Preoperative chemoradiation may not always be needed for patients with T3 and T2N+ rectal cancer

Cancer

Volumn 117, Issue 14, 2011, Pages 3118-3125

  Frasson, Matteo ^a,b   Garcia Granero, Eduardo ^a   Roda, Desamparados ^a   Flor Lorente, Blas ^a   Rosellõ, Susana ^a   Esclapez, Pedro ^a   Faus, Carmen ^a   Navarro, Samuel ^a   Campos, Salvador ^a   Cervantes, Andrés ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

^b NONE   (Spain)

Author keywords

circumferential resection margin; localized rectal cancer; neoadjuvant therapy; staging; TME

Indexed keywords

FLUOROURACIL; FOLINIC ACID; OXALIPLATIN;

ADULT; AGED; ARTICLE; CANCER LOCALIZATION; CANCER RECURRENCE; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; CHEMORADIOTHERAPY; CONTROLLED STUDY; DISEASE FREE SURVIVAL; ENDOSCOPIC ECHOGRAPHY; FEMALE; FOLLOW UP; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; OUTCOME ASSESSMENT; POSTOPERATIVE PERIOD; PREOPERATIVE PERIOD; PRIORITY JOURNAL; RECTUM CANCER; SURGICAL TECHNIQUE; TOTAL MESORECTAL EXCISION;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; COMBINED MODALITY THERAPY; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOADJUVANT THERAPY; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; RECTAL NEOPLASMS; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 79959950514     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.25866     Document Type: Article

References (31)

