445
-
Chan EH, Nousiainen M, Chalamalasetty RB, Schafer A, Nigg EA, and Sillje HH. The Ste20-like kinase Mst2 acti-vates the human large tumor suppressor kinase Lats1. Oncogene 24: 2076-2086, 2005. (Pubitemid 40516201)
-
(2005)
Oncogene
, vol.24
, Issue.12
, pp. 2076-2086
-
-
Chan, E.H.Y.1
Nousiainen, M.2
Chalamalasetty, R.B.3
Schafer, A.4
Nigg, E.A.5
Sillje, H.H.W.6
-
35
-
-
0036289349
-
Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b
-
DOI 10.1016/S1097-2765(02)00525-7
-
Chang CI, Xu BE, Akella R, Cobb MH, and Goldsmith EJ. Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b. Mol Cell 9: 1241-1249, 2002. (Pubitemid 34722303)
-
(2002)
Molecular Cell
, vol.9
, Issue.6
, pp. 1241-1249
-
-
Chang, C.-I.1
Xu, B.-E.2
Akella, R.3
Cobb, M.H.4
Goldsmith, E.J.5
-
36
-
-
0032544309
-
Activation of Apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx
-
DOI 10.1126/science.281.5384.1860
-
Chang HY, Nishitoh H, Yang X, Ichijo H, and Baltimore D. Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx. Science 281: 1860-1863, 1998. (Pubitemid 28450508)
-
(1998)
Science
, vol.281
, Issue.5384
, pp. 1860-1863
-
-
Chang, H.Y.1
Nishitoh, H.2
Yang, X.3
Ichijo, H.4
Baltimore, D.5
-
37
-
-
13444311622
-
Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPK
-
Chen CH, Wang WJ, Kuo JC, Tsai HC, Lin JR, Chang ZF, and Chen RH. Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPK. EMBO J 24: 294-304, 2005.
-
(2005)
EMBO J
, vol.24
, pp. 294-304
-
-
Chen, C.H.1
Wang, W.J.2
Kuo, J.C.3
Tsai, H.C.4
Lin, J.R.5
Chang, Z.F.6
Chen, R.H.7
-
38
-
-
0035872409
-
2-terminal kinase-2-deficient mice
-
Chen N, Nomura M, She QB, Ma WY, Bode AM, Wang L, Flavell RA, and Dong Z. Suppression of skin tumorigenesis in c-Jun NH(2)-terminal kinase-2-deficient mice. Cancer Res 61: 3908-3912, 2001. (Pubitemid 32720949)
-
(2001)
Cancer Research
, vol.61
, Issue.10
, pp. 3908-3912
-
-
Chen, N.1
Nomura, M.2
She, Q.-B.3
Ma, W.-Y.4
Bode, A.M.5
Wang, L.6
Flavell, R.A.7
Dong, Z.8
-
39
-
-
56449113671
-
Copy number alterations in pancreatic cancer identify recurrent PAK4 amplification
-
Chen S, Auletta T, Dovirak O, Hutter C, Kuntz K, El-Ftesi S, Kendall J, Han H, Von Hoff DD, Ashfaq R, Maitra A, Ia-cobuzio-Donahue CA, Hruban RH, and Lucito R. Copy number alterations in pancreatic cancer identify recurrent PAK4 amplification. Cancer Biol Ther 7: 1793-1802, 2008.
-
(2008)
Cancer Biol Ther
, vol.7
, pp. 1793-1802
-
-
Chen, S.1
Auletta, T.2
Dovirak, O.3
Hutter, C.4
Kuntz, K.5
El-Ftesi, S.6
Kendall, J.7
Han, H.8
Von Hoff, D.D.9
Ashfaq, R.10
Maitra, A.11
Ia-Cobuzio-Donahue, C.A.12
Hruban, R.H.13
Lucito, R.14
-
40
-
-
38549134304
-
Antiapoptotic and trophic effects of dominant-negative forms of dual leucine zipper kinase in dopamine neurons of the substantia nigra in vivo
-
DOI 10.1523/JNEUROSCI.2132-07.2008
-
Chen X, Rzhetskaya M, Kareva T, Bland R, During MJ, Tank AW, Kholodilov N, and Burke RE. Antiapoptotic and trophic effects of dominant-negative forms of dual leucine zipper kinase in dopamine neurons of the substantia nigra in vivo. J Neurosci 28: 672-680, 2008. (Pubitemid 351159034)
-
(2008)
Journal of Neuroscience
, vol.28
, Issue.3
, pp. 672-680
-
-
Chen, X.1
Rzhetskaya, M.2
Kareva, T.3
Bland, R.4
During, M.J.5
Tank, A.W.6
Kholodilov, N.7
Burke, R.E.8
-
41
-
-
0033518126
-
Caspase-mediated cleavage and functional changes of hematopoietic progenitor kinase 1 (HPK1)
-
Chen YR, Meyer CF, Ahmed B, Yao Z, and Tan TH. Caspase-mediated cleavage and functional changes of hematopoietic progenitor kinase 1 (HPK1). Oncogene 18: 7370-7377, 1999. (Pubitemid 30032118)
-
(1999)
Oncogene
, vol.18
, Issue.51
, pp. 7370-7377
-
-
Chen, Y.-R.1
Meyer, C.F.2
Ahmed, B.3
Yao, Z.4
Tan, T.-H.5
-
42
-
-
0035844153
-
Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2
-
Chen Z and Cobb MH. Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2. J Biol Chem 276: 16070-16075, 2001.
-
(2001)
J Biol Chem
, vol.276
, pp. 16070-16075
-
-
Chen, Z.1
Cobb, M.H.2
-
43
-
-
0038605379
-
TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors
-
DOI 10.1074/jbc.M301173200
-
Chen Z, Raman M, Chen L, Lee SF, Gilman AG, and Cobb MH. TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors. J Biol Chem 278: 22278-22283, 2003. (Pubitemid 36830276)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.25
, pp. 22278-22283
-
-
Chen, Z.1
Raman, M.2
Chen, L.3
Lee, S.F.4
Gilman, A.G.5
Cobb, M.H.6
-
44
-
-
0038293152
-
Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase
-
DOI 10.1016/S0092-8674(03)00355-6
-
Cheung WL, Ajiro K, Samejima K, Kloc M, Cheung P, Mizzen CA, Beeser A, Etkin LD, Chernoff J, Earnshaw WC, and Allis CD. Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. Cell 113: 507-517, 2003. (Pubitemid 36603322)
-
(2003)
Cell
, vol.113
, Issue.4
, pp. 507-517
-
-
Cheung, W.L.1
Ajiro, K.2
Samejima, K.3
Kloc, M.4
Cheung, P.5
Mizzen, C.A.6
Beeser, A.7
Etkin, L.D.8
Chernoff, J.9
Earnshaw, W.C.10
Allis, C.D.11
-
45
-
-
14844354487
-
Loss of mitogen-activated protein kinase kinase kinase 4 (MEKK4) results in enhanced apoptosis and defective neural tube development
-
DOI 10.1073/pnas.0500026102
-
Chi H, Sarkisian MR, Rakic P, and Flavell RA. Loss of mitogen-activated protein kinase kinase kinase 4 (MEKK4) results in enhanced apoptosis and defective neural tube development. Proc Natl Acad Sci USA 102: 3846-3851, 2005. (Pubitemid 40354699)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.10
, pp. 3846-3851
-
-
Chi, H.1
Sarkisian, M.R.2
Rakic, P.3
Flavell, R.A.4
-
46
-
-
66449133280
-
Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation
-
Cho YS, Challa S, Moquin D, Genga R, Ray TD, Guildford M, and Chan FK. Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell 137: 1112-1123, 2009.
-
(2009)
Cell
, vol.137
, pp. 1112-1123
-
-
Cho, Y.S.1
Challa, S.2
Moquin, D.3
Genga, R.4
Ray, T.D.5
Guildford, M.6
Chan, F.K.7
-
47
-
-
41949130508
-
Ubiquitination and degradation of homeodomain-interacting protein kinase 2 by WD40 re-peat/SOCS box protein WSB-1
-
Choi DW, Seo YM, Kim EA, Sung KS, Ahn JW, Park SJ, Lee SR, and Choi CY. Ubiquitination and degradation of homeodomain-interacting protein kinase 2 by WD40 re-peat/SOCS box protein WSB-1. J Biol Chem 283: 4682-4689, 2008.
-
(2008)
J Biol Chem
, vol.283
, pp. 4682-4689
-
-
Choi, D.W.1
Seo, Y.M.2
Kim, E.A.3
Sung, K.S.4
Ahn, J.W.5
Park, S.J.6
Lee, S.R.7
Choi, C.Y.8
-
48
-
-
3242752788
-
Neutrophil protein kinase Cδ as a mediator of stroke-reperfusion injury
-
DOI 10.1172/JCI200421655
-
Chou WH, Choi DS, Zhang H, Mu D, McMahon T, Khar-azia VN, Lowell CA, Ferriero DM, and Messing RO. Neutrophil protein kinase Cδ as a mediator of stroke-reperfusion injury. J Clin Invest 114: 49-56, 2004 (Pubitemid 39071643)
-
(2004)
Journal of Clinical Investigation
, vol.114
, Issue.1
, pp. 49-56
-
-
Chou, W.-H.1
Choi, D.-S.2
Zhang, H.3
Mu, D.4
McMahon, T.5
Kharazia, V.N.6
Lowell, C.A.7
Ferriero, D.M.8
Messing, R.O.9
-
49
-
-
18844440144
-
Protein kinase C isozymes in stroke
-
DOI 10.1016/j.tcm.2005.01.003, PII S1050173805000046
-
Chou WH and Messing RO. Protein kinase C isozymes in stroke. Trends Cardiovasc Med 15: 47-51, 2005. (Pubitemid 40693386)
-
(2005)
Trends in Cardiovascular Medicine
, vol.15
, Issue.2
, pp. 47-51
-
-
Chou, W.-H.1
Messing, R.O.2
-
50
-
-
36749009773
-
The roles of PKCδ and ε isoenzymes in the regulation of myocardial ischaemia/reperfusion injury
-
DOI 10.1042/BST0351040
-
Churchill EN and Mochly-Rosen D. The roles of PKCδ and ε isoenzymes in the regulation of myocardial ischaemia/reperfusion injury. Biochem Soc Trans 35: 1040-1042, 2007 (Pubitemid 350206423)
-
(2007)
Biochemical Society Transactions
, vol.35
, Issue.5
, pp. 1040-1042
-
-
Churchill, E.N.1
Mochly-Rosen, D.2
-
51
-
-
35649014941
-
The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1
-
DOI 10.1038/sj.emboj.7601872, PII 7601872
-
Cinar B, Fang PK, Lutchman M, Di Vizio D, Adam RM, Pavlova N, Rubin MA, Yelick PC, and Freeman MR. The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1. EMBO J 26: 4523-4534, 2007. (Pubitemid 350036629)
-
(2007)
EMBO Journal
, vol.26
, Issue.21
, pp. 4523-4534
-
-
Cinar, B.1
Fang, P.-K.2
Lutchman, M.3
Di Vizio, D.4
Adam, R.M.5
Pavlova, N.6
Rubin, M.A.7
Yelick, P.C.8
Freeman, M.R.9
-
52
-
-
0031056002
-
2+/calmodulin-dependent, cytoskeletal-associated protein kinase, with cell death-inducing functions that depend on its catalytic activity
-
DOI 10.1093/emboj/16.5.998
-
Cohen O, Feinstein E, and Kimchi A. DAP-kinase is a Ca2+/calmodulin- dependent, cytoskeletal-associated pro-tein kinase, with cell death-inducing functions that depend on its catalytic activity. EMBO J 16: 998-1008, 1997. (Pubitemid 27113179)
-
(1997)
EMBO Journal
, vol.16
, Issue.5
, pp. 998-1008
-
-
Cohen, O.1
Feinstein, E.2
Kimchi, A.3
-
53
-
-
0033549557
-
DAP-kinase participates in TNF-α- and Fas-induced apoptosis and its function requires the death domain
-
DOI 10.1083/jcb.146.1.141
-
Cohen O, Inbal B, Kissil JL, Raveh T, Berissi H, Spivak-Kroizaman T, Feinstein E, and Kimchi A. DAP-kinase participates in TNF-α-and Fas-induced apoptosis and its function requires the death domain. J Cell Biol 146: 141-148, 1999. (Pubitemid 29349970)
-
(1999)
Journal of Cell Biology
, vol.146
, Issue.1
, pp. 141-148
-
-
Cohen, O.1
Inbal, B.2
Kissil, J.L.3
Raveh, T.4
Berissi, H.5
Spivak-Kroizaman, T.6
Feinstein, E.7
Kimchi, A.8
-
54
-
-
49549109150
-
Blood level of brain-derived neurotrophic factor mRNA is progressively reduced in rodent models of Huntington's disease: Restoration by the neuroprotective compound CEP-1347
-
Conforti P, Ramos C, Apostol BL, Simmons DA, Nguyen HP, Riess O, Thompson LM, Zuccato C, and Cattaneo E. Blood level of brain-derived neurotrophic factor mRNA is progressively reduced in rodent models of Huntington's disease: restoration by the neuroprotective compound CEP-1347. Mol Cell Neurosci 39: 1-7, 2008.
-
(2008)
Mol Cell Neurosci
, vol.39
, pp. 1-7
-
-
Conforti, P.1
Ramos, C.2
Apostol, B.L.3
Simmons, D.A.4
Nguyen, H.P.5
Riess, O.6
Thompson, L.M.7
Zuccato, C.8
Cattaneo, E.9
-
55
-
-
0033598783
-
C-Abl-induced apoptosis, but not cell cycle arrest, requires mitogen-activated protein kinase ki-nase 6 activation
-
Cong F and Goff SP. c-Abl-induced apoptosis, but not cell cycle arrest, requires mitogen-activated protein kinase ki-nase 6 activation. Proc Natl Acad Sci USA 96: 13819-13824, 1999.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 13819-13824
-
-
Cong, F.1
Goff, S.P.2
-
56
-
-
33645815687
-
Nucleocytoplasmic shuttling of Pak5 regulates its antiapoptotic properties
-
Cotteret S and Chernoff J. Nucleocytoplasmic shuttling of Pak5 regulates its antiapoptotic properties. Mol Cell Biol 26: 3215-3230, 2006.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 3215-3230
-
-
Cotteret, S.1
Chernoff, J.2
-
57
-
-
0041631073
-
P21-activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD
-
DOI 10.1128/MCB.23.16.5526-5539.2003
-
Cotteret S, Jaffer ZM, Beeser A, and Chernoff J. p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD. Mol Cell Biol 23: 5526-5539, 2003. (Pubitemid 36951321)
-
(2003)
Molecular and Cellular Biology
, vol.23
, Issue.16
, pp. 5526-5539
-
-
Cotteret, S.1
Jaffer, Z.M.2
Beeser, A.3
Chernoff, J.4
-
58
-
-
34547228831
-
Atypical mitogen-activated protein kinases: Structure, regulation and functions
-
DOI 10.1016/j.bbamcr.2006.11.001, PII S0167488906003703
-
Coulombe P and Meloche S. Atypical mitogen-activated protein kinases: structure, regulation and functions. Biochim Biophys Acta 1773: 1376-1387, 2007. (Pubitemid 47125971)
-
(2007)
Biochimica et Biophysica Acta - Molecular Cell Research
, vol.1773
, Issue.8
, pp. 1376-1387
-
-
Coulombe, P.1
Meloche, S.2
-
59
-
-
68649090472
-
P38(MAPK): Stress responses from molecular mechanisms to therapeutics
-
Coulthard LR, White DE, Jones DL, McDermott MF, and Burchill SA. p38(MAPK): stress responses from molecular mechanisms to therapeutics. Trends Mol Med 15: 369-379, 2009.
-
(2009)
Trends Mol Med
, vol.15
, pp. 369-379
-
-
Coulthard, L.R.1
White, D.E.2
Jones, D.L.3
McDermott, M.F.4
Burchill, S.A.5
-
60
-
-
0029788972
-
The Ste20-like protein kinase, Mst1, dimerizes and contains an inhibitory domain
-
DOI 10.1074/jbc.271.35.21049
-
Creasy CL, Ambrose DM, and Chernoff J. The Ste20-like protein kinase, Mst1, dimerizes and contains an inhibitory domain. J Biol Chem 271: 21049-21053, 1996. (Pubitemid 26292952)
-
(1996)
Journal of Biological Chemistry
, vol.271
, Issue.35
, pp. 21049-21053
-
-
Creasy, C.L.1
Ambrose, D.M.2
Chernoff, J.3
-
61
-
-
34547154349
-
P38 MAP-kinases pathway regulation, function and role in human diseases
-
DOI 10.1016/j.bbamcr.2007.03.010, PII S0167488907000705
-
Cuenda A and Rousseau S. p38 MAP-kinases pathway regulation, function and role in human diseases. Biochim Biophys Acta 1773: 1358-1375, 2007. (Pubitemid 47125981)
-
(2007)
Biochimica et Biophysica Acta - Molecular Cell Research
, vol.1773
, Issue.8
, pp. 1358-1375
-
-
Cuenda, A.1
Rousseau, S.2
-
62
-
-
34248563299
-
Role of mitogen-activated protein kinase kinase kinases in signal integration
-
DOI 10.1038/sj.onc.1210409, PII 1210409
-
Cuevas BD, Abell AN, and Johnson GL. Role of mitogen-activated protein kinase kinase kinases in signal integra-tion. Oncogene 26: 3159-3171, 2007. (Pubitemid 46763012)
-
(2007)
Oncogene
, vol.26
, Issue.22
, pp. 3159-3171
-
-
Cuevas, B.D.1
Abell, A.N.2
Johnson, G.L.3
-
63
-
-
18244379872
-
Home-odomain-interacting protein kinase-2 phosphorylates p53 at ser 46 and mediates apoptosis
-
D'Orazi G, Cecchinelli B, Bruno T, Manni I, Higashimoto Y, Saito S, Gostissa M, Coen S, Marchetti A, Del Sal G, Piaggio G, Fanciulli M, Appella E, and Soddu S. Home-odomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis. Nat Cell Biol 4: 11-19, 2002.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 11-19
-
-
D'Orazi, G.1
Cecchinelli, B.2
Bruno, T.3
Manni, I.4
Higashimoto, Y.5
Saito, S.6
Gostissa, M.7
Coen, S.8
Marchetti, A.9
Del Sal, G.10
Piaggio, G.11
Fanciulli, M.12
Appella, E.13
Soddu, S.14
-
64
-
-
0036135015
-
PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells
-
DOI 10.1128/MCB.22.2.567-577.2002
-
Dan C, Nath N, Liberto M, and Minden A. PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells. Mol Cell Biol 22: 567-577, 2002. (Pubitemid 34027501)
-
(2002)
Molecular and Cellular Biology
, vol.22
, Issue.2
, pp. 567-577
-
-
Dan, C.1
Nath, N.2
Liberto, M.3
Minden, A.4
-
65
-
-
0037155191
-
Cloning of MASK, a novel member of the mammalian germinal center kinase III subfamily, with apoptosis-inducing properties
-
DOI 10.1074/jbc.M110882200
-
Dan I, Ong SE, Watanabe NM, Blagoev B, Nielsen MM, Kajikawa E, Kristiansen TZ, Mann M, and Pandey A. Cloning of MASK, a novel member of the mammalian germinal center kinase III subfamily, with apoptosis-inducing properties. J Biol Chem 277: 5929-5939, 2002. (Pubitemid 34968373)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.8
, pp. 5929-5939
-
-
Dan, I.1
Ong, S.-E.2
Watanabe, N.M.3
Blagoev, B.4
Nielsen, M.M.5
Kajikawa, E.6
Kristiansen, T.Z.7
Mann, M.8
Pandey, A.9
-
66
-
-
0035341895
-
The Ste20 group kinases as regulators of MAP kinase cascades
-
DOI 10.1016/S0962-8924(01)01980-8, PII S0962892401019808
-
Dan I, Watanabe NM, and Kusumi A. The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol 11: 220-230, 2001. (Pubitemid 32367879)
-
(2001)
Trends in Cell Biology
, vol.11
, Issue.5
, pp. 220-230
-
-
Dan, I.1
Watanabe, N.M.2
Kusumi, A.3
-
67
-
-
0034644522
-
Signal transduction by the JNK group of MAP kinases
-
Davis RJ. Signal transduction by the JNK group of MAP kinases. Cell 103: 239-252, 2000.
-
(2000)
Cell
, vol.103
, pp. 239-252
-
-
Davis, R.J.1
-
68
-
-
0036565878
-
Caspase-catalyzed cleavage and activation of Mst1 correlates with eosinophil but not neutrophil apoptosis
-
DOI 10.1182/blood.V99.9.3432
-
De Souza PM, Kankaanranta H, Michael A, Barnes PJ, Giembycz MA, and Lindsay MA. Caspase-catalyzed cleavage and activation of Mst1 correlates with eosinophil but not neutrophil apoptosis. Blood 99: 3432-3438, 2002. (Pubitemid 34525327)
-
(2002)
Blood
, vol.99
, Issue.9
, pp. 3432-3438
-
-
De Souza, P.M.1
Kankaanranta, H.2
Michael, A.3
Barnes, P.J.4
Giembycz, M.A.5
Lindsay, M.A.6
-
69
-
-
0032510794
-
Fas-induced proteolytic activation and intracellular redistribution of the stress-signaling kinase MEKK1
-
DOI 10.1073/pnas.95.10.5595
-
Deak JC, Cross JV, Lewis M, Qian Y, Parrott LA, Distelhorst CW, and Templeton DJ. Fas-induced proteolytic activation and intracellular redistribution of the stress-signaling kinase MEKK1. Proc Natl Acad Sci USA 95: 5595-5600, 1998. (Pubitemid 28224140)
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, Issue.10
, pp. 5595-5600
-
-
Deak, J.C.1
Cross, J.V.2
Lewis, M.3
Qian, Y.4
Parrott, L.A.5
Distelhorst, C.W.6
Templeton, D.J.7
-
70
-
-
42249102086
-
Identification of RIP1 kinase as a specific cellular target of necrostatins
-
DOI 10.1038/nchembio.83, PII NCHEMBIO83
-
Degterev A, Hitomi J, Germscheid M, Ch'en IL, Korkina O, Teng X, Abbott D, Cuny GD, Yuan C, Wagner G, Hedrick SM, Gerber SA, Lugovskoy A, and Yuan J. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol 4: 313-321, 2008. (Pubitemid 351550892)
-
(2008)
Nature Chemical Biology
, vol.4
, Issue.5
, pp. 313-321
-
-
Degterev, A.1
Hitomi, J.2
Germscheid, M.3
Ch'en, I.L.4
Korkina, O.5
Teng, X.6
Abbott, D.7
Cuny, G.D.8
Yuan, C.9
Wagner, G.10
Hedrick, S.M.11
Gerber, S.A.12
Lugovskoy, A.13
Yuan, J.14
-
71
-
-
0028831202
-
Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the γ interferon-induced cell death
-
Deiss LP, Feinstein E, Berissi H, Cohen O, and Kimchi A. Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the γ interferon-induced cell death. Genes Dev 9: 15-30, 1995.
-
(1995)
Genes Dev
, vol.9
, pp. 15-30
-
-
Deiss, L.P.1
Feinstein, E.2
Berissi, H.3
Cohen, O.4
Kimchi, A.5
-
72
-
-
68149089761
-
The mammalian family of sterile 20p-like protein kinases
-
Delpire E. The mammalian family of sterile 20p-like protein kinases. Pflugers Arch 458: 953-967, 2009.
-
(2009)
Pflugers Arch
, vol.458
, pp. 953-967
-
-
Delpire, E.1
-
73
-
-
0038485597
-
Regulation of mammalian STE20-like kinase 2 (MST2) by protein phosphorylation/dephosphorylation and proteolysis
-
DOI 10.1074/jbc.M211085200
-
Deng Y, Pang A, and Wang JH. Regulation of mammalian STE20-like kinase 2 (MST2) by protein phosphoryla-tion/dephosphorylation and proteolysis. J Biol Chem 278: 11760-11767, 2003. (Pubitemid 36800144)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.14
, pp. 11760-11767
-
-
Deng, Y.1
Pang, A.2
Wang, J.H.3
-
74
-
-
0141953270
-
A JNK-dependent pathway is required for TNFα-induced apoptosis
-
DOI 10.1016/S0092-8674(03)00757-8
-
Deng Y, Ren X, Yang L, Lin Y, and Wu X. A JNK-depen-dent pathway is required for TNFα-induced apoptosis. Cell 115: 61-70, 2003. (Pubitemid 37255318)
-
(2003)
Cell
, vol.115
, Issue.1
, pp. 61-70
-
-
Deng, Y.1
Ren, X.2
Yang, L.3
Lin, Y.4
Wu, X.5
-
75
-
-
35048839667
-
MEKK3 is required for endothelium function but is not essential for tumor growth and angiogenesis
-
DOI 10.1152/ajpcell.00058.2007
-
Deng Y, Yang J, McCarty M, and Su B. MEKK3 is required for endothelium function but is not essential for tumor growth and angiogenesis. Am J Physiol Cell Physiol 293: C1404-C1411, 2007. (Pubitemid 47556739)
-
(2007)
American Journal of Physiology - Cell Physiology
, vol.293
, Issue.4
-
-
Deng, Y.1
Yang, J.2
McCarty, M.3
Su, B.4
-
76
-
-
71949111129
-
MST kinases monitor actin cyto-skeletal integrity and signal via c-Jun N-terminal kinase stress-activated kinase to regulate p21Waf1/Cip1 stability
-
Densham RM, O'Neill E, Munro J, Konig I, Anderson K, Kolch W, and Olson MF. MST kinases monitor actin cyto-skeletal integrity and signal via c-Jun N-terminal kinase stress-activated kinase to regulate p21Waf1/Cip1 stability. Mol Cell Biol 29: 6380-6390, 2009.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 6380-6390
-
-
Densham, R.M.1
O'Neill, E.2
Munro, J.3
Konig, I.4
Anderson, K.5
Kolch, W.6
Olson, M.F.7
-
77
-
-
0028329953
-
JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
-
DOI 10.1016/0092-8674(94)90380-8
-
Derijard B, Hibi M, Wu IH, Barrett T, Su B, Deng T, Karin M, and Davis RJ. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76: 1025-1037, 1994. (Pubitemid 24106383)
-
(1994)
Cell
, vol.76
, Issue.6
, pp. 1025-1037
-
-
Derijard, B.1
Hibi, M.2
Wu, I.-H.3
Barrett, T.4
Su, B.5
Deng, T.6
Karin, M.7
Davis, R.J.8
-
78
-
-
49149087048
-
High-resolution, dual-platform aCGH analysis reveals frequent HIPK2 amplification and increased expression in pilocytic astrocytomas
-
Deshmukh H, Yeh TH, Yu J, Sharma MK, Perry A, Leonard JR, Watson MA, Gutmann DH, and Nagarajan R High-resolution, dual-platform aCGH analysis reveals frequent HIPK2 amplification and increased expression in pilocytic astrocytomas. Oncogene 27: 4745-4751, 2008.
-
(2008)
Oncogene
, vol.27
, pp. 4745-4751
-
-
Deshmukh, H.1
Yeh, T.H.2
Yu, J.3
Sharma, M.K.4
Perry, A.5
Leonard, J.R.6
Watson, M.A.7
Gutmann, D.H.8
Nagarajan, R.9
-
79
-
-
0037110732
-
Nuclear import of PKCδ is required for apoptosis: Identification of a novel nuclear import sequence
-
DOI 10.1093/emboj/cdf606
-
DeVries TA, Neville MC, and Reyland ME. Nuclear import of PKCδ is required for apoptosis: identification of a novel nuclear import sequence. EMBO J 21: 6050-6060, 2002 (Pubitemid 35415323)
-
(2002)
EMBO Journal
, vol.21
, Issue.22
, pp. 6050-6060
-
-
DeVries, T.A.1
Neville, M.C.2
Reyland, M.E.3
-
80
-
-
54249119561
-
JNK signaling in apo-ptosis
-
Dhanasekaran DN and Reddy EP. JNK signaling in apo-ptosis. Oncogene 27: 6245-6251, 2008.
-
(2008)
Oncogene
, vol.27
, pp. 6245-6251
-
-
Dhanasekaran, D.N.1
Reddy, E.P.2
-
81
-
-
33846811520
-
P38α MAP kinase as a sensor of reactive oxygen species in tumorigenesis
-
DOI 10.1016/j.ccr.2006.12.013, PII S1535610806003801
-
Dolado I, Swat A, Ajenjo N, De Vita G, Cuadrado A, and Nebreda AR. p38α MAP kinase as a sensor of reactive oxygen species in tumorigenesis. Cancer Cell 11: 191-205, 2007. (Pubitemid 46209847)
-
(2007)
Cancer Cell
, vol.11
, Issue.2
, pp. 191-205
-
-
Dolado, I.1
Swat, A.2
Ajenjo, N.3
De Vita, G.4
Cuadrado, A.5
Nebreda, A.R.6
-
82
-
-
0037174934
-
JNK phosphorylation and activation of bad couples the stress-activated signaling pathway to the cell death machinery
-
DOI 10.1074/jbc.M206113200
-
Donovan N, Becker EB, Konishi Y, and Bonni A. JNK phosphorylation and activation of BAD couples the stress-activated signaling pathway to the cell death machinery. J Biol Chem 277: 40944-40949, 2002. (Pubitemid 35215682)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.43
, pp. 40944-40949
-
-
Donovan, N.1
Becker, E.B.E.2
Konishi, Y.3
Bonni, A.4
-
83
-
-
0033194037
-
Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics
-
Edwards DC, Sanders LC, Bokoch GM, and Gill GN. Ac-tivation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics. Nat Cell Biol 1: 253-259, 1999. (Pubitemid 129495774)
-
(1999)
Nature Cell Biology
, vol.1
, Issue.5
, pp. 253-259
-
-
Edwards, D.C.1
Sanders, L.C.2
Bokoch, G.M.3
Gill, G.N.4
-
84
-
-
67349096401
-
Protein kinase D1 regulates cofilin-mediated F-actin reorganization and cell motility through slingshot
-
Eiseler T, Doppler H, Yan IK, Kitatani K, Mizuno K, and Storz P. Protein kinase D1 regulates cofilin-mediated F-actin reorganization and cell motility through slingshot. Nat Cell Biol 11: 545-556, 2009.
