Methylenetetrahydrofolate reductase 677 C->T polymorphism: A link between birth weight and insulin resistance in obese adolescents

International Journal of Pediatric Obesity

Volumn 6, Issue 2 -2, 2011, Pages

  Frelut, Marie Laure ^a   Nicolas, Jean Pierre ^b   Guilland, Jean Claude ^c   De Courcy, Genevieve Potier ^d  

^a université Paris Cité   (France)

^b INSERM   (France)

^c DIJON UNIVERSITY HOSPITAL   (France)

^d UNIVERSITÉ PARIS 13   (France)

Author keywords

Genetics; Growth; Insulin; Methylenetetrahydrofolate reductase; Obesity

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); HEMOGLOBIN A1C; HOMOCYSTEINE; LEPTIN; LIPID;

ADOLESCENT; ARTICLE; BIRTH WEIGHT; BODY COMPOSITION; BODY HEIGHT; BODY MASS; CARDIOVASCULAR RISK; DIASTOLIC BLOOD PRESSURE; FEMALE; FOLATE METABOLISM; GENE MUTATION; GENETIC POLYMORPHISM; GLUCOSE BLOOD LEVEL; HETEROZYGOTE; HOMOZYGOTE; HUMAN; INSULIN RESISTANCE; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD; OBESITY; PRIORITY JOURNAL; SYSTOLIC BLOOD PRESSURE; WEIGHT REDUCTION;

ADOLESCENT; AGE FACTORS; AGING; ANALYSIS OF VARIANCE; BIRTH WEIGHT; BLOOD GLUCOSE; BODY MASS INDEX; CHILD; CHILD, PRESCHOOL; FEMALE; FRANCE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HETEROZYGOTE; HOMOZYGOTE; HUMANS; INFANT; INFANT, NEWBORN; INSULIN; INSULIN RESISTANCE; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); OBESITY; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK ASSESSMENT; RISK FACTORS;

EID: 79959924145     PISSN: 17477166     EISSN: 17477174     Source Type: Journal    
DOI: 10.3109/17477166.2010.486835     Document Type: Article

References (40)

