Neonatal seizures: An expression of fetal or neonatal brain disorders

Fetal and Neonatal Brain Injury, Fourth Edition

Volumn , Issue , 2009, Pages 499-526

  Scher, Mark S ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 79960013482     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1017/CBO9780511581281.045     Document Type: Chapter

References (127)

1. Scher MS. Seizures in the neonate: diagnostic and therapeutic considerations. In Spitzer AR, ed., Intensive Care of the Fetus and Neonate, 2nd edn. Philadelphia, PA: Saunders, 2004.
2. Scher MS. Neonatal seizures: an expression of fetal or neonatal brain disorders. In Stevenson DK, Benitz WE, Sunshine P, eds., Fetal and Neonatal Brain Injury, 3rd edn. Cambridge: Cambridge University Press, 2002: 735-84.
3. Clancy RR. Prolonged electroencephalogram monitoring for seizures and their treatment. Clin Perinatol 2006; 33: 649-65.
4. Proposal for revised clinical and electroencephalographic classification of epileptic seizures. From the Commission on Classification and Terminology of the International League Against Epilepsy. Epilepsia 1981; 22: 489-501.
5. Mizrahi EM, Kellaway P. Diagnosis and Management of Neonatal Seizures. Philadelphia, PA: Lippincott-Raven, 1998.
6. Weiner SP, Painter MJ, Geva D, et al. Neonatal seizures: electroclinical dissociation. Pediatr Neurol 1991; 7: 363-8.
7. Biagioni E, Ferrari F, Boldrini A, et al. Electroclinical correlation in neonatal seizures. Eur J Paediatr Neurol 1998; 2: 117-25.
8. Volpe JJ. Neonatal seizures. In Neurology of the Newborn, 4th edn. Philadelphia, PA: Saunders. 2001: 178-214.
9. Scher MS. Electroencephalography of the newborn: normal and abnormal features. In Niedermeyer E, Lopes da Silva F, eds., Electroencephalography: Basic Principles, Clinical Applications, and Related Fields, 5th edn. Philadelphia, PA: Lippincott Williams and Wilkins, 2005: 937-89.
10. Scher MS. Normal electrographic-polysomnographic patterns in preterm and fullterm infants. Semin Pediatr Neurol 1996; 3: 2-12.
11. DaSilva O, Guzman GMC, Young GB. The value of standard electroencephalograms in the evaluation of the newborn with recurrent apneas. J Perinatol 1998; 18: 377-80.
12. Fenichel GM, Olson BJ, Fitzpatrick JE. Heart rate changes in convulsive and nonconvulsive neonatal apnea. Ann Neurol 1980; 7: 577-82.
13. Bye AM, Flanagan D. Spatial and temporal characteristics of neonatal seizures. Epilepsia 1995; 36: 1009-16.
14. Boylan GB, Pressler RM, Rennie JM, et al. Outcome of electroclinical, electrographic, and clinical seizures in the newborn infant. Dev Med Child Neurol 1999; 41: 819-25.
15. Mizrahi EM, Kellaway P. Characterization and classification of neonatal seizures. Neurology 1987; 37: 1837-44.
16. Scher MS, Klesh KW, Murphy TF, et al. Seizures and infarction in neonates with persistent pulmonary hypertension. Pediatr Neurol 1986; 2: 332-9.
17. Clancy R, Malin S, Laraque D, et al. Focal motor seizures heralding stroke in full-term neonates. Am J Dis Child 1985; 139: 601-6.
18. Levy SR, Abroms IF, Marshall PC, et al. Seizures and cerebral infarction in the full-term newborn. Ann Neurol 1985; 17: 366-70.
19. Holmes G. Diagnosis and management of seizures in childhood. In Markowitz M, ed., Major Problems in Clinical Pediatrics. Philadelphia, PA: Saunders, 1987: 237-61.
20. Karayiannis NB, Srinivasan S, Bhattacharya R, et al. Extraction of motion strength and motor activity signals from video recordings of neonatal seizures. IEEE Trans Med Imaging 2001; 20: 965-80.
21. Rose AL, Lombroso CT. A study of clinical, pathological, and electroencephalographic features in 137 full-term babies with a long-term follow-up. Pediatrics 1970; 45: 404-25.
22. Kellaway P, Hrachovy RA. Status epilepticus in newborns: a perspective on neonatal seizures. In Delgado-Escueta AV, Wasterlain CG, Treiman DM, et al., eds., Status Epilepticus: Mechanisms of Brain Damage and Treatment. New York, NY: Raven Press, 1983: 93-9.
