An ex vivo platform to simulate cardiac physiology: A new dimension for therapy development and assessment

International Journal of Artificial Organs

Volumn 34, Issue 6, 2011, Pages 495-505

  de Hart, Jurgen ^a   Weger, Arend ^b   van Tuijl, Sjoerd ^a   Stijnen, Johannes M A ^a   van den Broek, Chantal N ^a,c   Rutten, Marcel C M ^c   de Mol, Bas A ^c,d  

^a Hemolab Cardiovascular Engineering   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c EINDHOVEN UNIVERSITY OF TECHNOLOGY   (Netherlands)

^d ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Blood pumps; Cardiac hemodynamics; Cardiac implants; Electrophysiology; Ex vivo model; Isolated beating heart

Indexed keywords

ELECTROPHYSIOLOGY; HEMODYNAMICS; PHYSIOLOGICAL MODELS;

BEATING HEART; BLOOD PUMP; CARDIAC HEMODYNAMIC; CARDIAC IMPLANT; EX VIVO MODEL; EX-VIVO; HAEMODYNAMICS; ISOLATED BEATING HEART; PERFORMANCE; VIVO MODELS;

HEART;

ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE; CORONARY ARTERY BLOOD FLOW; DEVICE; EX VIVO STUDY; FEMALE; HEART HEMODYNAMICS; HEART OUTPUT; HEART PERFORMANCE; HEART PERFUSION; HEART TRANSPLANTATION; NONHUMAN; SWINE;

EID: 79959983862     PISSN: 03913988     EISSN: None     Source Type: Journal    
DOI: 10.5301/IJAO.2011.8456     Document Type: Article

References (24)

1. Langendorff O. Untersuchungen am Überlebenden Säugethierherzen. Pflügers Arch: European Journal of Physiology. 1895;61(6):291-332. doi:10.1007/BF01812150
2. van Rijk-Zwikker GL, Schipperheyn JJ, Huysmans HA, Bruschke AV. Influence of mitral valve prosthesis or rigid mitral ring on left ventricular pump function. A study on exposed and isolated blood-perfused porcine hearts. Circulation. 1989;80(3 Pt 1):I1-I7.
3. van Rijk-Zwikker GL, Mast F, Schipperheyn JJ, Huysmans HA, Bruschke AV. Comparison of rigid and flexible rings for annuloplasty of the porcine mitral valve. Circulation. 1990;82(5)(Suppl):IV58-IV64.
4. Rosenstrauch D, Akay HM, Bolukoglu H, et al. Ex vivo resuscitation of adult pig hearts. Tex Heart Inst J. 2003;30(2):121-127.
5. Araki Y, Usui A, Kawaguchi O, et al. Pressure-volume relationship in isolated working heart with crystalloid perfusate in swine and imaging the valve motion. Eur J Cardiothorac Surg. 2005;28(3):435-442. Medline. doi:10.1016/j. ejcts.2005.06.015
6. Saito S, Araki Y, Usui A, et al. Mitral valve motion assessed by high-speed video camera in isolated swine heart. Eur J Cardiothorac Surg. 2006;30(4):584-591. Medline. doi:10.1016/j.ejcts.2006.07.021
7. Chinchoy E, Soule CL, Houlton AJ, et al. Isolated fourchamber working swine heart model. Ann Thorac Surg. 2000;70(5):1607-1614. Medline. doi:10.1016/S0003-4975(00)01977-9
8. Laske TG, Skadsberg ND, Iaizzo PA. A novel ex vivo heart model for the assessment of cardiac pacing systems.J Biomech Eng. 2005;127(6):894-898. Medline. doi:10.1115/1.2049312
9. Sigg DC, Iaizzo PA. In vivo versus in vitro comparison of swine cardiac performance: induction of cardiodepression with halothane. Eur J Pharmacol. 2006;543(1-3):97-107.Medline. doi:10.1016/j.ejphar.2006.06.011
10. Görge G, Erbel R, Dobbertin A, Hanggi M, Hake U, Meyer J. Isolated in-vitro perfusion of pig hearts obtained from the abattoir: an alternative to animal experiments? Eur Heart J. 1994;15(6):851-857.
11. Modersohn D, Eddicks S, Grosse-Siestrup C, Ast I, Holinski S, Konertz W. Isolated hemoperfused heart model of slaughterhouse pigs. Int J Artif Organs. 2001;24(4):215-221
12. Westerhof N, Elzinga G, Sipkema P. An artificial arterial sys tem for pumping hearts. J Appl Physiol. 1971;31(5):776-781.
13. Stergiopulos N, Westerhof BE, Westerhof N. Total arterial inertance as the fourth element of the windkessel model. Am J Physiol. 1999;276(1 Pt 2):H81-H88.
14. Westerhof N, Lankhaar JW, Westerhof BE. The arterial Windkessel. Med Biol Eng Comput. 2009;47(2):131-141. Medline. doi:10.1007/s11517-008-0359-2
15. Suga H, Sagawa K. End-diastolic and end-systolic ventricular volume clamper for isolated canine heart. Am J Physiol. 1977;233(6):H718-H722.
16. Sunagawa K, Burkhoff D, Lim KO, Sagawa K. Impedance loading servo pump system for excised canine ventricle. Am J Physiol. 1982;243:H346-H350.
17. de Weger A, de Hart J, Stijnen M, van Tuijl S, Dion RA. Ex vivo 2 chamber working pig heart-lung model. Interactive CardioVascular and Thoracic Surgery 2007;6:223-280. doi: 10.1510/icvts.2007.0000s7
18. Geven MC, Bohte VN, Aarnoudse WH, et al. A physiologically representative in vitro model of the coronary circulation. Physiol Meas. 2004;25:891-904. Medline. doi:10.1088/0967-3334/25/4/009
19. http://www.visibleheart.com
20. de Weger A, van Tuijl S, Stijnen M, Steendijk P, de Hart J. Images in cardiovascular medicine. Direct endoscopic visual assessment of a transcatheter aortic valve implantation and performance in the Physioheart, an isolated working heart platform. Circulation. 2010;121(13):e261-e262. Medline. doi:10.1161/CIR.0b013e3181d9b879
21. Guyton AC, Hall JE. Textbook of Medical Physiology, 10th ed. New York, NY: Lange Medical Books/McGraw-Hill; 2006.
22. Meyns B, Stolinski J, Leunens V, Verbeken E, Flameng W. Left ventricular support by catheter-mounted axial flow pump reduces infarct size. J Am Coll Cardiol. 2003;41(7):1087-1095. Medline. doi:10.1016/S0735-1097(03)00084-6
23. De Hart J, Peters GWM, Schreurs PJG, Baaijens FPT. A computational fluid-structure interaction analysis of a fiber-reinforced stentless aortic valve. J Biomech. 2003;36(5):699-712. Medline. doi:10.1016/S0021-9290(02)00448-7
24. Henze E, Schoser K, Lietzenmayer R, et al. Studies of myocardial metabolism using P-31-NMR spectroscopy and a simple heart perfusion model of slaughtered animals - an approach to avoiding in vivo animal experiments. Z Kardiol 1989;78(9): 553-560.