Acute joint pathology and synovial inflammation is associated with increased intra-articular fracture severity in the mouse knee

Osteoarthritis and Cartilage

Volumn 19, Issue 7, 2011, Pages 864-873

  Lewis, J S ^a   Hembree, W C ^a   Furman, B D ^a   Tippets, L ^a   Cattel, D ^a   Huebner, J L ^a   Little, D ^a   DeFrate, L E ^a   Kraus, V B ^a   Guilak, F ^a   Olson, S A ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Cartilage; Inflammation; Intra articular fracture; Osteoarthritis; Synovium; Trauma

Indexed keywords

CARTILAGE OLIGOMERIC MATRIX PROTEIN; HYALURONIC ACID; INTERLEUKIN 10; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE; BONE DENSITY; CARTILAGE; CARTILAGE CELL; CARTILAGE DEGENERATION; CELL VIABILITY; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; INTRAARTICULAR FRACTURE; MORPHOLOGY; MOUSE; NONHUMAN; PATHOLOGY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SYNOVITIS; SYNOVIUM;

ANALYSIS OF VARIANCE; ANIMALS; BIOLOGICAL MARKERS; CHONDROCYTES; CYTOKINES; DISEASE MODELS, ANIMAL; INFLAMMATION; INTRA-ARTICULAR FRACTURES; KNEE JOINT; MALE; MICE; MICE, INBRED BALB C; SYNOVIAL MEMBRANE;

EID: 79960000454     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2011.04.011     Document Type: Article

References (56)

