Inflammation promotes the loss of adeno-associated virusmediated transgene expression in mouse liver

Gastroenterology

Volumn 141, Issue 1, 2011, Pages

  Breous, Ekaterina ^a   Somanathan, Suryanarayan ^a   Bell, Peter ^a   Wilson, James M ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b NONE   (United States)

Author keywords

Hepatic Gene Therapy; Immune Response; Liver Inflammation; Loss of Tolerance

Indexed keywords

TUMOR NECROSIS FACTOR ALPHA;

ADENO ASSOCIATED VIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; GENE EXPRESSION; GENE TRANSFER; HEPATITIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENE; TRANSGENE EXPRESSION; VIRUS GENE;

EID: 79959927765     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2011.04.002     Document Type: Article

References (36)

1. R.O. Snyder, C.H. Miao, and G.A. Patijn Persistent and therapeutic concentrations of human factor IX in mice after hepatic gene transfer of recombinant AAV vectors Nat Genet 16 1997 270 276 (Pubitemid 27280211)
2. F. Mingozzi, Y.L. Liu, and E. Dobrzynski Induction of immune tolerance to coagulation factor IX antigen by in vivo hepatic gene transfer J Clin Invest 111 2003 1347 1356 (Pubitemid 36554705)
3. E. Breous, S. Somanathan, and L.H. Vandenberghe Hepatic regulatory T cells and Kupffer cells are crucial mediators of systemic T cell tolerance to antigens targeting murine liver Hepatology 50 2009 612 621
4. D.D. Koeberl, I.E. Alexander, and C.L. Halbert Persistent expression of human clotting factor IX from mouse liver after intravenous injection of adeno-associated virus vectors Proc Natl Acad Sci U S A 94 1997 1426 1431 (Pubitemid 27087867)
5. G. Gao, Q. Wang, and R. Calcedo Adeno-associated virus-mediated gene transfer to nonhuman primate liver can elicit destructive transgene-specific T cell responses Hum Gene Ther 20 2009 930 942
6. H.P. Fischer, M.E. Ortiz-Pallardo, and Y. Ko Chronic liver disease in heterozygous alpha1-antitrypsin deficiency PiZ J Hepatol 33 2000 883 892
7. J.T. Real, S. Martinez-Hervas, and A.B. Garcia-Garcia Circulating mononuclear cells nuclear factor-kappa B activity, plasma xanthine oxidase, and low grade inflammatory markers in adult patients with familial hypercholesterolaemia Eur J Clin Invest 40 2010 89 94
8. S. Ehl, J. Hombach, and P. Aichele Viral and bacterial infections interfere with peripheral tolerance induction and activate CD8+ T cells to cause immunopathology J Exp Med 187 1998 763 774 (Pubitemid 28115192)
9. M. Rocken, J.F. Urban, and E.M. Shevach Infection breaks T-cell tolerance Nature 359 1992 79 82
10. P. Bell, M. Limberis, and G. Gao An optimized protocol for detection of E. coli beta-galactosidase in lung tissue following gene transfer Histochem Cell Biol 124 2005 77 85 (Pubitemid 41253165)
11. M.A. Kay, J.C. Glorioso, and L. Naldini Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics Nat Med 7 2001 33 40 (Pubitemid 32095639)
12. M.P. Limberis, J. Figueredo, and R. Calcedo Activation of CFTR-specific T Cells in cystic fibrosis mice following gene transfer Mol Ther 15 2007 1694 1700 (Pubitemid 47303943)
13. I. Hoerr, R. Obst, and H.G. Rammensee In vivo application of RNA leads to induction of specific cytotoxic T lymphocytes and antibodies Eur J Immunol 30 2000 1 7 (Pubitemid 30011760)
14. E. Breous, S. Somanathan, and J.M. Wilson Identification of the immunodominant cytotoxic T-cell epitope of human alpha-1 antitrypsin Gene Ther 16 2009 1380 1382
15. B. Beutler, and E.T. Rietschel Innate immune sensing and its roots: the story of endotoxin Nat Rev Immunol 3 2003 169 176 (Pubitemid 37328694)