23. Sarnat HB. Anatomic and physiologic correlates of neurologic development in prematurity. In Sarnat HB, ed., Topics in Neonatal Neurology. Orlando, FL: Grune and Stratton, 1984: 1-25.
24. Scher MS. Pathologic myoclonus of the newborn: electrographic and clinical correlations. Pediatr Neurol 1985; 1: 342-8.
25. Coulter DL, Allen RJ. Benign neonatal sleep myoclonus. Arch Neurol 1982; 39: 191-2.
26. Resnick TJ, Moshe SL, Perotta L, et al. Benign neonatal sleep myoclonus: relationship to sleep states. Arch Neurol 1986; 43: 266-8.
27. Clancy RR. The contribution of EEG to the understanding of neonatal seizures. Epilepsia 1996; 37: S52-9.
28. Shuper A, Zalzberg J, Weitz R, et al. Jitteriness beyond the neonatal period: a benign pattern of movement in infancy. J Child Neurol 1991; 6: 243-5.
29. Parker S, Zuckerman B, Bauchner H, et al. Jitteriness in full-term neonates: prevalence and correlates. Pediatrics 1990; 85: 17-23.
30. Hakamada S, Watanabe K, Hara K, et al. Development of the motor behavior during sleep in newborn infants. Brain Dev 1981; 3: 345-50.
31. Scher MS, Belfar H, Martin J, et al. Destructive brain lesions of presumed fetal onset: antepartum causes of cerebral palsy. Pediatrics 1991; 88: 898-906.
32. Sexson WR, Thigpen J, Stajich GV. Stereotypic movements after lorazepam administration in premature neonates: a series and review of the literature. J Perinatol 1995; 15: 146-51.
33. Brown P, Rothwell JC, Thompson PD, et al. The hyperekplexias and their relationship to the normal startle reflex. Brain 1991; 114: 1903-28.
34. Andermann F, Andermann E. Startle disorders of man: hyperekplexia, jumping and startle epilepsy. Brain Dev 1988; 10: 213-22.
35. Barth PJ. Inherited progressive disorders of the fetal brain: a field in need of recognition. In Fukuyama Y, Suzuki Y, Kamoshia S, et al., eds., Fetal and Perinatal Neurology. New York, NY: Karger, 1992: 299-313.
36. Lyon G, Adams RD, Kolodny EH. Hypoglycemia. In Neurology of Hereditary Metabolic Diseases of Children, 2nd edn. New York, NY: McGraw-Hill, 1996: 6-44.
37. Scher MS. Seizures in the newborn infant: diagnosis, treatment, and outcome. Clin Perinatol 1997; 24: 735-72.
38. Oliveira AJ, Nunes ML, da Costa JC. Polysomnography in neonatal seizures. Clin Neurophysiol 2000; 111: S74-80.
39. Watanabe K, Kuroyanagi M, Hara K, et al. Neonatal seizures and subsequent epilepsy. Brain Dev 1982; 4: 341-6.
40. Hrachovy R, Mizrahi E, Kellaway P. Electroencephalography of the newborn. In Daly D, Pedley T, eds., Current Practice of Clinical Electroencephalography, 2nd edn. New York, NY: Raven Press, 1990: 201-42.
41. Stockard-Pope JE, Werner SS, Bickford RG. Atlas of Neonatal Electroencephalography, 2nd edn. New York, NY: Raven Press, 1992.
42. Lombroso CT. Neonatal polygraphy in full-term and premature infants: a review of normal and abnormal findings. J Clin Neurophysiol 1985; 2: 105-55.
43. Hellstrom-Westas L. Comparison between tape-recorded and amplitudeintegrated EEG monitoring in sick newborn infants. Acta Paediatr 1992; 81: 812-9.
44. Klebermass K, Kuhle S, Kohlhauser-Vollmuth C, et al. Evaluation of the Cerebral Function Monitor as a tool for neurophysiological surveillance in neonatal intensive care patients. Childs Nerv Syst 2001; 17: 544-50.
45. Alfonso I, Jayakar P, Yelin K, et al. Continuous-display four-channel electroencephalographic monitoring in the evaluation of neonates with paroxysmal motor events. J Child Neurol 2001; 16: 625-8.
46. Scher MS, Hamid MY, Steppe DA, et al. Ictal and interictal electrographic seizure durations in preterm and term neonates. Epilepsia 1993; 34: 284-8.
47. Clancy RR, Legido A. The exact ictal and interictal duration of electroencephalographic neonatal seizures. Epilepsia 1987; 28: 537-41.