1. Swiontkowski M.F., Chapman J.R. Cost and effectiveness issues in care of injured patients. Clin Orthop Relat Res 1995, 318:17-24.
2. Brown T.D., Johnston R.C., Saltzman C.L., Marsh J.L., Buckwalter J.A. Post-traumatic osteoarthritis: a first estimate of incidence, prevalence, and burden of disease. J Orthop Trauma 2006, 20:739-744.
3. Swiontkowski M.F., Agel J., McAndrew M.P., Burgess A.R., MacKenzie E.J. Outcome validation of the AO/OTA fracture classification system. J Orthop Trauma 2000, 14:534-541.
4. Beardsley C.L., Anderson D.D., Marsh J.L., Brown T.D. Interfragmentary surface area as an index of comminution severity in cortical bone impact. J Orthop Res 2005, 23:686-690.
5. Lovasz G., Llinas A., Benya P.D., Park S.H., Sarmiento A., Luck J.V. Cartilage changes caused by a coronal surface stepoff in a rabbit model. Clin Orthop Relat Res 1998, 354:224-234.
6. Llinas A., McKellop H.A., Marshall G.J., Sharpe F., Kirchen M., Sarmiento A. Healing and remodeling of articular incongruities in a rabbit fracture model. J Bone Joint Surg Am 1993, 75:1508-1523.
7. Lefkoe T.P., Walsh W.R., Anastasatos J., Ehrlich M.G., Barrach H.J. Remodeling of articular step-offs. Clin Orthop Relat Res 1995, 314:253-265.
8. Delamarter R.B., Hohl M., Hopp E. Ligament injuries associated with tibial plateau fractures. Clin Orthop Relat Res 1990, 250:226-233.
9. Lansinger O., Bergman B., Korner L., Andersson G.B. Tibial condylar fractures. A twenty-year follow-up. J Bone Joint Surg Am 1986, 68:13-19.
10. Kamekura S., Hoshi K., Shimoaka T., Chung U., Chikuda H., Yamada T., et al. Osteoarthritis development in novel experimental mouse models induced by knee joint instability. Osteoarthritis Cartilage 2005, 13:632-641.
11. Torzilli P.A., Grigiene R., Borrelli J., Helfet D.L. Effect of impact load on articular cartilage: cell metabolism and viability, and matrix water content. J Biomech Eng 1999, 121:433-441.
12. Ewers B.J., Dvoracek-Driksna D., Orth M.W., Haut R.C. The extent of matrix damage and chondrocyte death in mechanically traumatized articular cartilage explants depends on rate of loading. J Orthop Res 2001, 19:779-784.
13. Donohue J.M., Buss D., Oegema T.R., Thompson R.C. The effects of indirect blunt trauma on adult canine articular cartilage. J Bone Joint Surg Am 1983, 65:948-957.
14. Thompson R.C., Oegema T.R., Lewis J.L., Wallace L. Osteoarthrotic changes after acute transarticular load. An animal model. J Bone Joint Surg Am 1991, 73:990-1001.
15. Borrelli J., Zhu Y., Burns M., Sandell L., Silva M.J. Cartilage tolerates single impact loads of as much as half the joint fracture threshold. Clin Orthop Relat Res 2004, 426:266-273.
16. Loening A.M., James I.E., Levenston M.E., Badger A.M., Frank E.H., Kurz B., et al. Injurious mechanical compression of bovine articular cartilage induces chondrocyte apoptosis. Arch Biochem Biophys 2000, 381:205-212.
17. Blanco F.J., Guitian R., Vazquez-Martul E., de Toro F.J., Galdo F. Osteoarthritis chondrocytes die by apoptosis. A possible pathway for osteoarthritis pathology. Arthritis Rheum 1998, 41:284-289.
18. D'Lima D., Hashimoto S., Chen P., Colwell C.J., Lotz M. Impact of mechanical trauma on matrix and cells. Clin Orthop Relat Res 2001, 391(supplement):S90-S99.
19. Fernandes J., Martel-Pelletier J., Pelletier J. The role of cytokines in osteoarthritis pathophysiology. Biorheology 2002, 39:237.
20. Goldring M.B. Osteoarthritis and cartilage: the role of cytokines. Curr Rheumatol Rep 2000, 2:459-465.
21. Benito M.J., Veale D.J., FitzGerald O., van den Berg W.B., Bresnihan B. Synovial tissue inflammation in early and late osteoarthritis. Ann Rheum Dis 2005, 64:1263-1267.
22. Smeets T.J., Kraan M.C., van Loon M.E., Tak P.P. Tumor necrosis factor alpha blockade reduces the synovial cell infiltrate early after initiation of treatment, but apparently not by induction of apoptosis in synovial tissue. Arthritis Rheum 2003, 48:2155-2162.
23. Furman B.D., Strand J., Hembree W.C., Ward B.D., Guilak F., Olson S.A. Joint degeneration following closed intraarticular fracture in the mouse knee: a model of posttraumatic arthritis. J Orthop Res 2007, 25:578-592.
24. Beamer W.G., Donahue L.R., Rosen C.J., Baylink D.J. Genetic variability in adult bone density among inbred strains of mice. Bone 1996, 18:397-403.
25. Sheng M.H.-C., Baylink D.J., Beamer W.G., Donahue L.R., Rosen C.J., Lau K.-H.W., et al. Histomorphometric studies show that bone formation and bone mineral apposition rates are greater in C3H/HeJ (high-density) than C57BL/6J (low-density) mice during growth. Bone 1999, 25:421-429.
26. Lazarus B., Messina A., Barker J.E., Hurley J.V., Romeo R., Morrison W.A., et al. The role of mast cells in ischaemia-reperfusion injury in murine skeletal muscle. J Pathol 2000, 191:443-448.
27. Lewis J.L., Deloria L.B., Oyen-Tiesma M., Thompson J., Roby C., Ericson M., et al. Cell death after cartilage impact occurs around matrix cracks. J Orthop Res 2003, 21:881-887.
28. Caputo A.M., Lee J.Y., Spritzer C.E., Easley M.E., DeOrio J.K., Nunley J.A., et al. In vivo kinematics of the tibiotalar joint after lateral ankle instability. Am J Sports Med 2009, 37:2241-2248.
29. Krenn V., Morawietz L., Burmester G.R., Kinne R.W., Mueller-Ladner U., Muller B., et al. Synovitis score: discrimination between chronic low-grade and high-grade synovitis. Histopathology 2006, 49:358-364.
30. Carlson C.S., Guilak F., Vail T.P., Gardin J.F., Kraus V.B. Synovial fluid biomarker levels predict articular cartilage damage following complete medial meniscectomy in the canine knee. J Orthop Res 2002, 20:92-100.
