Long-term control of epileptic drop attacks with the combination of valproate, lamotrigine, and a benzodiazepine: A 'proof of concept,' open label study

Epilepsia

Volumn 52, Issue 7, 2011, Pages 1303-1310

  MacHado, Vitor Hugo ^a   Palmini, Andre ^a,b   Bastos, Fernanda Almeida ^a   Rotert, Rosana ^a  

^a Neurology Service   (Brazil)

^b PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

AED; Benzodiazepines; Drop attacks; Lamotrigine; Severe epilepsies; Valproate

Indexed keywords

BENZODIAZEPINE; CLOBAZAM; CLONAZEPAM; LAMOTRIGINE; NITRAZEPAM; VALPROIC ACID;

ADOLESCENT; ADULT; ARTICLE; ATONIC SEIZURE; CAREGIVER; CHILD; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CLINICAL FEATURE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG EFFICACY; ELECTROENCEPHALOGRAPHY; FEMALE; HAIR LOSS; HUMAN; LONG TERM CARE; MALE; OPEN STUDY; PATIENT MONITORING; PRESCHOOL CHILD; PRIORITY JOURNAL; RASH; SCHOOL CHILD; SEDATION; SIDE EFFECT; STEVENS JOHNSON SYNDROME; TREMOR; WEIGHT GAIN;

ADOLESCENT; ADULT; ANTICONVULSANTS; BENZODIAZEPINES; CHILD; CHILD, PRESCHOOL; DRUG THERAPY, COMBINATION; ELECTROENCEPHALOGRAPHY; EPILEPSY; FEMALE; HUMANS; MALE; MIDDLE AGED; SYNCOPE; TRIAZINES; VALPROIC ACID; YOUNG ADULT;

EID: 79959948437     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2011.03075.x     Document Type: Article

References (29)

