Sildenafil therapy for pulmonary hypertension: Before and after pediatric congenital heart surgery

Texas Heart Institute Journal

Volumn 38, Issue 3, 2011, Pages 238-242

  Palma, Gaetano ^a   Giordano, Raffaele ^a   Russolillo, Veronica ^a   Cioffi, Sabato ^a   Palumbo, Sergio ^a   Mucerino, Marco ^a   Poli, Vincenzo ^a   Vosa, Carlo ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

3 ,5 cyclic GMP phosphodiesterases antagonists Inhibitors; Antihypertensive agents therapeutic use; Congenital surgery; Heart defects; Hemodynamics drug effects; Hypertension; Piperazines therapeutic use; Postoperative complications prevention Control; Pulmonary drug therapy prevention Control; Sildenafil; Treatment outcome; Vasodilator agents therapeutic use

Indexed keywords

ADRENALIN; CISATRACURIUM; DOPAMINE; MIDAZOLAM; REMIFENTANIL; SILDENAFIL;

AORTA CLAMPING; AORTA PRESSURE; ARTICLE; ARTIFICIAL VENTILATION; CARDIOPULMONARY BYPASS; CHILD; CLINICAL ARTICLE; CONGENITAL HEART MALFORMATION; DISEASE SEVERITY; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG SAFETY; FEMALE; HEART VENTRICLE CONTRACTILITY; HOSPITALIZATION; HUMAN; HYPERTENSIVE CRISIS; INFANT; INTENSIVE CARE UNIT; LENGTH OF STAY; LOW DRUG DOSE; LUNG ARTERY PRESSURE; LUNG BLOOD FLOW; LUNG VASCULAR RESISTANCE; MALE; MONOTHERAPY; MORTALITY; NASOGASTRIC TUBE; OXYGEN SATURATION; POSTOPERATIVE PERIOD; PREOPERATIVE TREATMENT; PRESCHOOL CHILD; PULMONARY HYPERTENSION; RETROSPECTIVE STUDY; SYSTEMIC CIRCULATION;

ADMINISTRATION, ORAL; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; CARDIAC SURGICAL PROCEDURES; CARDIOPULMONARY BYPASS; CHILD, PRESCHOOL; DRUG ADMINISTRATION SCHEDULE; FEMALE; HEART DEFECTS, CONGENITAL; HUMANS; HYPERTENSION, PULMONARY; INFANT; INTENSIVE CARE UNITS; ITALY; LENGTH OF STAY; MALE; PHOSPHODIESTERASE 5 INHIBITORS; PIPERAZINES; PURINES; RESPIRATION, ARTIFICIAL; RETROSPECTIVE STUDIES; SULFONES; TIME FACTORS; TREATMENT OUTCOME; VASODILATOR AGENTS;

EID: 79960002376     PISSN: 07302347     EISSN: 15266702     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Knoderer CA, Ebenroth ES, Brown JW. Chronic outpatient sildenafil therapy for pulmonary hypertension in a child after cardiac surgery. Pediatr Cardiol 2005;26(6):859-861.
2. Atz AM, Wessel DL. Sildenafil ameliorates effects of inhaled nitric oxide withdrawal. Anesthesiology 1999;91(1):307-310.
3. Michelakis ED, Tymchak W, Noga M, Webster L, Wu XC, Lien D, et al. Long-term treatment with oral sildenafil is safe and improves functional capacity and hemodynamics in patients with pulmonary arterial hypertension. Circulation 2003;108(17):2066-2069.
4. Bhatia S, Frantz RP, Severson CJ, Durst LA, McGoon MD. Immediate and long-term hemodynamic and clinical effects of sildenafil in patients with pulmonary arterial hypertension receiving vasodilator therapy. Mayo Clin Proc 2003;78(10): 1207-1213.
5. Stocker C, Penny DJ, Brizard CP, Cochrane AD, Soto R, Shekerdemian LS. Intravenous sildenafil and inhaled nitric oxide: a randomised trial in infants after cardiac surgery. Intensive Care Med 2003;29(11):1996-2003.
6. Schulze-Neick I, Hartenstein P, Li J, Stiller B, Nagdyman N, Hubler M, et al. Intravenous sildenafil is a potent pulmonary vasodilator in children with congenital heart disease. Circulation 2003;108 Suppl 1:II167-73.
7. Ghofrani HA, Olschewski H, Seeger W, Grimminger F. Sildenafil for treatment of severe pulmonary hypertension and commencing right-heart failure [in German]. Pneumologie 2002;56(11):665-672.
8. Kothari SS, Duggal B. Chronic oral sildenafil therapy in severe pulmonary artery hypertension. Indian Heart J 2002;54 (4):404-409.
9. Reffelmann T, Kloner RA. Therapeutic potential of phosphodiesterase 5 inhibition for cardiovascular disease. Circulation 2003;108(2):239-244.
10. Prasad S, Wilkinson J, Gatzoulis MA. Sildenafil in primary pulmonary hypertension. N Engl J Med 2000;343(18):1342.
11. Abrams D, Schulze-Neick I, Magee AG. Sildenafil as a selective pulmonary vasodilator in childhood primary pulmonary hypertension. Heart 2000;84(2):E4.
12. Zhao L, Mason NA, Morrell NW, Kojonazarov B, Sadykov A, Maripov A, et al. Sildenafil inhibits hypoxia-induced pulmonary hypertension. Circulation 2001;104(4):424-428.
13. Atz AM, Lefler AK, Fairbrother DL, Uber WE, Bradley SM. Sildenafil augments the effect of inhaled nitric oxide for postoperative pulmonary hypertensive crises. J Thorac Cardiovasc Surg 2002;124(3):628-629.
14. Trachte AL, Lobato EB, Urdaneta F, Hess PJ, Klodell CT, Martin TD, et al. Oral sildenaf il reduces pulmonary hypertension after cardiac surgery. Ann Thorac Surg 2005;79 (1):194-197.
15. Bentlin MR, Saito A, De Luca AK, Bossolan G, Bonatto RC, Martins AS, Rugolo LM. Sildenafil for pulmonary hypertension treatment after cardiac surgery [in Portuguese]. J Pediatr (Rio J) 2005;81(2):175-178.
16. Peiravian F, Amirghofran AA, Borzouee M, Ajami GH, Sabri MR, Kolaee S. Oral sildenafil to control pulmonary hypertension after congenital heart surgery. Asian Cardiovasc Thorac Ann 2007;15(2):113-117.
17. Chai PJ, Williamson JA, Lodge AJ, Daggett CW, Scarborough JE, Meliones JN, et al. Effects of ischemia on pulmonary dysfunction after cardiopulmonary bypass. Ann Thorac Surg 1999;67(3):731-735.
18. Lindberg L, Olsson AK, Jogi P, Jonmarker C. How common is severe pulmonary hypertension after pediatric cardiac surgery? J Thorac Cardiovasc Surg 2002;123(6):1155-1163.