31. Mankin H., Dorfman H., Lippiello L., Zarins A. Biochemical and metabolic abnormalities in articular cartilage from osteoarthritic human hips. II. Correlation of morphology with biochemical and metabolic data. J Bone Joint Surg Am 1971, 53:523-537.
32. Bulstra S., Buurman W.A., Walenkamp G.H., van der Linden A.J. Metabolic characteristics of in vitro cultured human chondrocytes in relation to the histopathologic grade of osteoarthritis. Clin Orthop Relat Res 1989, 242:294-302.
33. Lee J.H., Fitzgerald J.B., DiMicco M.A., Cheng D.M., Flannery C.R., Sandy J.D., et al. Co-culture of mechanically injured cartilage with joint capsule tissue alters chondrocyte expression patterns and increases ADAMTS5 production. Arch Biochem Biophys 2009, 489:118-126.
34. Goldring M.B. Update on the biology of the chondrocyte and new approaches to treating cartilage diseases. Concepts of pathogenesis and emerging treatments for rheumatic diseases. Best Pract Res Clin Rheumatol 2006, 20:1003-1025.
35. Krasnokutsky S., Samuels J., Abramson S.B. Osteoarthritis in 2007. Bull NYU Hosp Jt Dis 2007, 65:222-228.
36. Attur M., Samuels J., Krasnokutsky S., Abramson S.B. Targeting the synovial tissue for treating osteoarthritis (OA): where is the evidence?. Best Pract Res Clin Rheumatol 2010, 24:71-79.
37. Anderson D.D., Mosqueda T., Thomas T., Hermanson E.L., Brown T.D., Marsh J.L. Quantifying tibial plafond fracture severity: absorbed energy and fragment displacement agree with clinical rank ordering. J Orthop Res 2008, 26:1046-1052.
38. Furman B.D., Olson S.A., Guilak F. The development of posttraumatic arthritis after articular fracture. J Orthop Trauma 2006, 20:719-725.
39. Green M.J., Deodhar A.A. Bone changes in early rheumatoid arthritis. Best Pract Res Clin Rheumatol 2001, 15:105-123.
40. Shimizu S., Shiozawa S., Shiozawa K., Imura S., Fujita T. Quantitative histologic studies on the pathogenesis of periarticular osteoporosis in rheumatoid arthritis. Arthritis Rheum 1985, 28:25-31.
41. Rantakokko J., Uusitalo H., Jamsa T., Tuukkanen J., Aro H.T., Vuorio E. Expression profiles of mRNAs for osteoblast and osteoclast proteins as indicators of bone loss in mouse immobilization osteopenia model. J Bone Miner Res 1999, 14:1934-1942.
42. Hembree W.C., Ward B.D., Furman B.D., Zura R.D., Nichols L.A., Guilak F., et al. Viability and apoptosis of human chondrocytes in osteochondral fragments following joint trauma. J Bone Joint Surg Br 2007, 89:1388-1395.
43. Kim H.T., Lo M.Y., Pillarisetty R. Chondrocyte apoptosis following intraarticular fracture in humans. Osteoarthritis Cartilage 2002, 10:747-749.
44. Murray M.M., Zurakowski D., Vrahas M.S. The death of articular chondrocytes after intra-articular fracture in humans. J Trauma 2004, 56:128-131.
45. Tew S.R., Kwan A.P., Hann A., Thomson B.M., Archer C.W. The reactions of articular cartilage to experimental wounding: role of apoptosis. Arthritis Rheum 2000, 43:215-225.
46. D'Lima D.D., Hashimoto S., Chen P.C., Colwell J.C.W., Lotz M.K. Human chondrocyte apoptosis in response to mechanical injury. Osteoarthritis Cartilage 2001, 9:712-719.
47. Saxne T., Heinegard D. Synovial fluid analysis of two groups of proteoglycan epitopes distinguishes early and late cartilage lesions. Arthritis Rheum 1992, 35:385-390.
48. Hazell P.K., Dent C., Fairclough J.A., Bayliss M.T., Hardingham T.E. Changes in glycosaminoglycan epitope levels in knee joint fluid following injury. Arthritis Rheum 1995, 38:953-959.
49. Lindhorst E., Vail T.P., Guilak F., Wang H., Setton L.A., Vilim V., et al. Longitudinal characterization of synovial fluid biomarkers in the canine meniscectomy model of osteoarthritis. J Orthop Res 2000, 18:269-280.
50. Sharif M., George E., Shepstone L., Knudson W., Thonar E.J., Cushnaghan J., et al. Serum hyaluronic acid level as a predictor of disease progression in osteoarthritis of the knee. Arthritis Rheum 1995, 38:760-767.
51. Mazieres B., Garnero P., Gueguen A., Abbal M., Berdah L., Lequesne M., et al. Molecular markers of cartilage breakdown and synovitis at baseline as predictors of structural progression of hip osteoarthritis. The ECHODIAH cohort. Ann Rheum Dis 2006, 65:354-359.
52. Otterness I.G., Swindell A.C., Zimmerer R.O., Poole A.R., Ionescu M., Weiner E. An analysis of 14 molecular markers for monitoring osteoarthritis: segregation of the markers into clusters and distinguishing osteoarthritis at baseline. Osteoarthritis Cartilage 2000, 8:180-185.
53. Garnero P., Piperno M., Gineyts E., Christgau S., Delmas P.D., Vignon E. Cross sectional evaluation of biochemical markers of bone, cartilage, and synovial tissue metabolism in patients with knee osteoarthritis: relations with disease activity and joint damage. Ann Rheum Dis 2001, 60:619-626.
54. Pavelka K., Forejtová S., Olejárová M., Gatterová J., Senolt L., Spaek P., et al. Hyaluronic acid levels may have predictive value for the progression of knee osteoarthritis. Osteoarthritis Cartilage 2004, 12:277.
55. Bruyere O., Collette J., Kothari M., Zaim S., White D., Genant H., et al. Osteoarthritis, magnetic resonance imaging, and biochemical markers: a one year prospective study. Ann Rheum Dis 2006, 65:1050-1054.
56. Jung Y.O., Do J.H., Kang H.J., Yoo S.A., Yoon C.H., Kim H.A., et al. Correlation of sonographic severity with biochemical markers of synovium and cartilage in knee osteoarthritis patients. Clin Exp Rheumatol 2006, 24:253-259.