1. Bokor S, Frelut ML, Vania A et al. Prevalence of metabolic syndrome in European obese children. Int J Pediatr Obes. 2008;3 Suppl 2:3-8.
2. Ekelund U, Ong KK, Linne Y et al. Association of weight gain in infancy and early childhood with metabolic risk in young adults. J Clin Endocrinol Metab. 2007;92:98-103. (Pubitemid 46067515)
3. Ong KK. Size at birth, postnatal growth and risk of obesity. Horm Res. 2006;65 Suppl 3:65-9. (Pubitemid 44689435)
4. Harder T, Rodekamp E, Schellong K et al. Birth weight and subsequent risk of type 2 diabetes: a meta-analysis. Am J Epidemiol. 2007;165:849-57. (Pubitemid 46536657)
5. Lunde A, Melve KK, Gjessing HK et al. Genetic and environmental infl uences on birth weight, birth length, head circumference, and gestational age by use of population-based parent-offspring data. Am J Epidemiol. 2007;165:734-41. (Pubitemid 46434610)
6. Le Stunff C, Bougneres P. Early changes in postprandial insulin secretion, not in insulin sensitivity, characterize juvenile obesity. Diabetes. 1994;43:696-702. (Pubitemid 24138784)
7. Dos Santos C, Fallin D, Le Stunff C et al. INS VNTR is a QTL for the insulin response to oral glucose in obese children. Physiol Genomics. 2004;16:309-13. (Pubitemid 38420049)
8. Le Fur S, Auffray C, Letourneur F et al. Heterogeneity of class I INS VNTR allele association with insulin secretion in obese children. Physiol Genomics. 2006;25:480-4. (Pubitemid 43764769)
9. Hall JG, Solehdin F. Folate and its various ramifi cations. Adv Pediatr. 1998;45:1-35.
10. Goyette P, Sumner JS, Milos R et al. Human methylenetetrahydrofolate reductase: isolation of cDNA mapping and mutation identifi cation. Nat Genet. 1994;7:551. (Pubitemid 24308346)
11. Goyette P, Frosst P, Rosenblatt DS et al. Seven novel mutations in the methylenetetrahydrofolate reductase gene and genotype/phenotype correlations in severe methylenetetrahydrofolate reductase defi ciency. Am J Hum Genet. 1995;56: 1052-9.
12. Gueant-Rodriguez RM, Gueant JL, Debard R et al. Prevalence of methylenetetrahydrofolate reductase 677T and 1298C alleles and folate status: a comparative study in Mexican, West African, and European populations. Am J Clin Nutr. 2006;83:701-7. (Pubitemid 44699219)
13. Donnelly JG. Folic acid. Crit Rev Clin Lab Sci. 2001;38: 183-223. (Pubitemid 32614075)
14. Lucock M, Yates Z. Folic acid - vitamin and panacea or genetic time bomb? Nat Rev Genet. 2005;6:235-40. (Pubitemid 40293033)
15. Sinclair KD, Allegrucci C, Singh R et al. DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status. Proc Natl Acad Sci U S A. 2007;104:19351-6.
16. Glanville T, Yates Z, Ovadia L et al. Fetal folate C677T methylenetetrahydrofolate reductase gene polymorphism and low birth weight. J Obstet Gynaecol. 2006;26:11-4. (Pubitemid 43062144)
17. Lewis SJ, Lawlor DA, Nordestgaard BG et al. The methylenetetrahydrofolate reductase C677T genotype and the risk of obesity in three large population-based cohorts. Eur J Endocrinol. 2008;159:35-40. (Pubitemid 351969128)
18. Brulhart MC, Dussoix P, Ruiz J et al. The (Ala-Val) mutation of methylenetetrahydrofolate reductase as a genetic risk factor for vascular disease in non-insulin-dependent diabetic patients. Am J Hum Genet. 1997;60:228-9. (Pubitemid 26427797)
19. Frelut ML, Emery-Fillon N, Guilland JC et al. Alanine amino transferase concentrations are linked to folate intakes and methylenetetrahydrofolate reductase polymorphism in obese adolescent girls. J Pediatr Gastroenterol Nutr. 2006;43: 234-9. (Pubitemid 44180511)
20. Angulo P. Nonalcoholic fatty liver disease. N Engl J Med. 2002;346:1221-31.
21. Matthews DR, Hosker JP, Rudenski AS et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412-9. (Pubitemid 15018832)
22. Barker DJ. Intrauterine programming of adult disease. Mol Med Today. 1995;1:418-23.
23. Le Stunff C, Dechartres A, Miraglia Del Giudice E et al. A single-nucleotide polymorphism in the p110beta gene promoter is associated with partial protection from insulin resistance in severely obese adolescents. J Clin Endocrinol Metab. 2008;93:212-5.
24. Le Stunff C, Fallin D, Schork NJ et al. The insulin gene VNTR is associated with fasting insulin levels and development of juvenile obesity. Nat Genet. 2000;26:444-6.
25. Gluckman PD, Hanson MA, Cooper C et al. Effect of in utero and early-life conditions on adult health and disease. N Engl J Med. 2008;359:61-73.
26. Wilson PW, Umpierrez GE. Insulin resistance and pubertal changes. J Clin Endocrinol Metab. 2008;93:2472-3. (Pubitemid 352008507)
27. Morino K, Petersen KF, Shulman GI. Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction. Diabetes. 2006;55 Suppl 2:S9 - 15.
28. Dao HH, Frelut ML, Peres G et al. Effects of a multidisciplinary weight loss intervention on anaerobic and aerobic aptitudes in severely obese adolescents. Int J Obes Relat Metab Disord. 2004;28:870-8. (Pubitemid 39005687)
29. Le Fur S, Le Stunff C, Bougneres P. Increased insulin resistance in obese children who have both 972 IRS-1 and 1057 IRS-2 polymorphisms. Diabetes. 2002;51 Suppl 3: S304 - 7. (Pubitemid 35403408)
30. Ong KK, Emmett P, Northstone K et al. Infancy weight gain predicts childhood body fat and age at menarche in girls. J Clin Endocrinol Metab. 2009;94(5):1527-32.
31. Vidailhet M, Bocquet A, Bresson JL et al. [Folic acid and prevention of neural tube closure defects: the question is not solved yet]. Arch Pediatr. 2008;15:1223-31.
32. Nurk E, Tell GS, Refsum H et al. Associations between maternal methylenetetrahydrofolate reductase polymorphisms and adverse outcomes of pregnancy: the Hordaland Homocysteine Study. Am J Med. 2004;117:26-31. (Pubitemid 38798017)
33. Hernandez-Diaz S, Wu XF, Hayes C et al. Methylenetetrahydrofolate reductase polymorphisms and the risk of gestational hypertension. Epidemiology. 2005;16:628-34. (Pubitemid 41233616)
34. Relton CL, Pearce MS, Burn J et al. An investigation of folate-related genetic factors in the determination of birthweight. Paediatr Perinat Epidemiol. 2005;19:360-7. (Pubitemid 41232384)
35. Yajnik CS, Deshpande SS, Jackson AA et al. Vitamin B12 and folate concentrations during pregnancy and insulin resistance in the offspring: the Pune Maternal Nutrition Study. Diabetologia. 2008;51:29-38. (Pubitemid 350197985)
36. Klerk M, Verhoef P, Clarke R et al. MTHFR 677C-> T polymorphism and risk of coronary heart disease: a metaanalysis. JAMA. 2002;288:2023-31. (Pubitemid 35204693)
37. Lewis SJ, Ebrahim S, Davey Smith G. Meta-analysis of MTHFR 677C-> T polymorphism and coronary heart disease: does totality of evidence support causal role for homocysteine and preventive potential of folate? BMJ. 2005; 331:1053.
38. Cardo E, Monros E, Colome C et al. Children with stroke: polymorphism of the MTHFR gene, mild hyperhomocysteinemia, and vitamin status. J Child Neurol. 2000;15: 295-8. (Pubitemid 30341360)
39. Tounian P, Aggoun Y, Dubern B et al. Presence of increased stiffness of the common carotid artery and endothelial dysfunction in severely obese children: a prospective study. Lancet. 2001;358:1400-4. (Pubitemid 33055740)
40. Dunger DB, Petry CJ, Ong KK. Genetic variations and normal fetal growth. Horm Res. 2006;65 Suppl 3:34-40. (Pubitemid 44689431)