-
(2009)
Nat Cell Biol
, vol.11
, pp. 545-556
-
-
Eiseler, T.1
Doppler, H.2
Yan, I.K.3
Kitatani, K.4
Mizuno, K.5
Storz, P.6
-
85
-
-
35548946698
-
DAP kinase regulates JNK signaling by binding and activating protein kinase D under oxidative stress
-
DOI 10.1038/sj.cdd.4402212, PII 4402212
-
Eisenberg-Lerner A and Kimchi A. DAP kinase regu-lates JNK signaling by binding and activating protein kinase D under oxidative stress. Cell Death Differ 14: 1908-1915, 2007. (Pubitemid 350011666)
-
(2007)
Cell Death and Differentiation
, vol.14
, Issue.11
, pp. 1908-1915
-
-
Eisenberg-Lerner, A.1
Kimchi, A.2
-
86
-
-
13344259987
-
Proteolytic activation of protein kinase C δ by an ICE-like protease in apoptotic cells
-
Emoto Y, Manome Y, Meinhardt G, Kisaki H, Kharbanda S, Robertson M, Ghayur T, Wong WW, Kamen R, Weichsel-baum R, et al. Proteolytic activation of protein kinase C δ by an ICE-like protease in apoptotic cells. EMBO J 14: 6148-6156, 1995 (Pubitemid 26007576)
-
(1995)
EMBO Journal
, vol.14
, Issue.24
, pp. 6148-6156
-
-
Emoto, Y.1
Manome, Y.2
Meinhardt, G.3
Kisaki, H.4
Kharbanda, S.5
Robertson, M.6
Ghayur, T.7
Wong, W.W.8
Kamen, R.9
Weichselbaum, R.10
Kufe, D.11
-
87
-
-
0034674678
-
Proteolytic cleavage and activation of protein kinase C μ by caspase-3 in the apoptotic response of cells to 1-β-D-arabinofuranosylcytosine and other genotoxic agents
-
DOI 10.1074/jbc.M002266200
-
Endo K, Oki E, Biedermann V, Kojima H, Yoshida K, Johannes FJ, Kufe D, and Datta R Proteolytic cleavage and activation of protein kinase C [micro] by caspase-3 in the apoptotic response of cells to 1-/ï-D- arabinofuranosylcytosine and other genotoxic agents. J Biol Chem 275: 18476-18481, 2000. (Pubitemid 30414807)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.24
, pp. 18476-18481
-
-
Endo, K.1
Oki, E.2
Biedermann, V.3
Kojima, H.4
Yoshida, K.5
Johannes, F.-J.6
Kufe, D.7
Datta, R.8
-
88
-
-
18844383961
-
P38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes
-
DOI 10.1101/gad.1306705
-
Engel FB, Schebesta M, Duong MT, Lu G, Ren S, Madwed JB, Jiang H, Wang Y, and Keating MT. p38 MAP kinase inhibition enables proliferation of adult mammalian cardi-omyocytes. Genes Dev 19: 1175-1187, 2005. (Pubitemid 40696184)
-
(2005)
Genes and Development
, vol.19
, Issue.10
, pp. 1175-1187
-
-
Engel, F.B.1
Schebesta, M.2
Duong, M.T.3
Lu, G.4
Ren, S.5
Madwed, J.B.6
Jiang, H.7
Wang, Y.8
Keating, M.T.9
-
90
-
-
0031813436
-
Stress-induced Fas ligand expression in T cells is mediated through a MEK kinase 1-regulated response element in the Fas ligand promoter
-
Faris M, Latinis KM, Kempiak SJ, Koretzky GA, and Nel A. Stress-induced Fas ligand expression in T cells is mediated through a MEK kinase 1-regulated response element in the Fas ligand promoter. Mol Cell Biol 18: 5414-5424, 1998. (Pubitemid 28388124)
-
(1998)
Molecular and Cellular Biology
, vol.18
, Issue.9
, pp. 5414-5424
-
-
Paris, M.1
Latinis, K.M.2
Kempiak, S.J.3
Koretzky, G.A.4
Nel, A.5
-
91
-
-
34548437549
-
Cleavage of RIP3 inactivates its caspase-independent apoptosis pathway by removal of kinase domain
-
DOI 10.1016/j.cellsig.2007.05.016, PII S089865680700157X
-
Feng S, Yang Y, Mei Y, Ma L, Zhu DE, Hoti N, Castanares M, and Wu M. Cleavage of RIP3 inactivates its caspase-independent apoptosis pathway by removal of kinase do-main. Cell Signal 19: 2056-2067, 2007. (Pubitemid 47353808)
-
(2007)
Cellular Signalling
, vol.19
, Issue.10
, pp. 2056-2067
-
-
Feng, S.1
Yang, Y.2
Mei, Y.3
Ma, L.4
Zhu, D.-e.5
Hoti, N.6
Castanares, M.7
Wu, M.8
-
92
-
-
42949099439
-
Requirement of protein kinase D1 for pathological cardiac remodeling
-
DOI 10.1073/pnas.0712265105
-
Fielitz J, Kim MS, Shelton JM, Qi X, Hill JA, Richardson JA, Bassel-Duby R, and Olson EN. Requirement of protein ki-nase D1 for pathological cardiac remodeling. Proc Natl Acad Sci USA 105: 3059-3063, 2008. (Pubitemid 351723667)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.8
, pp. 3059-3063
-
-
Fielitz, J.1
Kim, M.-S.2
Shelton, J.M.3
Qi, X.4
Hill, J.A.5
Richardson, J.A.6
Bassel-Duby, R.7
Olson, E.N.8
-
93
-
-
0034733041
-
Stimulation of NFκB activity by multiple signaling pathways requires PAK1
-
DOI 10.1074/jbc.M909860199
-
Frost JA, Swantek JL, Stippec S, Yin MJ, Gaynor R, and Cobb MH. Stimulation of NF?B activity by multiple sig-naling pathways requires PAK1. J Biol Chem 275: 19693-19699, 2000. (Pubitemid 30441565)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.26
, pp. 19693-19699
-
-
Frost, J.A.1
Swantek, J.L.2
Stippec, S.3
Yin, M.J.4
Gaynor, R.5
Cobb, M.H.6
-
94
-
-
0032169459
-
JNK targets p53 ubiquitination and degradation in nonstressed cells
-
Fuchs SY, Adler V, Buschmann T, Yin Z, Wu X, Jones SN, and Ronai Z. JNK targets p53 ubiquitination and deg-radation in nonstressed cells. Genes Dev 12: 2658-2663, 1998. (Pubitemid 28420646)
-
(1998)
Genes and Development
, vol.12
, Issue.17
, pp. 2658-2663
-
-
Fuchs, S.Y.1
Adler, V.2
Buschmann, T.3
Yin, Z.4
Wu, X.5
Jones, S.N.6
Ronai, Z.7
-
95
-
-
3042782560
-
Negative control of apoptosis signal-regulating kinase 1 through phosphorylation of Ser-1034
-
DOI 10.1038/sj.onc.1207668
-
Fujii K, Goldman EH, Park HR, Zhang L, Chen J, and Fu H. Negative control of apoptosis signal-regulating kinase 1 through phosphorylation of Ser-1034. Oncogene 23: 5099-5104, 2004. (Pubitemid 38938745)
-
(2004)
Oncogene
, vol.23
, Issue.29
, pp. 5099-5104
-
-
Fujii, K.1
Goldman, E.H.2
Park, H.R.3
Zhang, L.4
Chen, J.5
Fu, H.6
-
96
-
-
0036731701
-
Mixed-lineage kinase control of JNK and p38 MAPK pathways
-
DOI 10.1038/nrm906
-
Gallo KA and Johnson GL. Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol 3: 663-672, 2002. (Pubitemid 34987787)
-
(2002)
Nature Reviews Molecular Cell Biology
, vol.3
, Issue.9
, pp. 663-672
-
-
Gallo, K.A.1
Johnson, G.L.2
-
98
-
-
0032499687
-
SEK1 deficiency reveals mitogen-activated protein kinase cascade crossregulation and leads to abnormal hepatogenesis
-
DOI 10.1073/pnas.95.12.6881
-
Ganiatsas S, Kwee L, Fujiwara Y, Perkins A, Ikeda T, La-bow MA, and Zon LI. SEK1 deficiency reveals mitogen-activated protein kinase cascade crossregulation and leads to abnormal hepatogenesis. Proc Natl Acad Sci USA 95: 6881-6886, 1998. (Pubitemid 28278075)
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, Issue.12
, pp. 6881-6886
-
-
Ganiatsas, S.1
Kwee, L.2
Fujiwara, Y.3
Perkins, A.4
Ikeda, T.5
Labow, M.A.6
Zon, L.I.7
-
99
-
-
12644268232
-
Proteolytic activation of protein kinase C δ by an ICE/CED 3-like protease induces characteristics of apoptosis
-
DOI 10.1084/jem.184.6.2399
-
Ghayur T, Hugunin M, Talanian RV, Ratnofsky S, Quinlan C, Emoto Y, Pandey P, Datta R, Huang Y, Kharbanda S, Allen H, Kamen R, Wong W, and Kufe D. Proteolytic ac-tivation of protein kinase C δ by an ICE/CED 3-like protease induces characteristics of apoptosis. J Exp Med 184: 2399-2404, 1996 (Pubitemid 27023739)
-
(1996)
Journal of Experimental Medicine
, vol.184
, Issue.6
, pp. 2399-2404
-
-
Ghayur, T.1
Hugunin, M.2
Talanian, R.V.3
Ratnofsky, S.4
Quinlan, C.5
Emoto, Y.6
Pandey, P.7
Datta, R.8
Huang, Y.9
Kharbanda, S.10
Allen, H.11
Kamen, R.12
Wong, W.13
Kufe, D.14
-
100
-
-
0142123165
-
Death receptor-induced acti-vation of initiator caspase 8 is antagonized by serine/threonine kinase PAK4
-
DOI 10.1128/MCB.23.21.7838-7848.2003
-
Gnesutta N and Minden A. Death receptor-induced acti-vation of initiator caspase 8 is antagonized by serine/threonine kinase PAK4. Mol Cell Biol 23: 7838-7848, 2003. (Pubitemid 37271480)
-
(2003)
Molecular and Cellular Biology
, vol.23
, Issue.21
, pp. 7838-7848
-
-
Gnesutta, N.1
Minden, A.2
-
101
-
-
0035957986
-
The serine/threonine kinase PAK4 prevents caspase activation and protects cells from apoptosis
-
Gnesutta N, Qu J, and Minden A. The serine/threonine kinase PAK4 prevents caspase activation and protects cells from apoptosis. J Biol Chem 276: 14414-14419, 2001.
-
(2001)
J Biol Chem
, vol.276
, pp. 14414-14419
-
-
Gnesutta, N.1
Qu, J.2
Minden, A.3
-
102
-
-
1642410790
-
Activation of Apoptosis Signal-regulating Kinase 1 by Reactive Oxygen Species through Dephosphorylation at Serine 967 and 14-3-3 Dissociation
-
DOI 10.1074/jbc.M311129200
-
Goldman EH, Chen L, and Fu H. Activation of apoptosis signal-regulating kinase 1 by reactive oxygen species through dephosphorylation at serine 967 and 14-3-3 dis-sociation. J Biol Chem 279: 10442-10449, 2004. (Pubitemid 38372653)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.11
, pp. 10442-10449
-
-
Goldman, E.H.1
Chen, L.2
Fu, H.3
-
103
-
-
33846018602
-
Cell death by necrosis: Towards a molecular definition
-
DOI 10.1016/j.tibs.2006.11.001, PII S0968000406003185
-
Golstein P and Kroemer G. Cell death by necrosis: towards a molecular definition. Trends Biochem Sci 32: 37-43, 2007. (Pubitemid 46043552)
-
(2007)
Trends in Biochemical Sciences
, vol.32
, Issue.1
, pp. 37-43
-
-
Golstein, P.1
Kroemer, G.2
-
104
-
-
0033600234
-
The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
-
DOI 10.1038/21690
-
Gong JG, Costanzo A, Yang HQ, Melino G, Kaelin WG, Jr., Levrero M, and Wang JY. The tyrosine kinase c-Abl regu-lates p73 in apoptotic response to cisplatin-induced DNA damage. Nature 399: 806-809, 1999. (Pubitemid 29293179)
-
(1999)
Nature
, vol.399
, Issue.6738
, pp. 806-809
-
-
Gong, J.1
Costanzo, A.2
Yang, H.-Q.3
Mellno, G.4
Kaelin Jr., W.G.5
Levrero, M.6
Wang, J.Y.J.7
-
105
-
-
12844276658
-
Novel regions of chromosomal amplification at 6p21, 5p13, and 12q14 in gastric cancer identified by array comparative genomic hybridization
-
DOI 10.1002/gcc.20136
-
Gorringe KL, Boussioutas A, and Bowtell DD. Novel re-gions of chromosomal amplification at 6p21, 5p13, and 12q14 in gastric cancer identified by array comparative genomic hybridization. Genes Chromosomes Cancer 42: 247-259, 2005. (Pubitemid 40171189)
-
(2005)
Genes Chromosomes and Cancer
, vol.42
, Issue.3
, pp. 247-259
-
-
Gorringe, K.L.1
Boussioutas, A.2
Bowtell, D.D.L.3
-
106
-
-
56349138968
-
DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagic cell death
-
Gozuacik D, Bialik S, Raveh T, Mitou G, Shohat G, Sabanay H, Mizushima N, Yoshimori T, and Kimchi A. DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagic cell death. Cell Death Differ 15: 1875-1886, 2008.
-
(2008)
Cell Death Differ
, vol.15
, pp. 1875-1886
-
-
Gozuacik, D.1
Bialik, S.2
Raveh, T.3
Mitou, G.4
Shohat, G.5
Sabanay, H.6
Mizushima, N.7
Yoshimori, T.8
Kimchi, A.9
-
107
-
-
0035805593
-
Both phosphorylation and caspase-mediated cleavage contribute to regulation of the Ste20-like protein kinase Mst1 during CD95/Fas-induced apoptosis
-
Graves JD, Draves KE, Gotoh Y, Krebs EG, and Clark EA. Both phosphorylation and caspase-mediated cleavage contribute to regulation of the Ste20-like protein kinase Mst1 during CD95/Fas-induced apoptosis. J Biol Chem 276: 14909-14915, 2001.
-
(2001)
J Biol Chem
, vol.276
, pp. 14909-14915
-
-
Graves, J.D.1
Draves, K.E.2
Gotoh, Y.3
Krebs, E.G.4
Clark, E.A.5
-
108
-
-
0032522704
-
Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1
-
DOI 10.1093/emboj/17.8.2224
-
Graves JD, Gotoh Y, Draves KE, Ambrose D, Han DK, Wright M, Chernoff J, Clark EA, and Krebs EG Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1. EMBO J 17: 2224-2234, 1998. (Pubitemid 28171908)
-
(1998)
EMBO Journal
, vol.17
, Issue.8
, pp. 2224-2234
-
-
Graves, J.D.1
Gotoh, Y.2
Draves, K.E.3
Ambrose, D.4
Han, D.K.M.5
Wright, M.6
Chernoff, J.7
Clark, E.A.8
Krebs, E.G.9
-
109
-
-
15744392181
-
Regulation of zipper-interacting protein kinase activity in vitro and in vivo by multisite phosphorylation
-
DOI 10.1074/jbc.M412538200
-
Graves PR, Winkfield KM, and Haystead TA. Regulation of zipper-interacting protein kinase activity in vitro and in vivo by multisite phosphorylation. J Biol Chem 280: 9363-9374, 2005. (Pubitemid 40409630)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.10
, pp. 9363-9374
-
-
Graves, P.R.1
Winkfield, K.M.2
Haystead, T.A.J.3
-
110
-
-
33646589651
-
Autoregulatory control of the p53 re-sponse by caspase-mediated processing of HIPK2
-
Gresko E, Roscic A, Ritterhoff S, Vichalkovski A, del Sal G, and Schmitz ML. Autoregulatory control of the p53 re-sponse by caspase-mediated processing of HIPK2. EMBO J 25: 1883-1894, 2006.
-
(2006)
EMBO J
, vol.25
, pp. 1883-1894
-
-
Gresko, E.1
Roscic, A.2
Ritterhoff, S.3
Vichalkovski, A.4
Del Sal, G.5
Schmitz, M.L.6
-
111
-
-
0036315121
-
Disruption of Mekk2 in mice reveals an unexpected role for MEKK2 in modulating T-cell receptor signal transduction
-
DOI 10.1128/MCB.22.16.5761-5768.2002
-
Guo Z, Clydesdale G, Cheng J, Kim K, Gan L, McConkey DJ, Ullrich SE, Zhuang Y, and Su B. Disruption of MEKK2 in mice reveals an unexpected role for MEKK2 in modu-lating T-cell receptor signal transduction. Mol Cell Biol 22: 5761-5768, 2002. (Pubitemid 34815825)
-
(2002)
Molecular and Cellular Biology
, vol.22
, Issue.16
, pp. 5761-5768
-
-
Guo, Z.1
Clydesdale, G.2
Cheng, J.3
Kim, K.4
Gan, L.5
McConkey, D.J.6
Ullrich, S.E.7
Zhuang, Y.8
Su, B.9
-
112
-
-
7944222398
-
Regulation of phosphoglucomutase 1 phosphorylation and activity by a signaling kinase
-
DOI 10.1038/sj.onc.1207969
-
Gururaj A, Barnes CJ, Vadlamudi RK, and Kumar R Reg-ulation of phosphoglucomutase 1 phosphorylation and activity by a signaling kinase. Oncogene 23: 8118-8127, 2004. (Pubitemid 39531852)
-
(2004)
Oncogene
, vol.23
, Issue.49
, pp. 8118-8127
-
-
Gururaj, A.1
Barnes, C.J.2
Vadlamudi, R.K.3
Kumar, R.4
-
113
-
-
33846636886
-
Caspase-3 regulates catalytic activity and scaffolding functions of the protein tyrosine phosphatase PEST, a novel modulator of the apoptotic response
-
DOI 10.1128/MCB.02462-05
-
Halle M, Liu YC, Hardy S, Theberge JF, Blanchetot C, Bourdeau A, Meng TC, and Tremblay ML. Caspase-3 reg-ulates catalytic activity and scaffolding functions of the protein tyrosine phosphatase PEST, a novel modulator of the apoptotic response. Mol Cell Biol 27: 1172-1190, 2007. (Pubitemid 46174576)
-
(2007)
Molecular and Cellular Biology
, vol.27
, Issue.3
, pp. 1172-1190
-
-
Halle, M.1
Liu, Y.-C.2
Hardy, S.3
Theberge, J.-F.4
Blanchetot, C.5
Bourdeau, A.6
Meng, T.-C.7
Tremblay, M.L.8
-
114
-
-
0027936755
-
A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
-
Han J, Lee JD, Bibbs L, and Ulevitch RJ. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 265: 808-811, 1994. (Pubitemid 24266145)
-
(1994)
Science
, vol.265
, Issue.5173
, pp. 808-811
-
-
Man, J.1
Lee, J.-D.2
Bibbs, L.3
Ulevitch, R.J.4
-
115
-
-
34547212349
-
The pathways to tumor suppression via route p38
-
DOI 10.1016/j.tibs.2007.06.007, PII S0968000407001491
-
Han J and Sun P. The pathways to tumor suppression via route p38. Trends Biochem Sci 32: 364-371, 2007. (Pubitemid 47126858)
-
(2007)
Trends in Biochemical Sciences
, vol.32
, Issue.8
, pp. 364-371
-
-
Han, J.1
Sun, P.2
-
116
-
-
1542328927
-
Structure, regulation and function of PKB/AKT - A major therapeutic target
-
DOI 10.1016/j.bbapap.2003.11.009, PII S1570963903003613
-
Hanada M, Feng J, and Hemmings BA. Structure, regula-tion and function of PKB/AKT\a major therapeutic target. Biochim Biophys Acta 1697: 3-16, 2004. (Pubitemid 38326757)
-
(2004)
Biochimica et Biophysica Acta - Proteins and Proteomics
, vol.1697
, Issue.1-2
, pp. 3-16
-
-
Hanada, M.1
Feng, J.2
Hemmings, B.A.3
-
117
-
-
0344626925
-
A myristoyl/phosphotyrosine switch regulates c-Abl
-
DOI 10.1016/S0092-8674(03)00191-0
-
Hantschel O, Nagar B, Guettler S, Kretzschmar J, Dorey K, Kuriyan J, and Superti-Furga G. A myristoyl/phosphotyrosine switch regulates c-Abl. Cell 112: 845-857, 2003. (Pubitemid 36378886)
-
(2003)
Cell
, vol.112
, Issue.6
, pp. 845-857
-
-
Hantschel, O.1
Nagar, B.2
Guettler, S.3
Kretzschmar, J.4
Dorey, K.5
Kuriyan, J.6
Superti-Furga, G.7
-
118
-
-
33645651908
-
Induction of apoptosis by the Ste20-like kinase SLK, a germinal center kinase that activates apoptosis signal-regulating kinase and p38
-
DOI 10.1074/jbc.M511744200
-
Hao W, Takano T, Guillemette J, Papillon J, Ren G, and Cybulsky AV. Induction of apoptosis by the Ste20-like ki-nase SLK, a germinal center kinase that activates apoptosis signal-regulating kinase and p38. J Biol Chem 281: 3075-3084, 2006. (Pubitemid 43845917)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.6
, pp. 3075-3084
-
-
Hao, W.1
Takano, T.2
Guillemette, J.3
Papillon, J.4
Ren, G.5
Cybulsky, A.V.6
-
119
-
-
0037353039
-
An integrated stress response regulates amino acid metabolism and resistance to oxidative stress
-
DOI 10.1016/S1097-2765(03)00105-9
-
Harding HP, Zhang Y, Zeng H, Novoa I, Lu PD, Calfon M, Sadri N, Yun C, Popko B, Paules R, Stojdl DF, Bell JC, Hettmann T, Leiden JM, and Ron D. An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell 11: 619-633, 2003. (Pubitemid 36385118)
-
(2003)
Molecular Cell
, vol.11
, Issue.3
, pp. 619-633
-
-
Harding, H.P.1
Zhang, Y.2
Zeng, H.3
Novoa, I.4
Lu, P.D.5
Calfon, M.6
Sadri, N.7
Yun, C.8
Popko, B.9
Paules, R.10
Stojdl, D.F.11
Bell, J.C.12
Hettmann, T.13
Leiden, J.M.14
Ron, D.15
-
120
-
-
43949145220
-
DAPK-1 binding to a linear pep-tide motif in MAP1B stimulates autophagy and membrane blebbing
-
Harrison B, Kraus M, Burch L, Stevens C, Craig A, Gordon-Weeks P, and Hupp TR. DAPK-1 binding to a linear pep-tide motif in MAP1B stimulates autophagy and membrane blebbing. J Biol Chem 283: 9999-10014, 2008.
-
(2008)
J Biol Chem
, vol.283
, pp. 9999-10014
-
-
Harrison, B.1
Kraus, M.2
Burch, L.3
Stevens, C.4
Craig, A.5
Gordon-Weeks, P.6
Hupp, T.R.7
-
121
-
-
33847206401
-
The Salvador-Warts-Hippo path-way\an emerging tumour-suppressor network
-
Harvey K and Tapon N. The Salvador-Warts-Hippo path-way\an emerging tumour-suppressor network. Nat Rev Cancer 7: 182-191, 2007.
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 182-191
-
-
Harvey, K.1
Tapon, N.2
-
122
-
-
38549084725
-
A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-κB activation
-
DOI 10.1038/sj.emboj.7601962, PII 7601962
-
Hasegawa M, Fujimoto Y, Lucas PC, Nakano H, Fukase K, Nunez G, and Inohara N. A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-?B activation. EMBO J 27: 373-383, 2008. (Pubitemid 351161652)
-
(2008)
EMBO Journal
, vol.27
, Issue.2
, pp. 373-383
-
-
Hasegawa, M.1
Fujimoto, Y.2
Lucas, P.C.3
Nakano, H.4
Fukase, K.5
Nunez, G.6
Inohara, N.7
-
123
-
-
54049122614
-
The role of the transcription factor AP-1 in colitis-associated and/ï-catenin-dependent intestinal tu-morigenesis in mice
-
Hasselblatt P, Gresh L, Kudo H, Guinea-Viniegra J, and Wagner EF. The role of the transcription factor AP-1 in colitis-associated and/ï-catenin- dependent intestinal tu-morigenesis in mice. Oncogene 27: 6102-6109, 2008.
-
(2008)
Oncogene
, vol.27
, pp. 6102-6109
-
-
Hasselblatt, P.1
Gresh, L.2
Kudo, H.3
Guinea-Viniegra, J.4
Wagner, E.F.5
-
124
-
-
0034714355
-
Execution of apoptosis signal-regulating kinase 1 (ASK1)-induced apoptosis by the mitochondria-dependent caspase activation
-
Hatai T, Matsuzawa A, Inoshita S, Mochida Y, Kuroda T, Sakamaki K, Kuida K, Yonehara S, Ichijo H, and Takeda K. Execution of apoptosis signal-regulating kinase 1 (ASK1)-induced apoptosis by the mitochondria-dependent caspase activation. J Biol Chem 275: 26576-26581, 2000.
-
(2000)
J Biol Chem
, vol.275
, pp. 26576-26581
-
-
Hatai, T.1
Matsuzawa, A.2
Inoshita, S.3
Mochida, Y.4
Kuroda, T.5
Sakamaki, K.6
Kuida, K.7
Yonehara, S.8
Ichijo, H.9
Takeda, K.10
-
125
-
-
66749183275
-
Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-α
-
He S, Wang L, Miao L, Wang T, Du F, Zhao L, and Wang X. Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-α. Cell 137: 1100-1111, 2009.
-
(2009)
Cell
, vol.137
, pp. 1100-1111
-
-
He, S.1
Wang, L.2
Miao, L.3
Wang, T.4
Du, F.5
Zhao, L.6
Wang, X.7
-
126
-
-
0034693261
-
The mixed lineage kinase DLK is oligomer-ized by tissue transglutaminase during apoptosis
-
Hebert SS, Daviau A, Grondin G, Latreille M, Aubin RA, and Blouin R. The mixed lineage kinase DLK is oligomer-ized by tissue transglutaminase during apoptosis. J Biol Chem 275: 32482-32490, 2000.
-
(2000)
J Biol Chem
, vol.275
, pp. 32482-32490
-
-
Hebert, S.S.1
Daviau, A.2
Grondin, G.3
Latreille, M.4
Aubin, R.A.5
Blouin, R.6
-
127
-
-
13444282230
-
Protein S-nitrosylation: Purview and parameters
-
DOI 10.1038/nrm1569
-
Hess DT, Matsumoto A, Kim SO, Marshall HE, and Stamler JS. Protein S-nitrosylation: purview and parameters. Nat Rev Mol Cell Biol 6: 150-166, 2005. (Pubitemid 40215810)
-
(2005)
Nature Reviews Molecular Cell Biology
, vol.6
, Issue.2
, pp. 150-166
-
-
Hess, D.T.1
Matsumoto, A.2
Kim, S.-O.3
Marshall, H.E.4
Stamler, J.S.5
-
128
-
-
0027423418
-
Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain
-
Hibi M, Lin A, Smeal T, Minden A, and Karin M. Identi-fication of an oncoprotein-and UV-responsive protein ki-nase that binds and potentiates the c-Jun activation domain. Genes Dev 7: 2135-2148, 1993. (Pubitemid 23336140)
-
(1993)
Genes and Development
, vol.7
, Issue.11
, pp. 2135-2148
-
-
Hibi, M.1
Lin, A.2
Smeal, T.3
Minden, A.4
Karin, M.5
-
129
-
-
33751082080
-
The c-Jun N-terminal kinase activator dual leucine zipper kinase regulates axon growth and neuronal migration in the developing cerebral cortex
-
DOI 10.1523/JNEUROSCI.2272-06.2006
-
Hirai S, Cui de F, Miyata T, Ogawa M, Kiyonari H, Suda Y, Aizawa S, Banba Y, and Ohno S. The c-Jun N-terminal ki-nase activator dual leucine zipper kinase regulates axon growth and neuronal migration in the developing cerebral cortex. J Neurosci 26: 11992-12002, 2006. (Pubitemid 44772110)
-
(2006)
Journal of Neuroscience
, vol.26
, Issue.46
, pp. 11992-12002
-
-
Hirai, S.-I.1
De, F.C.2
Miyata, T.3
Ogawa, M.4
Kiyonari, H.5
Suda, Y.6
Aizawa, S.7
Banba, Y.8
Ohno, S.9
-
130
-
-
0037153158
-
A central, role for JNK in obesity and insulin resistance
-
DOI 10.1038/nature01137
-
Hirosumi J, Tuncman G, Chang L, Gorgun CZ, Uysal KT, Maeda K, Karin M, and Hotamisligil GS. A central role for JNK in obesity and insulin resistance. Nature 420: 333-336, 2002. (Pubitemid 35398190)
-
(2002)
Nature
, vol.420
, Issue.6913
, pp. 333-336
-
-
Hirosumi, J.1
Tuncman, G.2
Chang, L.3
Gorgun, C.Z.4
Uysal, K.T.5
Maeda, K.6
Karin, M.7
Hotamisligil, G.S.8
-
131
-
-
57649181391
-
Identification of a molecular sig-naling network that regulates a cellular necrotic cell death pathway
-
Hitomi J, Christofferson DE, Ng A, Yao J, Degterev A, Xavier RJ, and Yuan J. Identification of a molecular sig-naling network that regulates a cellular necrotic cell death pathway. Cell 135: 1311-1323, 2008.
-
(2008)
Cell
, vol.135
, pp. 1311-1323
-
-
Hitomi, J.1
Christofferson, D.E.2
Ng, A.3
Yao, J.4
Degterev, A.5
Xavier, R.J.6
Yuan, J.7
-
132
-
-
0036141392
-
Regulation of p53 activity by its interaction with homeodomain- interacting protein kinase-2
-
DOI 10.1038/ncb715
-
Hofmann TG, Moller A, Sirma H, Zentgraf H, Taya Y, Droge W, Will H, and Schmitz ML. Regulation of p53 ac-tivity by its interaction with homeodomain-interacting protein kinase-2. Nat Cell Biol 4: 1-10, 2002. (Pubitemid 34071974)
-
(2002)
Nature Cell Biology
, vol.4
, Issue.1
, pp. 1-10
-
-
Hofmann, T.G.1
Moller, A.2
Sirma, H.3
Zentgraf, H.4
Taya, Y.5
Droge, W.6
Will, H.7
Lienhard Schmitz, M.8
-
133
-
-
0345734277
-
2-Terminal Kinase Activation and Apoptosis in Human Hepatoma Cells
-
Hofmann TG, Stollberg N, Schmitz ML, and Will H. HIPK2 regulates transforming growth factor-/ï-induced c-Jun NH(2)-terminal kinase activation and apoptosis in human hepatoma cells. Cancer Res 63: 8271-8277, 2003. (Pubitemid 37549478)
-
(2003)
Cancer Research
, vol.63
, Issue.23
, pp. 8271-8277
-
-
Hofmann, T.G.1
Stollberg, N.2
Schmitz, M.L.3
Will, H.4
-
134
-
-
0030825190
-
MKK7 is a stress-activated mitogen-activated protein kinase kinase functionally related to hemipterous
-
DOI 10.1074/jbc.272.40.24994
-
Holland PM, Suzanne M, Campbell JS, Noselli S, and Cooper JA. MKK7 is a stress-activated mitogen-activated protein kinase kinase functionally related to hemipterous. J Biol Chem 272: 24994-24998, 1997. (Pubitemid 27415678)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.40
, pp. 24994-24998
-
-
Holland, P.M.1
Suzanne, M.2
Campbell, J.S.3
Noselli, S.4
Cooper, J.A.5
-
135
-
-
67649586652
-
Targeting ASK1 in ER stress-related neurodegenerative diseases
-
Homma K, Katagiri K, Nishitoh H, and Ichijo H. Targeting ASK1 in ER stress-related neurodegenerative diseases. Ex-pert Opin Ther Targets 13: 653-664, 2009.