16. C.R. Raetz Biochemistry of endotoxins Annu Rev Biochem 59 1990 129 170
17. G.B. Lipford, M. Bauer, and C. Blank CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: a new class of vaccine adjuvants Eur J Immunol 27 1997 2340 2344 (Pubitemid 27404319)
18. D.M. Klinman, A.K. Yi, and S.L. Beaucage CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma Proc Natl Acad Sci U S A 93 1996 2879 2883 (Pubitemid 26116242)
19. S.W. Lin, S.E. Hensley, and N. Tatsis Recombinant adeno-associated virus vectors induce functionally impaired transgene product-specific CD8+ T cells in mice J Clin Invest 117 2007 3958 3970 (Pubitemid 350224105)
20. V.M. Velazquez, D.G. Bowen, and C.M. Walker Silencing of T lymphocytes by antigen-driven programmed death in recombinant adeno-associated virus vector-mediated gene therapy Blood 113 2009 538 545
21. V.J. Cavanaugh, L.G. Guidotti, and F.V. Chisari Inhibition of hepatitis B virus replication during adenovirus and cytomegalovirus infections in transgenic mice J Virol 72 1998 2630 2637 (Pubitemid 28175496)
22. L.G. Guidotti, and F.V. Chisari Noncytolytic control of viral infections by the innate and adaptive immune response Annu Rev Immunol 19 2001 65 91 (Pubitemid 32368030)
23. N. Tao, G.P. Gao, and M. Parr Sequestration of adenoviral vector by Kupffer cells leads to a nonlinear dose response of transduction in liver Mol Ther 3 2001 28 35 (Pubitemid 32509802)
24. L. Wang, H. Wang, and P. Bell Systematic evaluation of AAV vectors for liver directed gene transfer in murine models Mol Ther 18 2010 118 125
25. J.A. Solis-Herruzo, D.A. Brenner, and M. Chojkier Tumor necrosis factor alpha inhibits collagen gene transcription and collagen synthesis in cultured human fibroblasts J Biol Chem 263 1988 5841 5845
26. R.S. Sung, L. Qin, and J.S. Bromberg TNFalpha and IFNgamma induced by innate anti-adenoviral immune responses inhibit adenovirus-mediated transgene expression Mol Ther 3 2001 757 767 (Pubitemid 32509872)
27. T. Andus, T. Geiger, and T. Hirano Action of recombinant human interleukin 6, interleukin 1 beta and tumor necrosis factor alpha on the mRNA induction of acute-phase proteins Eur J Immunol 18 1988 739 746
28. J.R. Wispe, J.C. Clark, and B.B. Warner Tumor necrosis factor-alpha inhibits expression of pulmonary surfactant protein J Clin Invest 86 1990 1954 1960
29. E.G. Rhee, J.N. Blattman, and S.P. Kasturi Multiple innate immune pathways contribute to the immunogenicity of recombinant adenovirus vaccine vectors J Virol 85 2011 315 323
30. Q. Zhu, C. Egelston, and S. Gagnon Using 3 TLR ligands as a combination adjuvant induces qualitative changes in T cell responses needed for antiviral protection in mice J Clin Invest 120 2010 607 616
31. T. Warger, P. Osterloh, and G. Rechtsteiner Synergistic activation of dendritic cells by combined Toll-like receptor ligation induces superior CTL responses in vivo Blood 108 2006 544 550 (Pubitemid 44061354)
32. C. Pasare, and R. Medzhitov Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells Science 299 2003 1033 1036 (Pubitemid 36222922)
33. Z. Urry, E. Xystrakis, and D.F. Richards Ligation of TLR9 induced on human IL-10-secreting Tregs by 1alpha,25-dihydroxyvitamin D3 abrogates regulatory function J Clin Invest 119 2009 387 398
34. G. Peng, Z. Guo, and Y. Kiniwa Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function Science 309 2005 1380 1384 (Pubitemid 41209366)
35. A. Mencin, J. Kluwe, and R.F. Schwabe Toll-like receptors as targets in chronic liver diseases Gut 58 2009 704 720
36. H. Kanzler, F.J. Barrat, and E.M. Hessel Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists Nat Med 13 2007 552 559 (Pubitemid 46830615)