48. Sheth RD. Electroencephalogram confirmatory rate in neonatal seizures. Pediatr Neurol 1999; 20: 27-30.
49. Painter MJ, Scher MS, Stein AD, et al. Phenobarbital compared with phenytoin for the treatment of neonatal seizures. N Engl J Med 1999; 341: 485-9.
50. Scher MS, Steppe DA, Beggarly M. Timing of neonatal seizures and intrapartum obstetrical factors. J Child Neurol 2008; 23: 640-3.
51. Scher MS, Alvin J, Gaus L, et al. Uncoupling of EEG-clinical neonatal seizures after antiepileptic drug use. Pediatr Neurol 2003; 28: 277-80.
52. Veliskova J, Miller AM, Lunes, ML, et al. Regional neural activity within the substantia nigra during peri-ictal flurothyl generalized seizure stages. Neurobiol Dis 2005; 20: 752-9.
53. Merrill MA, Clough RW, Dailey JW, et al. Localization of the serotonergic terminal fields modulating seizures in the genetically epilepsy-prone rat. Epilepsy Res 2007; 76: 93-102.
54. Alfonso I, Papazian O, Litt R, et al. Single photon emission computed tomographic evaluation of brainstem release phenomenon and seizure in neonates. J Child Neurol 2000; 15: 56-8.
55. Kilic S, Tarim O, Eralp O. Serum prolactin in neonatal seizures. Pediatr Int 1999; 41: 61-4.
56. Browning RA. Role of the brainstem reticular formation in tonic-clonic seizures: lesion and pharmacological studies. Fed Proc 1985; 44: 2425-31.
57. Caveness WF, Kato M, Malamut BL, et al. Propagation of focal motor seizures in the pubescent monkey. Ann Neurol 1980; 7: 213-21, 232-5.
58. Hosokawa S, Iguchi T, Caveness WF, et al. Effects of manipulation of the sensorimotor system on focal motor seizures in the monkey. Ann Neurol 1980; 7: 222-9, 236-7.
59. Danner R, Shewmon DA, Sherman MP. Seizures in an atelencephalic infant: is the cortex essential for neonatal seizures? Arch Neurol 1985; 42: 1014-16.
60. Subcortical Control of Cortical Excitability, Plenary Session. American Epilepsy Society Meeting, Philadelphia, PA, December, 2005.
61. Scher MS, Aso K, Beggarly ME, et al. Electrographic seizures in preterm and full-term neonates: clinical correlates, associated brain lesions, and risk for neurologic sequelae. Pediatrics 1993; 91: 128-34.
62. Coen RW, McCutchen CB, Wermer D, et al. Continuous monitoring of the electroencephalogram following perinatal asphyxia. J Pediatr 1982; 100: 628-30.
63. O'Meara MW, Bye AM, Flanagan D. Clinical features of neonatal seizures. J Paediatr Child Health 1995; 31: 237-40.
64. Staudt F, Roth JG, Engel RC. The usefulness of electroencephalography in curarized newborns. Electroencephalogr Clin Neurophysiol 1981; 51: 205-8.
65. Eyre JA, Oozeer RC, Wilkinson AR. Continuous electroencephalographic recording to detect seizures in paralyzed newborn babies. Br Med J 1983; 286: 1017-18.
66. Goldberg RN, Goldman SL, Ramsay RE, et al. Detection of seizure activity in the paralyzed neonate using continuous monitoring. Pediatrics 1982; 69: 583-6.
67. Ronen GM, Penney S, Andrews W. The epidemiology of clinical neonatal seizures in Newfoundland: a population-based study. J Pediatr 1999; 134: 71-5.
68. Eriksson M, Zetterstrom R. Neonatal convulsions: incidence and causes in the Stockholm area. Acta Paediatr Scand 1979; 68: 807-11.
69. Seay AR, Bray PF. Significance of seizures in infants weighing less than 2, 500 grams. Arch Neurol 1977; 34: 381-2.
70. Saliba RM, Annegers FJ, Waller DK, et al. Risk factors for neonatal seizures: a population-based study, Harris County, Texas, 1992-1994. Am J Epidemiol 2001; 154: 14-20.
71. Lanska MJ, Lanska DJ, Baumann RJ, et al. Interobserver variability in the classification of neonatal seizures based on medical record data. Pediatr Neurol 1996; 15: 120-3.
72. Lanska MJ, Lanska DJ, Baumann RJ, et al. A population-based study of neonatal seizures in Fayette County, Kentucky. Neurology 1995; 45: 724-32.
73. Patterson CA, Graves WL, Bugg G, et al. Antenatal and intrapartum factors associated with the occurrence of seizures in the term infant. Obstet Gynecol 1989; 74: 361-5.
