Effects of systemic or nucleus accumbens-directed dopamine D1 receptor antagonism on sucrose seeking in rats

Psychopharmacology

Volumn 216, Issue 2, 2011, Pages 219-233

  Grimm, Jeffrey W ^a   Harkness, John H ^a   Ratliff, Christine ^a   Barnes, Jesse ^a   North, Kindsey ^a   Collins, Stefan ^a  

^a WESTERN WASHINGTON UNIVERSITY   (United States)

Author keywords

Addiction; Craving; Eating disorders; Incubation; Motivation; Relapse

Indexed keywords

8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; DOPAMINE 1 RECEPTOR; DOPAMINE 1 RECEPTOR BLOCKING AGENT; SODIUM CHLORIDE; SUCROSE;

ABSTINENCE; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASSOCIATION; CONTROLLED STUDY; DRUG DOSAGE FORM COMPARISON; DRUG SEEKING BEHAVIOR; MALE; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; REINFORCEMENT; WITHDRAWAL SYNDROME;

ANIMALS; BEHAVIOR, ADDICTIVE; BEHAVIOR, ANIMAL; BENZAZEPINES; CONDITIONING (PSYCHOLOGY); CONDITIONING, OPERANT; CUES; DOPAMINE ANTAGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-SEEKING BEHAVIOR; EXTINCTION, PSYCHOLOGICAL; MALE; NUCLEUS ACCUMBENS; RATS; RATS, LONG-EVANS; RECEPTORS, DOPAMINE D1; SELF ADMINISTRATION; SUCROSE; TIME FACTORS;

EID: 79959930800     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-011-2210-y     Document Type: Article

References (74)