-
(2009)
Ex-pert Opin Ther Targets
, vol.13
, pp. 653-664
-
-
Homma, K.1
Katagiri, K.2
Nishitoh, H.3
Ichijo, H.4
-
136
-
-
0029763450
-
Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade
-
Hu MC, Qiu WR, Wang X, Meyer CF, and Tan TH. Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade. Genes Dev 10: 2251-2264, 1996. (Pubitemid 26322362)
-
(1996)
Genes and Development
, vol.10
, Issue.18
, pp. 2251-2264
-
-
Hu, M.C.-T.1
Qiu, W.R.2
Wang, X.3
Meyer, C.F.4
Tan, T.-H.5
-
137
-
-
36249025726
-
Acinus-provoked protein kinase C δ isoform activation is essential for apoptotic chromatin condensation
-
DOI 10.1038/sj.cdd.4402214, PII 4402214
-
Hu Y, Liu Z, Yang SJ, and Ye K. Acinus-provoked protein kinase C δ isoform activation is essential for apoptotic chromatin condensation. Cell Death Differ 14: 2035-2046, 2007 (Pubitemid 350131153)
-
(2007)
Cell Death and Differentiation
, vol.14
, Issue.12
, pp. 2035-2046
-
-
Hu, Y.1
Liu, Z.2
Yang, S.-J.3
Ye, K.4
-
138
-
-
0037072882
-
Caspase activation of mammalian sterile 20-like kinase 3 (Mst3). Nuclear translocation and induction of apoptosis
-
Huang CY, Wu YM, Hsu CY, Lee WS, Lai MD, Lu TJ, Huang CL, Leu TH, Shih HM, Fang HI, Robinson DR, Kung HJ, and Yuan CJ. Caspase activation of mammalian sterile 20-like kinase 3 (Mst3). Nuclear translocation and induction of apoptosis. J Biol Chem 277: 34367-34374, 2002.
-
(2002)
J Biol Chem
, vol.277
, pp. 34367-34374
-
-
Huang, C.Y.1
Wu, Y.M.2
Hsu, C.Y.3
Lee, W.S.4
Lai, M.D.5
Lu, T.J.6
Huang, C.L.7
Leu, T.H.8
Shih, H.M.9
Fang, H.I.10
Robinson, D.R.11
Kung, H.J.12
Yuan, C.J.13
-
139
-
-
34548289502
-
Dynamic FoxO transcription factors
-
DOI 10.1242/jcs.001222
-
Huang H and Tindall DJ. Dynamic FoxO transcription factors. J Cell Sci 120: 2479-2487, 2007. (Pubitemid 47323857)
-
(2007)
Journal of Cell Science
, vol.120
, Issue.15
, pp. 2479-2487
-
-
Huang, H.1
Tindall, D.J.2
-
140
-
-
23744458034
-
The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila homolog of YAP
-
DOI 10.1016/j.cell.2005.06.007, PII S0092867405005520
-
Huang J, Wu S, Barrera J, Matthews K, and Pan D. The Hippo signaling pathway coordinately regulates cell pro-liferation and apoptosis by inactivating Yorkie, the Droso-phila Homolog of YAP. Cell 122: 421-434, 2005. (Pubitemid 41127143)
-
(2005)
Cell
, vol.122
, Issue.3
, pp. 421-434
-
-
Huang, J.1
Wu, S.2
Barrera, J.3
Matthews, K.4
Pan, D.5
-
141
-
-
0030812347
-
Apoptosis signaling pathway in T cells is composed of ICE/Ced-3 family proteases and MAP kinase kinase 6b
-
DOI 10.1016/S1074-7613(00)80449-5
-
Huang S, Jiang Y, Li Z, Nishida E, Mathias P, Lin S, Ule-vitch RJ, Nemerow GR, and Han J. Apoptosis signaling pathway in T cells is composed of ICE/Ced-3 family pro-teases and MAP kinase kinase 6b. Immunity 6: 739-749, 1997. (Pubitemid 27305736)
-
(1997)
Immunity
, vol.6
, Issue.6
, pp. 739-749
-
-
Huang, S.1
Jiang, Y.2
Li, Z.3
Nishida, E.4
Mathias, P.5
Lin, S.6
Ulevitch, R.J.7
Nemerow, G.R.8
Han, J.9
-
142
-
-
34249334506
-
P38α suppresses normal and cancer cell proliferation by antagonizing the JNK-c-Jun pathway
-
DOI 10.1038/ng2033, PII NG2033
-
Hui L, Bakiri L, Mairhorfer A, Schweifer N, Haslinger C, Kenner L, Komnenovic V, Scheuch H, Beug H, and Wagner EF. p38α suppresses normal and cancer cell proliferation by antagonizing the JNK-c-Jun pathway. Nat Genet 39: 741-749, 2007. (Pubitemid 46848584)
-
(2007)
Nature Genetics
, vol.39
, Issue.6
, pp. 741-749
-
-
Hui, L.1
Bakiri, L.2
Mairhorfer, A.3
Schweifer, N.4
Haslinger, C.5
Kenner, L.6
Komnenovic, V.7
Scheuch, H.8
Beug, H.9
Wagner, E.F.10
-
143
-
-
35848938280
-
P38α: A suppressor of cell proliferation and tumorigenesis
-
Hui L, Bakiri L, Stepniak E, and Wagner EF. p38α: a sup-pressor of cell proliferation and tumorigenesis. Cell Cycle 6: 2429-2433, 2007. (Pubitemid 350058657)
-
(2007)
Cell Cycle
, vol.6
, Issue.20
, pp. 2429-2433
-
-
Hui, L.1
Bakiri, L.2
Stepniak, E.3
Wagner, E.F.4
-
144
-
-
57449109370
-
Proliferation of human HCC cells and chemically in-duced mouse liver cancers requires JNK1-dependent p21 downregulation
-
Hui L, Zatloukal K, Scheuch H, Stepniak E, and Wagner EF. Proliferation of human HCC cells and chemically in-duced mouse liver cancers requires JNK1-dependent p21 downregulation. J Clin Invest 118: 3943-3953, 2008.
-
(2008)
J Clin Invest
, vol.118
, pp. 3943-3953
-
-
Hui, L.1
Zatloukal, K.2
Scheuch, H.3
Stepniak, E.4
Wagner, E.F.5
-
145
-
-
33646901676
-
Suppression of apoptosis in the protein kinase Cδ null mouse in vivo
-
DOI 10.1074/jbc.M507851200
-
Humphries MJ, Limesand KH, Schneider JC, Nakayama KI, Anderson SM, and Reyland ME. Suppression of apoptosis in the protein kinase Cδ null mouse in vivo. J Biol Chem 281: 9728-9737, 2006 (Pubitemid 43864691)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.14
, pp. 9728-9737
-
-
Humphries, M.J.1
Limesand, K.H.2
Schneider, J.C.3
Nakayama, K.I.4
Anderson, S.M.5
Reyland, M.E.6
-
146
-
-
0037192716
-
Protein kinase D complexes with C-Jun N-terminal kinase via activation loop phosphorylation and phosphorylates the C-Jun N-terminus
-
DOI 10.1038/sj.onc.1205290
-
Hurd C, Waldron RT, and Rozengurt E. Protein kinase D complexes with C-Jun N-terminal kinase via activation loop phosphorylation and phosphorylates the C-Jun N-terminus. Oncogene 21: 2154-2160, 2002. (Pubitemid 34311369)
-
(2002)
Oncogene
, vol.21
, Issue.14
, pp. 2154-2160
-
-
Hurd, C.1
Waldron, R.T.2
Rozengurt, E.3
-
147
-
-
0032582644
-
Isolation of TAO1, a protein kinase that activates MEKs in stress- activated protein kinase cascades
-
DOI 10.1074/jbc.273.44.28625
-
Hutchison M, Berman KS, and Cobb MH. Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades. J Biol Chem 273: 28625-28632, 1998. (Pubitemid 28507546)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.44
, pp. 28625-28632
-
-
Hutchison, M.1
Berman, K.S.2
Cobb, M.H.3
-
148
-
-
14444281569
-
Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways
-
DOI 10.1126/science.275.5296.90
-
Ichijo H, Nishida E, Irie K, ten Dijke P, Saitoh M, Moriguchi T, Takagi M, Matsumoto K, Miyazono K, and Gotoh Y. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science 275: 90-94, 1997. (Pubitemid 27020316)
-
(1997)
Science
, vol.275
, Issue.5296
, pp. 90-94
-
-
Ichijo, H.1
Nishida, E.2
Irie, K.3
Ten Dijke, P.4
Saitoh, M.5
Moriguchi, T.6
Takagi, M.7
Matsumoto, K.8
Miyazono, K.9
Gotoh, Y.10
-
149
-
-
0037193474
-
DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death
-
DOI 10.1083/jcb.200109094
-
Inbal B, Bialik S, Sabanay I, Shani G, and Kimchi A. DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death. J Cell Biol 157: 455-468, 2002. (Pubitemid 34839809)
-
(2002)
Journal of Cell Biology
, vol.157
, Issue.3
, pp. 455-468
-
-
Inbal, B.1
Bialik, S.2
Sabanay, I.3
Shani, G.4
Kimchi, A.5
-
150
-
-
0033960235
-
Death-associated protein kinase-related protein 1, a novel serine/threonine kinase involved in apoptosis
-
DOI 10.1128/MCB.20.3.1044-1054.2000
-
Inbal B, Shani G, Cohen O, Kissil JL, and Kimchi A. Death-associated protein kinase-related protein 1, a novel ser-ine/threonine kinase involved in apoptosis. Mol Cell Biol 20: 1044-1054, 2000. (Pubitemid 30044241)
-
(2000)
Molecular and Cellular Biology
, vol.20
, Issue.3
, pp. 1044-1054
-
-
Inbal, B.1
Shani, G.2
Cohen, O.3
Kissil, J.L.4
Kimchi, A.5
-
151
-
-
0037113878
-
Phosphorylation and inactivation of myeloid cell leukemia 1 by JNK in response to oxidative stress
-
DOI 10.1074/jbc.M207951200
-
Inoshita S, Takeda K, Hatai T, Terada Y, Sano M, Hata J, Umezawa A, and Ichijo H. Phosphorylation and inactiva-tion of myeloid cell leukemia 1 by JNK in response to ox-idative stress. J Biol Chem 277: 43730-43734, 2002. (Pubitemid 36157790)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.46
, pp. 43730-43734
-
-
Inoshita, S.1
Takeda, K.2
Hatai, T.3
Terada, Y.4
Sano, M.5
Hata, J.6
Umezawa, A.7
Ichijo, H.8
-
152
-
-
33645765290
-
Mitogen-activated protein kinase kinase 3 is a pivotal pathway regulating p38 activation in inflammatory arthritis
-
Inoue T, Boyle DL, Corr M, Hammaker D, Davis RJ, Flavell RA, and Firestein GS. Mitogen-activated protein kinase kinase 3 is a pivotal pathway regulating p38 activation in inflammatory arthritis. Proc Natl Acad Sci USA 103: 5484-5489, 2006.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 5484-5489
-
-
Inoue, T.1
Boyle, D.L.2
Corr, M.3
Hammaker, D.4
Davis, R.J.5
Flavell, R.A.6
Firestein, G.S.7
-
153
-
-
65449146296
-
ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis
-
Iriyama T, Takeda K, Nakamura H, Morimoto Y, Kuroiwa T, Mizukami J, Umeda T, Noguchi T, Naguro I, Nishitoh H, Saegusa K, Tobiume K, Homma T, Shimada Y, Tsuda H, Aiko S, Imoto I, Inazawa J, Chida K, Kamei Y, Kozuma S, Taketani Y, Matsuzawa A, and Ichijo H. ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis. EMBO J 28: 843-853, 2009.
-
(2009)
EMBO J
, vol.28
, pp. 843-853
-
-
Iriyama, T.1
Takeda, K.2
Nakamura, H.3
Morimoto, Y.4
Kuroiwa, T.5
Mizukami, J.6
Umeda, T.7
Noguchi, T.8
Naguro, I.9
Nishitoh, H.10
Saegusa, K.11
Tobiume, K.12
Homma, T.13
Shimada, Y.14
Tsuda, H.15
Aiko, S.16
Imoto, I.17
Inazawa, J.18
Chida, K.19
Kamei, Y.20
Kozuma, S.21
Taketani, Y.22
Matsuzawa, A.23
Ichijo, H.24
more..
-
154
-
-
0242266963
-
Apoptosis Signal-Regulating Kinase 1 Plays a Pivotal Role in Angiotensin II-Induced Cardiac Hypertrophy and Remodeling
-
DOI 10.1161/01.RES.0000100665.67510.F5
-
Izumiya Y, Kim S, Izumi Y, Yoshida K, Yoshiyama M, Matsuzawa A, Ichijo H, and Iwao H. Apoptosis signal-regulating kinase 1 plays a pivotal role in angiotensin II-induced cardiac hypertrophy and remodeling. Circ Res 93: 874-883, 2003. (Pubitemid 37363062)
-
(2003)
Circulation Research
, vol.93
, Issue.9
, pp. 874-883
-
-
Izumiya, Y.1
Kim, S.2
Izumi, Y.3
Yoshida, K.4
Yoshiyama, M.5
Matsuzawa, A.6
Ichijo, H.7
Iwao, H.8
-
155
-
-
34547219895
-
Metabolic stress signaling medi-ated by mixed-lineage kinases
-
DOI 10.1016/j.molcel.2007.07.008, PII S1097276507004789
-
Jaeschke A and Davis RJ. Metabolic stress signaling medi-ated by mixed-lineage kinases. Mol Cell 27: 498-508, 2007. (Pubitemid 47126942)
-
(2007)
Molecular Cell
, vol.27
, Issue.3
, pp. 498-508
-
-
Jaeschke, A.1
Davis, R.J.2
-
156
-
-
33748436341
-
JNK2 Is a Positive Regulator of the cJun Transcription Factor
-
DOI 10.1016/j.molcel.2006.07.028, PII S1097276506005296
-
Jaeschke A, Karasarides M, Ventura JJ, Ehrhardt A, Zhang C, Flavell RA, Shokat KM, and Davis RJ. JNK2 is a positive regulator of the cJun transcription factor. Mol Cell 23: 899-911, 2006. (Pubitemid 44344520)
-
(2006)
Molecular Cell
, vol.23
, Issue.6
, pp. 899-911
-
-
Jaeschke, A.1
Karasarides, M.2
Ventura, J.-J.3
Ehrhardt, A.4
Zhang, C.5
Flavell, R.A.6
Shokat, K.M.7
Davis, R.J.8
-
157
-
-
0141532132
-
Caspase-activated PAK-2 is regulated by subcellular targeting and proteasomal degradation
-
DOI 10.1074/jbc.M306494200
-
Jakobi R, McCarthy CC, Koeppel MA, and Stringer DK. Caspase-activated PAK-2 is regulated by subcellular tar-geting and proteasomal degradation. J Biol Chem 278: 38675-38685, 2003. (Pubitemid 37221764)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.40
, pp. 38675-38685
-
-
Jakobi, R.1
McCarthy, C.C.2
Koeppel, M.A.3
Stringer, D.K.4
-
158
-
-
0035907371
-
P21-activated protein kinase y-PAK suppresses programmed cell death of BALB3T3 fibroblasts
-
Jakobi R, Moertl E, and Koeppel MA. p21-activated protein kinase y-PAK suppresses programmed cell death of BALB3T3 fibroblasts. J Biol Chem 276: 16624-16634, 2001.
-
(2001)
J Biol Chem
, vol.276
, pp. 16624-16634
-
-
Jakobi, R.1
Moertl, E.2
Koeppel, M.A.3
-
159
-
-
1542328956
-
A mitochondrial protein, Bit1, mediates apoptosis regulated by integrins and Groucho/TLE corepressors
-
DOI 10.1016/S0092-8674(04)00204-1, PII S0092867404002041
-
Jan Y, Matter M, Pai JT, Chen YL, Pilch J, Komatsu M, Ong E, Fukuda M, and Ruoslahti E. A mitochondrial protein, Bit1, mediates apoptosis regulated by integrins and Grou-cho/TLE corepressors. Cell 116: 751-762, 2004. (Pubitemid 38326732)
-
(2004)
Cell
, vol.116
, Issue.5
, pp. 751-762
-
-
Jan, Y.1
Matter, M.2
Pai, J.-T.3
Chen, Y.-L.4
Pilch, J.5
Komatsu, M.6
Ong, E.7
Fukuda, M.8
Ruoslahti, E.9
-
160
-
-
0036144377
-
TGF-jS induces apoptosis through Smad-mediated expression of DAP-kinase
-
Jang CW, Chen CH, Chen CC, Chen JY, Su YH, and Chen RH. TGF-jS induces apoptosis through Smad-mediated expression of DAP-kinase. Nat Cell Biol 4: 51-58, 2002.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 51-58
-
-
Jang, C.W.1
Chen, C.H.2
Chen, C.C.3
Chen, J.Y.4
Su, Y.H.5
Chen, R.H.6
-
161
-
-
35649004861
-
Akt phosphorylates MstI and prevents its proteolytic activation, blocking FOXO3 phosphorylation and nuclear translocation
-
DOI 10.1074/jbc.M704542200
-
Jang SW, Yang SJ, Srinivasan S, and Ye K. Akt phosphor-ylates MstI and prevents its proteolytic activation, blocking FOXO3 phosphorylation and nuclear translocation. J Biol Chem 282: 30836-30844, 2007. (Pubitemid 350035233)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.42
, pp. 30836-30844
-
-
Jang, S.-W.1
Yang, S.-J.2
Srinivasan, S.3
Ye, K.4
-
162
-
-
34547164540
-
The c-jun kinase/stress-activated pathway: Regulation, function and role in human disease
-
DOI 10.1016/j.bbamcr.2006.12.009, PII S0167488906004629
-
Johnson GL and Nakamura K. The c-jun kinase/stress-activated pathway: regulation, function and role in human disease. Biochim Biophys Acta 1773: 1341-1348, 2007. (Pubitemid 47125977)
-
(2007)
Biochimica et Biophysica Acta - Molecular Cell Research
, vol.1773
, Issue.8
, pp. 1341-1348
-
-
Johnson, G.L.1
Nakamura, K.2
-
163
-
-
34547453816
-
Regulation of p73-mediated apoptosis by c-Jun N-terminal kinase
-
DOI 10.1042/BJ20061778
-
Jones EV, Dickman MJ, and Whitmarsh AJ. Regulation of p73-mediated apoptosis by c-Jun N-terminal kinase. Bio-chem J 405: 617-623, 2007. (Pubitemid 47172060)
-
(2007)
Biochemical Journal
, vol.405
, Issue.3
, pp. 617-623
-
-
Jones, E.V.1
Dickman, M.J.2
Whitmarsh, A.J.3
-
164
-
-
0031015043
-
Fas activation of the p38 mitogen-activated protein kinase signalling pathway requires ICE/CED-3 family proteases
-
Juo P, Kuo CJ, Reynolds SE, Konz RF, Raingeaud J, Davis RJ, Biemann HP, and Blenis J. Fas activation of the p38 mitogen-activated protein kinase signalling pathway re-quires ICE/CED-3 family proteases. Mol Cell Biol 17: 24-35, 1997. (Pubitemid 26425591)
-
(1997)
Molecular and Cellular Biology
, vol.17
, Issue.1
, pp. 24-35
-
-
Juo, P.1
Kuo, C.J.2
Reynolds, S.E.3
Konz, R.F.4
Raingeaud, J.5
Davis, R.J.6
Biemann, H.-P.7
Blenis, J.8
-
165
-
-
19944426148
-
Amyloid β induces neuronal cell death through ROS-mediated ASK1 activation
-
DOI 10.1038/sj.cdd.4401528
-
Kadowaki H, Nishitoh H, Urano F, Sadamitsu C, Matsu-zawa A, Takeda K, Masutani H, Yodoi J, Urano Y, Nagano T, and Ichijo H. Amyloid ß induces neuronal cell death through ROS-mediated ASK1 activation. Cell Death Differ 12: 19-24, 2005. (Pubitemid 40090025)
-
(2005)
Cell Death and Differentiation
, vol.12
, Issue.1
, pp. 19-24
-
-
Kadowaki, H.1
Nishitoh, H.2
Urano, F.3
Sadamitsu, C.4
Matsuzawa, A.5
Takeda, K.6
Masutani, H.7
Yodoi, J.8
Urano, Y.9
Nagano, T.10
Ichijo, H.11
-
166
-
-
2442534165
-
Targeted inhibition of p38 mitogen-activated protein kinase antagonizes cardiac injury and cell death following ischemia-reperfusion in vivo
-
DOI 10.1074/jbc.M313717200
-
Kaiser RA, Bueno OF, Lips DJ, Doevendans PA, Jones F, Kimball TF, and Molkentin JD. Targeted inhibition of p38 mitogen-activated protein kinase antagonizes cardiac injury and cell death following ischemia-reperfusion in vivo. J Biol Chem 279: 15524-15530, 2004. (Pubitemid 38618953)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.15
, pp. 15524-15530
-
-
Kaiser, R.A.1
Bueno, O.F.2
Lips, D.J.3
Doevendans, P.A.4
Jones, F.5
Kimball, T.F.6
Molkentin, J.D.7
-
167
-
-
25444482606
-
Genetic inhibition or activation of JNK1/2 protects the myocardium from ischemia-reperfusion-induced cell death in vivo
-
DOI 10.1074/jbc.M500684200
-
Kaiser RA, Liang Q, Bueno O, Huang Y, Lackey T, Kle-vitsky R, Hewett TE, and Molkentin JD. Genetic inhibition or activation of JNK1/2 protects the myocardium from ischemia-reperfusion-induced cell death in vivo. J Biol Chem 280: 32602-32608, 2005. (Pubitemid 41368302)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.38
, pp. 32602-32608
-
-
Kaiser, R.A.1
Liang, Q.2
Bueno, O.3
Huang, Y.4
Lackey, T.5
Klevitsky, R.6
Hewett, T.E.7
Molkentin, J.D.8
-
168
-
-
0032212459
-
Caspase-mediated activation of a 36-kDa myelin basic protein kinase during anticancer drug-induced apoptosis
-
Kakeya H, Onose R, and Osada H. Caspase-mediated ac-tivation of a 36-kDa myelin basic protein kinase during anticancer drug-induced apoptosis. Cancer Res 58: 4888-4894, 1998. (Pubitemid 28503686)
-
(1998)
Cancer Research
, vol.58
, Issue.21
, pp. 4888-4894
-
-
Kakeya, H.1
Onose, R.2
Osada, H.3
-
169
-
-
14844327760
-
Reactive oxygen species promote TNFα-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases
-
DOI 10.1016/j.cell.2004.12.041
-
Kamata H, Honda S, Maeda S, Chang L, Hirata H, and Karin M. Reactive oxygen species promote TNFα-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 120: 649-661, 2005. (Pubitemid 40343077)
-
(2005)
Cell
, vol.120
, Issue.5
, pp. 649-661
-
-
Kamata, H.1
Honda, S.-I.2
Maeda, S.3
Chang, L.4
Hirata, H.5
Karin, M.6
-
170
-
-
34548421950
-
Dual roles of autophagy in the survival of Caenorhabditis elegans during starvation
-
DOI 10.1101/gad.1573107
-
Kang C, You YJ, and Avery L. Dual roles of autophagy in the survival of Caenorhabditis elegans during starvation. Genes Dev 21: 2161-2171, 2007. (Pubitemid 47360838)
-
(2007)
Genes and Development
, vol.21
, Issue.17
, pp. 2161-2171
-
-
Kang, C.1
You, N.-J.2
Avery, L.3
-
171
-
-
44449100233
-
Macrophage deletion of p38α partially impairs li-popolysaccharide- induced cellular activation
-
Kang YJ, Chen J, Otsuka M, Mols J, Ren S, Wang Y, and Han J. Macrophage deletion of p38α partially impairs li-popolysaccharide-induced cellular activation. J Immunol 180: 5075-5082, 2008.
-
(2008)
J Immunol
, vol.180
, pp. 5075-5082
-
-
Kang, Y.J.1
Chen, J.2
Otsuka, M.3
Mols, J.4
Ren, S.5
Wang, Y.6
Han, J.7
-
172
-
-
65649126736
-
Mst1 controls lymphocyte trafficking and inter-stitial motility within lymph nodes
-
Katagiri K, Katakai T, Ebisuno Y, Ueda Y, Okada T, and Kinashi T. Mst1 controls lymphocyte trafficking and inter-stitial motility within lymph nodes. EMBO J 28: 1319-1331, 2009.
-
(2009)
EMBO J
, vol.28
, pp. 1319-1331
-
-
Katagiri, K.1
Katakai, T.2
Ebisuno, Y.3
Ueda, Y.4
Okada, T.5
Kinashi, T.6
-
173
-
-
0031028730
-
Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB
-
DOI 10.1038/385544a0
-
Kauffmann-Zeh A, Rodriguez-Viciana P, Ulrich E, Gilbert C, Coffer P, Downward J, and Evan G. Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB. Nature 385: 544-548, 1997. (Pubitemid 27074674)
-
(1997)
Nature
, vol.385
, Issue.6616
, pp. 544-548
-
-
Kauffmann-Zeh, A.1
Rodriguez-Viciana, P.2
Ulrich, E.3
Gilbert, C.4
Coffer, P.5
Downward, J.6
Evan, G.7
-
174
-
-
0031911792
-
Zip kinase, a novel serine/threonine kinase which mediates apoptosis
-
Kawai T, Matsumoto M, Takeda K, Sanjo H, and Akira S. ZIP kinase, a novel serine/threonine kinase which mediates apoptosis. Mol Cell Biol 18: 1642-1651, 1998. (Pubitemid 28100930)
-
(1998)
Molecular and Cellular Biology
, vol.18
, Issue.3
, pp. 1642-1651
-
-
Kawai, T.1
Matsumoto, M.2
Takeda, K.3
Sanjo, H.4
Akira, S.5
-
175
-
-
0032033132
-
The death domain kinase RIP mediates the TNF-induced NF-κB signal
-
DOI 10.1016/S1074-7613(00)80535-X
-
Kelliher MA, Grimm S, Ishida Y, Kuo F, Stanger BZ, and Leder P. The death domain kinase RIP mediates the TNF-induced NF-?B signal. Immunity 8: 297-303, 1998. (Pubitemid 28188890)
-
(1998)
Immunity
, vol.8
, Issue.3
, pp. 297-303
-
-
Kelliher, M.A.1
Grimm, S.2
Ishida, Y.3
Kuo, F.4
Stanger, B.Z.5
Leder, P.6
-
176
-
-
63449096345
-
Bim and Bmf sy-nergize to induce apoptosis in Neisseria gonorrhoeae in-fection
-
Kepp O, Gottschalk K, Churin Y, Rajalingam K, Brinkmann V, Machuy N, Kroemer G, and Rudel T. Bim and Bmf sy-nergize to induce apoptosis in Neisseria gonorrhoeae in-fection. PLoS Pathog 5: e1000348, 2009.
-
(2009)
PLoS Pathog
, vol.5
-
-
Kepp, O.1
Gottschalk, K.2
Churin, Y.3
Rajalingam, K.4
Brinkmann, V.5
MacHuy, N.6
Kroemer, G.7
Rudel, T.8
-
177
-
-
0035133227
-
Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1
-
DOI 10.1128/MCB.21.3.893-901.2001
-
Kim AH, Khursigara G, Sun X, Franke TF, and Chao MV. Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1. Mol Cell Biol 21: 893-901, 2001. (Pubitemid 32104737)
-
(2001)
Molecular and Cellular Biology
, vol.21
, Issue.3
, pp. 893-901
-
-
Kim, A.H.1
Khursigara, G.2
Sun, X.3
Franke, T.F.4
Chao, M.V.5
-
178
-
-
50049122380
-
The kinase p38α serves cell type-specific inflammatory functions in skin injury and coordinates pro-and anti-inflammatory gene expression
-
Kim C, Sano Y, Todorova K, Carlson BA, Arpa L, Celada A, Lawrence T, Otsu K, Brissette JL, Arthur JS, and Park JM. The kinase p38α serves cell type-specific inflammatory functions in skin injury and coordinates pro-and anti-inflammatory gene expression. Nat Immunol 9: 1019-1027, 2008.
