Are gait initiation parameters early markers of Huntington's disease in pre-manifest mutation carriers?

Gait and Posture

Volumn 34, Issue 2, 2011, Pages 202-207

  Delval, Arnaud ^a,b   Bleuse, Séverine ^a,b   Simonin, Clémence ^a,c,d   Delliaux, Marie ^a   Rolland, Benjamin ^a   Destee, Alain ^a,d   Defebvre, Luc ^a,b   Krystkowiak, Pierre ^b,c   Dujardin, Kathy ^a,b  

^a LILLE UNIVERSITY HOSPITAL   (France)

^b UNIV LILLE   (France)

^c AMIENS UNIVERSITY HOSPITAL   (France)

^d JEAN PIERRE AUBERT RESEARCH CENTER   (France)

Author keywords

Gait; Gait initiation; Huntington's disease; Pre manifest

Indexed keywords

ADULT; ARTICLE; BODY POSTURE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GAIT; GAIT DISORDER; GAIT INITIATION; GENE MUTATION; HETEROZYGOTE; HUMAN; HUNTINGTON CHOREA; KINEMATICS; MALE; MOTOR CONTROL; PRIORITY JOURNAL; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY; WALKING SPEED;

ADULT; BIOMECHANICS; CASE-CONTROL STUDIES; CUES; FEMALE; GAIT; HETEROZYGOTE; HUMANS; HUNTINGTON DISEASE; MALE; MIDDLE AGED; PSYCHOMOTOR PERFORMANCE; ROC CURVE; SENSITIVITY AND SPECIFICITY; WALKING;

EID: 79959959905     PISSN: 09666362     EISSN: 18792219     Source Type: Journal    
DOI: 10.1016/j.gaitpost.2011.04.011     Document Type: Article

References (29)