1. AT Alleweireldt RJ Hobbs AR Taylor JL Neisewander 2006 Effects of SCH-23390 infused into the amygdala or adjacent cortex and basal ganglia on cocaine seeking and self-administration in rats Neuropsychopharmacology 31 363 374 15957007 10.1038/sj.npp.1300794 1:CAS:528:DC%2BD28XkvFyntQ%3D%3D (Pubitemid 43113400)
2. AT Alleweireldt SM Weber KF Kirschner BL Bullock JL Neisewander 2002 Blockade or stimulation of D1 dopamine receptors attenuates cue reinstatement of extinguished cocaine-seeking behavior in rats Psychopharmacology (Berl) 159 284 293 10.1007/s002130100904 1:CAS:528:DC%2BD38XisVKltLg%3D (Pubitemid 34143377)
3. RK Bachtell K Whisler D Karanian DW Self 2005 Effects of intra-nucleus accumbens shell administration of dopamine agonists and antagonists on cocaine-taking and cocaine-seeking behaviors in the rat Psychopharmacology (Berl) 183 41 53 10.1007/s00213-005-0133-1 1:CAS:528:DC%2BD2MXhtFemurvK (Pubitemid 41484181)
4. BA Baldo K Sadeghian AM Basso AE Kelley 2002 Effects of selective dopamine D1 or D2 receptor blockade within nucleus accumbens subregions on ingestive behavior and associated motor activity Behav Brain Res 137 165 177 12445722 10.1016/S0166-4328(02)00293-0 1:CAS:528:DC%2BD38Xoslanu78%3D (Pubitemid 35346435)
5. AA Bari RC Pierce 2005 D1-like and D2 dopamine receptor antagonists administered into the shell subregion of the rat nucleus accumbens decrease cocaine, but not food, reinforcement Neuroscience 135 959 968 16111825 10.1016/j.neuroscience.2005.06.048 1:CAS:528:DC%2BD2MXhtVymtrvI (Pubitemid 41408585)
6. D Belin S Jonkman A Dickinson TW Robbins BJ Everitt 2009 Parallel and interactive learning processes within the basal ganglia: relevance for the understanding of addiction Behav Brain Res 199 89 102 18950658 10.1016/j.bbr.2008.09.027
7. JM Bossert GC Poles KA Wihbey E Koya Y Shaham 2007 Differential effects of blockade of dopamine D1-family receptors in nucleus accumbens core or shell on reinstatement of heroin seeking induced by contextual and discrete cues J Neurosci 27 12655 12663 18003845 10.1523/JNEUROSCI.3926-07.2007 1:CAS:528:DC%2BD2sXhsVSgsL%2FL (Pubitemid 350127821)
8. JM Bossert KA Wihbey CL Pickens SG Nair Y Shaham 2009 Role of dopamine D(1)-family receptors in dorsolateral striatum in context-induced reinstatement of heroin seeking in rats Psychopharmacology (Berl) 206 51 60 10.1007/s00213-009-1580-x 1:CAS:528:DC%2BD1MXmvFGntr4%3D
9. KD Brownell TA Wadden 1992 Etiology and treatment of obesity: understanding a serious, prevalent, and refractory disorder J Consult Clin Psychol 60 505 517 1506499 10.1037/0022-006X.60.4.505 1:STN:280: DyaK38znt1OltA%3D%3D
10. M Cador TW Robbins BJ Everitt 1989 Involvement of the amygdala in stimulus-reward associations: interaction with the ventral striatum Neuroscience 30 77 86 2664556 10.1016/0306-4522(89)90354-0 1:STN:280:DyaL1MzhsVertQ%3D%3D (Pubitemid 19159797)
11. SB Caine SC Heinrichs VL Coffin GF Koob 1995 Effects of the dopamine D-1 antagonist SCH 23390 microinjected into the accumbens, amygdala or striatum on cocaine self-administration in the rat Brain Res 692 47 56 8548319 10.1016/0006-8993(95)00598-K 1:CAS:528:DyaK2MXot1yrs7Y%3D
12. BL Carter ST Tiffany 1999 Meta-analysis of cue-reactivity in addiction research Addiction 94 327 340 10605857 10.1046/j.1360-0443.1999.9433273.x 1:STN:280:DC%2BD3c%2FntlOqsg%3D%3D (Pubitemid 29137413)
13. N Chaudhri LL Sahuque PH Janak 2009 Ethanol seeking triggered by environmental context is attenuated by blocking dopamine D1 receptors in the nucleus accumbens core and shell in rats Psychopharmacology (Berl) 207 303 314 10.1007/s00213-009-1657-6 1:CAS:528:DC%2BD1MXhtFOhsrbE