-
(2008)
Nat Immunol
, vol.9
, pp. 1019-1027
-
-
Kim, C.1
Sano, Y.2
Todorova, K.3
Carlson, B.A.4
Arpa, L.5
Celada, A.6
Lawrence, T.7
Otsu, K.8
Brissette, J.L.9
Arthur, J.S.10
Park, J.M.11
-
179
-
-
0037178731
-
A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity
-
DOI 10.1126/science.1073759
-
Kim DH, Feinbaum R, Alloing G, Emerson FE, Garsin DA, Inoue H, Tanaka-Hino M, Hisamoto N Matsumoto K, Tan MW, and Ausubel FM. A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity. Science 297: 623-626, 2002. (Pubitemid 34815350)
-
(2002)
Science
, vol.297
, Issue.5581
, pp. 623-626
-
-
Kim, D.H.1
Feinbaum, R.2
Alloing, G.3
Emerson, F.E.4
Garsin, D.A.5
Inoue, H.6
Tanaka-Hino, M.7
Hisamoto, N.8
Hatsumoto, K.9
Tan, M.-W.10
Ausubel, F.H.11
-
180
-
-
3142741044
-
Mixed lineage kinase 3 (MLK3)-activated p38 MAP kinase mediates transforming growth factor-β-induced apoptosis in hepatoma cells
-
DOI 10.1074/jbc.M313947200
-
Kim KY, Kim BC, Xu Z, and Kim SJ. Mixed lineage kinase 3 (MLK3)-activated p38 MAP kinase mediates transforming growth factor-/ï-induced apoptosis in hepatoma cells. J Biol Chem 279: 29478-29484, 2004. (Pubitemid 38915827)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.28
, pp. 29478-29484
-
-
Kim, K.-Y.1
Kim, B.-C.2
Xu, Z.3
Kim, S.-J.4
-
181
-
-
0037059796
-
ERK-1/2 and p38 kinase oppositely regulate nitric oxide-induced apoptosis of chondrocytes in association with p53, caspase-3, and differentiation status
-
DOI 10.1074/jbc.M107231200
-
Kim SJ, Ju JW, Oh CD, Yoon YM, Song WK, Kim JH, Yoo YJ, Bang OS, Kang SS, and Chun JS. ERK-1/2 and p38 ki-nase oppositely regulate nitric oxide-induced apoptosis of chondrocytes in association with p53, caspase-3, and dif-ferentiation status. J Biol Chem 277: 1332-1339, 2002. (Pubitemid 34968887)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.2
, pp. 1332-1339
-
-
Kim, S.-J.1
Ju, N.-W.2
Oh, C.-D.3
Yoon, Y.-M.4
Song, W.K.5
Kim, J.-H.6
Yoo, Y.J.7
Bang, O.-S.8
Kang, S.-S.9
Chun, J.-S.10
-
182
-
-
58049221106
-
Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer
-
Kimmelman AC, Hezel AF, Aguirre AJ, Zheng H, Paik JH, Ying H, Chu GC, Zhang JX, Sahin E, Yeo G, Ponugoti A, Nabioullin R, Deroo S, Yang S, Wang X, McGrath JP, Pro-topopova M, Ivanova E, Zhang J, Feng B, Tsao MS, Redston M, Protopopov A, Xiao Y, Futreal PA, Hahn WC, Klimstra DS, Chin L, and DePinho RA. Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer. Proc Natl Acad Sci USA 105: 19372-19377, 2008.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 19372-19377
-
-
Kimmelman, A.C.1
Hezel, A.F.2
Aguirre, A.J.3
Zheng, H.4
Paik, J.H.5
Ying, H.6
Chu, G.C.7
Zhang, J.X.8
Sahin, E.9
Yeo, G.10
Ponugoti, A.11
Nabioullin, R.12
Deroo, S.13
Yang, S.14
Wang, X.15
McGrath, J.P.16
Pro-Topopova, M.17
Ivanova, E.18
Zhang, J.19
Feng, B.20
Tsao, M.S.21
Redston, M.22
Protopopov, A.23
Xiao, Y.24
Futreal, P.A.25
Hahn, W.C.26
Klimstra, D.S.27
Chin, L.28
Depinho, R.A.29
more..
-
183
-
-
0034625342
-
BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6
-
DOI 10.1074/jbc.M908622199
-
Kimura N, Matsuo R, Shibuya H, Nakashima K, and Taga T. BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6. J Biol Chem 275: 17647-17652, 2000. (Pubitemid 30430812)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.23
, pp. 17647-17652
-
-
Kimura, N.1
Matsuo, R.2
Shibuya, H.3
Nakashima, K.4
Taga, T.5
-
184
-
-
0037592952
-
Different properties of SEK1 and MKK7 in dual phosphorylation of stress-induced activated protein kinase SAPK/JNK in embryonic stem cells
-
DOI 10.1074/jbc.M213182200
-
Kishimoto H, Nakagawa K, Watanabe T, Kitagawa D, Momose H, Seo J, Nishitai G, Shimizu N, Ohata S, Tane-mura S, Asaka S, Goto T, Fukushi H, Yoshida H, Suzuki A, Sasaki T, Wada T, Penninger JM, Nishina H, and Katada T. Different properties of SEK1 and MKK7 in dual phos-phorylation of stress-induced activated protein kinase SAPK/JNK in embryonic stem cells. J Biol Chem 278: 16595-16601, 2003. (Pubitemid 36799521)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.19
, pp. 16595-16601
-
-
Kishimoto, H.1
Nakagawa, K.2
Watanabe, T.3
Kitagawa, D.4
Momose, H.5
Seo, J.6
Nishitai, G.7
Shimizu, N.8
Ohata, S.9
Tanemura, S.10
Asaka, S.11
Goto, T.12
Fukushi, H.13
Yoshida, H.14
Suzuki, A.15
Sasaki, T.16
Wada, T.17
Penninger, J.M.18
Nishina, H.19
Katada, T.20
more..
-
185
-
-
0028998794
-
Regulation of human leukocyte p21-activated kinases through G protein\coupled receptors
-
Knaus UG, Morris S, Dong HJ, Chernoff J, and Bokoch GM. Regulation of human leukocyte p21-activated kinases through G protein\coupled receptors. Science 269: 221-223, 1995.
-
(1995)
Science
, vol.269
, pp. 221-223
-
-
Knaus, U.G.1
Morris, S.2
Dong, H.J.3
Chernoff, J.4
Bokoch, G.M.5
-
186
-
-
62949138866
-
Antiapoptotic effect of c-Jun N-terminal Ki-nase-1 through Mcl-1 stabilization in TNF-induced hepa-tocyte apoptosis
-
Kodama Y, Taura K, Miura K, Schnabl B, Osawa Y, and Brenner DA. Antiapoptotic effect of c-Jun N-terminal Ki-nase-1 through Mcl-1 stabilization in TNF-induced hepa-tocyte apoptosis. Gastroenterology 136: 1423-1434, 2009.
-
(2009)
Gastroenterology
, vol.136
, pp. 1423-1434
-
-
Kodama, Y.1
Taura, K.2
Miura, K.3
Schnabl, B.4
Osawa, Y.5
Brenner, D.A.6
-
187
-
-
0033518141
-
C-terminal truncation of Dlk/ZIP kinase leads to abrogation of nuclear transport and high apoptotic activity
-
Kogel D, Bierbaum H, Preuss U, and Scheidtmann KH. C-terminal truncation of Dlk/ZIP kinase leads to abrogation of nuclear transport and high apoptotic activity. Oncogene 18: 7212-7218, 1999. (Pubitemid 30032099)
-
(1999)
Oncogene
, vol.18
, Issue.51
, pp. 7212-7218
-
-
Kogel, D.1
Bierbaum, H.2
Preuss, U.3
Scheidtmann, K.H.4
-
188
-
-
0035811071
-
2-treated cells and its activation by tyrosine kinase in vitro
-
DOI 10.1073/pnas.111158798
-
Konishi H, Yamauchi E, Taniguchi H, Yamamoto T, Mat-suzaki H, Takemura Y, Ohmae K, Kikkawa U, and Nishi-zuka Y. Phosphorylation sites of protein kinase C δ in H2O2-treated cells and its activation by tyrosine kinase in vitro. Proc Natl Acad Sci USA 98: 6587-6592, 2001 (Pubitemid 32538260)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.12
, pp. 6587-6592
-
-
Konishi, H.1
Yamauchi, E.2
Taniguchi, H.3
Yamamoto, T.4
Matsuzaki, H.5
Takemura, Y.6
Ohmae, K.7
Kikkawa, U.8
Nishizuka, Y.9
-
189
-
-
0033118607
-
The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development
-
DOI 10.1016/S0896-6273(00)80727-8
-
Kuan CY, Yang DD, Samanta Roy DR, Davis RJ, Rakic P, and Flavell RA. The Jnk1 and Jnk2 protein kinases are re-quired for regional specific apoptosis during early brain development. Neuron 22: 667-676, 1999. (Pubitemid 29203491)
-
(1999)
Neuron
, vol.22
, Issue.4
, pp. 667-676
-
-
Kuan, C.-Y.1
Yang, D.D.2
Samanta Roy, D.R.3
Davis, R.J.4
Rakic, P.5
Flavell, R.A.6
-
191
-
-
32644448252
-
The tumor suppressor DAPK inhibits cell motility by blocking the integrin-mediated polarity pathway
-
Kuo JC, Wang WJ, Yao CC, Wu PR, and Chen RH. The tumor suppressor DAPK inhibits cell motility by blocking the integrin-mediated polarity pathway. J Cell Biol 172: 619-631, 2006.
-
(2006)
J Cell Biol
, vol.172
, pp. 619-631
-
-
Kuo, J.C.1
Wang, W.J.2
Yao, C.C.3
Wu, P.R.4
Chen, R.H.5
-
192
-
-
0036712650
-
Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Drosophila
-
DOI 10.1038/ncb842
-
Kuranaga E, Kanuka H, Igaki T, Sawamoto K, Ichijo H, Okano H, and Miura M. Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Drosophila. Nat Cell Biol 4: 705-710, 2002. (Pubitemid 34993707)
-
(2002)
Nature Cell Biology
, vol.4
, Issue.9
, pp. 705-710
-
-
Kuranaga, E.1
Kanuka, H.2
Igaki, T.3
Sawamoto, K.4
Ichijo, H.5
Okano, H.6
Miura, M.7
-
193
-
-
69449095860
-
Caspases and kinases in a death grip
-
Kurokawa M and Kornbluth S. Caspases and kinases in a death grip. Cell 138: 838-854, 2009.
-
(2009)
Cell
, vol.138
, pp. 838-854
-
-
Kurokawa, M.1
Kornbluth, S.2
-
194
-
-
0035066383
-
Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation
-
Kyriakis JM and Avruch J. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev 81: 807-869, 2001. (Pubitemid 32267078)
-
(2001)
Physiological Reviews
, vol.81
, Issue.2
, pp. 807-869
-
-
Kyriakis, J.M.1
Avruch, J.2
-
195
-
-
0038433303
-
JunD mediates survival signaling by the JNK signal transduction pathway
-
DOI 10.1016/S1097-2765(03)00203-X
-
Lamb JA, Ventura JJ, Hess P, Flavell RA, and Davis RJ. JunD mediates survival signaling by the JNK signal trans-duction pathway. Mol Cell 11: 1479-1489, 2003. (Pubitemid 36776535)
-
(2003)
Molecular Cell
, vol.11
, Issue.6
, pp. 1479-1489
-
-
Lamb, J.A.1
Ventura, J.-J.2
Hess, P.3
Flavell, R.A.4
Davis, R.J.5
-
196
-
-
77649178841
-
The TAK1-TRAF6 signalling pathway
-
Landstrom M. The TAK1-TRAF6 signalling pathway. Int J Biochem Cell Biol 42: 585-589, 2010.
-
(2010)
Int J Biochem Cell Biol
, vol.42
, pp. 585-589
-
-
Landstrom, M.1
-
197
-
-
78649477489
-
Protein kinase D as a potential new target for cancer therapy
-
LaValle CR, George KM, Sharlow ER, Lazo JS, Wipf P, and Wang QJ. Protein kinase D as a potential new target for cancer therapy. Biochim Biophys Acta 1806: 183-192, 2010.
-
(2010)
Biochim Biophys Acta
, vol.1806
, pp. 183-192
-
-
Lavalle, C.R.1
George, K.M.2
Sharlow, E.R.3
Lazo, J.S.4
Wipf, P.5
Wang, Q.J.6
-
198
-
-
0032585615
-
Synergistic activation of SAPK1/JNK1 by two MAP kinase kinases in vitro
-
Lawler S, Fleming Y, Goedert M, and Cohen P. Synergistic activation of SAPK1/JNK1 by two MAP kinase kinases in vitro. Curr Biol 8: 1387-1390, 1998. (Pubitemid 29020147)
-
(1998)
Current Biology
, vol.8
, Issue.25
, pp. 1387-1390
-
-
Lawler, S.1
Fleming, Y.2
Goedert, M.3
Cohen, P.4
-
199
-
-
0027048684
-
The protein kinase homologue Ste20p is required to link the yeast pheromone response G-protein βγ subunits to downstream signalling components
-
Leberer E, Dignard D, Harcus D, Thomas DY, and White-way M. The protein kinase homologue Ste20p is required to link the yeast pheromone response G-protein ßy subunits to downstream signalling components. EMBO J 11: 4815-4824, 1992. (Pubitemid 23023424)
-
(1992)
EMBO Journal
, vol.11
, Issue.13
, pp. 4815-4824
-
-
Leberer, E.1
Dignard, D.2
Harcus, D.3
Thomas, D.Y.4
Whiteway, M.5
-
200
-
-
0032507878
-
Proteolytic activation of MST/Krs, STE20-related protein kinase, by caspase during apoptosis
-
Lee KK, Murakawa M, Nishida E, Tsubuki S, Kawashima S, Sakamaki K, and Yonehara S. Proteolytic activation of MST/Krs, STE20-related protein kinase, by caspase during apoptosis. Oncogene 16: 3029-3037, 1998. (Pubitemid 28297725)
-
(1998)
Oncogene
, vol.16
, Issue.23
, pp. 3029-3037
-
-
Lee, K.-K.1
Murakawa, M.2
Nishida, E.3
Tsubuki, S.4
Kawashima, S.-I.5
Sakamaki, K.6
Yonehara, S.7
-
201
-
-
0035379556
-
MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase acti-vation
-
Lee KK, Ohyama T, Yajima N, Tsubuki S, and Yonehara S. MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase acti-vation. J Biol Chem 276: 19276-19285, 2001.
-
(2001)
J Biol Chem
, vol.276
, pp. 19276-19285
-
-
Lee, K.K.1
Ohyama, T.2
Yajima, N.3
Tsubuki, S.4
Yonehara, S.5
-
202
-
-
0031443641
-
Activation of hPAK65 by caspase cleavage induces some of the morphological and biochemical changes of apoptosis
-
DOI 10.1073/pnas.94.25.13642
-
Lee N, MacDonald H, Reinhard C, Halenbeck R, Roulston A, Shi T, and Williams LT. Activation of hPAK65 by cas-pase cleavage induces some of the morphological and biochemical changes of apoptosis. Proc Natl Acad Sci USA 94: 13642-13647, 1997. (Pubitemid 28009636)
-
(1997)
Proceedings of the National Academy of Sciences of the United States of America
, vol.94
, Issue.25
, pp. 13642-13647
-
-
Lee, N.1
Macdonald, H.2
Reinhard, C.3
Halenbeck, R.4
Roulston, A.5
Shi, T.6
Williams, L.T.7
-
203
-
-
4143118028
-
Identification and characterization of the nuclear import and export signals of the mammalian Ste20-like protein kinase 3
-
Lee WS, Hsu CY, Wang PL, Huang CY, Chang CH, and Yuan CJ. Identification and characterization of the nuclear import and export signals of the mammalian Ste20-like protein kinase 3. FEBS Lett 572: 41-45, 2004.
-
(2004)
FEBS Lett
, vol.572
, pp. 41-45
-
-
Lee, W.S.1
Hsu, C.Y.2
Wang, P.L.3
Huang, C.Y.4
Chang, C.H.5
Yuan, C.J.6
-
204
-
-
0037474274
-
C-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade
-
DOI 10.1074/jbc.M208359200
-
Lee YH, Giraud J, Davis RJ, and White MF. c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade. J Biol Chem 278: 2896-2902, 2003. (Pubitemid 36801194)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.5
, pp. 2896-2902
-
-
Lee, Y.H.1
Giraud, J.2
Davis, R.J.3
White, M.F.4
-
205
-
-
33646934067
-
A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span
-
DOI 10.1016/j.cell.2006.03.046, PII S0092867406005599
-
Lehtinen MK, Yuan Z, Boag PR, Yang Y, Villen J, Becker EB, DiBacco S, de la Iglesia N, Gygi S, Blackwell TK, and Bonni A. A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. Cell 125: 987-1001, 2006. (Pubitemid 43795191)
-
(2006)
Cell
, vol.125
, Issue.5
, pp. 987-1001
-
-
Lehtinen, M.K.1
Yuan, Z.2
Boag, P.R.3
Yang, Y.4
Villen, J.5
Becker, E.B.E.6
DiBacco, S.7
De La Iglesia, N.8
Gygi, S.9
Blackwell, T.K.10
Bonni, A.11
-
207
-
-
0035179086
-
Exacerbated vein graft arteriosclerosis in protein kinase Cδ-null mice
-
DOI 10.1172/JCI200112902
-
Leitges M, Mayr M, Braun U, Mayr U, Li C, Pfister G, Ghaffari-Tabrizi N, Baier G, Hu Y, and Xu Q. Exacerbated vein graft arteriosclerosis in protein kinase Cδ-null mice. J Clin Invest 108: 1505-1512, 2001 (Pubitemid 33091988)
-
(2001)
Journal of Clinical Investigation
, vol.108
, Issue.10
, pp. 1505-1512
-
-
Leitges, M.1
Mayr, M.2
Braun, U.3
Mayr, U.4
Li, C.5
Pfister, G.6
Ghaffari-Tabrizi, N.7
Baier, G.8
Hu, Y.9
Xu, Q.10
-
208
-
-
54249096028
-
Caspases in apoptosis and beyond
-
Li J and Yuan J. Caspases in apoptosis and beyond. Onco-gene 27: 6194-6206, 2008.
-
(2008)
Onco-gene
, vol.27
, pp. 6194-6206
-
-
Li, J.1
Yuan, J.2
-
209
-
-
29244439927
-
PAK4 functions in tumor necrosis factor (TNF) α-induced survival pathways by facilitating TRADD binding to the TNF receptor
-
DOI 10.1074/jbc.M506884200
-
Li X and Minden A. PAK4 functions in tumor necrosis factor (TNF) α-induced survival pathways by facilitating TRADD binding to the TNF receptor. J Biol Chem 280: 41192-41200, 2005. (Pubitemid 41832173)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.50
, pp. 41192-41200
-
-
Li, X.1
Minden, A.2
-
210
-
-
0033214236
-
Cleavage of the death domain kinase RIP by Caspase-8 prompts TNF-induced apoptosis
-
DOI 10.1101/gad.13.19.2514
-
Lin Y, Devin A, Rodriguez Y, and Liu ZG. Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis. Genes Dev 13: 2514-2526, 1999. (Pubitemid 29489643)
-
(1999)
Genes and Development
, vol.13
, Issue.19
, pp. 2514-2526
-
-
Lin, Y.1
Devin, A.2
Rodriguez, Y.3
Liu, Z.-G.4
-
211
-
-
43049155951
-
Biosignaling of mammalian Ste20-related kinases
-
Ling P, Lu TJ, Yuan CJ, and Lai MD. Biosignaling of mammalian Ste20-related kinases. Cell Signal 20:1237-1247, 2008.
-
(2008)
Cell Signal
, vol.20
, pp. 1237-1247
-
-
Ling, P.1
Lu, T.J.2
Yuan, C.J.3
Lai, M.D.4
-
212
-
-
37549051733
-
Protein kinase C<5 induces transcription of the TP53 tumor suppressor gene by controlling death-promoting factor Btf in the apoptotic response to DNA damage
-
Liu H, Lu ZG, Miki Y, and Yoshida K. Protein kinase C<5 induces transcription of the TP53 tumor suppressor gene by controlling death-promoting factor Btf in the apoptotic response to DNA damage. Mol Cell Biol 27: 8480-8491, 2007
-
(2007)
Mol Cell Biol
, vol.27
, pp. 8480-8491
-
-
Liu, H.1
Lu, Z.G.2
Miki, Y.3
Yoshida, K.4
-
213
-
-
33646566490
-
Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth
-
DOI 10.1128/MCB.26.10.3785-3797.2006
-
Liu Q, Wilkins BJ, Lee YJ, Ichijo H, and Molkentin JD. Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth. Mol Cell Biol 26: 3785-3797, 2006. (Pubitemid 43726396)
-
(2006)
Molecular and Cellular Biology
, vol.26
, Issue.10
, pp. 3785-3797
-
-
Liu, Q.1
Wilkins, B.J.2
Lee, Y.J.3
Ichijo, H.4
Molkentin, J.D.5
-
214
-
-
0001583878
-
Activation of MLK2-mediated signaling cascades by polyglutamine-expanded huntingtin
-
DOI 10.1074/jbc.C000180200
-
Liu YF, Dorow D, and Marshall J. Activation of MLK2-mediated signaling cascades by polyglutamine-expanded huntingtin. J Biol Chem 275: 19035-19040, 2000. (Pubitemid 30422870)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.25
, pp. 19035-19040
-
-
Liu, Y.F.1
Dorow, D.2
Marshall, J.3
-
215
-
-
17144402891
-
The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase
-
DOI 10.1038/sj.emboj.7600584
-
Llambi F, Lourenco FC, Gozuacik D, Guix C, Pays L, Del Rio G, Kimchi A, and Mehlen P. The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase. EMBO J 24: 1192-1201, 2005. (Pubitemid 40516602)
-
(2005)
EMBO Journal
, vol.24
, Issue.6
, pp. 1192-1201
-
-
Llambi, F.1
Calheiros-Lourenco, F.2
Gozuacik, D.3
Guix, C.4
Pays, L.5
Del Rio, G.6
Kimchi, A.7
Mehlen, P.8
-
216
-
-
33846799159
-
The C. elegans anaphase promoting complex and MBK-2/DYRK kinase act redundantly with CUL-3/MEL-26 ubiquitin ligase to degrade MEI-1 microtubule-severing activity after meiosis
-
DOI 10.1016/j.ydbio.2006.09.053, PII S0012160606012693
-
Lu C and Mains PE. The C. elegans anaphase promot-ing complex and MBK-2/DYRK kinase act redundantly with CUL-3/MEL-26 ubiquitin ligase to degrade MEI-1 microtubule-severing activity after meiosis. Dev Biol 302: 438-447, 2007. (Pubitemid 46216263)
-
(2007)
Developmental Biology
, vol.302
, Issue.2
, pp. 438-447
-
-
Lu, C.1
Mains, P.E.2
-
217
-
-
0033118982
-
Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice
-
Lu HT, Yang DD, Wysk M, Gatti E, Mellman I, Davis RJ, and Flavell RA. Defective IL-12 production in mitogen-ac-tivated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice. EMBO J 18: 1845-1857, 1999. (Pubitemid 29158528)
-
(1999)
EMBO Journal
, vol.18
, Issue.7
, pp. 1845-1857
-
-
Lu, H.-T.1
Yang, D.D.2
Wysk, M.3
Gatti, E.4
Mellman, I.5
Davis, R.J.6
Flavell, R.A.7
-
218
-
-
33845989128
-
Inhibition of cell migration by autophosphorylated mammalian sterile 20-like kinase 3 (MST3) involves paxillin and protein-tyrosine phosphatase-PEST
-
Lu TJ, Lai WY, Huang CY, Hsieh WJ, Yu JS, Hsieh YJ, Chang WT, Leu TH, Chang WC, Chuang WJ, Tang MJ, Chen TY, Lu TL, and Lai MD. Inhibition of cell migration by autophosphorylated mammalian sterile 20-like kinase 3 (MST3) involves paxillin and protein-tyrosine phosphatase-PEST. J Biol Chem 281: 38405-38417, 2006.
-
(2006)
J Biol Chem
, vol.281
, pp. 38405-38417
-
-
Lu, T.J.1
Lai, W.Y.2
Huang, C.Y.3
Hsieh, W.J.4
Yu, J.S.5
Hsieh, Y.J.6
Chang, W.T.7
Leu, T.H.8
Chang, W.C.9
Chuang, W.J.10
Tang, M.J.11
Chen, T.Y.12
Lu, T.L.13
Lai, M.D.14
-
219
-
-
0030770419
-
2-terminal protein kinase (JNK)-activating kinase 2 as an activator of JNK but not p38
-
DOI 10.1074/jbc.272.40.24751
-
Lu X, Nemoto S, and Lin A. Identification of c-Jun NH2-terminal protein kinase (JNK)-activating kinase 2 as an activator of JNK but not p38. J Biol Chem 272: 24751-24754, 1997. (Pubitemid 27415641)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.40
, pp. 24751-24754
-
-
Lu, X.1
Nemoto, S.2
Lin, A.3
-
220
-
-
0036279167
-
The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2
-
DOI 10.1016/S1097-2765(02)00519-1
-
Lu Z, Xu S, Joazeiro C, Cobb MH, and Hunter T. The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and me-diates ubiquitination and degradation of ERK1/2. Mol Cell 9: 945-956, 2002. (Pubitemid 34626666)
-
(2002)
Molecular Cell
, vol.9
, Issue.5
, pp. 945-956
-
-
Lu, Z.1
Xu, S.2
Joazeiro, C.3
Cobb, M.H.4
Hunter, T.5
-
221
-
-
36048948364
-
MKK3-p38 signaling promotes apoptosis and the early inflammatory response in the obstructed mouse kidney
-
DOI 10.1152/ajprenal.00010.2007
-
Ma FY, Tesch GH, Flavell RA, Davis RJ, and Nikolic-Paterson DJ. MKK3-p38 signaling promotes apoptosis and the early inflammatory response in the obstructed mouse kidney. Am J Physiol Renal Physiol 293: F1556-F1563, 2007. (Pubitemid 350085991)
-
(2007)
American Journal of Physiology - Renal Physiology
, vol.293
, Issue.5
-
-
Ma, F.Y.1
Tesch, G.H.2
Flavell, R.A.3
Davis, R.J.4
Nikolic-Paterson, D.J.5
-
222
-
-
20444419344
-
Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance
-
DOI 10.1038/ncb1258
-
MacKeigan JP, Murphy LO, and Blenis J. Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance. Nat Cell Biol 7: 591-600, 2005. (Pubitemid 40796982)
-
(2005)
Nature Cell Biology
, vol.7
, Issue.6
, pp. 591-600
-
-
MacKeigan, J.P.1
Murphy, L.O.2
Blenis, J.3
-
223
-
-
64049091261
-
Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase
-
Maddika S and Chen J. Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase. Nat Cell Biol 11: 409-419, 2009.
-
(2009)
Nat Cell Biol
, vol.11
, pp. 409-419
-
-
Maddika, S.1
Chen, J.2
-
224
-
-
50149121101
-
Both cIAP1 and cIAP2 regulate TNFα-mediated NF-?B activation
-
Mahoney DJ, Cheung HH, Mrad RL, Plenchette S, Simard C, Enwere E, Arora V, Mak TW, Lacasse EC, Waring J, and Korneluk RG. Both cIAP1 and cIAP2 regulate TNFα-mediated NF-?B activation. Proc Natl Acad Sci USA 105: 11778-11783, 2008.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 11778-11783
-
-
Mahoney, D.J.1
Cheung, H.H.2
Mrad, R.L.3
Plenchette, S.4
Simard, C.5
Enwere, E.6
Arora, V.7
Mak, T.W.8
Lacasse, E.C.9
Waring, J.10
Korneluk, R.G.11
-
225
-
-
11344286593
-
2/M transition and S phase progression in response to UV irradiation
-
DOI 10.1016/j.molcel.2004.11.021, PII S1097276504007129
-
Manke IA, Nguyen A, Lim D, Stewart MQ, Elia AE, and Yaffe MB. MAPKAP kinase-2 is a cell cycle checkpoint ki-nase that regulates the G2/M transition and S phase pro-gression in response to UV irradiation. Mol Cell 17: 37-48, 2005. (Pubitemid 40075363)
-
(2005)
Molecular Cell
, vol.17
, Issue.1
, pp. 37-48
-
-
Manke, I.A.1
Nguyen, A.2
Lim, D.3
Stewart, M.Q.4
Elia, A.E.H.5
Yaffe, M.B.6
-
226
-
-
0035816685
-
Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family
-
Maroney AC, Finn JP, Connors TJ, Durkin JT, Angeles T, Gessner G, Xu Z, Meyer SL, Savage MJ, Greene LA, Scott RW, and Vaught JL. Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family. J Biol Chem 276: 25302-25308, 2001.
-
(2001)
J Biol Chem
, vol.276
, pp. 25302-25308
-
-
Maroney, A.C.1
Finn, J.P.2
Connors, T.J.3
Durkin, J.T.4
Angeles, T.5
Gessner, G.6
Xu, Z.7
Meyer, S.L.8
Savage, M.J.9
Greene, L.A.10
Scott, R.W.11
Vaught, J.L.12
-
227
-
-
17344374130
-
Motoneuron apoptosis is blocked by CEP-1347 (KT 7515), a novel inhibitor of the JNK signaling pathway
-
Maroney AC, Glicksman MA, Basma AN, Walton KM, Knight E, Jr., Murphy CA, Bartlett BA, Finn JP, Angeles T, Matsuda Y, Neff NT, and Dionne CA. Motoneuron apo-ptosis is blocked by CEP-1347 (KT 7515), a novel inhibitor of the JNK signaling pathway. J Neurosci 18: 104-111,1998. (Pubitemid 28046771)
-
(1998)
Journal of Neuroscience
, vol.18
, Issue.1
, pp. 104-111
-
-
Maroney, A.C.1
Glicksman, M.A.2
Basma, A.N.3
Walton, K.M.4
Knight Jr., E.5
Murphy, C.A.6
Bartlett, B.A.7
Finn, J.P.8
Angeles, T.9
Matsuda, Y.10
Neff, N.T.11
Dionne, C.A.12
-
228
-
-
77955421222
-
CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response
-
Maruyama T, Kadowaki H, Okamoto N, Nagai A, Naguro I, Matsuzawa A, Shibuya H, Tanaka K, Murata S, Takeda K, Nishitoh H, and Ichijo H. CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response. EMBO J 29: 2501-2514, 2010.
-
(2010)
EMBO J
, vol.29
, pp. 2501-2514
-
-
Maruyama, T.1
Kadowaki, H.2
Okamoto, N.3
Nagai, A.4
Naguro, I.5
Matsuzawa, A.6
Shibuya, H.7
Tanaka, K.8
Murata, S.9
Takeda, K.10
Nishitoh, H.11
Ichijo, H.12
-
229
-
-
34748812613
-
RASSF1A Elicits Apoptosis through an MST2 Pathway Directing Proapoptotic Transcription by the p73 Tumor Suppressor Protein
-
DOI 10.1016/j.molcel.2007.08.008, PII S1097276507005515
-
Matallanas D, Romano D, Yee K, Meissl K, Kucerova L, Piazzolla D, Baccarini M, Vass JK, Kolch W, and O'Neill E. RASSF1A elicits apoptosis through an MST2 pathway di-recting proapoptotic transcription by the p73 tumor sup-pressor protein. Mol Cell 27: 962-975, 2007. (Pubitemid 47495894)
-
(2007)
Molecular Cell
, vol.27
, Issue.6
, pp. 962-975
-
-
Matallanas, D.1
Romano, D.2
Yee, K.3
Meissl, K.4
Kucerova, L.5
Piazzolla, D.6
Baccarini, M.7
Vass, J.K.8
Kolch, W.9
O'Neill, E.10
-
230
-
-
58149358873
-
Lats2 is a negative regulator of myocyte size in the heart
-
Matsui Y, Nakano N Shao D, Gao S, Luo W, Hong C, Zhai P, Holle E, Yu X, Yabuta N, Tao W, Wagner T, Nojima H, and Sadoshima J. Lats2 is a negative regulator of myocyte size in the heart. Circ Res 103: 1309-1318, 2008.
