Maternal cytokine profiles during pregnancy - Predictors for later allergy or just reading the tea leaves?

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 66, Issue 8, 2011, Pages 987-988

  Pfefferle, P ^a   Bocking C ^a   Renz, H ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 8;

ALLERGY; ATOPIC DERMATITIS; CHILDHOOD DISEASE; EDITORIAL; HUMAN; IMMUNE RESPONSE; MATERNAL STRESS; PREECLAMPSIA; PREGNANCY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; TEA; TH1 CELL; TH1 TH2 BALANCE; TH2 CELL;

CYTOKINES; FEMALE; FETAL DISEASES; HUMANS; HYPERSENSITIVITY; IMMUNE SYSTEM; INFANT, NEWBORN; MOTHERS; PREDICTIVE VALUE OF TESTS; PREGNANCY;

EID: 79959950532     PISSN: 01054538     EISSN: 13989995     Source Type: Journal    
DOI: 10.1111/j.1398-9995.2011.02665.x     Document Type: Editorial

References (15)

1. Ege MJ, Bieli C, Frei R, van Strien RT, Riedler J, Ublagger E, et al., Prenatal farm exposure is related to the expression of receptors of the innate immunity and to atopic sensitization in school-age children. J Allergy Clin Immunol 2006; 117: 817-823.
2. Breckler LA, Hale J, Jung W, Westcott L, Dunstan JA, Thornton CA, et al., Modulation of in vivo and in vitro cytokine production over the course of pregnancy in allergic and non-allergic mothers. Pediatr Allergy Immunol 2010; 21: 14-21.
3. Kim JH, Kim K, Woo HY, Shim JY,. Maternal cytokine production during pregnancy and the development of childhood wheezing and allergic disease in offspring three years of age. J Asthma 2008; 45: 948-952.
4. Larsson A, Nilsson C, Höglind A, Sverremark-Ekström E, Lilja G, Troye-Blomberg M,. Relationship between maternal and child cytokine responses to allergen and phytohaemagglutinin 2 years after delivery. Clin Exp Immunol 2006; 144: 401-408. (Pubitemid 43799922)
5. Neaville WA, Tisler C, Bhattacharya A, Anklam K, Gilbertson-White S, Hamilton R, et al., Developmental cytokine response profiles and the clinical and immunologic expression of atopy during the first year of life. J Allergy Clin Immunol 2003; 112: 740-746. (Pubitemid 37260391)
6. Wegmann TG, Lin H, Guilbert L, Mosmann TR,. Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon. Immunol Today 1993; 14: 353-356. (Pubitemid 23198169)
7. Prokesová L, Lodinová-Zádníková R, Zizka J, Kocourková I, Novotná O, Petrásková P, et al., Cytokine levels in healthy and allergic mothers and their children during the first year of life. Pediatr Allergy Immunol 2006; 17: 175-183.
8. Aris A, Lambert F, Bessette P, Moutquin J,. Maternal circulating interferon-gamma and interleukin-6 as biomarkers of Th1/Th2 immune status throughout pregnancy. J Obstet Gynaecol Res 2008; 34: 7-11. (Pubitemid 351143710)
9. Dealtry GB, O'Farrell MK, Fernandez N,. The Th2 cytokine environment of the placenta. Int Arch Allergy Immunol 2000; 123: 107-119.
10. Wood RA, Bloomberg GR, Kattan M, Conroy K, Sandel MT, Dresen A, et al., Relationships among environmental exposures, cord blood cytokine responses, allergy, and wheeze at 1 year of age in an inner-city birth cohort (Urban Environment and Childhood Asthma study). J Allergy Clin Immunol 2011; 127: 913-919.
11. Sullivan Dillie KT, Tisler CJ, Dasilva DF, Pappas TE, Roberg KA, Carlson-Dakes KT, et al., The influence of processing factors and non-atopy-related maternal and neonate characteristics on yield and cytokine responses of cord blood mononuclear cells. Clin Exp Allergy 2008; 38: 298-304.
12. Pfefferle PI, Büchele G, Blümer N, Roponen M, Ege MJ, Krauss-Etschmann S, et al., Cord blood cytokines are modulated by maternal farming activities and consumption of farm dairy products during pregnancy: the PASTURE Study. J Allergy Clin Immunol 2010; 125: 108-15.
13. Herberth G, Hinz D, Röder S, Schlink U, Sack U, Diez U, et al., Maternal immune status in pregnancy is related to offspring's immune responses and atopy risk. Allergy 2011; doi:. [Epub ahead of print].
14. Halonen M, Lohman IC, Stern DA, Spangenberg A, Anderson D, Mobley S, et al., Th1/Th2 patterns and balance in cytokine production in the parents and infants of a large birth cohort. J Immunol 2009; 182: 3285-3293.
15. Bussmann C, Weidinger S, Novak N,. Genetics of atopic dermatitis. J Dtsch Dermatol Ges 2011; doi:. [Epub ahead of print].