1. Rao A.K., Muratori L., Louis E.D., Moskowitz C.B., Marder K.S. Spectrum of gait impairments in presymptomatic and symptomatic Huntington's disease. Mov Disord 2008, 23:1100-1107.
2. Delval A., Krystkowiak P., Blatt J., Delliaux M., Destée A., Derambure P., et al. Evolution of locomotion disorders in Huntington's disease. Neurophysiol Clin 2008, 38:117-125.
3. Delval A., Krystkowiak P., Blatt J., Labyt E., Bourriez J., Dujardin K., et al. A biomechanical study of gait initiation in Huntington's disease. Gait Posture 2007, 25:279-288.
4. Bouisset S., Zattara M. Biomechanical study of the programming of anticipatory postural adjustments associated with voluntary movement. J Biomech 1987, 20:735-742.
5. Brenière Y., Do M.C. Control of gait initiation. J Mot Behav 1991, 23:235-240.
6. MacKinnon C.D., Bissig D., Chiusano J., Miller E., Rudnick L., Jager C., et al. Preparation of anticipatory postural adjustments prior to stepping. J Neurophysiol 2007, 97:4368-4379.
7. Dibble L.E., Nicholson D.E., Shultz B., MacWilliams B.A., Marcus R.L., Moncur C. Sensory cueing effects on maximal speed gait initiation in persons with Parkinson's disease and healthy elders. Gait Posture 2004, 19:215-225.
8. Cunnington R., Windischberger C., Deecke L., Moser E. The preparation and execution of self-initiated and externally-triggered movement: a study of event-related fMRI. Neuroimage 2002, 15:373-385.
9. Jahanshahi M., Jenkins I.H., Brown R.G., Marsden C.D., Passingham R.E., Brooks D.J. Self-initiated versus externally triggered movements I. An investigation using measurement of regional cerebral blood flow with PET and movement-related potentials in normal and Parkinson's disease subjects. Brain 1995, 118:913-933.
10. Aylward E.H., Sparks B.F., Field K.M., Yallapragada V., Shpritz B.D., Rosenblatt A., et al. Onset and rate of striatal atrophy in preclinical Huntington disease. Neurology 2004, 63:66-72.
11. Paulsen J.S., Langbehn D.R., Stout J.C., Aylward E., Ross C.A., Nance M., et al. Detection of Huntington's disease decades before diagnosis: the Predict-HD study. J Neurol Neurosurg Psychiatr 2008, 79:874-880.
12. Unified Huntington's Disease Rating Scale: reliability and consistency. Huntington Study Group. Mov Disord 1996;11:136-142.
13. Hogarth P., Kayson E., Kieburtz K., Marder K., Oakes D., Rosas D., et al. Interrater agreement in the assessment of motor manifestations of Huntington's disease. Mov Disord 2005, 20:293-297.
14. Shoulson I., Fahn S. Huntington disease: clinical care and evaluation. Neurology 1979, 29:1-3.
15. Mattis S. Mental status examination for organic mental syndrome in the elderly patient. Geriatric psychiatry: a handbook for psychiatrists and primary care physicians 1976, 71-121. Grune and Stratton, New York. L. Bellak, B. Karasu (Eds.).
16. Montgomery S.A., Asberg M. A new depression scale designed to be sensitive to change. Br J Psychiatry 1979, 134:382-389.
17. Jacobs J.V., Nutt J.G., Carlson-Kuhta P., Stephens M., Horak F.B. Knee trembling during freezing of gait represents multiple anticipatory postural adjustments. Exp Neurol 2009, 215:334-341.
18. Nachev P., Wydell H., O'neill K., Husain M., Kennard C. The role of the pre-supplementary motor area in the control of action. Neuroimage 2007, 36(Suppl 2):T155-T163.
19. Forstmann B.U., Dutilh G., Brown S., Neumann J., von Cramon D.Y., Ridderinkhof K.R., et al. Striatum and pre-SMA facilitate decision-making under time pressure. Proc Natl Acad Sci U S A 2008, 105:17538-17542.
20. Duyao M., Ambrose C., Myers R., Novelletto A., Persichetti F., Frontali M., et al. Trinucleotide repeat length instability and age of onset in Huntington's disease. Nat Genet 1993, 4:387-392.
21. Klöppel S., Chu C., Tan G.C., Draganski B., Johnson H., Paulsen J.S., et al. Automatic detection of preclinical neurodegeneration: presymptomatic Huntington disease. Neurology 2009, 72:426-431.
22. Kirkwood S.C., Siemers E., Hodes M.E., Conneally P.M., Christian J.C., Foroud T. Subtle changes among presymptomatic carriers of the Huntington's disease gene. J Neurol Neurosurg Psychiatr 2000, 69:773-779.
23. Berrios G.E., Wagle A.C., Marková I.S., Wagle S.A., Ho L.W., Rubinsztein D.C., et al. Psychiatric symptoms and CAG repeats in neurologically asymptomatic Huntington's disease gene carriers. Psychiatry Res 2001, 102:217-225.
24. Reilmann R., Bohlen S., Klopstock T., Bender A., Weindl A., Saemann P., et al. Tongue force analysis assesses motor phenotype in premanifest and symptomatic Huntington's disease. Mov Disord 2010, 25:2195-2202.
25. Reilmann R., Bohlen S., Klopstock T., Bender A., Weindl A., Saemann P., et al. Grasping premanifest Huntington's disease - shaping new endpoints for new trials. Mov Disord 2010, 25:2858-2862.
26. Koller W.C., Trimble J. The gait abnormality of Huntington's disease. Neurology 1985, 35:1450-1454.
27. Delval A., Krystkowiak P., Blatt J., Labyt E., Dujardin K., Destée A., et al. Role of hypokinesia and bradykinesia in gait disturbances in Huntington's disease: a biomechanical study. J Neurol 2006, 253:73-80.
28. Hausdorff J.M., Cudkowicz M.E., Firtion R., Wei J.Y., Goldberger A.L. Gait variability and basal ganglia disorders: stride-to-stride variations of gait cycle timing in Parkinson's disease and Huntington's disease. Mov Disord 1998, 13:428-437.
29. Brach J.S., Perera S., Studenski S., Katz M., Hall C., Verghese J. Meaningful change in measures of gait variability in older adults. Gait Posture 2010, 31:175-179.