-
(2008)
Circ Res
, vol.103
, pp. 1309-1318
-
-
Matsui, Y.1
Nakano Shao N, D.2
Gao, S.3
Luo, W.4
Hong, C.5
Zhai, P.6
Holle, E.7
Yu, X.8
Yabuta, N.9
Tao, W.10
Wagner, T.11
Nojima, H.12
Sadoshima, J.13
-
231
-
-
0030597160
-
Ectopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cells
-
DOI 10.1016/0014-5793(96)01016-2
-
Matsumoto M, Minami M, Takeda K, Sakao Y, and Akira S. Ectopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cells. FEBS Lett 395: 143-147, 1996. (Pubitemid 26356172)
-
(1996)
FEBS Letters
, vol.395
, Issue.2-3
, pp. 143-147
-
-
Matsumoto, M.1
Minami, M.2
Takeda, K.3
Sakao, Y.4
Akira, S.5
-
232
-
-
20644433073
-
ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity
-
DOI 10.1038/ni1200
-
Matsuzawa A, Saegusa K, Noguchi T, Sadamitsu C, Nish-itoh H, Nagai S, Koyasu S, Matsumoto K, Takeda K, and Ichijo H. ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity. Nat Immunol 6: 587-592, 2005. (Pubitemid 41710729)
-
(2005)
Nature Immunology
, vol.6
, Issue.6
, pp. 587-592
-
-
Matsuzawa, A.1
Saegusa, K.2
Noguchi, T.3
Sadamitsu, C.4
Nishitoh, H.5
Nagai, S.6
Koyasu, S.7
Matsumoto, K.8
Takeda, K.9
Ichijo, H.10
-
233
-
-
0035144493
-
Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bc12 and perturbing the cellular redox state
-
DOI 10.1128/MCB.21.4.1249-1259.2001
-
McCullough KD, Martindale JL, Klotz LO, Aw TY, and Holbrook NJ. Gadd153 sensitizes cells to endoplasmic re-ticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Mol Cell Biol 21: 1249-1259, 2001. (Pubitemid 32114973)
-
(2001)
Molecular and Cellular Biology
, vol.21
, Issue.4
, pp. 1249-1259
-
-
McCullough, K.D.1
Martindale, J.L.2
Klotz, L.-O.3
Aw, T.-Y.4
Holbrook, N.J.5
-
234
-
-
4644240851
-
Regulation of B-cell survival by BAFF-dependent PKCδ-mediated nuclear signalling
-
DOI 10.1038/nature02955
-
Mecklenbrauker I, Kalled SL, Leitges M, Mackay F, and Tarakhovsky A. Regulation of B-cell survival by BAFF-dependent PKCδ-mediated nuclear signalling. Nature 431: 456-461, 2004 (Pubitemid 39329585)
-
(2004)
Nature
, vol.431
, Issue.7007
, pp. 456-461
-
-
Mecklenbrauker, I.1
Kalled, S.L.2
Lettges, M.3
Mackay, F.4
Tarakhovsky, A.5
-
235
-
-
73649118820
-
Death-associated protein kinase (DAPK) and signal trans-duction: Regulation in cancer
-
Michie AM, McCaig AM, Nakagawa R, and Vukovic M. Death-associated protein kinase (DAPK) and signal trans-duction: regulation in cancer. FEBS J 277: 74-80, 2010.
-
(2010)
FEBS J
, vol.277
, pp. 74-80
-
-
Michie, A.M.1
McCaig, A.M.2
Nakagawa, R.3
Vukovic, M.4
-
236
-
-
17744384002
-
Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene
-
DOI 10.1093/emboj/20.8.1952
-
Mikula M, Schreiber M, Husak Z, Kucerova L, Ruth J, Wieser R, Zatloukal K, Beug H, Wagner EF, and Baccarini M. Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene. EMBO J 20: 1952-1962, 2001. (Pubitemid 32397397)
-
(2001)
EMBO Journal
, vol.20
, Issue.8
, pp. 1952-1962
-
-
Mikula, M.1
Schreiber, M.2
Husak, Z.3
Kucerova, L.4
Ruth, J.5
Wieser, R.6
Zatloukal, K.7
Beug, H.8
Wagner, E.F.9
Baccarini, M.10
-
237
-
-
63649153518
-
A dual leucine kinase-dependent axon self-destruction program promotes Wallerian degeneration
-
Miller BR, Press C, Daniels RW, Sasaki Y, Milbrandt J, and DiAntonio A. A dual leucine kinase-dependent axon self-destruction program promotes Wallerian degeneration. Nat Neurosci 12: 387-389, 2009.
-
(2009)
Nat Neurosci
, vol.12
, pp. 387-389
-
-
Miller, B.R.1
Press, C.2
Daniels, R.W.3
Sasaki, Y.4
Milbrandt, J.5
Diantonio, A.6
-
238
-
-
0041672360
-
Amplification and overexpression of the dual-specificity tyrosine-(Y)phosphorylation regulated kinase 2 (DYRK2) gene in esophageal and lung adenocarcinomas
-
Miller CT, Aggarwal S, Lin TK, Dagenais SL, Contreras JI, Orringer MB, Glover TW, Beer DG, and Lin L. Amplifica-tion and overexpression of the dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 (DYRK2) gene in esophageal and lung adenocarcinomas. Cancer Res 63: 4136-4143, 2003. (Pubitemid 36917938)
-
(2003)
Cancer Research
, vol.63
, Issue.14
, pp. 4136-4143
-
-
Miller, C.T.1
Aggarwal, S.2
Lin, T.K.3
Dagenais, S.L.4
Contreras, J.I.5
Orringer, M.B.6
Glover, T.W.7
Beer, D.G.8
Lin, L.9
-
239
-
-
0037171731
-
Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cδ
-
DOI 10.1038/416865a
-
Miyamoto A, Nakayama K, Imaki H, Hirose S, Jiang Y, Abe M, Tsukiyama T, Nagahama H, Ohno S, Hatakeyama S, and Nakayama KI. Increased proliferation of B cells and autoimmunity in mice lacking protein kinase Cδ. Nature 416: 865-869, 2002 (Pubitemid 34453744)
-
(2002)
Nature
, vol.416
, Issue.6883
, pp. 865-869
-
-
Miyamoto, A.1
Nakayama, K.2
Imaki, H.3
Hirose, S.4
Jiang, Y.5
Abe, M.6
Tsukiyama, T.7
Nagahama, H.8
Ohno, S.9
Hatakeyama, S.10
Nakayama, K.I.11
-
240
-
-
39849109338
-
Autophagy fights disease through cellular self-digestion
-
DOI 10.1038/nature06639, PII NATURE06639
-
Mizushima N, Levine B, Cuervo AM, and Klionsky DJ. Autophagy fights disease through cellular self-digestion. Nature 451: 1069-1075, 2008. (Pubitemid 351317450)
-
(2008)
Nature
, vol.451
, Issue.7182
, pp. 1069-1075
-
-
Mizushima, N.1
Levine, B.2
Cuervo, A.M.3
Klionsky, D.J.4
-
241
-
-
67651097663
-
PAK signaling in oncogenesis
-
Molli PR, Li DQ, Murray BW, Rayala SK, and Kumar R. PAK signaling in oncogenesis. Oncogene 28: 2545-2555,2009.
-
(2009)
Oncogene
, vol.28
, pp. 2545-2555
-
-
Molli, P.R.1
Li, D.Q.2
Murray, B.W.3
Rayala, S.K.4
Kumar, R.5
-
242
-
-
0035503696
-
Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress
-
DOI 10.1093/emboj/20.21.6028
-
Morita K, Saitoh M, Tobiume K, Matsuura H, Enomoto S, Nishitoh H, and Ichijo H. Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxi-dative stress. EMBO J 20: 6028-6036, 2001. (Pubitemid 33049278)
-
(2001)
EMBO Journal
, vol.20
, Issue.21
, pp. 6028-6036
-
-
Morita, K.-I.1
Saitoh, M.2
Tobiume, K.3
Matsuura, H.4
Enomoto, S.5
Nishitoh, H.6
Ichijo, H.7
-
243
-
-
0035879151
-
Evidence for a role of mixed lineage kinases in neuronal apoptosis
-
Mota M, Reeder M, Chernoff J, and Bazenet CE. Evidence for a role of mixed lineage kinases in neuronal apoptosis. J Neurosci 21: 4949-4957, 2001. (Pubitemid 32622920)
-
(2001)
Journal of Neuroscience
, vol.21
, Issue.14
, pp. 4949-4957
-
-
Mota, M.1
Reeder, M.2
Chernoff, J.3
Bazenet, C.E.4
-
244
-
-
0034641614
-
Essential role for p38α mitogen-activated protein kinase in placental angiogenesis
-
Mudgett JS, Ding J, Guh-Siesel L, Chartrain NA, Yang L, Gopal S, and Shen MM. Essential role for p38α mitogen-activated protein kinase in placental angiogenesis. Proc Natl Acad Sci USA 97: 10454-10459, 2000.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 10454-10459
-
-
Mudgett, J.S.1
Ding, J.2
Guh-Siesel, L.3
Chartrain, N.A.4
Yang, L.5
Gopal, S.6
Shen, M.M.7
-
245
-
-
9144256765
-
Protein kinase Cδ activation induces apoptosis in response to cardiac ischemia and reperfusion damage: A mechanism involving bad and the mitochondria
-
DOI 10.1074/jbc.M405071200
-
Murriel CL, Churchill E, Inagaki K, Szweda LI, and Mochly-Rosen D. Protein kinase Cδ activation induces ap-optosis in response to cardiac ischemia and reperfusion damage: a mechanism involving BAD and the mitochon-dria. J Biol Chem 279: 47985-47991, 2004 (Pubitemid 39540950)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.46
, pp. 47985-47991
-
-
Murriel, C.L.1
Churchill, E.2
Inagaki, K.3
Szweda, L.I.4
Mochly-Rosen, D.5
-
246
-
-
71449117666
-
Ubiquitin-like sequence in ASK1 plays critical roles in the recognition and stabilization by USP9x and oxidative stress-induced cell death
-
Nagai H, Noguchi T, Homma K, Katagiri K, Takeda K, Matsuzawa A, and Ichijo H. Ubiquitin-like sequence in ASK1 plays critical roles in the recognition and stabilization by USP9x and oxidative stress-induced cell death. Mol Cell 36: 805-818, 2009.
-
(2009)
Mol Cell
, vol.36
, pp. 805-818
-
-
Nagai, H.1
Noguchi, T.2
Homma, K.3
Katagiri, K.4
Takeda, K.5
Matsuzawa, A.6
Ichijo, H.7
-
247
-
-
0344626926
-
Structural basis for the autoinhibition of c-Abl tyrosine kinase
-
DOI 10.1016/S0092-8674(03)00194-6
-
Nagar B, Hantschel O, Young MA, Scheffzek K, Veach D, Bornmann W, Clarkson B, Superti-Furga G, and Kuriyan J. Structural basis for the autoinhibition of c-Abl tyrosine ki-nase. Cell 112: 859-871, 2003. (Pubitemid 36378887)
-
(2003)
Cell
, vol.112
, Issue.6
, pp. 859-871
-
-
Nagar, B.1
Hantschel, O.2
Young, M.A.3
Scheffzek, K.4
Veach, D.5
Bornmann, W.6
Clarkson, B.7
Superti-Furga, G.8
Kuriyan, J.9
-
248
-
-
24644478136
-
Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development
-
DOI 10.1038/nature03914
-
Nateri AS, Spencer-Dene B, and Behrens A. Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development. Nature 437: 281-285, 2005. (Pubitemid 41294493)
-
(2005)
Nature
, vol.437
, Issue.7056
, pp. 281-285
-
-
Nateri, A.S.1
Spencer-Dene, B.2
Behrens, A.3
-
249
-
-
10044261073
-
P38α mitogen-activated protein kinase plays a critical role in cardiomyocyte survival but not in cardiac hypertrophic growth in response to pressure overload
-
DOI 10.1128/MCB.24.24.10611-10620.2004
-
Nishida K, Yamaguchi O, Hirotani S, Hikoso S, Higuchi Y, Watanabe T, Takeda T, Osuka S, Morita T, Kondoh G, Uno Y, Kashiwase K, Taniike M, Nakai A, Matsumura Y, Miyazaki J, Sudo T, Hongo K, Kusakari Y, Kurihara S, Chien KR, Takeda J, Hori M, and Otsu K. p38α mitogen-activated protein kinase plays a critical role in cardiomyo-cyte survival but not in cardiac hypertrophic growth in response to pressure overload. Mol Cell Biol 24: 10611-10620, 2004. (Pubitemid 39603120)
-
(2004)
Molecular and Cellular Biology
, vol.24
, Issue.24
, pp. 10611-10620
-
-
Nishida, K.1
Yamaguchi, O.2
Hirotani, S.3
Hikoso, S.4
Higuchi, Y.5
Watanabe, T.6
Takeda, T.7
Osuka, S.8
Morita, T.9
Kondoh, G.10
Uno, Y.11
Kashiwase, K.12
Taniike, M.13
Nakai, A.14
Matsumura, Y.15
Miyazaki, J.-I.16
Sudo, T.17
Hongo, K.18
Kusakari, Y.19
Kurihara, S.20
Chien, K.R.21
Takeda, J.22
Hori, M.23
Otsu, K.24
more..
-
250
-
-
0031029214
-
Stress-signalling kinase Sek1 protects thy-mocytes from apoptosis mediated by CD95 and CD3
-
Nishina H, Fischer KD, Radvanyi L, Shahinian A, Hakem R, Rubie EA, Bernstein A, Mak TW, Woodgett JR, and Penninger JM. Stress-signalling kinase Sek1 protects thy-mocytes from apoptosis mediated by CD95 and CD3. Nature 385: 350-353, 1997.
-
(1997)
Nature
, vol.385
, pp. 350-353
-
-
Nishina, H.1
Fischer, K.D.2
Radvanyi, L.3
Shahinian, A.4
Hakem, R.5
Rubie, E.A.6
Bernstein, A.7
Mak, T.W.8
Woodgett, J.R.9
Penninger, J.M.10
-
251
-
-
0032193185
-
Impaired TCR-mediated apoptosis and Bcl-XL expression in T cells lacking the stress kinase acti-vator SEK1/MKK4
-
Nishina H, Radvanyi L, Raju K, Sasaki T, Kozieradzki I, and Penninger JM. Impaired TCR-mediated apoptosis and Bcl-XL expression in T cells lacking the stress kinase acti-vator SEK1/MKK4. J Immunol 161: 3416-3420, 1998.
-
(1998)
J Immunol
, vol.161
, pp. 3416-3420
-
-
Nishina, H.1
Radvanyi, L.2
Raju, K.3
Sasaki, T.4
Kozieradzki, I.5
Penninger, J.M.6
-
252
-
-
0033063568
-
Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4
-
Nishina H, Vaz C, Billia P, Nghiem M, Sasaki T, De la Pompa JL, Furlonger K, Paige C, Hui C, Fischer KD, Kishimoto H, Iwatsubo T, Katada T, Woodgett JR, and Penninger JM. Defective liver formation and liver cell ap-optosis in mice lacking the stress signaling kinase SEK1/MKK4. Development 126: 505-516, 1999. (Pubitemid 29082037)
-
(1999)
Development
, vol.126
, Issue.3
, pp. 505-516
-
-
Nishina, H.1
Vaz, C.2
Billia, P.3
Nghiem, M.4
Sasaki, T.5
De La Pompa, J.L.6
Furlonger, K.7
Paige, C.8
Hui, C.-C.9
Fischer, K.-D.10
Kishimoto, H.11
Iwatsubo, T.12
Katada, T.13
Woodgett, J.R.14
Penninger, J.M.15
-
253
-
-
4644362788
-
Physiological roles of SAPK/JNK signaling pathway
-
DOI 10.1093/jb/mvh117
-
Nishina H, Wada T, and Katada T. Physiological roles of SAPK/JNK signaling pathway. J Biochem 136: 123-126,2004. (Pubitemid 39264964)
-
(2004)
Journal of Biochemistry
, vol.136
, Issue.2
, pp. 123-126
-
-
Nishina, H.1
Wada, T.2
Katada, T.3
-
254
-
-
44849124411
-
ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1
-
DOI 10.1101/gad.1640108
-
Nishitoh H, Kadowaki H, Nagai A, Maruyama T, Yokota T, Fukutomi H, Noguchi T, Matsuzawa A, Takeda K, and Ichijo H. ALS-linked mutant SOD1 induces ER stress-and ASK1-dependent motor neuron death by targeting Derlin-1. Genes Dev 22: 1451-1464, 2008. (Pubitemid 351793080)
-
(2008)
Genes and Development
, vol.22
, Issue.11
, pp. 1451-1464
-
-
Nishitoh, H.1
Kadowaki, H.2
Nagai, A.3
Maruyama, T.4
Yokota, T.5
Fukutomi, H.6
Noguchi, T.7
Matsuzawa, A.8
Takeda, K.9
Ichijo, H.10
-
255
-
-
0036606540
-
ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats
-
DOI 10.1101/gad.992302
-
Nishitoh H, Matsuzawa A, Tobiume K, Saegusa K, Takeda K, Inoue K, Hori S, Kakizuka A, and Ichijo H. ASK1 is essential for endoplasmic reticulum stress-induced neuro-nal cell death triggered by expanded polyglutamine re-peats. Genes Dev 16: 1345-1355, 2002. (Pubitemid 34615088)
-
(2002)
Genes and Development
, vol.16
, Issue.11
, pp. 1345-1355
-
-
Nishitoh, H.1
Matsuzawa, A.2
Tobiume, K.3
Saegusa, K.4
Takeda, K.5
Inoue, K.6
Hori, S.7
Kakizuka, A.8
Ichijo, H.9
-
256
-
-
0032158987
-
ASK1 is essential for JNK/SAPK activation by TRAF2
-
Nishitoh H, Saitoh M, Mochida Y, Takeda K, Nakano H, Rothe M, Miyazono K, and Ichijo H. ASK1 is essential for JNK/SAPK activation by TRAF2. Mol Cell 2: 389-395,1998. (Pubitemid 128379279)
-
(1998)
Molecular Cell
, vol.2
, Issue.3
, pp. 389-395
-
-
Nishitoh, H.1
Saitoh, M.2
Mochida, Y.3
Takeda, K.4
Nakano, H.5
Rothe, M.6
Miyazono, K.7
Ichijo, H.8
-
257
-
-
0029060391
-
Protein kinase C and lipid signaling for sus-tained cellular responses
-
Nishizuka Y. Protein kinase C and lipid signaling for sus-tained cellular responses. FASEB J 9: 484-496, 1995.
-
(1995)
FASEB J
, vol.9
, pp. 484-496
-
-
Nishizuka, Y.1
-
258
-
-
43149114461
-
Requirement of reactive oxygen species-dependent activation of ASK1-p38 MAPK pathway for extracellular ATP-induced apoptosis in macrophage
-
Noguchi T, Ishii K, Fukutomi H, Naguro I, Matsuzawa A, Takeda K, and Ichijo H. Requirement of reactive oxygen species-dependent activation of ASK1-p38 MAPK pathway for extracellular ATP-induced apoptosis in macrophage. J Biol Chem 283: 7657-7665, 2008.
-
(2008)
J Biol Chem
, vol.283
, pp. 7657-7665
-
-
Noguchi, T.1
Ishii, K.2
Fukutomi, H.3
Naguro, I.4
Matsuzawa, A.5
Takeda, K.6
Ichijo, H.7
-
259
-
-
27744559915
-
Recruitment of tumor necrosis factor receptor-associated factor family proteins to apoptosis signal-regulating kinase 1 signalosome is essential for oxidative stress-induced cell death
-
DOI 10.1074/jbc.M506771200
-
Noguchi T, Takeda K, Matsuzawa A, Saegusa K, Nakano H, Gohda J, Inoue J, and Ichijo H. Recruitment of tumor necrosis factor receptor-associated factor family proteins to apoptosis signal-regulating kinase 1 signalosome is essen-tial for oxidative stress-induced cell death. J Biol Chem 280: 37033-37040, 2005. (Pubitemid 41587787)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.44
, pp. 37033-37040
-
-
Noguchi, T.1
Takeda, K.2
Matsuzawa, A.3
Saegusa, K.4
Nakano, H.5
Gohda, J.6
Inoue, J.-I.7
Ichijo, H.8
-
260
-
-
47049088906
-
SOK1 translocates from the Golgi to the nucleus upon chemical anoxia and in-duces apoptotic cell death
-
Nogueira E, Fidalgo M, Molnar A, Kyriakis J, Force T, Zalvide J, and Pombo CM. SOK1 translocates from the Golgi to the nucleus upon chemical anoxia and in-duces apoptotic cell death. J Biol Chem 283: 16248-16258, 2008.
-
(2008)
J Biol Chem
, vol.283
, pp. 16248-16258
-
-
Nogueira, E.1
Fidalgo, M.2
Molnar, A.3
Kyriakis, J.4
Force, T.5
Zalvide, J.6
Pombo, C.M.7
-
261
-
-
11144267126
-
Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1
-
DOI 10.1126/science.1103233
-
O'Neill E, Rushworth L, Baccarini M, and Kolch W. Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1. Science 306: 2267-2270, 2004. (Pubitemid 40024466)
-
(2004)
Science
, vol.306
, Issue.5705
, pp. 2267-2270
-
-
O'Neill, E.1
Rushworth, L.2
Baccarini, M.3
Kolch, W.4
-
262
-
-
34248353095
-
Inhibition of endogenous Mst1 prevents apoptosis and cardiac dysfunction without affecting cardiac hypertrophy after myocardial infarction
-
DOI 10.1161/01.RES.0000265846.23485.7a, PII 0000301220070511000012
-
Odashima M, Usui S, Takagi H, Hong C, Liu J, Yokota M, and Sadoshima J. Inhibition of endogenous Mst1 prevents apoptosis and cardiac dysfunction without affecting car-diac hypertrophy after myocardial infarction. Circ Res 100: 1344-1352, 2007. (Pubitemid 46742925)
-
(2007)
Circulation Research
, vol.100
, Issue.9
, pp. 1344-1352
-
-
Odashima, M.1
Usui, S.2
Takagi, H.3
Hong, C.4
Liu, J.5
Yokota, M.6
Sadoshima, J.7
-
263
-
-
71949114463
-
Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse
-
Oh S, Lee D, Kim T, Kim TS, Oh HJ, Hwang CY, Kong YY, Kwon KS, and Lim DS. Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse. Mol Cell Biol 29: 6309-6320, 2009.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 6309-6320
-
-
Oh, S.1
Lee, D.2
Kim, T.3
Kim, T.S.4
Oh, H.J.5
Hwang, C.Y.6
Kong, Y.Y.7
Kwon, K.S.8
Lim, D.S.9
-
264
-
-
33745851830
-
TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis
-
DOI 10.1074/jbc.M603384200
-
Omori E, Matsumoto K, Sanjo H, Sato S, Akira S, Smart RC, and Ninomiya-Tsuji J. TAK1 is a master regulator of epi-dermal homeostasis involving skin inflammation and ap-optosis. J Biol Chem 281: 19610-19617, 2006. (Pubitemid 44035464)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.28
, pp. 19610-19617
-
-
Omori, E.1
Matsumoto, K.2
Sanjo, H.3
Sato, S.4
Akira, S.5
Smart, R.C.6
Ninomiya-Tsuji, J.7
-
265
-
-
33645983982
-
The NF-?B-mediated control of the JNK cascade in the antagonism of pro-grammed cell death in health and disease
-
Papa S, Bubici C, Zazzeroni F, Pham CG, Kuntzen C, Knabb JR, Dean K, and Franzoso G. The NF-?B-mediated control of the JNK cascade in the antagonism of pro-grammed cell death in health and disease. Cell Death Differ 13: 712-729, 2006.