74. Bergman I, Painter MJ, Hirsh RP, et al. Outcome in neonates with convulsions treated in an intensive care unit. Ann Neurol 1983; 14: 642-7.
75. Evard P, Kadhim HJ, de Saint-George P, et al. Abnormal development and destructive processes of the human brain during the second half of gestation. In Evans P, Minkowski A, eds., Developmental Neurobiology. New York, NY: Raven Press, 1989: 21-39.
76. Lieberman E, Eichenwald E, Mathur G, et al. Intrapartum fever and unexplained seizures in term infants. Pediatrics 2000; 106: 983-8.
77. Scher MS. Fetal neurologic consultations. Pediatr Neurol 2003; 29: 193-202.
78. American College of Obstetricians and Gynecologists and American Academy of Pediatrics. Neonatal Encephalopathy in Cerebral Palsy: Defining the Pathogenesis and Pathophysiology. Washington, DC: ACOG, 2003.
79. Parent JM. The role of seizure-induced neurogenesis in epileptogenesis and brain repair. Epilepsy Res 2002; 50: 179-89.
80. Swann JW. The effects of seizures on the connectivity and circuitry of the developing brain. Ment Retard Dev Disabil Res Rev 2004; 10: 96-100.
81. Eriksson SH, Malmgren K, Nordborg C. Microdysgenesis in epilepsy. Acta Neurol Scand 2005; 111: 279-90.
82. Squier M, Keeling JW. The incidence of prenatal brain injury. Neuropathol Appl Neurobiol 1991; 17: 29-38.
83. Scher MS. Neonatal seizure classification: a fetal perspective concerning childhood epilepsy. Epilepsy Res 2006; 70: S41-57.
84. Scher MS, Trucco J, Beggarly ME, et al. Neonates with electrically confirmed seizures and possible placental associations. Pediatr Neurol 1998; 19: 37-41.
85. Friede RL. Porencephaly, hydranencephaly, multilocular cystic encephalopathy. In Developmental Neuropathology. New York, NY: Springer-Verlag, 1975: 102-13.
86. Miller V. Neonatal cerebral infarction. Semin Pediatr Neurol 2001; 7: 278-88.
87. de Vries LS, Groenendaal F, Eken P, et al. Infarcts in the vascular distribution of the middle cerebral artery in preterm and fullterm infants. Neuropediatrics 1997; 28: 88-96.
88. Baergen RN. The placenta as witness. Clin Perinatol 2007; 34: 393-407.
89. Leth H, Toft PB, Herning M, et al. Neonatal seizures associated with cerebral lesions shown by magnetic resonance imaging. Arch Dis Child Fetal Neonatal Ed 1997; 77: F105-10.
90. Rutherford M, Ward P, Allsop J, et al. Magnetic resonance imaging in neonatal encephalopathy. Early Hum Dev 2004; 81: 13-25.
91. Enns GM. Inborn errors of metabolism masquerading as hypoxic-ischemic encephalopathy. Neo Reviews 2005; 6: e549-58.
92. Scher MS, Painter MJ. Controversies concerning neonatal seizures. Pediatr Clin North Am 1989; 36: 281-310.
93. Clancy RR, Legido A. Postnatal epilepsy after EEG-confirmed neonatal seizures. Epilepsia 1991; 32: 69-76.
94. Temple CM, Dennis J, Carney R, et al. Neonatal seizures: long-term outcome and cognitive development among “normal” survivors. Dev Med Child Neurol 1995; 37: 109-18.
95. Holmes GL, Ben-Ari Y. The neurobiology and consequences of epilepsy in the developing brain. Pediatr Res 2001; 49: 320-5.
96. Monod N, Pajot N, Guidasci S. The neonatal EEG: statistical studies and prognostic value in full-term and preterm babies. Electroencephalogr Clin Neurophysiol 1972; 32: 529-44.
97. Tharp BR, Cukier F, Monod N. The prognostic value of the electroencephalogram in premature infants. Electroencephalogr Clin Neurophysiol 1981; 51: 219.
98. McBride M, Laroia N, Guillet R. Electrographic seizures in neonates correlate with poor neurodevelopmental outcome. Neurology 2002; 55: 506-13.
99. Hellström-Westas L. Comparison between tape-recorded and amplitudeintegrated EEG monitoring in sick newborn infants. Acta Paediatr 1992; 81: 812-19.
100. Watanabe K, Kuroyanagi M, Hara K, et al. Neonatal seizures and subsequent epilepsy. Brain Dev 1982; 4: 341-6.
101. Holden KR, Mellits ED, Freeman JM. Neonatal seizures. I: Correlation of prenatal and perinatal events with outcomes. Pediatrics 1982; 70: 165-76.