1. Kapiteijn E, Marijnen CA, Nagtegaal ID, et al. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med. 2001; 345: 638-646.
2. Sebag-Montefiore D, Stephens RJ, Steele R, et al. Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial. Lancet. 2009; 373: 811-820.
3. Sauer R, Becker H, Hohenberger W, et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med. 2004; 351: 1731-1740.
4. NIH Consensus Conference. Adjuvant therapy for patients with colon and rectal cancer. JAMA. 1990; 264: 1444-1450.
5. Heald RJ, Moran BJ, Ryall RD, et al. Rectal cancer: the Basingstoke experience of total mesorectal excision, 1978-1997. Arch Surg. 1998; 133: 894-899. (Pubitemid 28374285)
6. Garcia-Aguilar J, Pollack J, Lee SH, et al. Accuracy of endorectal ultrasonography in preoperative staging of rectal tumors. Dis Colon Rectum. 2002; 45: 10-15. (Pubitemid 34072746)
7. Brown G, Radcliffe AG, Newcombe RG, et al. Preoperative assessment of prognostic factors in rectal cancer using high-resolution magnetic resonance imaging. Br J Surg. 2003; 90: 355-364. (Pubitemid 36324117)
8. MERCURY Study Group. Diagnostic accuracy of preoperative magnetic resonance imaging in predicting curative resection of rectal cancer: prospective observational study. BMJ. 2006; 333: 779. Accessed August 20, 2010.
9. Burton S, Brown G, Daniels IR, et al. MRI directed multidisciplinary team preoperative treatment strategy: the way to eliminate positive circumferential margins? Br J Cancer. 2006; 94: 351-357. (Pubitemid 43237559)
10. Cervantes A, Rosello S, Rodriguez-Braun E, et al. Progress in the multidisciplinary treatment of gastrointestinal cancer and the impact on clinical practice: perioperative management of rectal cancer. Ann Oncol. 2008; 19 (suppl 7): 266-272.
11. Eriksen MT, Wibe A, Hestvik UE, et al. Surgical treatment of primary locally advanced rectal cancer in Norway. Eur J Surg Oncol. 2006; 32: 174-180. (Pubitemid 43257119)
12. Cervantes A, Rodriguez-Braun E, Navarro S, et al. Integrative decisions in rectal cancer. Ann Oncol. 2007; 18 (suppl 9): ix127-ix131.
13. Hildebrandt U, Feifel G,. Preoperative staging of rectal cancer by intrarectal ultrasound. Dis Colon Rectum. 1985; 28: 42-46. (Pubitemid 15199393)
14. Munoz E, Blanco F, Garcia-Granero E, et al. Accuracy of rectal ultrasound to assess circumferential margin involvement of anteriorly located rectal tumours [abstract]. Colorectal Dis. 2009; 11 (suppl 2): 18-25.
15. Brown G, Richards CJ, Newcombe RG, et al. Rectal carcinoma: thin-section MR imaging for staging in 28 patients. Radiology. 1999; 211: 215-222. (Pubitemid 29161754)
16. Garcia-Granero E, Marti-Obiol R, Gomez-Barbadillo J, et al. Impact of surgeon organization and specialization in rectal cancer outcome. Colorectal Dis. 2001; 3: 179-184. (Pubitemid 32782807)
17. Quirke P, Durdey P, Dixon MF, Williams NS,. Local recurrence of rectal adenocarcinoma due to inadequate surgical resection. Histopathological study of lateral tumour spread and surgical excision. Lancet. 1986; 2: 996-999. (Pubitemid 16005611)
18. Garcia-Granero E, Faiz O, Munoz E, et al. Macroscopic assessment of mesorectal excision in rectal cancer: a useful tool for improving quality control in a multidisciplinary team. Cancer. 2009; 115: 3400-3411.
19. Quirke P,. Limitation of existing system of staging for rectal cancer: the forgotten margin. In:, Soreide O, ed. Rectal Cancer Surgery. Optimisation-Standardisation-Documentation. New York: Springer; 1997: 63-81.
20. Nagtegaal ID, van de Velde CJ, van der Worp E, et al. Macroscopic evaluation of rectal cancer resection specimen: clinical significance of the pathologist in quality control. J Clin Oncol. 2002; 20: 1729-1734. (Pubitemid 34273260)
21. Bujko K, Nowacki MP, Nasierowska-Guttmejer A, et al. Long-term results of a randomized trial comparing preoperative short-course radiotherapy with preoperative conventionally fractionated chemoradiation for rectal cancer. Br J Surg. 2006; 93: 1215-1223. (Pubitemid 44547018)
22. Camma C, Giunta M, Fiorica F, et al. Preoperative radiotherapy for resectable rectal cancer: a meta-analysis. JAMA. 2000; 284: 1008-1015. (Pubitemid 30659131)
23. Colorectal Cancer Collaborative Group. Adjuvant radiotherapy for rectal cancer: a systematic overview of 8,507 patients from 22 randomised trials. Lancet. 2001; 358: 1291-1304.
24. Peeters KC, van de Velde CJ, Leer JW, et al. Late side effects of short-course preoperative radiotherapy combined with total mesorectal excision for rectal cancer: increased bowel dysfunction in irradiated patientsâa Dutch Colorectal Cancer Group study. J Clin Oncol. 2005; 23: 6199-6206.
25. Stephens RJ, Thompson LC, Quirke P, et al. Impact of short-course preoperative radiotherapy for rectal cancer on patients' quality of life: data from the Medical Research Council CR07/National Cancer Institute of Canada Clinical Trials Group C016 randomized clinical trial. J Clin Oncol. 2010; 28: 4233-4239.
26. Wibe A, Moller B, Norstein J, et al. A national strategic change in treatment policy for rectal cancerâimplementation of total mesorectal excision as routine treatment in Norway. A national audit. Dis Colon Rectum. 2002; 45: 857-866. (Pubitemid 34761463)
27. Beets-Tan RG, Beets GL,. Rectal cancer: review with emphasis on MR imaging. Radiology. 2004; 232: 335-346. (Pubitemid 38971269)
28. Esclapez P, Garcia-Granero E, Flor B, et al. Prognostic heterogeneity of endosonographic T3 rectal cancer. Dis Colon Rectum. 2009; 52: 685-691.
29. Nagtegaal ID, Quirke P,. What is the role for the circumferential margin in the modern treatment of rectal cancer? J Clin Oncol. 2008; 26: 303-312.
30. Bernstein TE, Endreseth BH, Romundstad P, Wibe A,. Circumferential resection margin as a prognostic factor in rectal cancer. Br J Surg. 2009; 96: 1348-1357.
31. Cecil TD, Sexton R, Moran BJ, Heald RJ,. Total mesorectal excision results in low local recurrence rates in lymph node-positive rectal cancer. Dis Colon Rectum. 2004; 47: 1145-1149; discussion 1149-1150. (Pubitemid 38857061)