-
(2006)
Cell Death Differ
, vol.13
, pp. 712-729
-
-
Papa, S.1
Bubici, C.2
Zazzeroni, F.3
Pham, C.G.4
Kuntzen, C.5
Knabb, J.R.6
Dean, K.7
Franzoso, G.8
-
266
-
-
0036840931
-
Heat shock protein Hsp72 is a negative regulator of apoptosis signal-regulating kinase 1
-
DOI 10.1128/MCB.22.22.7721-7730.2002
-
Park HS, Cho SG, Kim CK, Hwang HS, Noh KT, Kim MS, Huh SH, Kim MJ, Ryoo K, Kim EK, Kang WJ, Lee JS, Seo JS, Ko YG, Kim S, and Choi EJ. Heat shock protein hsp72 is a negative regulator of apoptosis signal-regulating kinase 1. Mol Cell Biol 22: 7721-7730, 2002. (Pubitemid 35217284)
-
(2002)
Molecular and Cellular Biology
, vol.22
, Issue.22
, pp. 7721-7730
-
-
Park, H.-S.1
Cho, S.-G.2
Kim, C.K.3
Hwang, H.S.4
Noh, K.T.5
Kim, M.-S.6
Huh, S.-H.7
Kim, M.J.8
Ryoo, K.9
Kim, E.K.10
Kang, W.J.11
Lee, J.-S.12
Seo, J.-S.13
Ko, Y.-G.14
Kim, S.15
Choi, E.-J.16
-
267
-
-
0034687778
-
Nitric oxide negatively regulates c-Jun N-terminal kinase/stress- activated protein kinase by means of S-nitrosylation
-
DOI 10.1073/pnas.97.26.14382
-
Park HS, Huh SH, Kim MS, Lee SH, and Choi EJ. Nitric oxide negatively regulates c-Jun N-terminal kinase/stress-activated protein kinase by means of S-nitrosylation. Proc Natl Acad Sci USA 97: 14382-14387, 2000. (Pubitemid 32016584)
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, Issue.26
, pp. 14382-14387
-
-
Park, H.-S.1
Huh, S.-H.2
Kim, M.-S.3
Lee, S.H.4
Choi, E.-J.5
-
268
-
-
1542320091
-
Inhibition of Apoptosis Signal-regulating Kinase 1 by Nitric Oxide through a Thiol Redox Mechanism
-
DOI 10.1074/jbc.M304183200
-
Park HS, Yu JW, Cho JH, Kim MS, Huh SH, Ryoo K, and Choi EJ. Inhibition of apoptosis signal-regulating kinase 1 by nitric oxide through a thiol redox mechanism. J Biol Chem 279: 7584-7590, 2004. (Pubitemid 38294637)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.9
, pp. 7584-7590
-
-
Park, H.-S.1
Yu, J.-W.2
Cho, J.-H.3
Kim, M.-S.4
Huh, S.-H.5
Ryoo, K.6
Choi, E.-J.7
-
269
-
-
23844445836
-
Colorectal cancer: Mutations in a signalling pathway
-
DOI 10.1038/436792a
-
Parsons DW, Wang TL, Samuels Y, Bardelli A, Cummins JM, DeLong L, Silliman N, Ptak J, Szabo S, Willson JK, Markowitz S, Kinzler KW, Vogelstein B, Lengauer C, and Velculescu VE. Colorectal cancer: mutations in a signalling pathway. Nature 436: 792, 2005. (Pubitemid 41160630)
-
(2005)
Nature
, vol.436
, Issue.7052
, pp. 792
-
-
Parsons, D.W.1
Wang, T.-L.2
Samuels, Y.3
Bardelli, A.4
Cummins, J.M.5
DeLong, L.6
Silliman, N.7
Ptak, J.8
Szabo, S.9
Willson, J.K.V.10
Markowitz, S.11
Kinzler, K.W.12
Vogelstein, B.13
Lengauer, C.14
Velculescu, V.E.15
-
270
-
-
0037127269
-
Death-associated protein (DAP) kinase plays a central role in ceramide-induced apoptosis in cultured hippocampal neurons
-
DOI 10.1074/jbc.M104677200
-
Pelled D, Raveh T, Riebeling C, Fridkin M, Berissi H, Fu-terman AH, and Kimchi A. Death-associated protein (DAP) kinase plays a central role in ceramide-induced apoptosis in cultured hippocampal neurons. J Biol Chem 277: 1957-1961, 2002. (Pubitemid 34968774)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.3
, pp. 1957-1961
-
-
Pelled, D.1
Raveh, T.2
Riebeling, C.3
Fridkin, M.4
Berissi, H.5
Futerman, A.H.6
Kimchi, A.7
-
271
-
-
33947100032
-
Genetic analysis of p38 MAP kinases in myogenesis: Fundamental role of p38α in abrogating myoblast proliferation
-
DOI 10.1038/sj.emboj.7601587, PII 7601587
-
Perdiguero E, Ruiz-Bonilla V, Gresh L, Hui L, Ballestar E, Sousa-Victor P, Baeza-Raja B, Jardi M, Bosch-Comas A, Esteller M, Caelles C, Serrano AL, Wagner EF, and Munoz-Canoves P. Genetic analysis of p38 MAP kinases in myo-genesis: fundamental role of p38α in abrogating myoblast proliferation. EMBO J 26: 1245-1256, 2007. (Pubitemid 46398710)
-
(2007)
EMBO Journal
, vol.26
, Issue.5
, pp. 1245-1256
-
-
Perdiguero, E.1
Ruiz-Bonilla, V.2
Gresh, L.3
Hui, L.4
Ballestar, E.5
Sousa-Victor, P.6
Baeza-Raja, B.7
Jardi, M.8
Bosch-Comas, A.9
Esteller, M.10
Caelles, C.11
Serrano, A.L.12
Wagner, E.F.13
Muoz-Canoves, P.14
-
272
-
-
33847398755
-
High-mobility group A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2
-
DOI 10.1172/JCI29852
-
Pierantoni GM, Rinaldo C, Mottolese M, Di Benedetto A, Esposito F, Soddu S, and Fusco A. High-mobility group A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2. J Clin Invest 117: 693-702, 2007. (Pubitemid 46348527)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.3
, pp. 693-702
-
-
Pierantoni, G.M.1
Rinaldo, C.2
Mottolese, M.3
Benedetto, A.D.4
Esposito, F.5
Soddu, S.6
Fusco, A.7
-
273
-
-
33746253982
-
A dimeric ki-nase assembly underlying autophosphorylation in the p21 activated kinases
-
DOI 10.1016/j.jmb.2006.06.017, PII S0022283606007285
-
Pirruccello M, Sondermann H, Pelton JG, Pellicena P, Hoelz A, Chernoff J, Wemmer DE, and Kuriyan J. A dimeric ki-nase assembly underlying autophosphorylation in the p21 activated kinases. J Mol Biol 361: 312-326, 2006. (Pubitemid 44092781)
-
(2006)
Journal of Molecular Biology
, vol.361
, Issue.2
, pp. 312-326
-
-
Pirruccello, M.1
Sondermann, H.2
Pelton, J.G.3
Pellicena, P.4
Hoelz, A.5
Chernoff, J.6
Wemmer, D.E.7
Kuriyan, J.8
-
274
-
-
0029814060
-
Activation of a human Ste20-like kinase by oxidant stress defines a novel stress response pathway
-
Pombo CM, Bonventre JV, Molnar A, Kyriakis J, and Force T. Activation of a human Ste20-like kinase by oxidant stress defines a novel stress response pathway. EMBO J 15: 4537-4546, 1996. (Pubitemid 26294572)
-
(1996)
EMBO Journal
, vol.15
, Issue.17
, pp. 4537-4546
-
-
Pombo, C.M.1
Bonventre, J.V.2
Molnar, A.3
Kyriakis, J.4
Force, T.5
-
275
-
-
34250758642
-
ER stress triggers apoptosis by activating BH3-only protein Bim
-
DOI 10.1016/j.cell.2007.04.027, PII S0092867407005375
-
Puthalakath H, O'Reilly LA, Gunn P, Lee L, Kelly PN, Huntington ND, Hughes PD, Michalak EM, McKimm-Breschkin J, Motoyama N, Gotoh T, Akira S, Bouillet P, and Strasser A. ER stress triggers apoptosis by activating BH3-only protein Bim. Cell 129: 1337-1349, 2007. (Pubitemid 46962086)
-
(2007)
Cell
, vol.129
, Issue.7
, pp. 1337-1349
-
-
Puthalakath, H.1
O'Reilly, L.A.2
Gunn, P.3
Lee, L.4
Kelly, P.N.5
Huntington, N.D.6
Hughes, P.D.7
Michalak, E.M.8
McKimm-Breschkin, J.9
Motoyama, N.10
Gotoh, T.11
Akira, S.12
Bouillet, P.13
Strasser, A.14
-
276
-
-
33845934175
-
165-induced angiogenesis through its interaction and regulation of phospholipase Cγ phosphorylation
-
DOI 10.1074/jbc.M604853200
-
Qin L, Zeng H, and Zhao D. Requirement of protein kinase D tyrosine phosphorylation for VEGF-A165-induced an-giogenesis through its interaction and regulation of phos-pholipase Cy phosphorylation. J Biol Chem 281: 32550-32558, 2006. (Pubitemid 46036810)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.43
, pp. 32550-32558
-
-
Qin, L.1
Zeng, H.2
Zhao, D.3
-
277
-
-
75749113347
-
C-Abl tyrosine kinase regulates cardiac growth and development
-
Qiu Z, Cang Y, and Goff SP. c-Abl tyrosine kinase regulates cardiac growth and development. Proc Natl Acad Sci USA 107: 1136-1141, 2010.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 1136-1141
-
-
Qiu, Z.1
Cang, Y.2
Goff, S.P.3
-
278
-
-
33748055445
-
MUC1 oncoprotein blocks nuclear targeting of c-Abl in the apoptotic response to DNA damage
-
DOI 10.1038/sj.emboj.7601263, PII 7601263
-
Raina D, Ahmad R, Kumar S, Ren J, Yoshida K, Kharbanda S, and Kufe D. MUC1 oncoprotein blocks nuclear targeting of c-Abl in the apoptotic response to DNA damage. EMBO J 25: 3774-3783, 2006. (Pubitemid 44300263)
-
(2006)
EMBO Journal
, vol.25
, Issue.16
, pp. 3774-3783
-
-
Raina, D.1
Ahmad, R.2
Kumar, S.3
Ren, J.4
Yoshida, K.5
Kharbanda, S.6
Kufe, D.7
-
279
-
-
34247269029
-
TAO kinases mediate activation of p38 in response to DNA damage
-
DOI 10.1038/sj.emboj.7601668, PII 7601668
-
Raman M, Earnest S, Zhang K, Zhao Y, and Cobb MH. TAO kinases mediate activation of p38 in response to DNA damage. EMBO J 26: 2005-2014, 2007. (Pubitemid 46625802)
-
(2007)
EMBO Journal
, vol.26
, Issue.8
, pp. 2005-2014
-
-
Raman, M.1
Earnest, S.2
Zhang, K.3
Zhao, Y.4
Cobb, M.H.5
-
280
-
-
0035141040
-
ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation
-
DOI 10.1038/35050500
-
Raveh T, Droguett G, Horwitz MS, DePinho RA, and Kimchi A. DAP kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transforma-tion. Nat Cell Biol 3: 1-7, 2001. (Pubitemid 32114825)
-
(2001)
Nature Cell Biology
, vol.3
, Issue.1
, pp. 1-7
-
-
Raveh, T.1
Droguett, G.2
Horwitz, M.S.3
DePinho, R.A.4
Kimchi, A.5
-
281
-
-
33846821915
-
P53-deficient cells rely on ATM-and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for sur-vival after DNA damage
-
DOI 10.1016/j.ccr.2006.11.024, PII S1535610806003825
-
Reinhardt HC, Aslanian AS, Lees JA, and Yaffe MB. p53-deficient cells rely on ATM-and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for sur-vival after DNA damage. Cancer Cell 11: 175-189, 2007. (Pubitemid 46209849)
-
(2007)
Cancer Cell
, vol.11
, Issue.2
, pp. 175-189
-
-
Reinhardt, H.C.1
Aslanian, A.S.2
Lees, J.A.3
Yaffe, M.B.4
-
282
-
-
0033520927
-
Bisphosphonates act directly on the osteoclast to induce caspase cleavage of Mst1 kinase during apoptosis: A link between inhibition of the mevalonate pathway and regulation of an apoptosis-promoting kinase
-
Reszka AA, Halasy-Nagy JM, Masarachia PJ, and Rodan GA. Bisphosphonates act directly on the osteoclast to in-duce caspase cleavage of mst1 kinase during apoptosis. A link between inhibition of the mevalonate pathway and regulation of an apoptosis-promoting kinase. J Biol Chem 274: 34967-34973, 1999. (Pubitemid 129509546)
-
(1999)
Journal of Biological Chemistry
, vol.274
, Issue.49
, pp. 34967-34973
-
-
Reszka, A.A.1
Halasy-Nagy, J.M.2
Masarachia, P.J.3
Rodan, G.A.4
-
283
-
-
36749025313
-
Protein kinase C<5 and apoptosis
-
Reyland ME. Protein kinase C<5 and apoptosis. Biochem Soc Trans 35: 1001-1004, 2007
-
(2007)
Biochem Soc Trans
, vol.35
, pp. 1001-1004
-
-
Reyland, M.E.1
-
284
-
-
33847365838
-
MDM2-Regulated Degradation of HIPK2 Prevents p53Ser46 Phosphorylation and DNA Damage-Induced Apoptosis
-
DOI 10.1016/j.molcel.2007.02.008, PII S1097276507000883
-
Rinaldo C, Prodosmo A, Mancini F, Iacovelli S, Sacchi A, Moretti F, and Soddu S. MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis. Mol Cell 25: 739-750, 2007. (Pubitemid 46341925)
-
(2007)
Molecular Cell
, vol.25
, Issue.5
, pp. 739-750
-
-
Rinaldo, C.1
Prodosmo, A.2
Mancini, F.3
Iacovelli, S.4
Sacchi, A.5
Moretti, F.6
Soddu, S.7
-
286
-
-
0030918572
-
Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2
-
DOI 10.1126/science.276.5318.1571
-
Rudel T and Bokoch GM. Membrane and morphological changes in apoptotic
-
(1997)
Science
, vol.276
, Issue.5318
, pp. 1571-1574
-
-
Rudel, T.1
Bokoch, G.M.2
-
287
-
-
4444341881
-
Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation
-
DOI 10.1016/j.molcel.2004.08.028, PII S1097276504005143
-
Sabapathy K, Hochedlinger K, Nam SY, Bauer A, Karin M, and Wagner EF. Distinct roles for JNK1 and JNK2 in reg-ulating JNK activity and c-Jun-dependent cell proliferation. Mol Cell 15: 713-725, 2004. (Pubitemid 39194902)
-
(2004)
Molecular Cell
, vol.15
, Issue.5
, pp. 713-725
-
-
Sabapathy, K.1
Hochedlinger, K.2
Nam, S.Y.3
Bauer, A.4
Karin, M.5
Wagner, E.F.6
-
288
-
-
20244365497
-
P38γ regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP
-
DOI 10.1038/sj.emboj.7600578
-
Sabio G, Arthur JS, Kuma Y, Peggie M, Carr J, Murray-Tait V, Centeno F, Goedert M, Morrice NA, and Cuenda A. p38y regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP. EMBO J 24: 1134-1145, 2005. (Pubitemid 40516597)
-
(2005)
EMBO Journal
, vol.24
, Issue.6
, pp. 1134-1145
-
-
Sabio, G.1
Arthur, J.S.C.2
Kuma, Y.3
Peggie, M.4
Carr, J.5
Murray-Tait, V.6
Centeno, F.7
Goedert, M.8
Morrice, N.A.9
Cuenda, A.10
-
289
-
-
70449927269
-
Prevention of steatosis by hepatic JNK1
-
Sabio G, Cavanagh-Kyros J, Ko HJ, Jung DY, Gray S, Jun JY, Barrett T, Mora A, Kim JK, and Davis RJ. Prevention of steatosis by hepatic JNK1. Cell Metab 10: 491-498, 2009.
-
(2009)
Cell Metab
, vol.10
, pp. 491-498
-
-
Sabio, G.1
Cavanagh-Kyros, J.2
Ko, H.J.3
Jung, D.Y.4
Gray, S.5
Jun, J.Y.6
Barrett, T.7
Mora, A.8
Kim, J.K.9
Davis, R.J.10
-
290
-
-
57349101675
-
A stress signaling pathway in adi-pose tissue regulates hepatic insulin resistance
-
Sabio G, Das M, Mora A, Zhang Z, Jun JY, Ko HJ, Barrett T, Kim JK, and Davis RJ. A stress signaling pathway in adi-pose tissue regulates hepatic insulin resistance. Science 322: 1539-1543, 2008.
-
(2008)
Science
, vol.322
, pp. 1539-1543
-
-
Sabio, G.1
Das, M.2
Mora, A.3
Zhang, Z.4
Jun, J.Y.5
Ko, H.J.6
Barrett, T.7
Kim, J.K.8
Davis, R.J.9
-
291
-
-
0033539894
-
Induction of apoptosis by SLK, a Ste20-related kinase
-
Sabourin LA and Rudnicki MA. Induction of apoptosis by SLK, a Ste20-related kinase. Oncogene 18: 7566-7575, 1999. (Pubitemid 30035058)
-
(1999)
Oncogene
, vol.18
, Issue.52
, pp. 7566-7575
-
-
Sabourin, L.A.1
Rudnicki, M.A.2
-
292
-
-
0033961249
-
Caspase 3 cleavage of the Ste20-related kinase SLK releases and activates an apoptosis-inducing kinase domain and an actin-disassembling region
-
DOI 10.1128/MCB.20.2.684-696.2000
-
Sabourin LA, Tamai K, Seale P, Wagner J, and Rudnicki MA. Caspase 3 cleavage of the Ste20-related kinase SLK releases and activates an apoptosis-inducing kinase domain and an actin-disassembling region. Mol Cell Biol 20: 684-696, 2000. (Pubitemid 30023110)
-
(2000)
Molecular and Cellular Biology
, vol.20
, Issue.2
, pp. 684-696
-
-
Sabourin, L.A.1
Seale, P.2
Wagner, J.3
Rudnicki, M.A.4
-
293
-
-
0035917475
-
The CaMKII UNC-43 activates the MAPKKK NSY-1 to execute a lateral signaling decision required for asymmetric olfactory neuron fates
-
DOI 10.1016/S0092-8674(01)00313-0
-
Sagasti A, Hisamoto N, Hyodo J, Tanaka-Hino M, Matsu-moto K, and Bargmann CI. The CaMKII UNC-43 activates the MAPKKK NSY-1 to execute a lateral signaling decision required for asymmetric olfactory neuron fates. Cell 105: 221-232, 2001. (Pubitemid 32429512)
-
(2001)
Cell
, vol.105
, Issue.2
, pp. 221-232
-
-
Sagasti, A.1
Hisamoto, N.2
Hyodo, J.3
Tanaka-Hino, M.4
Matsumoto, K.5
Bargmann, C.I.6
-
294
-
-
34547413496
-
Regulation of apoptosis signal-regulating kinase 1 by protein phosphatase 2Cε
-
DOI 10.1042/BJ20070231
-
Saito J, Toriumi S, Awano K, Ichijo H, Sasaki K, Kobayashi T, and Tamura S. Regulation of apoptosis signal-regulating kinase 1 by protein phosphatase 2Cε. Biochem J 405: 591-596, 2007. (Pubitemid 47172057)
-
(2007)
Biochemical Journal
, vol.405
, Issue.3
, pp. 591-596
-
-
Saito, J.-I.1
Toriumi, S.2
Awano, K.3
Ichijo, H.4
Sasaki, K.5
Kobayashi, T.6
Tamura, S.7
-
295
-
-
0032080283
-
Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1
-
DOI 10.1093/emboj/17.9.2596
-
Saitoh M, Nishitoh H, Fujii M, Takeda K, Tobiume K, Sa-wada Y, Kawabata M, Miyazono K, and Ichijo H. Mam-malian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. EMBO J 17: 2596-2606, 1998. (Pubitemid 28221195)
-
(1998)
EMBO Journal
, vol.17
, Issue.9
, pp. 2596-2606
-
-
Saitoh, M.1
Nishitoh, H.2
Fujii, M.3
Takeda, K.4
Tobiume, K.5
Sawada, Y.6
Kawabata, M.7
Miyazono, K.8
Ichijo, H.9
-
296
-
-
33746032571
-
Loss of hepatic NF-κB activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation
-
DOI 10.1073/pnas.0603499103
-
Sakurai T, Maeda S, Chang L, and Karin M. Loss of hepatic NF-?B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation. Proc Natl Acad Sci USA 103: 10544-10551, 2006. (Pubitemid 44078014)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.28
, pp. 10544-10551
-
-
Sakurai, T.1
Maeda, S.2
Chang, L.3
Karin, M.4
-
297
-
-
0035903325
-
The stress kinase Mitogen-activated protein kinase kinase (MKK)7 is a negative regulator of antigen receptor and growth factor receptor-induced proliferation in hematopoietic cells
-
DOI 10.1084/jem.194.6.757
-
Sasaki T, Wada T, Kishimoto H, Irie-Sasaki J, Matsumoto G, Goto T, Yao Z, Wakeham A, Mak TW, Suzuki A, Cho SK, Zuniga-Pflucker JC, Oliveira-dos-Santos AJ, Katada T, Nishina H, and Penninger JM. The stress kinase mitogen-activated protein kinase kinase (MKK)7 is a negative regulator of antigen receptor and growth factor receptor-induced proliferation in hematopoietic cells. J Exp Med 194: 757-768, 2001. (Pubitemid 32983012)
-
(2001)
Journal of Experimental Medicine
, vol.194
, Issue.6
, pp. 757-768
-
-
Sasaki, T.1
Wada, T.2
Kishimoto, H.3
Irie-Sasaki, J.4
Matsumoto, G.5
Goto, T.6
Yao, Z.7
Wakeham, A.8
Mak, T.W.9
Suzuki, A.10
Cho, S.K.11
Zuniga-Pflucker, J.C.12
Oliveira-Dos-Santos, A.J.13
Katada, T.14
Nishina, H.15
Penninger, J.M.16
-
298
-
-
27544434183
-
Essential function for the kinase TAK1 in innate and adaptive immune responses
-
DOI 10.1038/ni1255, PII N1255
-
Sato S, Sanjo H, Takeda K, Ninomiya-Tsuji J, Yamamoto M, Kawai T, Matsumoto K, Takeuchi O, and Akira S. Essential function for the kinase TAK1 in innate and adaptive im-mune responses. Nat Immunol 6: 1087-1095, 2005. (Pubitemid 41541786)
-
(2005)
Nature Immunology
, vol.6
, Issue.11
, pp. 1087-1095
-
-
Sato, S.1
Sanjo, H.2
Takeda, K.3
Ninomiya-Tsuji, J.4
Yamamoto, M.5
Kawai, T.6
Matsumoto, K.7
Takeuchi, O.8
Akira, S.9
-
300
-
-
0035815679
-
Kainate Receptor Activation Induces Mixed Lineage Kinase-mediated Cellular Signaling Cascades via Post-synaptic Density Protein 95
-
DOI 10.1074/jbc.M100190200
-
Savinainen A, Garcia EP, Dorow D, Marshall J, and Liu YF. Kainate receptor activation induces mixed lineage kinase-mediated cellular signaling cascades via post-synaptic density protein 95. J Biol Chem 276: 11382-11386, 2001. (Pubitemid 38089330)
-
(2001)
Journal of Biological Chemistry
, vol.276
, Issue.14
, pp. 11382-11386
-
-
Savinainen, A.1
Garcia, E.P.2
Dorow, D.3
Marshall, J.4
Liu, Y.F.5
-
301
-
-
0033614446
-
Chronic myeloid leukemia
-
DOI 10.1056/NEJM199904293401706
-
Sawyers CL. Chronic myeloid leukemia. N Engl J Med 340: 1330-1340, 1999. (Pubitemid 29196596)
-
(1999)
New England Journal of Medicine
, vol.340
, Issue.17
, pp. 1330-1340
-
-
Sawyers, C.L.1
-
302
-
-
66349138173
-
P38<5 Mitogen-activated protein kinase is essential for skin tumor development in mice
-
Schindler EM, Hindes A, Gribben EL, Burns CJ, Yin Y, Lin MH, Owen RJ, Longmore GD, Kissling GE, Arthur JS, and Efimova T. p38<5 Mitogen-activated protein kinase is essential for skin tumor development in mice. Cancer Res 69: 4648-4655, 2009
-
(2009)
Cancer Res
, vol.69
, pp. 4648-4655
-
-
Schindler, E.M.1
Hindes, A.2
Gribben, E.L.3
Burns, C.J.4
Yin, Y.5
Lin, M.H.6
Owen, R.J.7
Longmore, G.D.8
Kissling, G.E.9
Arthur, J.S.10
Efimova, T.11
-
303
-
-
0030657770
-
Cloning and characterization of a human STE20-like protein kinase with unusual cofactor requirements
-
DOI 10.1074/jbc.272.45.28695
-
Schinkmann K and Blenis J. Cloning and characterization of a human STE20-like protein kinase with unusual cofac-tor requirements. J Biol Chem 272: 28695-28703, 1997. (Pubitemid 27517826)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.45
, pp. 28695-28703
-
-
Schinkmann, K.1
Blenis, J.2
-
304
-
-
0036460487
-
Immune-related mechanisms participating in resistance and susceptibility to glutamate toxicity
-
DOI 10.1046/j.1460-9568.2002.02134.x
-
Schori H, Yoles E, Wheeler LA, Raveh T, Kimchi A, and Schwartz M. Immune-related mechanisms participating in resistance and susceptibility to glutamate toxicity. Eur J Neurosci 16: 557-564, 2002. (Pubitemid 35471826)
-
(2002)
European Journal of Neuroscience
, vol.16
, Issue.4
, pp. 557-564
-
-
Schori, H.1
Yoles, E.2
Wheeler, L.A.3
Raveh, T.4
Kimchi, A.5
Schwartz, M.6
-
305
-
-
0036682941
-
Hematopoietic progenitor kinase 1 supports apoptosis of T lymphocytes
-
DOI 10.1182/blood-2002-01-0089
-
Schulze-Luehrmann J, Santner-Nanan B, Jha MK, Schimpl A, Avots A, and Serfling E. Hematopoietic progenitor ki-nase 1 supports apoptosis of T lymphocytes. Blood 100: 954-960, 2002. (Pubitemid 34832623)
-
(2002)
Blood
, vol.100
, Issue.3
, pp. 954-960
-
-
Schulze-Luehrmann, J.1
Santner-Nanan, B.2
Jha, M.K.3
Schimpl, A.4
Avots, A.5
Serfling, E.6
-
306
-
-
0040056864
-
P21-Activated kinase 1 phosphorylates the death agonist Bad and protects cells from apoptosis
-
DOI 10.1128/MCB.20.2.453-461.2000
-
Schurmann A, Mooney AF, Sanders LC, Sells MA, Wang HG, Reed JC, and Bokoch GM. p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis. Mol Cell Biol 20: 453-461, 2000. (Pubitemid 30023086)
-
(2000)
Molecular and Cellular Biology
, vol.20
, Issue.2
, pp. 453-461
-
-
Schurmann, A.1
Mooney, A.F.2
Sanders, L.C.3
Sells, M.A.4
Wang, H.G.5
Reed, J.C.6
Bokoch, G.M.7
-
307
-
-
34548643396
-
Targeted deletion of MKK4 gene potentiates TNF-induced apoptosis through the down-regulation of NF-?B activation and NF-?B-regulated antiapoptotic gene products
-
Sethi G, Ahn KS, Xia D, Kurie JM, and Aggarwal BB. Targeted deletion of MKK4 gene potentiates TNF-induced apoptosis through the down-regulation of NF-?B activation and NF-?B-regulated antiapoptotic gene products. J Im-munol 179: 1926-1933, 2007
-
(2007)
J Im-munol
, vol.179
, pp. 1926-1933
-
-
Sethi, G.1
Ahn, K.S.2
Xia, D.3
Kurie, J.M.4
Aggarwal, B.B.5
-
308
-
-
0037175024
-
A p21-activated kinase-controlled metabolic switch up-regulates phagocyte NADPH oxidase
-
DOI 10.1074/jbc.M206650200
-
Shalom-Barak T and Knaus UG. A p21-activated kinase-controlled metabolic switch up-regulates phagocyte NADPH oxidase. J Biol Chem 277: 40659-40665, 2002. (Pubitemid 35215647)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.43
, pp. 40659-40665
-
-
Shalom-Barak, T.1
Knaus, U.G.2
-
309
-
-
27144458235
-
Death-associated protein kinase as a sensor of mitochondrial membrane potential: Role of lysosome in mitochondrial toxin-induced cell death
-
DOI 10.1074/jbc.M506466200
-
Shang T, Joseph J, Hillard CJ, and Kalyanaraman B. Death-associated protein kinase as a sensor of mitochondrial membrane potential: role of lysosome in mitochondrial toxin-induced cell death. J Biol Chem 280: 34644-34653, 2005. (Pubitemid 41504595)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.41
, pp. 34644-34653
-
-
Shang, T.1
Joseph, J.2
Hillard, C.J.3
Kalyanaraman, B.4
-
310
-
-
0035283099
-
Autophosphorylation restrains the apoptotic activity of DRP-1 kinase by controlling dimerization and calmodulin binding
-
DOI 10.1093/emboj/20.5.1099
-
Shani G, Henis-Korenblit S, Jona G, Gileadi O, Eisenstein M, Ziv T, Admon A, and Kimchi A. Autophosphorylation restrains the apoptotic activity of DRP-1 kinase by con-trolling dimerization and calmodulin binding. EMBO J 20: 1099-1113, 2001. (Pubitemid 32186800)
-
(2001)
EMBO Journal
, vol.20
, Issue.5
, pp. 1099-1113
-
-
Shani, G.1
Henis-Korenblit, S.2
Jona, G.3
Gileadi, O.4
Eisenstein, M.5
Ziv, T.6
Admon, A.7
Kimchi, A.8
-
311
-
-
4544374632
-
Death-associated protein kinase phosphorylates ZIP kinase, forming a unique kinase hierarchy to activate its cell death functions
-
DOI 10.1128/MCB.24.19.8611-8626.2004
-
Shani G, Marash L, Gozuacik D, Bialik S, Teitelbaum L, Shohat G, and Kimchi A. Death-associated protein kinase phosphorylates ZIP kinase, forming a unique kinase hier-archy to activate its cell death functions. Mol Cell Biol 24: 8611-8626, 2004. (Pubitemid 39245081)
-
(2004)
Molecular and Cellular Biology
, vol.24
, Issue.19
, pp. 8611-8626
-
-
Shani, G.1
Marash, L.2
Gozuacik, D.3
Bialik, S.4
Teitelbaum, L.5
Shohat, G.6
Kimchi, A.7
-
312
-
-
0036494195
-
2-terminal kinase-1 in mice enhances skin tumor development by 12-O-tetradecanoylphorbol-13-acetate
-
She QB, Chen N, Bode AM, Flavell RA, and Dong Z. De-ficiency of c-Jun-NH(2)-terminal kinase-1 in mice enhances skin tumor development by 12-O-tetradecanoylphorbol-13-acetate. Cancer Res 62: 1343-1348, 2002. (Pubitemid 34407790)
-
(2002)
Cancer Research
, vol.62
, Issue.5
, pp. 1343-1348
-
-
She, Q.-B.1
Chen, N.2
Bode, A.M.3
Flavell, R.A.4
Dong, Z.5
-
313
-
-
48549093239
-
C-Jun NH2-terminal kinase 1 is a critical regulator for the devel-opment of gastric cancer in mice
-
Shibata W, Maeda S, Hikiba Y, Yanai A, Sakamoto K, Nakagawa H, Ogura K, Karin M, and Omata M. c-Jun NH2-terminal kinase 1 is a critical regulator for the devel-opment of gastric cancer in mice. Cancer Res 68: 5031-5039, 2008.
-
(2008)
Cancer Res
, vol.68
, pp. 5031-5039
-
-
Shibata, W.1
Maeda, S.2
Hikiba, Y.3
Yanai, A.4
Sakamoto, K.5
Nakagawa, H.6
Ogura, K.7
Karin, M.8
Omata, M.9
-
314
-
-
0032481312
-
Role of TAK1 and TAB1 in BMP signaling in early Xenopus development
-
DOI 10.1093/emboj/17.4.1019
-
Shibuya H, Iwata H, Masuyama N, Gotoh Y, Yamaguchi K, Irie K, Matsumoto K, Nishida E, and Ueno N. Role of TAK1 and TAB1 in BMP signaling in early Xenopus development. EMBO J 17: 1019-1028, 1998. (Pubitemid 28077656)
-
(1998)
EMBO Journal
, vol.17
, Issue.4
, pp. 1019-1028
-
-
Shibuya, H.1
Iwata, H.2
Masuyama, N.3
Gotoh, Y.4
Yamaguchi, K.5
Irie, K.6
Matsumoto, K.7
Nishida, E.8
Ueno, N.9
-
315
-
-
0035861546
-
The pro-apoptotic function of death-associated protein kinase is controlled by a unique inhibitory autophosphorylation-based mecha-nism
-
Shohat G, Spivak-Kroizman T, Cohen O, Bialik S, Shani G, Berrisi H, Eisenstein M, and Kimchi A. The pro-apoptotic function of death-associated protein kinase is controlled by a unique inhibitory autophosphorylation-based mecha-nism. J Biol Chem 276: 47460-47467, 2001.
-
(2001)
J Biol Chem
, vol.276
, pp. 47460-47467
-
-
Shohat, G.1
Spivak-Kroizman, T.2
Cohen, O.3
Bialik, S.4
Shani, G.5
Berrisi, H.6
Eisenstein, M.7
Kimchi, A.8
-
316
-
-
33747883766
-
Cell surface-associated mucins in signal transduction
-
DOI 10.1016/j.tcb.2006.07.006, PII S0962892406001954
-
Singh PK and Hollingsworth MA. Cell surface-associated mucins in signal transduction. Trends Cell Biol 16: 467-476, 2006. (Pubitemid 44293402)
-
(2006)
Trends in Cell Biology
, vol.16
, Issue.9
, pp. 467-476
-
-
Singh, P.K.1
Hollingsworth, M.A.2
-
317
-
-
58249110508
-
How cells switch HIPK2 on and off
-
Sombroek D and Hofmann TG. How cells switch HIPK2 on and off. Cell Death Differ 16: 187-194, 2009.
-
(2009)
Cell Death Differ
, vol.16
, pp. 187-194
-
-
Sombroek, D.1
Hofmann, T.G.2
-
318
-
-
33747377165
-
C-Jun/AP-1 controls liver regener-ation by repressing p53/p21 and p38 MAPK activity
-
Stepniak E, Ricci R, Eferl R, Sumara G, Sumara I, Rath M, Hui L, and Wagner EF. c-Jun/AP-1 controls liver regener-ation by repressing p53/p21 and p38 MAPK activity. Genes Dev 20: 2306-2314, 2006.
-
(2006)
Genes Dev
, vol.20
, pp. 2306-2314
-
-
Stepniak, E.1
Ricci, R.2
Eferl, R.3
Sumara, G.4
Sumara, I.5
Rath, M.6
Hui, L.7
Wagner, E.F.8
-
319
-
-
33845953689
-
Mitochondrial ROS - radical detoxification, mediated by protein kinase D
-
DOI 10.1016/j.tcb.2006.11.003, PII S0962892406003254
-
Storz P. Mitochondrial ROS\radical detoxification, mediated by protein kinase D. Trends Cell Biol 17: 13-18, 2007. (Pubitemid 46028964)
-
(2007)
Trends in Cell Biology
, vol.17
, Issue.1
, pp. 13-18
-
-
Storz, P.1
-
320
-
-
25444449225
-
Protein kinase D mediates mitochondrion-to-nucleus signaling and detoxification from mitochondrial reactive oxygen species
-
DOI 10.1128/MCB.25.19.8520-8530.2005
-
Storz P, Doppler H, and Toker A. Protein kinase D medi-ates mitochondrion-to-nucleus signaling and detoxification from mitochondrial reactive oxygen species. Mol Cell Biol 25: 8520-8530, 2005. (Pubitemid 41369173)
-
(2005)
Molecular and Cellular Biology
, vol.25
, Issue.19
, pp. 8520-8530
-
-
Storz, P.1
Doppler, H.2
Toker, A.3
-
321
-
-
0032191837
-
Differential roles of ERK and p38 MAP kinase pathways in positive and negative selection of T lymphocytes
-
DOI 10.1016/S1074-7613(00)80639-1
-
Sugawara T, Moriguchi T, Nishida E, and Takahama Y. Differential roles of ERK and p38 MAP kinase pathways in positive and negative selection of T lymphocytes. Immunity 9: 565-574, 1998. (Pubitemid 28499207)
-
(1998)
Immunity
, vol.9
, Issue.4
, pp. 565-574
-
-
Sugawara, T.1
Moriguchi, T.2
Nishida, E.3
Takahama, Y.4
-
322
-
-
58249087541
-
Regulation of PKD by the MAPK p38<5 in insulin secretion and glucose homeostasis
-
Sumara G, Formentini I, Collins S, Sumara I, Windak R, Bodenmiller B, Ramracheya R, Caille D, Jiang H, Platt KA, Meda P, Aebersold R, Rorsman P, and Ricci R Regulation of PKD by the MAPK p38<5 in insulin secretion and glucose homeostasis. Cell 136: 235-248, 2009
-
(2009)
Cell
, vol.136
, pp. 235-248
-
-
Sumara, G.1
Formentini, I.2
Collins, S.3
Sumara, I.4
Windak, R.5
Bodenmiller, B.6
Ramracheya, R.7
Caille, D.8
Jiang, H.9
Platt, K.A.10
Meda, P.11
Aebersold, R.12
Rorsman, P.13
Ricci, R.14
-
323
-
-
17744364870
-
Regulation of MAP kinase-dependent apoptotic pathway: Implication of reactive oxygen and nitrogen species
-
DOI 10.1016/j.abb.2005.02.021
-
Sumbayev VV and Yasinska IM. Regulation of MAP ki-nase-dependent apoptotic pathway: implication of reactive oxygen and nitrogen species. Arch Biochem Biophys 436: 406-412, 2005. (Pubitemid 40576280)
-
(2005)
Archives of Biochemistry and Biophysics
, vol.436
, Issue.2
, pp. 406-412
-
-
Sumbayev, V.V.1
Yasinska, I.M.2
-
324
-
-
33846282393
-
PRAK Is Essential for ras-Induced Senescence and Tumor Suppression
-
DOI 10.1016/j.cell.2006.11.050, PII S0092867407000049
-
Sun P, Yoshizuka N, New L, Moser BA, Li Y, Liao R, Xie C, Chen J, Deng Q, Yamout M, Dong MQ, Frangou CG, Yates JR, 3rd, Wright PE, and Han J. PRAK is essential for ras-induced senescence and tumor suppression. Cell 128: 295-308, 2007. (Pubitemid 46123511)
-
(2007)
Cell
, vol.128
, Issue.2
, pp. 295-308
-
-
Sun, P.1
Yoshizuka, N.2
New, L.3
Moser, B.A.4
Li, Y.5
Liao, R.6
Xie, C.7
Chen, J.8
Deng, Q.9
Yamout, M.10
Dong, M.-Q.11
Frangou, C.G.12
Yates III, J.R.13
Wright, P.E.14
Han, J.15
-
325
-
-
0037088632
-
Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3
-
DOI 10.1074/jbc.M109488200
-
Sun X, Yin J, Starovasnik MA, Fairbrother WJ, and Dixit VM. Identification of a novel homotypic interac-tion motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3. J Biol Chem 277: 9505-9511, 2002. (Pubitemid 34953039)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.11
, pp. 9505-9511
-
-
Sun, X.1
Yin, J.2
Starovasnik, M.A.3
Fairbrother, W.J.4
Dixit, V.M.5
-
326
-
-
22944479314
-
JNK antagonizes Akt-mediated survival signals by phosphorylating 14-3-3
-
DOI 10.1083/jcb.200409117
-
Sunayama J, Tsuruta F, Masuyama N, and Gotoh Y. JNK antagonizes Akt-mediated survival signals by phosphory-lating 14-3-3. J Cell Biol 170: 295-304, 2005. (Pubitemid 41043811)
-
(2005)
Journal of Cell Biology
, vol.170
, Issue.2
, pp. 295-304
-
-
Sunayama, J.1
Tsuruta, F.2
Masuyama, N.3
Gotoh, Y.4
-
327
-
-
0041703020
-
Involvement of MKK6 in TCRα?S(int)CD69lo: A target population for apoptotic cell death in thymocytes
-
Suzuki H, Wu J, Hossain K, Ohhata T, Du J, Akhand AA, Hayakawa A, Kimura H, Hagiwara M, and Nakashima I. Involvement of MKK6 in TCRα?S(int)CD69lo: a target population for apoptotic cell death in thymocytes. FASEB J 17: 1538-1540, 2003.
