Design of a drug delivery system with bimodal pH dependent release of a poorly soluble drug

Pharmazie

Volumn 66, Issue 6, 2011, Pages 465-466

  Kovacic B ^a,b   Vrecer F ^a,b   Planinšek, Odon ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b KRKA D D   (Slovenia)

Author keywords

[No Author keywords available]

Indexed keywords

CARVEDILOL; POLYMER; SILICON DIOXIDE;

ARTICLE; DISPERSION; DRUG DELIVERY SYSTEM; DRUG GRANULATION; DRUG RELEASE; DRUG SOLUBILITY; INTESTINE FLUID; PH; WETTABILITY;

ADRENERGIC BETA-ANTAGONISTS; BIOLOGICAL AVAILABILITY; CARBAZOLES; DRUG DELIVERY SYSTEMS; DRUG DESIGN; EXCIPIENTS; HYDROGEN-ION CONCENTRATION; METHYLCELLULOSE; PHARMACEUTICAL PREPARATIONS; POLYMETHACRYLIC ACIDS; PROPANOLAMINES; SOLUBILITY;

EID: 79960013680     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: 10.1691/ph.2011.0325     Document Type: Article

References (9)

1. Amidon GL, Lennernäs H, Shah VP, Crison JR (1995) A theoretical basis for a biopharmaceutic drug classification: The correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm Res 12: 413-420.
2. Morgan T (1994) Clinical pharmacokinetics and pharmacodynamics of carvedilol. Clin Pharmacokinet 26: 335-346.
3. Wei L, Sun P, Nie S, Pan W (2005) Preparation and evaluation of SEDDS and SMEDDS containing carvedilol. Drug Dev Ind Pharm 31: 785-794. (Pubitemid 41356195)
4. Rowe CW, Katstra WE, Palazzolo RD, Giritlioglu B et al. (2000) Multimechanism oral dosage forms fabricated by three dimensional printing TM. J Control Release 66: 11-17. (Pubitemid 30116680)
5. Rupprecht H, Biersack MJ, Kindl G (1974) Freigabe schwer löslicher Substanzen von den Oberflächen partiell belegter Kieselsäuren. Colloid Polym Sci 252: 415-416.
6. RxList (2010) The internet drug index, Coreg CR, Dosage and administration. Available : http://www.rxlist.com/coreg-cr-drug.htm.
7. Speybroeck MV, Barillaro V, Do Thi T et al. (2008) Ordered mesoporous silica materials SBA-15: A broad spectrum formulation platform for poorly soluble drugs. J Pharm Sci 98: 2648-2658.
8. Streubel A, Siepmann J, Peppas NA, Bodmeier R (2000) Bimodal drug release achieved with multi-layer matrix tablets: transport mechanisms and device design. J Control Release 69: 455-468.
9. Vrečer F (1992). Ph.D. Thesis, University of Ljubljana.