14. AR Childress PD Mozley W McElgin J Fitzgerald M Reivich CP O'Brien 1999 Limbic activation during cue-induced cocaine craving Am J Psychiatry 156 11 18 9892292 1:STN:280:DyaK1M7gsleisg%3D%3D (Pubitemid 29034874)
15. WY Choi C Morvan PD Balsam JC Horvitz 2009 Dopamine D1 and D2 antagonist effects on response likelihood and duration Behav Neurosci 123 1279 1287 20001111 10.1037/a0017702 1:CAS:528:DC%2BC3cXltF2rt74%3D
16. R Ciccocioppo PP Sanna F Weiss 2001 Cocaine-predictive stimulus induces drug-seeking behavior and neural activation in limbic brain regions after multiple months of abstinence: reversal by D(1) antagonists Proc Natl Acad Sci USA 98 1976 1981 11172061 10.1073/pnas.98.4.1976 1:CAS:528:DC%2BD3MXhsVWitrg%3D (Pubitemid 32165608)
17. HS Crombag JW Grimm Y Shaham 2002 Effect of dopamine receptor antagonists on renewal of cocaine seeking by reexposure to drug-associated contextual cues Neuropsychopharmacology 27 1006 1015 12464457 10.1016/S0893-133X(02)00356-1 1:CAS:528:DC%2BD38XptFKis7g%3D (Pubitemid 35447637)
18. P Di Ciano TW Robbins BJ Everitt 2008 Differential effects of nucleus accumbens core, shell, or dorsal striatal inactivations on the persistence, reacquisition, or reinstatement of responding for a drug-paired conditioned reinforcer Neuropsychopharmacology 33 1413 1425 17712353 10.1038/sj.npp.1301522 (Pubitemid 351521725)
19. DH Epstein KL Preston J Stewart Y Shaham 2006 Toward a model of drug relapse: an assessment of the validity of the reinstatement procedure Psychopharmacology (Berl) 189 1 16 10.1007/s00213-006-0529-6 1:CAS:528:DC%2BD28XhtV2rs7jJ (Pubitemid 44607255)
20. DH Epstein J Willner-Reid M Vahabzadeh M Mezghanni JL Lin KL Preston 2009 Real-time electronic diary reports of cue exposure and mood in the hours before cocaine and heroin craving and use Arch Gen Psychiatry 66 88 94 19124692 10.1001/archgenpsychiatry.2008.509
21. SB Floresco CD Blaha CR Yang AG Phillips 2001 Modulation of hippocampal and amygdalar-evoked activity of nucleus accumbens neurons by dopamine: cellular mechanisms of input selection J Neurosci 21 2851 2860 11306637 1:CAS:528:DC%2BD3MXjtVWrs70%3D (Pubitemid 32298226)
22. FA Gonzalez SR Goldberg 1977 Effects of cocaine and d-amphetamine on behavior maintained under various schedules of food presentation in squirrel monkeys J Pharmacol Exp Ther 201 33 43 403281 1:CAS:528:DyaE2sXhs1Gns78%3D (Pubitemid 8085994)
23. JW Grimm AM Fyall DP Osincup 2005 Incubation of sucrose craving: effects of reduced training and sucrose pre-loading Physiol Behav 84 73 79 15642609 10.1016/j.physbeh.2004.10.011 1:CAS:528:DC%2BD2MXisFygtQ%3D%3D (Pubitemid 40092067)
24. JW Grimm BT Hope RA Wise Y Shaham 2001 Neuroadaptation. Incubation of cocaine craving after withdrawal Nature 412 141 142 11449260 10.1038/35084134 1:CAS:528:DC%2BD3MXlsFWnsr0%3D (Pubitemid 32674700)
25. JW Grimm PJ Kruzich RE See 2000 Contingent access to stimuli associated with cocaine self-administration is required for reinstatement of drug-seeking behavior Psychobiology 28 383 386 1:CAS:528:DC%2BD3cXos12htrw%3D
26. JW Grimm M Manaois D Osincup B Wells C Buse 2007 Naloxone attenuates incubated sucrose craving in rats Psychopharmacology (Berl) 194 537 544 10.1007/s00213-007-0868-y 1:CAS:528:DC%2BD2sXhtVynur%2FL (Pubitemid 47492998)
27. JW Grimm D Osincup B Wells M Manaois A Fyall C Buse JH Harkness 2008 Environmental enrichment attenuates cue-induced reinstatement of sucrose seeking in rats Behav Pharmacol 19 777 785 19020412 10.1097/FBP.0b013e32831c3b18
28. F Grodstein R Levine L Troy T Spencer GA Colditz MJ Stampfer 1996 Three-year follow-up of participants in a commercial weight loss program. Can you keep it off? Arch Intern Med 156 1302 1306 8651838 10.1001/archinte.156.12. 1302 1:STN:280:DyaK283lsFGlsA%3D%3D (Pubitemid 26196888)