-
(2003)
FASEB J
, vol.17
, pp. 1538-1540
-
-
Suzuki, H.1
Wu, J.2
Hossain, K.3
Ohhata, T.4
Du, J.5
Akhand, A.A.6
Hayakawa, A.7
Kimura, H.8
Hagiwara, M.9
Nakashima, I.10
-
328
-
-
17344375955
-
SEK1/MKK4 is required for maintenance of a normal peripheral lymphoid compartment but not for lymphocyte development
-
DOI 10.1016/S1074-7613(00)80567-1
-
Swat W, Fujikawa K, Ganiatsas S, Yang D, Xavier RJ, Harris NL, Davidson L, Ferrini R, Davis RJ, Labow MA, Flavell RA, Zon LI, and Alt FW. SEK1/MKK4 is required for maintenance of a normal peripheral lymphoid com-partment but not for lymphocyte development. Immunity 8: 625-634, 1998. (Pubitemid 28264753)
-
(1998)
Immunity
, vol.8
, Issue.5
, pp. 625-634
-
-
Swat, W.1
Fujikawa, K.2
Ganiatsas, S.3
Yang, D.4
Xavier, R.J.5
Harris, N.L.6
Davidson, L.7
Ferrini, R.8
Davis, R.J.9
Labow, M.A.10
Flavell, R.A.11
Zon, L.I.12
Alt, F.W.13
-
329
-
-
33847350861
-
DYRK2 Is Targeted to the Nucleus and Controls p53 via Ser46 Phosphorylation in the Apoptotic Response to DNA Damage
-
DOI 10.1016/j.molcel.2007.02.007, PII S1097276507000871
-
Taira N, Nihira K, Yamaguchi T, Miki Y, and Yoshida K. DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage. Mol Cell 25: 725-738, 2007. (Pubitemid 46341924)
-
(2007)
Molecular Cell
, vol.25
, Issue.5
, pp. 725-738
-
-
Taira, N.1
Nihira, K.2
Yamaguchi, T.3
Miki, Y.4
Yoshida, K.5
-
330
-
-
0034004126
-
TAK1 participates in c-Jun N-terminal kinase signaling during Drosophila development
-
DOI 10.1128/MCB.20.9.3015-3026.2000
-
Takatsu Y, Nakamura M, Stapleton M, Danos MC, Mat-sumoto K, O'Connor MB, Shibuya H, and Ueno N. TAK1 participates in c-Jun N-terminal kinase signaling during Drosophila development. Mol Cell Biol 20: 3015-3026, 2000. (Pubitemid 30215014)
-
(2000)
Molecular and Cellular Biology
, vol.20
, Issue.9
, pp. 3015-3026
-
-
Takatsu, Y.1
Nakamura, M.2
Stapleton, M.3
Danos, M.C.4
Matsumoto, K.5
O'Connor, M.B.6
Shibuya, H.7
Ueno, N.8
-
331
-
-
1642487129
-
2+ - Induced p38 MAP kinase activation
-
DOI 10.1038/sj.embor.7400072
-
Takeda K, Matsuzawa A, Nishitoh H, Tobiume K, Kishida S, Ninomiya-Tsuji J, Matsumoto K, and Ichijo H. Involve-ment of ASK1 in Ca2+-induced p38 MAP kinase activation. EMBO Rep 5: 161-166, 2004. (Pubitemid 38401195)
-
(2004)
EMBO Reports
, vol.5
, Issue.2
, pp. 161-166
-
-
Takeda, K.1
Matsuzawa, A.2
Nishitoh, H.3
Tobiume, K.4
Kishida, S.5
Ninomiya-Tsuji, J.6
Matsumoto, K.7
Ichijo, H.8
-
332
-
-
34147186130
-
Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1
-
DOI 10.1074/jbc.M607177200
-
Takeda K, Shimozono R, Noguchi T, Umeda T, Morimoto Y, Naguro I, Tobiume K, Saitoh M, Matsuzawa A, and Ichijo H. Apoptosis signal-regulating kinase (ASK) 2 func-tions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1. J Biol Chem 282: 7522-7531, 2007. (Pubitemid 47093697)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.10
, pp. 7522-7531
-
-
Takeda, K.1
Shimozono, R.2
Noguchi, T.3
Umeda, T.4
Morimoto, Y.5
Naguro, I.6
Tobiume, K.7
Saitoh, M.8
Matsuzawa, A.9
Ichijo, H.10
-
333
-
-
0032514967
-
A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK
-
Takekawa M and Saito H. A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. Cell 95:521-530,1998. (Pubitemid 28533308)
-
(1998)
Cell
, vol.95
, Issue.4
, pp. 521-530
-
-
Takekawa, M.1
Saito, H.2
-
334
-
-
0034697904
-
Requirement for p38α in erythropoietin ex-pression: A role for stress kinases in erythropoiesis
-
Tamura K, Sudo T, Senftleben U, Dadak AM, Johnson R, and Karin M. Requirement for p38α in erythropoietin ex-pression: a role for stress kinases in erythropoiesis. Cell 102: 221-231, 2000.
-
(2000)
Cell
, vol.102
, pp. 221-231
-
-
Tamura, K.1
Sudo, T.2
Senftleben, U.3
Dadak, A.M.4
Johnson, R.5
Karin, M.6
-
335
-
-
0036687249
-
Differential involvement of p38 mitogen-activated protein kinases MKK3 and MKK6 in T-cell apoptosis
-
DOI 10.1093/embo-reports/kvf153
-
Tanaka N, Kamanaka M, Enslen H, Dong C, Wysk M, Davis RJ, and Flavell RA. Differential involvement of p38 mitogen-activated protein kinase kinases MKK3 and MKK6 in T-cell apoptosis. EMBO Rep 3: 785-791, 2002. (Pubitemid 34966019)
-
(2002)
EMBO Reports
, vol.3
, Issue.8
, pp. 785-791
-
-
Tanaka, N.1
Kamanaka, M.2
Enslen, H.3
Dong, C.4
Wysk, M.5
Davis, R.J.6
Flavell, R.A.7
-
336
-
-
0034737807
-
The Akt proto-oncogene links Ras to Pak and cell survival signals
-
DOI 10.1074/jbc.275.13.9106
-
Tang Y, Zhou H, Chen A, Pittman RN, and Field J. The Akt proto-oncogene links Ras to Pak and cell survival signals. J Biol Chem 275: 9106-9109, 2000. (Pubitemid 30185123)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.13
, pp. 9106-9109
-
-
Tang, Y.1
Zhou, H.2
Chen, A.3
Pittman, R.N.4
Field, J.5
-
337
-
-
0033584846
-
Human JIK, a novel member of the STE20 kinase family that inhibits JNK and is negatively regulated by epidermal growth factor
-
Tassi E, Biesova Z, Di Fiore PP, Gutkind JS, and Wong WT. Human JIK, a novel member of the STE20 kinase family that inhibits JNK and is negatively regulated by epidermal growth factor. J Biol Chem 274: 33287-33295, 1999. (Pubitemid 129511628)
-
(1999)
Journal of Biological Chemistry
, vol.274
, Issue.47
, pp. 33287-33295
-
-
Tassi, E.1
Biesova, Z.2
Di Fiore, P.P.3
Gutkind, J.S.4
Wong, W.T.5
-
338
-
-
0034721885
-
BRCA1 fa-cilitates stress-induced apoptosis in breast and ovarian cancer cell lines
-
Thangaraju M, Kaufmann SH, and Couch FJ. BRCA1 fa-cilitates stress-induced apoptosis in breast and ovarian cancer cell lines. J Biol Chem 275: 33487-33496, 2000.
-
(2000)
J Biol Chem
, vol.275
, pp. 33487-33496
-
-
Thangaraju, M.1
Kaufmann, S.H.2
Couch, F.J.3
-
339
-
-
0033567291
-
The stress-activated protein kinase pathways
-
DOI 10.1007/s000180050369
-
Tibbles LA and Woodgett JR. The stress-activated protein kinase pathways. Cell Mol Life Sci 55: 1230-1254, 1999. (Pubitemid 29410745)
-
(1999)
Cellular and Molecular Life Sciences
, vol.55
, Issue.10
, pp. 1230-1254
-
-
Tibbles, L.A.1
Woodgett, J.R.2
-
340
-
-
0141530895
-
MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1
-
DOI 10.1093/emboj/cdg447
-
Timm T, Li XY, Biernat J, Jiao J, Mandelkow E, Vande-kerckhove J, and Mandelkow EM. MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1. EMBO J 22: 5090-5101, 2003. (Pubitemid 37222029)
-
(2003)
EMBO Journal
, vol.22
, Issue.19
, pp. 5090-5101
-
-
Timm, T.1
Li, X.-Y.2
Biernat, J.3
Jiao, J.4
Mandelkow, E.5
Vandekerckhove, J.6
Mandelkow, E.-M.7
-
341
-
-
0035065836
-
ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis
-
DOI 10.1093/embo-reports/kve046
-
Tobiume K, Matsuzawa A, Takahashi T, Nishitoh H, Morita K, Takeda K, Minowa O, Miyazono K, Noda T, and Ichijo H. ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis. EMBO Rep 2: 222-228, 2001. (Pubitemid 32273301)
-
(2001)
EMBO Reports
, vol.2
, Issue.3
, pp. 222-228
-
-
Tobiume, K.1
Matsuzawa, A.2
Takahashi, T.3
Nishitoh, H.4
Morita, K.-I.5
Takeda, K.6
Minowa, O.7
Miyazono, K.8
Noda, T.9
Ichijo, H.10
-
342
-
-
60849119836
-
Nega-tive regulation of Caenorhabditis elegans epidermal damage responses by death-associated protein kinase
-
Tong A, Lynn G, Ngo V, Wong D, Moseley SL, Ewbank JJ, Goncharov A, Wu YC, Pujol N and Chisholm AD. Nega-tive regulation of Caenorhabditis elegans epidermal damage responses by death-associated protein kinase. Proc Natl Acad Sci USA 106: 1457-1461, 2009.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 1457-1461
-
-
Tong, A.1
Lynn, G.2
Ngo, V.3
Wong, D.4
Moseley, S.L.5
Ewbank, J.J.6
Goncharov, A.7
Wu, Y.C.8
Pujol, N.9
Chisholm, A.D.10
-
343
-
-
0034992168
-
MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines
-
DOI 10.1101/gad.888501
-
Tournier C, Dong C, Turner TK, Jones SN, Flavell RA, and Davis RJ. MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines. Genes Dev 15: 1419-1426, 2001. (Pubitemid 32524648)
-
(2001)
Genes and Development
, vol.15
, Issue.11
, pp. 1419-1426
-
-
Tournier, C.1
Dong, C.2
Turner, T.K.3
Jones, S.N.4
Flavell, R.A.5
Davis, R.J.6
-
344
-
-
0034607702
-
Requirement of JNK for stress-induced activation of the cytochrome c- mediated death pathway
-
DOI 10.1126/science.288.5467.870
-
Tournier C, Hess P, Yang DD, Xu J, Turner TK, Nimnual A, Bar-Sagi D, Jones SN, Flavell RA, and Davis RJ. Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science 288: 870-874, 2000. (Pubitemid 30257738)
-
(2000)
Science
, vol.288
, Issue.5467
, pp. 870-874
-
-
Tournier, C.1
Hess, P.2
Yang, D.D.3
Xu, J.4
Turner, T.K.5
Nimnual, A.6
Bar-Sagi, D.7
Jones, S.N.8
Flavell, R.A.9
Davis, R.J.10
-
345
-
-
0030786344
-
2-terminal kinase
-
DOI 10.1073/pnas.94.14.7337
-
Tournier C, Whitmarsh AJ, Cavanagh J, Barrett T, and Davis RJ. Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase. Proc Natl Acad Sci USA 94: 7337-7342, 1997. (Pubitemid 27345316)
-
(1997)
Proceedings of the National Academy of Sciences of the United States of America
, vol.94
, Issue.14
, pp. 7337-7342
-
-
Tournier, C.1
Whitmarsh, A.J.2
Cavanagh, J.3
Barrett, T.4
Davis, R.J.5
-
346
-
-
0025780879
-
Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene
-
Tybulewicz VL, Crawford CE, Jackson PK, Bronson RT, and Mulligan RC. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell 65: 1153-1163, 1991. (Pubitemid 121001329)
-
(1991)
Cell
, vol.65
, Issue.7
, pp. 1153-1163
-
-
Tybulewicz, V.L.J.1
Crawford, C.E.2
Jackson, P.K.3
Bronson, R.T.4
Mulligan, R.C.5
-
347
-
-
18844414517
-
JNK mediates hepatic ischemia reperfusion injury
-
DOI 10.1016/j.jhep.2005.01.030, PII S0168827805001881
-
Uehara T, Bennett B, Sakata ST, Satoh Y, Bilter GK, West-wick JK, and Brenner DA. JNK mediates hepatic ischemia reperfusion injury. J Hepatol 42: 850-859, 2005. (Pubitemid 40693202)
-
(2005)
Journal of Hepatology
, vol.42
, Issue.6
, pp. 850-859
-
-
Uehara, T.1
Bennett, B.2
Sakata, S.T.3
Satoh, Y.4
Bilter, G.K.5
Westwick, J.K.6
Brenner, D.A.7
-
348
-
-
0035964190
-
Caspase cleavage of MST1 promotes nuclear translocation and chromatin condensation
-
DOI 10.1073/pnas.181161698
-
Ura S, Masuyama N, Graves JD, and Gotoh Y. Caspase cleavage of MST1 promotes nuclear translocation and chromatin condensation. Proc Natl Acad Sci USA 98: 10148-10153, 2001. (Pubitemid 32802989)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.18
, pp. 10148-10153
-
-
Ura, S.1
Masuyama, N.2
Graves, J.D.3
Gotoh, Y.4
-
349
-
-
0034933130
-
MST1-JNK promotes apoptosis via caspase-dependent and independent pathways
-
DOI 10.1046/j.1365-2443.2001.00439.x
-
Ura S, Masuyama N, Graves JD, and Gotoh Y. MST1-JNK promotes apoptosis via caspase-dependent and indepen-dent pathways. Genes Cells 6: 519-530, 2001. (Pubitemid 32655384)
-
(2001)
Genes to Cells
, vol.6
, Issue.6
, pp. 519-530
-
-
Ura, S.1
Masuyama, N.2
Graves, J.D.3
Gotoh, Y.4
-
350
-
-
34547161916
-
Activation of the c-Jun N-terminal kinase pathway by MST1 is essential and sufficient for the induction of chromatin condensation during apoptosis
-
DOI 10.1128/MCB.00199-07
-
Ura S, Nishina H, Gotoh Y, and Katada T. Activation of the c-Jun N-terminal kinase pathway by MST1 is essen-tial and sufficient for the induction of chromatin con-densation during apoptosis. Mol Cell Biol 27: 5514-5522, 2007. (Pubitemid 47124403)
-
(2007)
Molecular and Cellular Biology
, vol.27
, Issue.15
, pp. 5514-5522
-
-
Ura, S.1
Nishina, H.2
Gotoh, Y.3
Katada, T.4
-
351
-
-
2942603255
-
Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes
-
DOI 10.1016/j.ccr.2004.05.022, PII S1535610804001473
-
Vadlamudi RK, Bagheri-Yarmand R, Yang Z, Balasenthil S, Nguyen D, Sahin AA, den Hollander P, and Kumar R. Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes. Cancer Cell 5: 575-585, 2004. (Pubitemid 38748919)
-
(2004)
Cancer Cell
, vol.5
, Issue.6
, pp. 575-585
-
-
Vadlamudi, R.K.1
Bagheri-Yarmand, R.2
Yang, Z.3
Balasenthil, S.4
Nguyen, D.5
Sahin, A.A.6
Den Hollander, P.7
Kumar, R.8
-
352
-
-
0036711657
-
Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1
-
DOI 10.1038/ncb838
-
Vadlamudi RK, Li F, Adam L, Nguyen D, Ohta Y, Stossel TP, and Kumar R Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1. Nat Cell Biol 4: 681-690, 2002. (Pubitemid 34993704)
-
(2002)
Nature Cell Biology
, vol.4
, Issue.9
, pp. 681-690
-
-
Vadlamudi, R.K.1
Li, F.2
Adam, L.3
Nguyen, D.4
Ohta, Y.5
Stossel, T.P.6
Kumar, R.7
-
353
-
-
1642446043
-
P-41-Arc subunit of human Arp2/3 complex is a p21-activated kinase-1-interacting substrate
-
DOI 10.1038/sj.embor.7400079
-
Vadlamudi RK, Li F, Barnes CJ, Bagheri-Yarmand R, and Kumar R. p41-Arc subunit of human Arp2/3 complex is a p21-activated kinase-1-interacting substrate. EMBO Rep 5: 154-160, 2004. (Pubitemid 38401194)
-
(2004)
EMBO Reports
, vol.5
, Issue.2
, pp. 154-160
-
-
Vadlamudi, R.K.1
Li, F.2
Barnes, C.J.3
Bagheri-Yarmand, R.4
Kumar, R.5
-
355
-
-
54049155149
-
C-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor a (TNFa)-induced NF-?B activation
-
Varfolomeev E, Goncharov T, Fedorova AV, Dynek JN, Zobel K, Deshayes K, Fairbrother WJ, and Vucic D. c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor a (TNFa)-induced NF-?B activation. J Biol Chem 283: 24295-24299, 2008.
-
(2008)
J Biol Chem
, vol.283
, pp. 24295-24299
-
-
Varfolomeev, E.1
Goncharov, T.2
Fedorova, A.V.3
Dynek, J.N.4
Zobel, K.5
Deshayes, K.6
Fairbrother, W.J.7
Vucic, D.8
-
356
-
-
34249807348
-
P38α MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation
-
DOI 10.1038/ng2037, PII NG2037
-
Ventura JJ, Tenbaum S, Perdiguero E, Huth M, Guerra C, Barbacid M, Pasparakis M, and Nebreda AR. p38a MAP kinase is essential in lung stem and progenitor cell prolif-eration and differentiation. Nat Genet 39: 750-758, 2007. (Pubitemid 46848588)
-
(2007)
Nature Genetics
, vol.39
, Issue.6
, pp. 750-758
-
-
Ventura, J.J.1
Tenbaum, S.2
Perdiguero, E.3
Huth, M.4
Guerra, C.5
Barbacid, M.6
Pasparakis, M.7
Nebreda, A.R.8
-
357
-
-
33646264815
-
Posttranslational myristoylation of caspase-activated p21-activated protein kinase 2 (PAK2) potentiates late apoptotic events
-
Vilas GL, Corvi MM, Plummer GJ, Seime AM, Lambkin GR, and Berthiaume LG. Posttranslational myristoylation of caspase-activated p21-activated protein kinase 2 (PAK2) potentiates late apoptotic events. Proc Natl Acad Sci USA 103: 6542-6547, 2006.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 6542-6547
-
-
Vilas, G.L.1
Corvi, M.M.2
Plummer, G.J.3
Seime, A.M.4
Lambkin, G.R.5
Berthiaume, L.G.6
-
358
-
-
12144290513
-
MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence
-
Wada T, Joza N, Cheng HY, Sasaki T, Kozieradzki I, Bachmaier K, Katada T, Schreiber M, Wagner EF, Nishina H, and Penninger JM. MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence. Nat Cell Biol 6: 215-226, 2004. (Pubitemid 38344359)
-
(2004)
Nature Cell Biology
, vol.6
, Issue.3
, pp. 215-226
-
-
Wada, T.1
Joza, N.2
Cheng, H.M.3
Sasaki, T.4
Kozieradzki, I.5
Bachmaier, K.6
Katada, T.7
Schreiber, M.8
Wagner, E.F.9
Nishina, H.10
Penninger, J.M.11
-
359
-
-
37349081594
-
Antagonistic control of cell fates by JNK and p38-MAPK signaling
-
DOI 10.1038/sj.cdd.4402222, PII 4402222, Special issue on Tumor stress, cell death and the ensuing immune response
-
Wada T, Stepniak E, Hui L, Leibbrandt A, Katada T, Nishina H, Wagner EF, and Penninger JM. Antagonistic control of cell fates by JNK and p38-MAPK signaling. Cell Death Differ 15: 89-93, 2008. (Pubitemid 350286176)
-
(2008)
Cell Death and Differentiation
, vol.15
, Issue.1
, pp. 89-93
-
-
Wada, T.1
Stepniak, E.2
Hui, L.3
Leibbrandt, A.4
Katada, T.5
Nishina, H.6
Wagner, E.F.7
Penninger, J.M.8
-
360
-
-
67749117934
-
Signal integration by JNK and p38 MAPK pathways in cancer development
-
Wagner EF and Nebreda AR. Signal integration by JNK and p38 MAPK pathways in cancer development. Nat Rev Cancer 9: 537-549, 2009.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 537-549
-
-
Wagner, E.F.1
Nebreda, A.R.2
-
361
-
-
0034693878
-
Regulation of cell death by the Abl tyrosine ki-nase
-
Wang JY. Regulation of cell death by the Abl tyrosine ki-nase. Oncogene 19: 5643-5650, 2000.
-
(2000)
Oncogene
, vol.19
, pp. 5643-5650
-
-
Wang, J.Y.1
-
362
-
-
43049152912
-
TNF-α induces two distinct caspase-8 activation pathways
-
DOI 10.1016/j.cell.2008.03.036, PII S0092867408005011
-
Wang L, Du F, and Wang X. TNF-a induces two distinct caspase-8 activation pathways. Cell 133: 693-703, 2008. (Pubitemid 351636305)
-
(2008)
Cell
, vol.133
, Issue.4
, pp. 693-703
-
-
Wang, L.1
Du, F.2
Wang, X.3
-
363
-
-
33845942768
-
C-Jun NH2-terminal kinase promotes apoptosis by down-regulating the transcriptional co-repressor CtBP
-
DOI 10.1074/jbc.M607484200
-
Wang SY, Iordanov M, and Zhang Q. c-Jun NH2-terminal kinase promotes apoptosis by down-regulating the tran-scriptional co-repressor CtBP. JBiol Chem 281: 34810-34815, 2006. (Pubitemid 46036520)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.46
, pp. 34810-34815
-
-
Wang, S.-Y.1
Iordanov, M.2
Zhang, Q.3
-
364
-
-
34548249520
-
The tumor suppressor DAPK is reciprocally regulated by tyrosine kinase Src and phosphatase LAR
-
DOI 10.1016/j.molcel.2007.06.037, PII S1097276507004790
-
Wang WJ, Kuo JC, Ku W, Lee YR, Lin FC, Chang YL, Lin YM, Chen CH, Huang YP, Chiang MJ, Yeh SW, Wu PR, Shen CH, Wu CT, and Chen RH. The tumor suppressor DAPK is reciprocally regulated by tyrosine kinase Src and phosphatase LAR. Mol Cell 27: 701-716, 2007. (Pubitemid 47333224)
-
(2007)
Molecular Cell
, vol.27
, Issue.5
, pp. 701-716
-
-
Wang, W.-J.1
Kuo, J.-C.2
Ku, W.3
Lee, Y.-R.4
Lin, F.-C.5
Chang, Y.-L.6
Lin, Y.-M.7
Chen, C.-H.8
Huang, Y.-P.9
Chiang, M.-J.10
Yeh, S.-W.11
Wu, P.-R.12
Shen, C.-H.13
Wu, C.-T.14
Chen, R.-H.15
-
365
-
-
21444439969
-
Complete inhibition of anisomycin and UV radiation but not cytokine induced JNK and p38 activation by an aryl-substituted dihydropyrrolopyrazole quinoline and mixed lineage kinase 7 small interfering RNA
-
DOI 10.1074/jbc.M413059200
-
Wang X, Mader MM, Toth JE, Yu X, Jin N, Campbell RM, Smallwood JK, Christe ME, Chatterjee A, Goodson T, Jr., Vlahos CJ, Matter WF, and Bloem LJ. Complete inhibition of anisomycin and UV radiation but not cytokine induced JNK and p38 activation by an aryl-substituted dihy-dropyrrolopyrazole quinoline and mixed lineage kinase 7 small interfering RNA. J Biol Chem 280: 19298-19305, 2005. (Pubitemid 41379637)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.19
, pp. 19298-19305
-
-
Wang, X.1
Mader, M.M.2
Toth, J.E.3
Yu, X.4
Jin, N.5
Campbell, R.M.6
Smallwood, J.K.7
Christe, M.E.8
Chatterjee, A.9
Goodson Jr., T.10
Vlahos, C.J.11
Matter, W.F.12
Bloem, L.J.13
-
366
-
-
0029954102
-
Molecular cloning and characterization of a novel protein kinase with a catalytic domain homologous to mitogen-activated protein kinase kinase kinase
-
DOI 10.1074/jbc.271.49.31607
-
Wang XS, Diener K, Jannuzzi D, Trollinger D, Tan TH, Lichenstein H, Zukowski M, and Yao Z. Molecular cloning and characterization of a novel protein kinase with a cat-alytic domain homologous to mitogen-activated protein kinase kinase kinase. J Biol Chem 271: 31607-31611, 1996. (Pubitemid 26408622)
-
(1996)
Journal of Biological Chemistry
, vol.271
, Issue.49
, pp. 31607-31611
-
-
Wang, X.S.1
Diener, K.2
Jannuzzi, D.3
Trollinger, D.4
Tan, T.-H.5
Lichenstein, H.6
Zukowski, M.7
Yao, Z.8
-
367
-
-
0032501407
-
MAPKKK6, a novel mitogen-activated protein kinase kinase kinase, that associates with MAPKKK5
-
DOI 10.1006/bbrc.1998.9749
-
Wang XS, Diener K, Tan TH, and Yao Z. MAPKKK6, a novel mitogen-activated protein kinase kinase kinase, that associates with MAPKKK5. Biochem Biophys Res Commun 253: 33-37, 1998. (Pubitemid 29015595)
-
(1998)
Biochemical and Biophysical Research Communications
, vol.253
, Issue.1
, pp. 33-37
-
-
Wang, X.S.1
Diener, K.2
Tan, T.-H.3
Yao, Z.4
-
368
-
-
34447545513
-
Opposing effects of Bad phosphorylation at two distinct sites by Akt1 and JNK1/2 on ischemic brain injury
-
DOI 10.1016/j.cellsig.2007.04.005, PII S0898656807001192
-
Wang XT, Pei DS, Xu J, Guan QH, Sun YF, Liu XM, and Zhang GY. Opposing effects of Bad phosphorylation at two distinct sites by Akt1 and JNK1/2 on ischemic brain injury. Cell Signal 19: 1844-1856, 2007. (Pubitemid 47081377)
-
(2007)
Cellular Signalling
, vol.19
, Issue.9
, pp. 1844-1856
-
-
Wang, X.-T.1
Pei, D.-S.2
Xu, J.3
Guan, Q.-H.4
Sun, Y.-F.5
Liu, X.-M.6
Zhang, G.-Y.7
-
369
-
-
0029938805
-
Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP kinase
-
Wang XZ and Ron D. Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase. Science 272: 1347-1349, 1996. (Pubitemid 26199977)
-
(1996)
Science
, vol.272
, Issue.5266
, pp. 1347-1349
-
-
Wang, X.1
Ron, D.2
-
370
-
-
34548695952
-
Mitogen-activated protein kinases in heart development and diseases
-
DOI 10.1161/CIRCULATIONAHA.106.679589, PII 0000301720070918000015
-
Wang Y. Mitogen-activated protein kinases in heart de-velopment and diseases. Circulation 116: 1413-1423, 2007. (Pubitemid 47417568)
-
(2007)
Circulation
, vol.116
, Issue.12
, pp. 1413-1423
-
-
Wang, Y.1
-
371
-
-
0036402460
-
SEK1/MKK4-mediated SAPK/JNK signaling participates in embryonic hepatoblast proliferation via a pathway different from NF-κB-induced anti-apoptosis
-
DOI 10.1016/S0012-1606(02)90781-5
-
Watanabe T, Nakagawa K, Ohata S, Kitagawa D, Nishitai G, Seo J, Tanemura S, Shimizu N, Kishimoto H, Wada T, Aoki J, Arai H, Iwatsubo T, Mochita M, Satake M, Ito Y, Matsuyama T, Mak TW, Penninger JM, Nishina H, and Katada T. SEK1/MKK4-mediated SAPK/JNK signaling participates in embryonic hepatoblast proliferation via a pathway different from NF-?B-induced anti-apoptosis. Dev Biol 250: 332-347, 2002. (Pubitemid 35216419)
-
(2002)
Developmental Biology
, vol.250
, Issue.2
, pp. 332-347
-
-
Watanabe, T.1
Nakagawa, K.2
Ohata, S.3
Kitagawa, D.4
Nishitai, G.5
Seo, J.6
Tanemura, S.7
Shimizu, N.8
Kishimoto, H.9
Wada, T.10
Aoki, J.11
Arai, H.12
Iwatsubo, T.13
Mochita, M.14
Watanabe, T.15
Satake, M.16
Ito, Y.17
Matsuyama, T.18
Mak, T.W.19
Penninger, J.M.20
Nishina, H.21
Katada, T.22
more..