102. Scher MS, Aso K, Beggarley ME, et al. Electrographic seizures in preterm and full-term neonates: clinical correlates, associated brain lesions, and risk for neurological sequelae. Pediatrics 1993; 91: 128-34.
103. Carmo KB, Barr P. Drug treatment of neonatal seizures by neonatologists and pediatric neurologists. J Paediatr Child Health 2005; 41: 313-16.
104. Sankar R, Painter MJ. Neonatal seizures: after all these years we still love what doesn't work. Neurology 2005; 64: 776-7.
105. Lockman LA, Kriel R, Zaske D, et al. Phenobarbital dosage for control of neonatal seizures. Neurology 1979; 29: 1445-9.
106. Painter MJ, Pippenger C, MacDonald H, et al. Phenobarbital and diphenylhydantoin levels in neonates with seizures. J Pediatr 1978; 92: 315-19.
107. Painter MJ, Pippenger C, Wasterlain C, et al. Phenobarbital and phenytoin in neonatal seizures: metabolism and tissue distribution. Neurology 1981; 31: 1107-12.
108. Smith BT, Masotti RE. Intravenous diazepam in the treatment of prolonged seizure activity in neonates and infants. Dev Med Child Neurol 1971; 13: 630-4.
109. Malingre MM, Van Rooij LG, Rademaker CM, et al. Development of an optimal lidocaine infusion strategy for neonatal seizures. Eur J Pediatr 2006; 165: 598-604.
110. Gal P, Toback J, Boer HR, et al. Efficacy of phenobarbital monotherapy in treatment of neonatal seizures-relationship to blood levels. Neurology 1982; 32: 1401-4.
111. Hall RT, Hall FK, Daily DK. High-dose phenobarbital therapy in term newborn infants with severe perinatal asphyxia: a randomized, prospective study with three-year follow-up. J Pediatr 1998; 132: 345-8.
112. Painter MJ, Minnigh B, Mollica L, et al. Binding profiles of anticonvulsants in neonates with seizures. Ann Neurol 1987; 22: 413.
113. Montenegro MA, Guerreiro MM, Caldas JP, et al. Epileptic manifestations induced by midazolam in the neonatal period. Arq Neuropsiquiatr 2001; 59: 242-3.
114. Camfield PR, Camfield CS. Neonatal seizures: a commentary on selected aspects. J Child Neurol 1987; 2: 244-51.
115. Hellstrom-Westas L, Blennow G, Lindroth M, et al. Low risk of seizure recurrence after early withdrawal of antiepileptic treatment in the neonatal period. Arch Dis Child Fetal Neonatal Ed 1995; 72: F97-101.
116. Mizrahi EM. Acute and chronic effects of seizures in the developing brain: lessons from clinical experience. Epilepsia 1999; 40: S42-50, S64-6.
117. Sanchez RM, Jensen FE. Maturational aspects of epilepsy mechanisms and consequences for the immature brain. Epilepsia 2001; 42: 577-85.
118. Koh S, Jensen FE. Topiramate blocks perinatal hypoxia-induced seizures in rat pups. Ann Neurol 2001; 50: 366-72.
119. Jensen FE, Wang C. Hypoxia-induced hyperexcitability in vivo and in vitro in the immature hippocampus. Epilepsy Res 1996; 26: 131-40.
120. Aronica EM, Gorter JA, Paupard MC, et al. Status epilepticus-induced alterations in metabotropic glutamate receptor expression in young and adult rats. J Neurosci 1997; 17: 8588-95.
121. Lie AA, Becker A, Behle K, et al. Up-regulation of the metabotropic glutamate receptor mGluR4 in hippocampal neurons with reduced seizure vulnerability. Ann Neurol 2000; 47: 26-35.
122. Brooks-Kayal AR. Rearranging receptors. Epilepsia 2005; 46: 29-38.
123. Staley KJ. Wrong-way chloride transport: is it a treatable cause of some intractable seizures? Epilepsy Curr 2006; 6: 124-7.
124. Dzhala VI, Talos DM, Sdrulla DA, et al. NKCC1 transporter facilitates seizures in the developing brain. Nat Med 2005; 11: 1205-13.
125. Haglund MM, Hochman DW. Furosemide and mannitol suppression of epileptic activity in the human brain. J Neurophysiol 2005; 94: 907-18.
126. Scher MS. Neonatal seizures and brain damage. Pediatr Neurol 2003; 29: 381-90.
127. Scher MS. Neonatal seizure classification: a fetal perspective concerning childhood epilepsy. Epilepsy Res 2006; 70: S41-57.