29. HJ Groenewegen CI Wright AV Beijer P Voorn 1999 Convergence and segregation of ventral striatal inputs and outputs Ann NY Acad Sci 877 49 63 10415642 10.1111/j.1749-6632.1999.tb09260.x 1:STN:280:DyaK1MzksVWgsw%3D%3D (Pubitemid 29351850)
30. CN Haile TA Kosten 2001 Differential effects of D1- and D2-like compounds on cocaine self-administration in Lewis and Fischer 344 inbred rats J Pharmacol Exp Ther 299 509 518 11602661 1:CAS:528:DC%2BD3MXnvV2qsbY%3D (Pubitemid 32979662)
31. AS Hamlin KE Blatchford GP McNally 2006 Renewal of an extinguished instrumental response: neural correlates and the role of D1 dopamine receptors Neuroscience 143 25 38 16949214 10.1016/j.neuroscience.2006.07.035 1:CAS:528:DC%2BD28XhtFKls77K (Pubitemid 44667307)
32. AS Hamlin KJ Clemens GP McNally 2007 Renewal of extinguished cocaine-seeking Neuroscience 151 659 670 18164822 10.1016/j.neuroscience.2007. 11.018
33. JH Harkness S Webb JW Grimm 2009 Abstinence-dependent transfer of lithium chloride-induced sucrose aversion to a sucrose-paired cue in rats Psychopharmacology (Berl) 208 521 530 10.1007/s00213-009-1755-5
34. PC Holland H Lasseter I Agarwal 2008 Amount of training and cue-evoked taste-reactivity responding in reinforcer devaluation J Exp Psychol Anim Behav Process 34 119 132 18248119 10.1037/0097-7403.34.1.119 (Pubitemid 351240978)
35. R Ito TW Robbins BL McNaughton BJ Everitt 2006 Selective excitotoxic lesions of the hippocampus and basolateral amygdala have dissociable effects on appetitive cue and place conditioning based on path integration in a novel Y-maze procedure Eur J Neurosci 23 3071 3080 16819997 10.1111/j.1460-9568.2006. 04883.x (Pubitemid 43882887)
36. A Jansen N Theunissen K Slechten C Nederkoorn B Boon S Mulkens A Roefs 2003 Overweight children overeat after exposure to food cues Eat Behav 4 197 209 15000982 10.1016/S1471-0153(03)00011-4 (Pubitemid 36790730)
37. CD Kilts KL Dew TD Ely RB Mailman 1985 Quantification of R-(+)-7-chloro-8-hydroxy-1-phenyl-2, 3, 4, 5-tetrahydro-1H-3-methyl-3- benzazepine in brain and blood by use of reversed-phase high-performance liquid chromatography with electrochemical detection J Chromatogr 342 452 457 2865269 10.1016/S0378-4347(00)84543-0 1:CAS:528:DyaL2MXmtVGgtrs%3D (Pubitemid 15243696)
38. E Koya JL Uejima KA Wihbey JM Bossert BT Hope Y Shaham 2009 Role of ventral medial prefrontal cortex in incubation of cocaine craving Neuropharmacology 56 177 185 18565549 10.1016/j.neuropharm.2008.04.022 1:CAS:528:DC%2BD1MXhsVKisA%3D%3D
39. B Lex W Hauber 2010 The role of nucleus accumbens dopamine in outcome encoding in instrumental and Pavlovian conditioning Neurobiol Learn Mem 93 283 290 19931626 10.1016/j.nlm.2009.11.002 1:CAS:528:DC%2BC3cXisFOitbg%3D
40. YQ Li FQ Li XY Wang P Wu M Zhao CM Xu Y Shaham L Lu 2008 Central amygdala extracellular signal-regulated kinase signaling pathway is critical to incubation of opiate craving J Neurosci 28 13248 13257 19052216 10.1523/JNEUROSCI.3027-08.2008 1:CAS:528:DC%2BD1cXhsV2mur%2FE
41. X Liu C Jernigen M Gharib S Booth AR Caggiula AF Sved 2010 Effects of dopamine antagonists on drug cue-induced reinstatement of nicotine-seeking behavior in rats Behav Pharmacol 21 153 160 20168211 10.1097/FBP. 0b013e328337be95 1:CAS:528:DC%2BC3cXjs1GitLg%3D
42. X Liu F Weiss 2002 Reversal of ethanol-seeking behavior by D1 and D2 antagonists in an animal model of relapse: differences in antagonist potency in previously ethanol-dependent versus nondependent rats J Pharmacol Exp Ther 300 882 889 11861794 10.1124/jpet.300.3.882 1:CAS:528:DC%2BD38XitVemtbk%3D (Pubitemid 34164992)
43. L Lu BT Hope J Dempsey SY Liu JM Bossert Y Shaham 2005 Central amygdala ERK signaling pathway is critical to incubation of cocaine craving Nat Neurosci 8 212 219 15657599 10.1038/nn1383 1:CAS:528:DC%2BD2MXnslKlsg%3D%3D (Pubitemid 40194052)