-
372
-
-
20544435441
-
Apoptosis signal-regulating kinase 1 is involved not only in apoptosis but also in non-apoptotic cardiomyocyte death
-
DOI 10.1016/j.bbrc.2005.05.151, PII S0006291X05010053
-
Watanabe T, Otsu K, Takeda T, Yamaguchi O, Hikoso S, Kashiwase K, Higuchi Y, Taniike M, Nakai A, Matsumura Y, Nishida K, Ichijo H, and Hori M. Apoptosis signal-regulating kinase 1 is involved not only in apoptosis but also in non-apoptotic cardiomyocyte death. Biochem Biophys Res Commun 333: 562-567, 2005. (Pubitemid 40848328)
-
(2005)
Biochemical and Biophysical Research Communications
, vol.333
, Issue.2
, pp. 562-567
-
-
Watanabe, T.1
Otsu, K.2
Takeda, T.3
Yamaguchi, O.4
Hikoso, S.5
Kashiwase, K.6
Higuchi, Y.7
Taniike, M.8
Nakai, A.9
Matsumura, Y.10
Nishida, K.11
Ichijo, H.12
Hori, M.13
-
373
-
-
55749091957
-
PEBP2-/Ï/CBF-/Ï-dependent phosphorylation of RUNX1 and p300 by HIPK2: Implications for leukemogenesis
-
Wee HJ, Voon DC, Bae SC, and Ito Y. PEBP2-/Ï/CBF-/Ï-dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesis. Blood 112: 3777-3787, 2008.
-
(2008)
Blood
, vol.112
, pp. 3777-3787
-
-
Wee, H.J.1
Voon, D.C.2
Bae, S.C.3
Ito, Y.4
-
374
-
-
34548740091
-
HIPK2 represses β-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis
-
DOI 10.1073/pnas.0703213104
-
Wei G, Ku S, Ma GK, Saito S, Tang AA, Zhang J, Mao JH, Appella E, Balmain A, and Huang EJ. HIPK2 represses ß-catenin-mediated transcription, epidermal stem cell ex-pansion, and skin tumorigenesis. Proc Natl Acad Sci USA 104: 13040-13045, 2007. (Pubitemid 351737589)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.32
, pp. 13040-13045
-
-
Wei, G.1
Ku, S.2
Ma, G.K.3
Saito, S.4
Tang, A.A.5
Zhang, J.6
Mao, J.-H.7
Appella, E.8
Balmain, A.9
Huang, E.J.10
-
375
-
-
74349102008
-
The emerging importance of group II PAKs
-
Wells CM and Jones GE. The emerging importance of group II PAKs. Biochem J 425: 465-473, 2010.
-
(2010)
Biochem J
, vol.425
, pp. 465-473
-
-
Wells, C.M.1
Jones, G.E.2
-
376
-
-
33847754623
-
The JNK signal transduction pathway
-
DOI 10.1016/j.ceb.2007.02.001, PII S0955067407000154
-
Weston CR and Davis RJ. The JNK signal transduction pathway. Curr Opin Cell Biol 19: 142-149, 2007. (Pubitemid 46386399)
-
(2007)
Current Opinion in Cell Biology
, vol.19
, Issue.2
, pp. 142-149
-
-
Weston, C.R.1
Davis, R.J.2
-
377
-
-
0031954631
-
MEK kinase 1, a substrate for DEVD-directed caspases, is involved in genotoxin-induced apoptosis
-
Widmann C, Gerwins P, Johnson NL, Jarpe MB, and Johnson GL. MEK kinase 1, a substrate for DEVD-directed caspases, is involved in genotoxin-induced apoptosis. Mol Cell Biol 18: 2416-2429, 1998. (Pubitemid 28152687)
-
(1998)
Molecular and Cellular Biology
, vol.18
, Issue.4
, pp. 2416-2429
-
-
Widmann, C.1
Gerwins, P.2
Johnson, N.L.3
Jarpe, M.B.4
Johnson, G.L.5
-
378
-
-
0032928614
-
Mitogen-activated protein kinase: Conservation of a three-kinase module from yeast to human
-
Widmann C, Gibson S, Jarpe MB, and Johnson GL. Mito-gen-activated protein kinase: conservation of a three-kinase module from yeast to human. Physiol Rev 79: 143-180,1999. (Pubitemid 29056951)
-
(1999)
Physiological Reviews
, vol.79
, Issue.1
, pp. 143-180
-
-
Widmann, C.1
Gibson, S.2
Jarpe, M.B.3
Johnson, G.L.4
-
379
-
-
62849093368
-
Death receptor sig-nal transducers: Nodes of coordination in immune signaling networks
-
Wilson NS, Dixit V, and Ashkenazi A. Death receptor sig-nal transducers: nodes of coordination in immune signaling networks. Nat Immunol 10: 348-355, 2009.
-
(2009)
Nat Immunol
, vol.10
, pp. 348-355
-
-
Wilson, N.S.1
Dixit, V.2
Ashkenazi, A.3
-
380
-
-
46449125390
-
Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR
-
DOI 10.1038/ncb1743, PII NCB1743
-
Winter M, Sombroek D, Dauth I, Moehlenbrink J, Scheuermann K, Crone J, and Hofmann TG. Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR. Nat Cell Biol 10: 812-824, 2008. (Pubitemid 351927710)
-
(2008)
Nature Cell Biology
, vol.10
, Issue.7
, pp. 812-824
-
-
Winter, M.1
Sombroek, D.2
Dauth, I.3
Moehlenbrink, J.4
Scheuermann, K.5
Crone, J.6
Hofmann, T.G.7
-
381
-
-
35649003370
-
Integrated activation of MAP3Ks balances cell fate in response to stress
-
DOI 10.1002/jcb.21522
-
Winter-Vann AM and Johnson GL. Integrated activation of MAP3Ks balances cell fate in response to stress. J Cell Bio-chem 102: 848-858, 2007. (Pubitemid 350036925)
-
(2007)
Journal of Cellular Biochemistry
, vol.102
, Issue.4
, pp. 848-858
-
-
Winter-Vann, A.M.1
Johnson, G.L.2
-
382
-
-
0030977312
-
Endothelial apoptosis in braf-deficient mice
-
DOI 10.1038/ng0797-293
-
Wojnowski L, Zimmer AM, Beck TW, Hahn H, Bernal R, Rapp UR, and Zimmer A. Endothelial apoptosis in Braf-deficient mice. Nat Genet 16: 293-297, 1997. (Pubitemid 27280215)
-
(1997)
Nature Genetics
, vol.16
, Issue.3
, pp. 293-297
-
-
Wojnowski, L.1
Zimmer, A.M.2
Beck, T.W.3
Hahn, H.4
Bernal, R.5
Rapp, U.R.6
Zimmer, A.7
-
383
-
-
58149353472
-
Apoptotic histone modification inhibits nuclear transport by regulating RCC1
-
Wong CH, Chan H, Ho CY, Lai SK, Chan KS, Koh CG, and Li HY. Apoptotic histone modification inhibits nuclear transport by regulating RCC1. Nat Cell Biol 11: 36-45, 2009.
-
(2009)
Nat Cell Biol
, vol.11
, pp. 36-45
-
-
Wong, C.H.1
Chan, H.2
Ho, C.Y.3
Lai, S.K.4
Chan, K.S.5
Koh, C.G.6
Li, H.Y.7
-
384
-
-
15044363028
-
Recent advances in the protein kinase B signaling pathway
-
DOI 10.1016/j.ceb.2005.02.010, Cell Regulation
-
Woodgett JR. Recent advances in the protein kinase B sig-naling pathway. Curr Opin Cell Biol 17: 150-157, 2005. (Pubitemid 40380938)
-
(2005)
Current Opinion in Cell Biology
, vol.17
, Issue.2
, pp. 150-157
-
-
Woodgett, J.R.1
-
385
-
-
4444240191
-
The functional interactions between the p53 and MAPK signaling pathways
-
Wu GS. The functional interactions between the p53 and MAPK signaling pathways. Cancer Biol Ther 3: 156-161, 2004.
-
(2004)
Cancer Biol Ther
, vol.3
, pp. 156-161
-
-
Wu, G.S.1
-
386
-
-
38649127572
-
Mam-malian Ste20-like protein kinase 3 mediates trophoblast apoptosis in spontaneous delivery
-
Wu HY, Lin CY, Lin TY, Chen TC, and Yuan CJ. Mam-malian Ste20-like protein kinase 3 mediates trophoblast apoptosis in spontaneous delivery. Apoptosis 13: 283-294, 2008.
-
(2008)
Apoptosis
, vol.13
, pp. 283-294
-
-
Wu, H.Y.1
Lin, C.Y.2
Lin, T.Y.3
Chen, T.C.4
Yuan, C.J.5
-
387
-
-
51849136395
-
P21 acti-vated kinase 5 activates Raf-1 and targets it to mitochon-dria
-
Wu X, Carr HS, Dan I, Ruvolo PP, and Frost JA. p21 acti-vated kinase 5 activates Raf-1 and targets it to mitochon-dria. J Cell Biochem 105: 167-175, 2008.
-
(2008)
J Cell Biochem
, vol.105
, pp. 167-175
-
-
Wu, X.1
Carr, H.S.2
Dan, I.3
Ruvolo, P.P.4
Frost, J.A.5
-
388
-
-
0030689618
-
2- terminal kinase-specific kinase
-
Wu Z, Wu J, Jacinto E, and Karin M. Molecular cloning and characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinase. Mol Cell Biol 17: 7407-7416, 1997. (Pubitemid 27505969)
-
(1997)
Molecular and Cellular Biology
, vol.17
, Issue.12
, pp. 7407-7416
-
-
Wu, Z.1
Wu, J.2
Jacinto, E.3
Karin, M.4
-
389
-
-
0033616588
-
Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression
-
DOI 10.1073/pnas.96.7.3763
-
Wysk M, Yang DD, Lu HT, Flavell RA, and Davis RJ. Re-quirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine ex-pression. Proc Natl Acad Sci USA 96: 3763-3768, 1999. (Pubitemid 29168984)
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, Issue.7
, pp. 3763-3768
-
-
Wysk, M.1
Yang, D.D.2
Lu, H.-T.3
Flavell, R.A.4
Davis, R.J.5
-
390
-
-
0034625170
-
MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration
-
DOI 10.1073/pnas.97.10.5243
-
Xia Y, Makris C, Su B, Li E, Yang J, Nemerow GR, and Karin M. MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration. Proc Natl Acad Sci USA 97: 5243-5248, 2000. (Pubitemid 30313703)
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, Issue.10
, pp. 5243-5248
-
-
Xia, Y.1
Makris, C.2
Su, B.3
Li, E.4
Yang, J.5
Nemerow, G.R.6
Karin, M.7
-
391
-
-
33846130923
-
MEKK1 mediates the ubiquitination and degradation of c-Jun in response to osmotic stress
-
DOI 10.1128/MCB.01355-06
-
Xia Y, Wang J, Xu S, Johnson GL, Hunter T, and Lu Z. MEKK1 mediates the ubiquitination and degradation of c-Jun in response to osmotic stress. Mol Cell Biol 27: 510-517, 2007. (Pubitemid 46080120)
-
(2007)
Molecular and Cellular Biology
, vol.27
, Issue.2
, pp. 510-517
-
-
Xia, Y.1
Wang, J.2
Xu, S.3
Johnson, G.L.4
Hunter, T.5
Lu, Z.6
-
392
-
-
0028880006
-
Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
-
Xia Z, Dickens M, Raingeaud J, Davis RJ, and Greenberg ME. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270: 1326-1331, 1995.
-
(1995)
Science
, vol.270
, pp. 1326-1331
-
-
Xia, Z.1
Dickens, M.2
Raingeaud, J.3
Davis, R.J.4
Greenberg, M.E.5
-
393
-
-
2342429688
-
TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis
-
Xu LG, Li LY, and Shu HB. TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis. J Biol Chem 279: 17278-17282, 2004.
-
(2004)
J Biol Chem
, vol.279
, pp. 17278-17282
-
-
Xu, L.G.1
Li, L.Y.2
Shu, H.B.3
-
394
-
-
0034954603
-
The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis
-
DOI 10.1128/MCB.21.14.4713-4724.2001
-
Xu Z, Maroney AC, Dobrzanski P, Kukekov NV, and Greene LA. The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis. Mol Cell Biol 21: 4713-4724, 2001. (Pubitemid 32588252)
-
(2001)
Molecular and Cellular Biology
, vol.21
, Issue.14
, pp. 4713-4724
-
-
Xu, Z.1
Maroney, A.C.2
Dobrzanski, P.3
Kukekov, N.V.4
Greene, L.A.5
-
395
-
-
8544283103
-
CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells
-
DOI 10.1074/jbc.M406933200
-
Yamaguchi H and Wang HG. CHOP is involved in endo-plasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells. J Biol Chem 279: 45495-45502, 2004. (Pubitemid 39491535)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.44
, pp. 45495-45502
-
-
Yamaguchi, H.1
Wang, H.-G.2
-
396
-
-
0029551805
-
Identification of a member of the MAPKKK family as a potential Mediator of TGF-β signal transduction
-
Yamaguchi K, Shirakabe K, Shibuya H, Irie K, Oishi I, Ueno N, Taniguchi T, Nishida E, and Matsumoto K. Identifica-tion of a member of the MAPKKK family as a potential mediator of TGF-signal transduction. Science 270: 2008-2011, 1995. (Pubitemid 26097194)
-
(1995)
Science
, vol.270
, Issue.5244
, pp. 2008-2011
-
-
Yamaguchi, K.1
Shirakabe, K.2
Shibuya, H.3
Irie, K.4
Oishi, I.5
Ueno, N.6
Taniguchi, T.7
Nishida, E.8
Matsumoto, K.9
-
397
-
-
9144231898
-
Targeted deletion of apoptosis signal-regulating kinase 1 attenuates left ventricular remodeling
-
DOI 10.1073/pnas.2136717100
-
Yamaguchi O, Higuchi Y, Hirotani S, Kashiwase K, Na-kayama H, Hikoso S, Takeda T, Watanabe T, Asahi M, Taniike M, Matsumura Y, Tsujimoto I, Hongo K, Kusakari Y, Kurihara S, Nishida K, Ichijo H, Hori M, and Otsu K. Targeted deletion of apoptosis signal-regulating kinase 1 attenuates left ventricular remodeling. Proc Natl Acad Sci USA 100: 15883-15888, 2003. (Pubitemid 38021084)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.26
, pp. 15883-15888
-
-
Yamaguchi, O.1
Higuchi, Y.2
Hirotani, S.3
Kashiwase, K.4
Nakayama, H.5
Hikoso, S.6
Takeda, T.7
Watanabe, T.8
Asahi, M.9
Taniike, M.10
Matsumura, Y.11
Tsujimoto, I.12
Hongo, K.13
Kusakari, Y.14
Kurihara, S.15
Nishida, K.16
Ichijo, H.17
Hori, M.18
Otsu, K.19
-
399
-
-
85047691556
-
Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy
-
DOI 10.1172/JCI200317459
-
Yamamoto S, Yang G, Zablocki D, Liu J, Hong C, Kim SJ, Soler S, Odashima M, Thaisz J, Yehia G, Molina CA, Yatani A, Vatner DE, Vatner SF, and Sadoshima J. Activation of Mst1 causes dilated cardiomyopathy by stimulating apo-ptosis without compensatory ventricular myocyte hyper-trophy. J Clin Invest 111: 1463-1474, 2003. (Pubitemid 38063279)
-
(2003)
Journal of Clinical Investigation
, vol.111
, Issue.10
, pp. 1463-1474
-
-
Yamamoto, S.1
Yang, G.2
Zablocki, D.3
Liu, J.4
Hong, C.5
Kim, S.-J.6
Soler, S.7
Odashima, M.8
Thaisz, J.9
Yehia, G.10
Molina, C.A.11
Yatani, A.12
Vatner, D.E.13
Vatner, S.F.14
Sadoshima, J.15
-
400
-
-
0030908341
-
2-terminal kinase activation, and defects in AP-1 transcriptional activity
-
DOI 10.1073/pnas.94.7.3004
-
Yang D, Tournier C, Wysk M, Lu HT, Xu J, Davis RJ, and Flavell RA. Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH2-terminal kinase activation, and defects in AP-1 transcriptional activity. Proc Natl Acad Sci USA 94: 3004-3009, 1997. (Pubitemid 27157254)
-
(1997)
Proceedings of the National Academy of Sciences of the United States of America
, vol.94
, Issue.7
, pp. 3004-3009
-
-
Yang, D.1
Tournier, C.2
Wysk, M.3
Lu, H.-T.4
Xu, J.5
Davis, R.J.6
Flavell, R.A.7
-
401
-
-
0030780804
-
Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene
-
DOI 10.1038/39899
-
Yang DD, Kuan CY, Whitmarsh AJ, Rincon M, Zheng TS, Davis RJ, Rakic P, and Flavell RA. Absence of ex-citotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene. Nature 389: 865-870, 1997. (Pubitemid 27462982)
-
(1997)
Nature
, vol.389
, Issue.6653
, pp. 865-870
-
-
Yang, D.D.1
Kuan, C.-Y.2
Whitmarsh, A.J.3
Rincon, M.4
Zheng, T.S.5
Davis, R.J.6
Rakic, P.7
Flavell, R.A.8
-
402
-
-
0034050739
-
Mekk3 is essential for early embryonic cardiovascular development
-
DOI 10.1038/73550
-
Yang J, Boerm M, McCarty M, Bucana C, Fidler IJ, Zhuang Y, and Su B. Mekk3 is essential for early embry-onic cardiovascular development. Nat Genet 24: 309-313, 2000. (Pubitemid 30132205)
-
(2000)
Nature Genetics
, vol.24
, Issue.3
, pp. 309-313
-
-
Yang, J.1
Boerm, M.2
McCarty, M.3
Bucana, C.4
Fidler, I.J.5
Zhuang, Y.6
Su, B.7
-
403
-
-
15144349962
-
Activation of stress-activated protein kinases/c-Jun N-terminal protein kinases (SAPKs/JNKs) by a novel mitogen-activated protein kinase kinase (MKK7)
-
DOI 10.1074/jbc.272.51.32378
-
Yao Z, Diener K, Wang XS, Zukowski M, Matsumoto G, Zhou G, Mo R, Sasaki T, Nishina H, Hui CC, Tan TH, Woodgett JP, and Penninger JM. Activation of stress-activated protein kinases/c-Jun N-terminal protein kinases (SAPKs/JNKs) by a novel mitogen-activated protein kinase kinase. J Biol Chem 272: 32378-32383, 1997. (Pubitemid 28011920)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.51
, pp. 32378-32383
-
-
Yao, Z.1
Diener, K.2
Wang, X.S.3
Zukowski, M.4
Matsumoto, G.5
Zhou, G.6
Mo, R.7
Sasaki, T.8
Nishina, H.9
Hui, C.C.10
Tan, T.-H.11
Woodgett, J.P.12
Penninger, J.M.13
-
404
-
-
46049090743
-
Nuclear trafficking of pro-apoptotic kinases in response to DNA damage
-
Yoshida K. Nuclear trafficking of pro-apoptotic kinases in response to DNA damage. Trends MolMed 14: 305-313,2008.
-
(2008)
Trends MolMed
, vol.14
, pp. 305-313
-
-
Yoshida, K.1
-
405
-
-
55949091108
-
Role for DYRK family kinases on regulation of apoptosis
-
Yoshida K. Role for DYRK family kinases on regulation of apoptosis. Biochem Pharmacol 76: 1389-1394, 2008.
-
(2008)
Biochem Pharmacol
, vol.76
, pp. 1389-1394
-
-
Yoshida, K.1
-
406
-
-
33646229039
-
46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage
-
DOI 10.1074/jbc.M512074200
-
Yoshida K, Liu H, and Miki Y. Protein kinase C δ regulates Ser46 phosphorylation of p53 tumor suppressor in the ap-optotic response to DNA damage. J Biol Chem 281: 5734-5740, 2006 (Pubitemid 43847672)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.9
, pp. 5734-5740
-
-
Yoshida, K.1
Liu, H.2
Miki, Y.3
-
407
-
-
14744301343
-
JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage
-
DOI 10.1038/ncb1228
-
Yoshida K, Yamaguchi T, Natsume T, Kufe D, and Miki Y. JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA dam-age. Nat Cell Biol 7: 278-285, 2005. (Pubitemid 40331129)
-
(2005)
Nature Cell Biology
, vol.7
, Issue.3
, pp. 278-285
-
-
Yoshida, K.1
Yamaguchi, T.2
Natsume, T.3
Kufe, D.4
Miki, Y.5
-
408
-
-
37549048249
-
The BCL-2 protein family: Op-posing activities that mediate cell death
-
Youle RJ and Strasser A. The BCL-2 protein family: op-posing activities that mediate cell death. Nat Rev Mol Cell Biol 9: 47-59, 2008.
-
(2008)
Nat Rev Mol Cell Biol
, vol.9
, pp. 47-59
-
-
Youle, R.J.1
Strasser, A.2
-
409
-
-
0038342509
-
AKT2 inhibition of cisplatin-induced JNK/p38 and bax activation by phosphorylation of ASK1. Implication of AKT2 in chemoresistance
-
DOI 10.1074/jbc.M302674200
-
Yuan ZQ, Feldman RI, Sussman GE, Coppola D, Nicosia SV, and Cheng JQ. AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by phosphorylation of ASK1: implication of AKT2 in chemoresistance. J Biol Chem 278: 23432-23440, 2003. (Pubitemid 36830160)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.26
, pp. 23432-23440
-
-
Yuan, Z.-Q.1
Feldman, R.I.2
Sussman, G.E.3
Coppola, D.4
Nicosia, S.V.5
Cheng, J.Q.6
-
410
-
-
0032483967
-
Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption
-
Yujiri T, Sather S, Fanger GR, and Johnson GL. Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption. Science 282: 1911-1914, 1998. (Pubitemid 28555274)
-
(1998)
Science
, vol.282
, Issue.5395
, pp. 1911-1914
-
-
Yujiri, T.1
Sather, S.2
Fanger, G.R.3
Johnson, G.L.4
-
411
-
-
0142057145
-
Comparative studies of a new subfamily of human Ste20-like kinases: Homodimerization, subcellular localization, and selective activation of MKK3 and p38
-
DOI 10.1038/sj.onc.1206605
-
Yustein JT, Xia L, Kahlenburg JM, Robinson D, Templeton D, and Kung HJ. Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellu-lar localization, and selective activation of MKK3 and p38. Oncogene 22: 6129-6141, 2003. (Pubitemid 37281642)
-
(2003)
Oncogene
, vol.22
, Issue.40
, pp. 6129-6141
-
-
Yustein, J.T.1
Xia, L.2
Kahlenburg, J.M.3
Robinson, D.4
Templeton, D.5
Kung, H.-J.6
-
412
-
-
61849102389
-
DAP-kinase-mediated phosphorylation on the BH3 do-main of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy
-
Zalckvar E, Berissi H, Mizrachy L, Idelchuk Y, Koren I, Eisenstein M, Sabanay H, Pinkas-Kramarski R, and Kimchi A. DAP-kinase-mediated phosphorylation on the BH3 do-main of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy. EMBO Rep 10: 285-292, 2009.
-
(2009)
EMBO Rep
, vol.10
, pp. 285-292
-
-
Zalckvar, E.1
Berissi, H.2
Mizrachy, L.3
Idelchuk, Y.4
Koren, I.5
Eisenstein, M.6
Sabanay, H.7
Pinkas-Kramarski, R.8
Kimchi, A.9
-
413
-
-
67650812332
-
RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necro-sis
-
Zhang DW, Shao J, Lin J, Zhang N, Lu BJ, Lin SC, Dong MQ, and Han J. RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necro-sis. Science 325: 332-336, 2009.
-
(2009)
Science
, vol.325
, pp. 332-336
-
-
Zhang, D.W.1
Shao, J.2
Lin, J.3
Zhang, N.4
Lu, B.J.5
Lin, S.C.6
Dong, M.Q.7
Han, J.8
-
414
-
-
33845889727
-
Essential function of HIPK2 in TGFβ-dependent survival of midbrain dopamine neurons
-
DOI 10.1038/nn1816, PII NN1816
-
Zhang J, Pho V, Bonasera SJ, Holtzman J, Tang AT, Hell-muth J, Tang S, Janak PH, Tecott LH, and Huang EJ. Es-sential function of HIPK2 in TGF/ï-dependent survival of midbrain dopamine neurons. Nat Neurosci 10: 77-86, 2007. (Pubitemid 46026530)
-
(2007)
Nature Neuroscience
, vol.10
, Issue.1
, pp. 77-86
-
-
Zhang, J.1
Pho, V.2
Bonasera, S.J.3
Holzmann, J.4
Tang, A.T.5
Hellmuth, J.6
Tang, S.7
Janak, P.H.8
Tecott, L.H.9
Huang, E.J.10
-
415
-
-
0142258245
-
Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP
-
DOI 10.1016/S0092-8674(03)00802-X
-
Zhang Q, Yoshimatsu Y, Hildebrand J, Frisch SM, and Goodman RH. Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP. Cell 115: 177-186, 2003. (Pubitemid 37329581)
-
(2003)
Cell
, vol.115
, Issue.2
, pp. 177-186
-
-
Zhang, Q.1
Yoshimatsu, Y.2
Hildebrand, J.3
Frisch, S.M.4
Goodman, R.H.5
-
416
-
-
35948961118
-
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control
-
DOI 10.1101/gad.1602907
-
Zhao B, Wei X, Li W, Udan RS, Yang Q, Kim J, Xie J, Ikenoue T, Yu J, Li L, Zheng P, Ye K, Chinnaiyan A, Halder G, Lai ZC, and Guan KL. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibi-tion and tissue growth control. Genes Dev 21: 2747-2761, 2007. (Pubitemid 350070721)
-
(2007)
Genes and Development
, vol.21
, Issue.21
, pp. 2747-2761
-
-
Zhao, B.1
Wei, X.2
Li, W.3
Udan, R.S.4
Yang, Q.5
Kim, J.6
Xie, J.7
Ikenoue, T.8
Yu, J.9
Li, L.10
Zheng, P.11
Ye, K.12
Chinnaiyan, A.13
Halder, G.14
Lai, Z.-C.15
Guan, K.-L.16
-
417
-
-
70350502865
-
Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepa-tocellular carcinoma development through inactivation of the Yap1 oncogene
-
Zhou D, Conrad C, Xia F, Park JS, Payer B, Yin Y, Lauwers GY, Thasler W, Lee JT, Avruch J, and Bardeesy N. Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepa-tocellular carcinoma development through inactivation of the Yap1 oncogene. Cancer Cell 16: 425-438, 2009.
-
(2009)
Cancer Cell
, vol.16
, pp. 425-438
-
-
Zhou, D.1
Conrad, C.2
Xia, F.3
Park, J.S.4
Payer, B.5
Yin, Y.6
Lauwers, G.Y.7
Thasler, W.8
Lee, J.T.9
Avruch, J.10
Bardeesy, N.11
-
418
-
-
58149520083
-
The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naive T cells
-
Zhou D, Medoff BD, Chen L, Li L, Zhang XF, Praskova M, Liu M, Landry A, Blumberg RS, Boussiotis VA, Xavier R, and Avruch J. The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naive T cells. Proc Natl Acad Sci USA 105: 20321-20326, 2008.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 20321-20326
-
-
Zhou, D.1
Medoff, B.D.2
Chen, L.3
Li, L.4
Zhang, X.F.5
Praskova, M.6
Liu, M.7
Landry, A.8
Blumberg, R.S.9
Boussiotis, V.A.10
Xavier, R.11
Avruch, J.12
-
419
-
-
0029055761
-
Components of a new human protein kinase signal transduction pathway
-
Zhou G, Bao ZQ, and Dixon JE. Components of a new human protein kinase signal transduction pathway. J Biol Chem 270: 12665-12669, 1995.
-
(1995)
J Biol Chem
, vol.270
, pp. 12665-12669
-
-
Zhou, G.1
Bao, Z.Q.2
Dixon, J.E.3
-
420
-
-
0037151032
-
P38 mitogen-activated protein kinase mediates hypoxic regulation of Mdm2 and p53 in neurons
-
DOI 10.1074/jbc.M200042200
-
Zhu Y, Mao XO, Sun Y, Xia Z, and Greenberg DA. p38 Mitogen-activated protein kinase mediates hypoxic regulation of Mdm2 and p53 in neurons. J Biol Chem 277: 22909-22914, 2002. (Pubitemid 34967274)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.25
, pp. 22909-22914
-
-
Zhu, Y.1
Mao, X.O.2
Sun, Y.3
Xia, Z.4
Greenberg, D.A.5
-
421
-
-
34250318632
-
Prostate-derived sterile 20-like kinase 1-α induces apoptosis: JNK- and caspase-dependent nuclear localization is a requirement for membrane blebbing
-
DOI 10.1074/jbc.M608336200
-
Zihni C, Mitsopoulos C, Tavares IA, Baum B, Ridley AJ, and Morris JD. Prostate-derived sterile 20-like kinase 1-α induces apoptosis. JNK-and caspase-dependent nuclear localization is a requirement for membrane blebbing. J Biol Chem 282: 6484-6493, 2007. (Pubitemid 47100886)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.9
, pp. 6484-6493
-
-
Zihni, C.1
Mitsopoulos, C.2
Tavares, I.A.3
Baum, B.4
Ridley, A.J.5
Morris, J.D.H.6
-
422
-
-
0032054744
-
CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum
-
Zinszner H, Kuroda M, Wang X, Batchvarova N, Lightfoot RT, Remotti H, Stevens JL, and Ron D. CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes Dev 12: 982-995,1998. (Pubitemid 28204605)
-
(1998)
Genes and Development
, vol.12
, Issue.7
, pp. 982-995
-
-
Zinszner, H.1
Kuroda, M.2
Wang, X.3
Batchvarova, N.4
Lightfoot, R.T.5
Remotti, H.6
Stevens, J.L.7
Ron, D.8
|