1. Arzimanoglou A, French J, Blume WT, Cross JH, Ernst JP, Feucht M, Genton P, Guerrini R, Kluger G, Pellock JM, Perucca E, Wheless J,. (2009) Lennox-Gastaut syndrome: a consensus approach on diagnosis, assessment, management, and trial methodology. Lancet Neurol 8: 82-93.
2. Beleza P,. (2009) Refractory epilepsy: a clinically oriented review. Eur Neurol 62: 65-71.
3. Bisulli F, Baruzzi A, Rosati A, Riva R, Avoni P, Cerullo A, Tinuper P,. (2001) Efficacy of lamotrigine add-on therapy in severe partial epilepsy in adults with drop seizures and secondary bilateral syncrony on EEG. Epileptic Disord 3: 151-156. (Pubitemid 32983191)
4. Blume WT,. (2006) The progression of epilepsy. Epilepsia 47 (Suppl 1): 71-78. (Pubitemid 44527139)
5. Brodie MJ,. (1996) Lamotrigine-an update. Can J Neurol Sci 23: 6-9.
6. Conry JA, Yu-Tze NG, Paolicchi JM, Kernitsky L, Mitchell WG, Ritter FJ, Collins SD, Tracy C, Kormany WN, Abdulnabi R, Riley B, Stolle J,. (2009) Clobazam in the treatment of Lennox-Gastaut syndrome. Epilepsia 50: 1158-1166.
7. Donaldson JA, Glauser TA, Olberding LS,. (1997) Lamotrigine adjunctive therapy in childhood epileptic encephalopathy (Lennox Gastaut Syndrome). Epilepsia 38: 68-73.
8. Engel J Jr, Wiebe S, French J, Williamson P, Spencer D, Gumnit R, Zahn C, Westbrook E, Enos B,; Quality Standards Subcommittee of the American Academy of Neurology; American Epilepsy Society; American Association of Neurological Surgeons. (2003) Practice parameter: temporal lobe and localized neocortical resections for epilepsy: report of the Quality Standards Subcommittee of the American Academy of Neurology, in association with the American Epilepsy Society and the American Association of Neurological Surgeons. Neurology 60: 538-547. (Pubitemid 36246066)
9. Ertam I, Sezgin AO, Unal I,. (2009) A case with Stevens-Johnson syndrome triggered by combination of clobazam, lamotrigine, and valproic acid treatment. Int J Dermatol 48: 98-99.
10. Faught E,. (1999) Lamotrigine for startle-induced seizures. Seizure 8: 361-363. (Pubitemid 29469328)
11. French JA, Kanner AM, Bautista J, Abou-Khalil B, Browne T, Harden CL, Theodore WH, Bazil C, Stern J, Schachter SC, Bergen D, Hirtz D, Montouris GD, Nespeca M, Gidal B, Marks WJ, Turk WR, Fischer JH, Bourgeois B, Wilner A, Faugth RE, Sachdeo RC, Beydoun A, Glauser TA,. (2004) Efficacy and tolerability of the new antiepileptic drugs II: treatment of refractory epilepsy. Report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Neurology 62: 1261-1273. (Pubitemid 38526036)
12. Gambardella A, Reutens DC, Andermann F, Cendes F, Gloor P, Dubeau F, Olivier A,. (1994) Late-onset drop attacks in temporal lobe epilepsy: a re-evaluation of the concept of temporal lobe syncope. Neurology 44: 1074-1078. (Pubitemid 24188180)
13. Glauser T, Kluger G, Sachdeo R, Krauss G, Perdomo C, Arroyo S,. (2008) Rufinamide for generalized seizures associated with Lennox-Gastaut syndrome. Neurology 70: 1950-1958.
14. Guerrini R, Genton P, Bureau M, Parmeggiani A, Salas-Puig X, Santucci M, Bonanni P, Ambrosetto G, Dravet C,. (1998) Multilobar polymicrogyria, intractable drop attack seizures, and sleep-related electrical status epilepticus. Neurology 51: 504-512. (Pubitemid 28406329)
15. Motte J, Trevathan E, Arvidsson JFV, Nieto Barrera M, Mullens EL, Manasco P,; The Lamictal Lennox-Gastaut study group. (1997) Lamotrigine for generalized seizures associated with the Lennox-Gastaut syndrome. N Engl J Med 337: 1807-1812. (Pubitemid 28006785)
16. Pellock JM,. (1999) Felbamate. Epilepsia 40 (Suppl 5): S57-S62. (Pubitemid 29484590)
17. Ritter FJ, Leppik IE, Dreifuss FE, Rak I, Santilli N, Homzie R, Dodson E, Glauser T, Sackellares C, Olson L, Garafolo EA, Shields WD, French J, Sperling M, Kramer LD, Kamin M, Rosenberg A, Shumaker R, Perhach JL, Dix R,. (1993) The Felbamate Study Group in Lennox-Gastaut Syndrome. Efficacy of Felbamate in Childhood Epileptic Encephalopathy (Lennox-Gastaut Syndrome). New Engl J Med 328: 29-33. (Pubitemid 23011468)
18. Rychlicki F, Zamponi N, Trignani R, Ricciuti RA, Iacoangeli M, Scerrati M,. (2006) Vagus nerve stimulation: clinical experience in drug-resistant pediatric epileptic patients. Seizure 15: 483-490. (Pubitemid 44296061)
19. Sachdeo RC, Glauser TA, Ritter F, Reife R, Lim P, Pledger G,; the Topiramate YL Study Group. (1999) A double-blind, randomized trial of topiramate in Lennox-Gastaut syndrome. Neurology 52: 1882-1887. (Pubitemid 29260904)
20. Schlienger RG, Shapiro LE, Shear NH,. (1998) Lamotrigine-induced severe cutaneous adverse reactions. Epilepsia 39 (Suppl 7): S22-S26. (Pubitemid 28485584)
21. Schmidt D, Löscher W,. (2005) Drug resistance in epilepsy: putative neurobiological and clinical mechanisms. Epilepsia 46: 858-877. (Pubitemid 40847354)
22. Schuele S, Lüders H,. (2008) Intractable epilepsy: management and therapeutic alternatives. Lancet Neurol 7: 514-524. (Pubitemid 351657492)
23. Sherard ES Jr, Steiman GS, Couri D,. (1980) Treatment of childhood epilepsy with valproic acid: results of the first 100 patients in a 6-month trial. Neurology 30: 31-35. (Pubitemid 10160212)
24. Sunaga S, Shimizu H, Sugano H,. (2009) Long-term follow-up of seizure outcomes after corpus callosotomy. Seizure 18: 124-128.
25. Tassinari CA, Ambrosetto G,. (1988) Tonic seizures in the Lennox-Gastaut syndrome: semiology and diferential diagnosis. In, Niedermeyer E, Degen R, (Eds) The Lennox-Gastaut syndrome. Allan R Liss, Inc., New York, pp. 109-124.
26. Thomé-Souza S, Freitas A, Fiore LA, Valente KD,. (2003) Lamotrigine and Valproate: efficacy of Co- Administration in a Pediatric Population. Pediatr Neurol 28: 360-364. (Pubitemid 36876135)
27. Vining EPG,. (2009) Tonic and atonic seizures: medical therapy and ketogenic diet. Epilepsia 50 (Suppl 8): 21-24.
28. Vossler DG, Lee JK, Ko TS,. (1999) Treatment of seizures in subcortical laminar heterotopia with corpus callosotomy and lamotrigine. J Child Neurol 14: 282-288. (Pubitemid 29239183)
29. Wechsler DW,. (2005) Abbreviated scale of intelligence. The Psychological Corporation, San Antonio.