44. A Markou F Weiss LH Gold B Caine G Schulteis GF Koob 1993 Animal models of drug craving Psychopharmacology 112 163 182 7871016 10.1007/BF02244907 1:CAS:528:DyaK3sXms1Wrurk%3D (Pubitemid 23278275)
45. Y Mashhoon LA Tsikitas KM Kantak 2009 Dissociable effects of cocaine-seeking behavior following D1 receptor activation and blockade within the caudal and rostral basolateral amygdala in rats Eur J Neurosci 29 1641 1653 19419427 10.1111/j.1460-9568.2009.06705.x
46. JH Mendelson NK Mello 1996 Management of cocaine abuse and dependence N Engl J Med 334 965 972 8596599 10.1056/NEJM199604113341507 1:CAS:528: DyaK28XislKmsbc%3D (Pubitemid 26114164)
47. SG Nair T Adams-Deutsch DH Epstein Y Shaham 2009 The neuropharmacology of relapse to food seeking: methodology, main findings, and comparison with relapse to drug seeking Prog Neurobiol 89 18 45 19497349 10.1016/j.pneurobio. 2009.05.003 1:CAS:528:DC%2BD1MXhtVehurrO
48. E Nann-Vernotica EC Donny GE Bigelow SL Walsh 2001 Repeated administration of the D1/5 antagonist ecopipam fails to attenuate the subjective effects of cocaine Psychopharmacology (Berl) 155 338 347 10.1007/s002130100724 1:CAS:528:DC%2BD3MXkvFShur0%3D (Pubitemid 32523104)
49. M Novak B Halbout EC O'Connor J Rodriguez Parkitna T Su M Chai HS Crombag A Bilbao R Spanagel DN Stephens G Schutz D Engblom 2010 Incentive learning underlying cocaine-seeking requires mGluR5 receptors located on dopamine D1 receptor-expressing neurons J Neurosci 30 11973 11982 20826661 10.1523/JNEUROSCI.2550-10.2010 1:CAS:528:DC%2BC3cXhtF2qsLnF
50. EJ Nunes PA Randall JL Santerre AB Given TN Sager M Correa JD Salamone 2010 Differential effects of selective adenosine antagonists on the effort-related impairments induced by dopamine D1 and D2 antagonism Neuroscience 170 268 280 20600675 10.1016/j.neuroscience.2010.05.068 1:CAS:528: DC%2BC3cXhtVKhu7nO
51. CP O'Brien AR Childress IO Arndt AT McLellan GE Woody I Maany 1988 Pharmacological and behavioral treatments of cocaine dependence: controlled studies J Clin Psychiatry 49 17 22 3276670 (Pubitemid 18060332)
52. Paxinos G, Watson C (2007) The rat brain in stereotaxic coordinates, 6th edn. Elsevier Academic, San Diego
53. G Phillips P Willner D Sampson J Nunn R Muscat 1991 Time-, schedule-, and reinforcer-dependent effects of pimozide and amphetamine Psychopharmacology (Berl) 104 125 131 10.1007/BF02244566 1:CAS:528:DyaK3MXktVSksr0%3D
54. CM Reichel RA Bevins 2009 Forced abstinence model of relapse to study pharmacological treatments of substance use disorder Curr Drug Abuse Rev 2 184 194 19630748 10.2174/1874473710902020184 1:CAS:528:DC%2BD1MXlvVahtLc%3D
55. IN Rusk SJ Cooper 1994 Parametric studies of selective D1 or D2 antagonists: effects on appetitive and feeding behaviour Behav Pharmacol 5 615 622 11224241 10.1097/00008877-199410000-00007 1:CAS:528:DyaK2MXis1Srtrk%3D (Pubitemid 24342989)
56. DJ Sanger 1987 The actions of SCH 23390, a D1 receptor antagonist, on operant and avoidance behavior in rats Pharmacol Biochem Behav 26 509 513 3554270 10.1016/0091-3057(87)90157-2 1:CAS:528:DyaL2sXitVOmu78%3D (Pubitemid 17047722)
57. RE See 2009 Dopamine D1 receptor antagonism in the prelimbic cortex blocks the reinstatement of heroin-seeking in an animal model of relapse Int J Neuropsychopharmacol 12 431 436 19236732 10.1017/S1461145709000054 1:CAS:528:DC%2BD1MXivFertrk%3D
58. RE See JC Elliott MW Feltenstein 2007 The role of dorsal vs ventral striatal pathways in cocaine-seeking behavior after prolonged abstinence in rats Psychopharmacology (Berl) 194 321 331 10.1007/s00213-007-0850-8 1:CAS:528:DC%2BD2sXhtVWqu7zF (Pubitemid 47389350)
59. RE See PJ Kruzich JW Grimm 2001 Dopamine, but not glutamate, receptor blockade in the basolateral amygdala attenuates conditioned reward in a rat model of relapse to cocaine-seeking behavior Psychopharmacology 154 301 310 11351937 10.1007/s002130000636 1:CAS:528:DC%2BD3MXjsVensL4%3D (Pubitemid 32247191)
60. U Shalev JW Grimm Y Shaham 2002 Neurobiology of relapse to heroin and cocaine seeking: a review Pharmacol Rev 54 1 42 11870259 10.1124/pr.54.1.1 1:CAS:528:DC%2BD38XislOgtLc%3D (Pubitemid 34208828)
61. L Sobik K Hutchison L Craighead 2005 Cue-elicited craving for food: a fresh approach to the study of binge eating Appetite 44 253 261 15876472 10.1016/j.appet.2004.12.001 (Pubitemid 40775749)
62. S Tobin AH Newman T Quinn U Shalev 2009 A role for dopamine D1-like receptors in acute food deprivation-induced reinstatement of heroin seeking in rats Int J Neuropsychopharmacol 12 217 226 18405418 10.1017/S1461145708008778 1:CAS:528:DC%2BD1MXit1ahtrk%3D
63. KM Tye GD Stuber B De Ridder A Bonci PH Janak 2008 Rapid strengthening of thalamo-amygdala synapses mediates cue-reward learning Nature 453 1253 1257 18469802 10.1038/nature06963 1:CAS:528:DC%2BD1cXnslGks7c%3D (Pubitemid 351913592)
64. JL Uejima JM Bossert GC Poles L Lu 2007 Systemic and central amygdala injections of the mGluR2/3 agonist LY379268 attenuate the expression of incubation of sucrose craving in rats Behav Brain Res 181 292 296 17537525 10.1016/j.bbr.2007.04.019 1:CAS:528:DC%2BD2sXmsFygtL0%3D (Pubitemid 46908754)
65. ND Volkow RA Wise 2005 How can drug addiction help us understand obesity? Nat Neurosci 8 555 560 15856062 10.1038/nn1452 1:CAS:528:DC%2BD2MXjsFyktb8%3D (Pubitemid 40594193)
66. TA Wadden 1993 Treatment of obesity by moderate and severe caloric restriction. Results of clinical research trials Ann Intern Med 119 688 693 8363198 1:STN:280:DyaK3szntVyhsw%3D%3D (Pubitemid 23313690)
67. KT Wakabayashi HL Fields SM Nicola 2004 Dissociation of the role of nucleus accumbens dopamine in responding to reward-predictive cues and waiting for reward Behav Brain Res 154 19 30 15302107 10.1016/j.bbr.2004.01.013 1:CAS:528:DC%2BD2cXmsVGisbc%3D (Pubitemid 39070449)
68. GJ Wang ND Volkow PK Thanos JS Fowler 2004 Similarity between obesity and drug addiction as assessed by neurofunctional imaging: a concept review J Addict Dis 23 39 53 15256343 10.1300/J069v23n03-04 (Pubitemid 39045340)
69. F Weiss R Martin-Fardon R Ciccocioppo TM Kerr DL Smith O Ben-Shahar 2001 Enduring resistance to extinction of cocaine-seeking behavior induced by drug-related cues Neuropsychopharmacology 25 361 372 11522464 10.1016/S0893-133X(01)00238-X 1:CAS:528:DC%2BD3MXmtFSqs7c%3D (Pubitemid 32777787)
70. R Weissenborn V Deroche GF Koob F Weiss 1996 Effects of dopamine agonists and antagonists on cocaine-induced operant responding for a cocaine-associated stimulus Psychopharmacology 126 311 322 8878347 10.1007/BF02247382 1:CAS:528:DyaK28XlsFelsr8%3D (Pubitemid 26276702)
71. RA Wheeler RM Carelli 2009 Dissecting motivational circuitry to understand substance abuse Neuropharmacology 56 149 159 18625253 10.1016/j.neuropharm.2008.06.028 1:CAS:528:DC%2BD1MXhsVKjug%3D%3D
72. RA Wise 2004 Dopamine, learning and motivation Nat Rev Neurosci 5 483 494 15152198 10.1038/nrn1406 1:CAS:528:DC%2BD2cXktVyisL4%3D (Pubitemid 38715515)
73. RA Wise J Spindler H deWit GJ Gerberg 1978 Neuroleptic-induced "anhedonia" in rats: pimozide blocks reward quality of food Science 201 262 264 566469 10.1126/science.566469 1:CAS:528:DyaE1cXlsVSms7w%3D (Pubitemid 8396751)
74. IA Yun SM Nicola HL Fields 2004 Contrasting effects of dopamine and glutamate receptor antagonist injection in the nucleus accumbens suggest a neural mechanism underlying cue-evoked goal-directed behavior Eur J Neurosci 20 249 263 15245497 10.1111/j.1460-9568.2004.03476.x (Pubitemid 38932145)